著者

井上哲次郎 著

出版者

富山房

巻号頁・発行日

1900

著者

三宅雪嶺 (雄二郎) 著

出版者

政教社

巻号頁・発行日

1893

著者

Yoshihiko Noguchi Ichiro Tatsuno Keiko Suyama Takahisa Shibata Tomohiko Yoshida Yuko Otsuka Masami Fuse Chikari Takeo Yasushi Saito

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.11, no.6, pp.335-340, 2004 (Released:2005-01-08)

参考文献数

37

被引用文献数

5 8

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Forty Type IIb or IV hyperlipidemic patients (serum triglyceride concentrations were higher than 150 mg/dl) were treated with fenofibrate (300 mg/day) for 12 weeks. Lipid profile and uric acid metabolism were evaluated before and after the treatment; the serum concentrations of total cholesterol and triglyceride respectively decreased from 224 ± 41.9 mg/dl to 199 ± 35.2 mg/dl and from 205 ± 71.7 mg/dl to 134 ± 67.5 mg/dl (p < 0.001). The uric acid concentrations in the serum also significantly decreased from 7.0 ± 1.58 mg/dl to 5.2 ± 1.57 mg/dl (p < 0.001). Fenofibrate treatment did not cause any change in the serum xanthine and hypoxanthine concentrations. Instead the urinary concentrations of uric acid decreased from 7.0 ± 1.58 mg/dl to 5.2 ± 1.57 mg/dl (p < 0.01), while the clearance ratio of uric acid and creatinin increased from 6.1 ± 2.56 to 9.9 ± 3.87 (p = 0.02) by the fenofibrate treatment. Fenofibrate decreases uric acid concentrations in the serum not as a result of inhibition of uric acid production but by increasing the urinary excretion of uric acid.

著者

Jun SATO Yasuhito YAMAMOTO Tsuneaki NAKAMURA Shigeru ISHIDA Yutaka TAKAGI

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.30, no.4, pp.339-347, 2005 (Released:2006-01-11)

参考文献数

14

被引用文献数

3 3

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We evaluated the toxicity of tetradecanoic acid methyl ester sodium salt (C14-MES), a major component of fabric detergents, following the test guidelines of the Organization for Economic Cooperation and Development. The rat acute oral LD50 was 1,000 mg/kg in males and 500 mg/kg in females. Applying the combined repeated dose and reproductive/developmental toxicity screening test (ReproTox), we exposed groups of Crj:CD (SD) IGS rats to C14-MES in the diet at concentrations of 0, 0.3, 0.6, or 1.2%. We observed decreases in fibrinogen levels and longer prothrombin time at the 1.2% treated level in females and decreases in serum triglyceride levels in both sexes at the 0.6% and 1.2% treatment levels, but the effects were not clinically significant. The no-observed-effect-level (NOEL) for repeated dose toxicity was 0.3% (175 mg/kg body weight/day for males, 249 for females). The NOEL for reproduction/developmental toxicity was 1.2% (740 mg/kg for males, 1039 for females). C14-MES was negative in the reverse gene mutation assay and the chromosomal aberration test and did not induce skin sensitization in the guinea pig maximization test. These data confirm that C14-MES is of low hazard potential.

著者

Toshiharu TAKEI Hiroshi ODAKE Kazuaki MIURA Yutaka TAKAGI

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.55, no.3, pp.121-126, 2006 (Released:2006-02-11)

参考文献数

21

被引用文献数

3 4

---

This paper reports the ecotoxicological study of “tetradecanoic acid, 2-sulfo-, 1-methylester, sodium salt (C14MES)”. This salt was synthesized by sulfonating 1-methyl tetradecanoic acid derived from palm oil and coconut oil with sulfur trioxide. The tests were attempted in accordance with the OECD (Organization for Economic Cooperation and Development) Guidelines for the Testing of Chemicals. The 72 h ErC50 exceeded 100 mg/L in the alga growth inhibition test. In the daphnia acute immobilization and reproduction tests, 17.2 mg/L of 48 h EC50 and 4.10 mg/L of NOEC were derived, respectively. These ecotoxicities of C14MES were equivalent to or lower than that of other similar anionic surfactants, such as LAS (linear alkylbenzene sulfonate) or AOS (alpha olefin sulfonate).

著者

山野金蔵 編

出版者

有斐閣

巻号頁・発行日

1908

著者

源光圀 編

出版者

吉川半七

巻号頁・発行日

vol.目録 索引, 1900

出版者

女子高等師範学校

巻号頁・発行日

vol.明治26年12月現在, 1894

出版者

東京人事興信所

巻号頁・発行日

vol.明治44年後期, 1911

著者

BUHLER J.

