著者

官沢 文彦 星 昭夫 榑谷 和男

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.65, no.1, pp.55-60, 1974-02-28 (Released:2008-10-23)

参考文献数

22

被引用文献数

3

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Interaction of antitumor agents in activity and in toxicity was examined separately. Ascites sarcoma-180 and ddN mice were used as the tumor system.Interaction was evaluated on the concept of pharmacological synergism and not of therapeutic synergism. In activity, 18 out of 91 combinations provided synergism and most of them contained alkylating agents and antibiotics. Antitumor agents were therefore classified into two groups from the point of drug interaction. Synergism was observed in combinations of agents in Group I, alkylating agents, antibiotics, and alkaloids. In combination of agents in Group II (antimetabolites and others), additive action was observed. As a result, 18, 65, and 8 combinations provided synergism, additive action, and antagonism, respectively.On the other hand, in toxicity, 13, 27, and 38 out of 78 combinations provided synergism, additive action, and antagonism, respectively. The combination that provided synergism in activity and antagonism in toxicity were 8 out of 91 combinations tested. In general, fortunately, combinations of antitumor agents were more than additive in activity and less than additive in toxicity.

著者

星 昭夫 池川 哲郎 池田 善明 白川 貞雄 飯郷 正明 榑谷 和男 福岡 文子

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.67, no.2, pp.321-326, 1976-04-30 (Released:2008-10-23)

参考文献数

13

---

The antitumor activity of berberine, berberrubine, and their derivatives against sarcoma-180 ascites was determined by the total packed cell volume method. Berberine and tetrahydroberberine derivatives had no antitumor activity, but berberrubine (9-demethylberberine) and the ester derivatives of berberrubine had a strong antitumor activity. ED90 of berberrubine, its acetate and benzoate, were 15, 23, and 44mg/kg, respectively. The therapeutic indices (LD10/ED90 by the present method) of these compounds were as follows: Berberrubine hydrochloride, 6.7∼9.4; 9-acetyl-9-demethylberberine (9-acetylberberrubine) chloride, 7.6∼8.7; 9-benzoyl-9-demethylberberine (9-benzoylberberrubine) chloride, 3.4∼4.9.

著者

Sandro GRILLI Giancarlo ARFELLINI Annamaria COLACCI Mario MAZZULLO Giorgio PRODI

出版者

The Japanese Cancer Association

雑誌

Japanese Journal of Cancer Research GANN (ISSN:09105050)

巻号頁・発行日

vol.76, no.8, pp.745-751, 1985 (Released:2008-03-17)

参考文献数

17

被引用文献数

1

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At 22hr after ip injection into male Wistar rats and BALB/c mice, chlorobenzene was covalently bound to DNA, RNA and proteins of the liver, kidney and lung, as has been found with various weak carcinogens. A microsome-mediated interaction with DNA occurred in vitro. The interaction was enhanced by pretreatment in vivo with phenobarbitone but was suppressed by addition of 2-diethylaminoethyl-2, 2-diphenylvalerate•HCl in vitro. These results indicate the involvement of cytochrome P-450. Liver microsomes were efficient bioactivators, whereas cytosol was ineffective. The extent of in vitro interaction of chlorobenzene with synthetic polyribonucleotides was of the same order as that with DNA. Finally, ultraviolet irradiation (λ=254nm or λmax=365nm) activated this environmental contaminant to forms capable of interacting with DNA. The results represent evidence for genotoxicity of chlorobenzene.

著者

藤井 節郎 中村 芳正 武田 節夫 森田 健一 佐藤 俊幸 丸中 照義 川口 安郎 采見 憲男

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.71, no.1, pp.30-44, 1980-02-29 (Released:2008-10-23)

参考文献数

14

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The metabolism, antitumor activity, and acute toxicity of 5-fluoro-1, 3-bis-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FD-1) were investigated in animals, compared with 5-fluoro-1-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FT). It was found that after oral administration of FD-1, the level of 5-fluorouracil (5-FU) was maintained higher and longer than after administration of FT, and that a large amount of 5-FU was released from FD-1 by liver microsomal drugmetabolizing enzymes or spontaneous hydrolysis via 5-fluoro-3-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (3-FT) and FT. FD-1 had a significant activity against the solid form of Ehrlich carcinoma, sarcoma-180, hepatoma AH130, Yoshida sarcoma, Walker carcinosarcoma-256, and leukemia L1210 and P388, but not the ascitic forms, and it produced greater inhibition of tumor growth than FT. The acute toxicity of FD-1 was less than that of FT.

著者

中島 松一 小野 史郎 林 宏仁

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.65, no.5, pp.411-416, 1974-10-31 (Released:2008-10-23)

参考文献数

25

---

Both humoral and cell-mediated immunity were suppressed by four intravenous injections of 100μg each of 4-hydroxyaminoquinoline 1-oxide, employing bacterial α-amylase and picryl chloride as antigens. Preimmunization of mice with diazotized 4-aminoquinoline 1-oxide-conjugated rabbit serum protein by the use of complete Freund's adjuvant prevented immunosuppression by 4-hydroxyaminoquinoline 1-oxide. Anti-hapten titers of these mice were 25 to 28 estimated by passive hemagglutination during the course of the experiments. Passive immunization by transfer of the specific anti-hapten antibody induced prevention from immunosuppression by the reagent. Therefore, it was suggested that the humoral anti-hapten antibody might play an important role in preventing mice from immunosuppression by the reagent by preimmunization with the hapten-carrier conjugate.