雑誌

American mathematical monthly

巻号頁・発行日

vol.101, pp.507-519, 1994

被引用文献数

4 17

著者

Kim Young-ho Zhao Jianwei Uosaki Kohei

出版者

American Institute of Physics

雑誌

Journal of Applied Physics (ISSN:00218979)

巻号頁・発行日

vol.94, no.12, pp.7733-7738, 2003-12-15

被引用文献数

8

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Nanosized patterns of tantalum oxide were fabricated on a tantalum substrate by applying a potential pulse utilizing current sensing atomic force microscopy (CSAFM). The dimensions of the dots were strongly dependent on the bias applied, scan rate, and potential pulse duration. By controlling these variables, the minimum size nanodots with full width at half maximum of 35 nm was achieved. Immediately after pattern formation, the electrical properties of the Ta oxide nanodots were measured using CSAFM. The charge transport at the CSAFM tip and the nanosized Ta oxide dot can be described by Poole–Frenkel type conduction. The relative dielectric constant of the nanosized Ta2O5 dots was calculated to be 17.8–24.3, showing that the quality of the oxide was high. In addition, by controlling the substrate bias applied, pulse duration, and tip scan speed, nanosized Ta oxide lines with the desired dimensions were prepared.

著者

増子喜一郎 著

出版者

哲学書院

巻号頁・発行日

1895

著者

ハーパー・リー著 菊池重三郎訳

出版者

暮しの手帖社

巻号頁・発行日

1964

著者

Khondkar Ehteshamul KABIR Daizo HIROWATARI Katsuhiro WATANABE Daizo KOGA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.70, no.1, pp.252-262, 2006 (Released:2006-01-23)

参考文献数

60

被引用文献数

17

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75-kDa chitinase, which showed potential as a biocontrol agent against Japanese pine sawyer, was characterized after purification from the integument of the fifth instar larvae of Bombyx mori by chromatography on diethylaminoethyl (DEAE)-Toyoperal 650 (M), hydroxylapatite, and Fractogel EMD DEAE 650 (M) columns. The optimum pH was 6.0 toward N-acetylchitopentaose (GlcNAc5) and 10 toward glycolchitin. The optimum temperature was 60 °C toward GlcNAc5 and 25 °C toward glycolchitn. The enzyme was stable at pH 7–10 and below 40 °C. Kinetic analysis and reaction-pattern analysis using glycolchitin and N-acetylchitooligosacchraides as substrates indicated that 75-kDa chitinase is an endo- or random-type hydrolytic enzyme to produce the β anomeric product and that it prefers the longer N-acetylchitooligosaccharides, suggesting, together with the N-terminal amino acid sequence, that the 75-kDa chitinase belongs to family 18 of glycosyl hydrolases.

著者

土屋良遵 編

出版者

六盟館

巻号頁・発行日

vol.上, 1905

著者

那珂通世 訳注

出版者

大日本図書

巻号頁・発行日

1907

著者

保田 明夫

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.125, no.5, pp.682-689, 2005 (Released:2005-08-01)

参考文献数

16

被引用文献数

2 2

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The objective of this paper is to give overviews of text mining or textual data mining in Japan from the practical aspects. Text mining is the technology utilized for analyzing large volumes of textual data applying various parameters for purpose of withdrawing useful knowledge and information. The essence of “Mining” is "the discovery of knowledge or information." And target of text mining is to objectively discover and extract knowledge, facts, and meaningful relationships from the text documents. This paper summarizes the related disciplines and application fields which are applied in text mining, and introduces features and application examples of text mining tools.

著者

Matsumoto Makoto Nishimura Takuji

出版者

ACM

雑誌

ACM Transactions on Modeling and Computer Simulation (ISSN:10493301)

巻号頁・発行日

vol.8, no.1, pp.3-30, 1998-01

被引用文献数

131 3937

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A new algorithm called Mersenne Twister (MT) is proposed for generating uniform pseudorandom numbers. For a particular choice of parameters, the algorithm provides a super astronomical period of 219937 - 1 and 623-dimensional equidistribution up to 32-bit accuracy, while using a working area of only 624 words. This is a new variant of the previously proposed generators, TGFSR, modified so as to admit a Mersenne-prime period. The characteristic polynomial has many terms. The distribution up to v bits accuracy for 1 ≤ v ≤ 32 is also shown to be good. An algorithm is also given that checks the primitivity of the characteristic polynomial of MT with computational complexity O(p2) where p is the degree of the polynomial. We implemented this generator in portable C-code. It passed several stringent statistical tests, including diehard. Its speed is comparable to other modern generators. Its merits are due to the efficient algorithms that are unique to polynomial calculations over the two-element field.

著者

濱田 康行

出版者

社団法人 全国信用組合中央協会

雑誌

信用組合

巻号頁・発行日

vol.52, no.5, pp.10-13, 2005-05

著者

藤枝 真宏 小野寺 夏生

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.49, no.2, pp.77-85, 2006 (Released:2006-05-01)

参考文献数

14

被引用文献数

2 2 1

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J-STAGE登載雑誌の論文を引用した論文数および引用した著者の地域分布を,J-STAGE登載の前後で比較した。また,J-STAGE利用団体へのインタビュー,調査対象誌を引用した著者への質問票調査を実施した。これらの結果から,わが国の学術雑誌が電子化されることによって,利用が拡大したか,当該分野への影響力が増したのかどうかを考察した。J-STAGEは流通の促進に貢献しているが,実際に引用に影響を与えるためには,審査レベルの向上や魅力的な記事の掲載等,編集方針の変更によって質を向上させることが必要であることを指摘した。