著者

Shozo TAKAYAMA Yoko NAKATSURU Mitsunobu MASUDA Hiroko OHGAKI Shigeaki SATO Takashi SUGIMURA

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.75, no.6, pp.467-470, 1984 (Released:2008-03-17)

参考文献数

22

---

The mutagenic compound 2-amino-3-methylimidazo[4, 5-f]quinoline, originally isolated from broiled sardines and also present in cooked beef and beef extract, is being tested for carcinogenicity in F344 rats of both sexes. High incidences of tumors of the Zymbal gland, colon, small intestine and liver in males have been observed in the first 300 days of the experiment.

著者

Mitsuaki MAEDA Noriko A. UCHIDA Takuma SASAKI

出版者

The Japanese Cancer Association

雑誌

Japanese Journal of Cancer Research GANN (ISSN:09105050)

巻号頁・発行日

vol.77, no.6, pp.523-525, 1986 (Released:2008-03-17)

参考文献数

5

被引用文献数

3

---

Seventeen liposoluble bis (carboxylato)-cyclohexane-1, 2-diammineplatinum (II) and bis (carboxylato)-cis-diammineplatinum(II) complexes were synthesized and tested for antitumor activity against leukemia L1210 cells in mice. The former complexes had excellent antitumor activity without any toxicity to the host at the therapeutic dose when used with lipiodol as a carrier solvent. The latter complexes had neither antitumor activity nor toxicity in vivo. The former complexes were gradually released from lipiodol to saline in vitro; the latter were not. The activity depended on the chain length of the carboxylato residue and also on the molecular shape of the ligand part of the complexes.

著者

Masaya IMOTO Kazuo UMEZAWA Keiko KOMURO Tsutomu SAWA Tomio TAKEUCHI Hamao UMEZAWA

出版者

The Japanese Cancer Association

雑誌

Japanese Journal of Cancer Research GANN (ISSN:09105050)

巻号頁・発行日

vol.78, no.4, pp.329-332, 1987 (Released:2008-03-17)

参考文献数

12

被引用文献数

3

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A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.

著者

河原 修三

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.46, no.2-3, pp.304-305, 1955-09-01 (Released:2008-11-14)

著者

Gerhard N. SCHRAUZER Tammy MOLENAAR Sherri MEAD Klaus KUEHN Hiroshi YAMAMOTO Eiji ARAKI

出版者

The Japanese Cancer Association

雑誌

Japanese Journal of Cancer Research GANN (ISSN:09105050)

巻号頁・発行日

vol.76, no.5, pp.374-377, 1985 (Released:2008-03-17)

参考文献数

15

---

Selenium concentrations in whole blood of Japanese and American women with and without breast cancer and benign fibrocystic breast disease were determined. The observed blood Se levels of healthy Japanese women (0.286±0.021μg/ml) were similar to previously reported values for healthy Japanese adults. The Japanese patients with benign breast disease and with breast cancer exhibited blood selenium concentrations of 0.200±0.045 and 0.195±0.057μg/ml, respectively. The mean blood Se concentration of Japanese breast cancer patients with recurrence was 0.188±0.061μg/ml. The mean blood Se concentrations of healthy American women from San Diego, Calif., were 0.191±0.023μg/ml; of women with benign fibrocystic disease, 0.142±0.010μg/ml; and of breast cancer patients, 0.167±0.032μg/ml. The higher blood Se concentrations of Japanese healthy subjects as compared to healthy Americans can be attributed to differences in the dietary Se intakes; low blood Se concentration may be indicative of increased breast cancer risk.

著者

永田 親義 福井 謙一 米沢 貞次郎 北野 尚男 稲本 善昭 金井 克至 田頭 勇作

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.46, no.2-3, pp.346-348, 1955-09-01 (Released:2008-11-14)

被引用文献数

2

著者

内田 正男 高木 弘

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.48, no.2, pp.205-217, 1957-08-01 (Released:2008-11-14)

参考文献数

21

---

砂川等が新しく合成した p-Phenylenediphosphoric acid tetraethyleneimid (O, O'-p-Phenylene N, N', N", N'''-tetraethylene-tetramidodiphosphate) は Ehrlich 腹水癌腹水型, 皮下腫瘍型, C3H系及びA系ハツカネズミ乳癌 (第一代雑種への移植癌) に対し制癌作用を示した。1) LD50 (マウス)腹腔内注射177~217mg/kg, 皮下注射202~224mg/kg, 静脈注射190~215mg/kg.2) 薬剤を試験管内で Ehrlich 腹水癌腹水に作用させたところ, 該腹水を接種したマウスは全く腹水癌の発生をみなかった。3) 毎日1回6日間連続腹腔内注射で Ehrlich 腹水癌の発生を抑制した。30mg~60mg/kgが有効量とみとめられる。4) Ehrlich 腹水癌細胞の有糸分裂を抑制した。5) Ehrlich 腹水癌皮下腫瘍周囲に皮下注射したが, いちじるしい効果はみとめなかった。6) C3H系マウスに自然発生した乳癌をSM×C3H/F1に移植し, またA系マウスに自然発生した乳癌をddN×A/F1に移植して, 腫瘍周囲に皮下注射したところ, 結節癌の増大抑制をみとみた。

著者

塚本 憲甫 酒井 一夫 網野 三郎

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.47, no.3, pp.661-662, 1956

著者

岩鶴 竜三 河田 肇 増田 泰造 池田 哲夫 川村 祐二

出版者

The Japanese Cancer Association

雑誌

癌 (ISSN:0016450X)

巻号頁・発行日

vol.48, no.4, pp.613-615, 1957