著者

伊野 陽子 上野 杏莉 舘 知也 大坪 愛実 勝野 隼人 杉田 郁人 兼松 勇汰 吉田 阿希 野口 義紘 堺 千紘 井口 和弘 川上 ちひろ 藤崎 和彦 寺町 ひとみ

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.10, pp.533-551, 2017-10-10 (Released:2018-10-10)

参考文献数

6

被引用文献数

1

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In recent years, multi-occupational collaboration aiming at patient-centered care is required to provide high-quality medical care. However, there are few studies on collaboration between hospitals or clinics and community pharmacies. In this study, we conducted a questionnaire survey to clarify the present conditions and awareness of hospitals or clinics in Gifu City regarding collaboration with community pharmacies. The following activities with community pharmacies were examined in the survey: “I. Participation in regional care meetings,” “II. Case discussion conferences,” “III. Workshops/study conferences,” “IV. Community service,” “V. Sharing information through medical cooperation network,” “VI. Accompanying community pharmacists at home medical care” and future plans for these items. The percentage of non-implementation was 80% or more in Items I, IV and IV in the hospital and 80% or more in items other than III in the clinics. The percentage of respondents who were not planning to implement Item VI was over 70% in the hospital, and the percentage of respondents who were not planning to implement Items I, IV, VI was over 70% in the clinic. In the comparison between the hospital and the clinic, the proportion of current collaboration is significantly higher for II and III in the hospital. For collaboration in the future, the proportion of respondents who were planning to implement these items other than VI was significantly higher in the hospital. Many hospitals and clinics currently do not collaborate with community pharmacies. And more hospitals are considering collaboration with community pharmacies than clinics.

著者

舘 知也 伊野 陽子 島内 あかり 野口 義紘 堺 千紘 井口 和弘 加納 亜紀 寺町 ひとみ

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.2, pp.327-339, 2019-02-01 (Released:2019-02-01)

参考文献数

17

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Construction of regional inclusive care system is being promoted and pharmacists are required to implement multidisciplinary collaboration in order to provide appropriate pharmaceutical care to patients. However, there are few studies on collaboration between medical facilities and community pharmacies. In this study, we conducted a questionnaire survey of community pharmacies in Gifu City, which assessed the experience and attitudes regarding collaboration with other medical facilities. The survey items are: I. Participation in regional care meetings, II. Case discussion conferences, III. Joint workshops/study conferences, IV. Community service, V. Sharing information through medical cooperation network, and VI. Accompanying community pharmacists at home medical care. For the implementation of collaboration, the percentage of “not implemented” were as high as 70% or more in II, IV, V and VI. Regarding the attitudes toward collaboration, more than half of pharmacies answered that they wanted to implement in all items. In the comparison by the number of pharmacists, pharmacies with two or more pharmacists had significantly higher implementation ratios than pharmacies with one pharmacist in IV and V. Regarding the attitudes toward collaboration, pharmacies with two or more pharmacists had significantly higher ratios of considering implementation than pharmacies with one pharmacist in I and VI. Based on the results of this survey, there were many items that were not implemented as collaboration with other medical facilities at community pharmacies. However, many community pharmacies are planning to collaborate with other medical facilities in the future.

著者

山下 修司 野口 義紘 窪田 傑文 井口 和弘 青木 慎也 多根井 重晴 中村 光浩 寺町 ひとみ 杉山 正

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.41, no.3, pp.198-204, 2015-03-10 (Released:2016-03-10)

参考文献数

15

被引用文献数

7 7

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Light emitting diodes (LEDs) are widely used in lighting applications. In this study, we examined the differences in the degree of the color change of various medicines between LED lighting and fluorescent lighting. The degree of the color change of the medicines was evaluated subjectively, by the observation of the evaluator, as well as objectively, using a colorimeter. Noticeable color changes were observed in the Lasix® 20-mg Tablet(Tab), Fluitran® 2-mg Tab, and Phenobal® powder after exposure to either LED lighting or fluorescent lighting. Interestingly, the color change of the Lasix® 20-mg Tab was smaller for the LED lighting than for the fluorescent lighting.

著者

島内 あかり 長沼 美紗 笹岡 沙也加 畠平 春奈 元岡 佑美 長谷川 栞 福田 昌穂 中尾 智史 堺 千紘 横山 聡 伊野 陽子 中村 光浩 井口 和弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.2, pp.259-267, 2018-02-01 (Released:2018-02-01)

参考文献数

13

被引用文献数

1

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The “self-medication tax deduction” system began in Japan in January 2017, allowing people to encourage the use of OTC drugs. Package inserts contain important information for consumers regarding their use. In this study, we first checked whether the items, as required in the notifications of the Japanese Ministry of Health, Labour and Welfare, are described in the package inserts of cold remedies and analgesic antipyretics in OTC drugs. The descriptions of almost all packages checked in this study were based on the notifications, but those of a small number of them were not. Next, we examined the description of the items, unrequired in the notification, but worthy for proper use of drugs; e.g., the description of prohibition for use by “patients with severe hypertension” in case of ibuprofen-containing products, and the description was found in only seven of 180 products. Manufactures should make package inserts along with notifications, including the description for proper use of drugs.

著者

笹岡 沙也加 畠平 春奈 長谷川 栞 元岡 佑美 福田 昌穂 長沼 美紗 梅津 亮冴 中尾 智史 島内 あかり 上田 夏実 平出 耕石 井口 和弘 中村 光浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.1, pp.123-134, 2018 (Released:2018-01-01)

参考文献数

22

被引用文献数

8

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OTC combination cold remedies are widely used in Japan. In the present study, we aimed to evaluate the adverse event profiles of OTC combination cold remedy based on the components using the Japanese Adverse Drug Event Report (JADER) database. The JADER database contained 430587 reports between April 2004 and November 2016. 1084 adverse events associated with the use of OTC combination cold remedy were reported. Reporting odds ratio (ROR) was used to detect safety signals. The ROR values for “skin and subcutaneous tissue disorders”, “hepatobiliary disorders”, and “immune system disorders” stratified by system organ class of the Medical Dictionary for Regulatory Activities (MedDRA) were 9.82 (8.71-11.06), 2.63 (2.25-3.07), and 3.13 (2.63-3.74), respectively. OTC combination cold remedy containing acetaminophen exhibited a significantly higher reporting ratio for “hepatobiliary disorders” than OTC combination cold remedy without acetaminophen. We demonstrated the potential risk of OTC combination cold remedy in a real-life setting. Our results suggested that the monitoring of individuals using OTC combination cold remedy is important.

著者

横山 雄一 井口 和弘 臼井 茂之 平野 和行 ヨコヤマ ユウイチ イグチ カズヒロ ウスイ シゲユキ ヒラノ カズユキ Yuichi YOKOYAMA Kazuhiro IGUCHI Shigeyuki USUI Kazuyuki HIRANO

雑誌

岐阜薬科大学紀要 = The annual proceedings of Gifu Pharmaceutical University

巻号頁・発行日

vol.62, pp.68-74, 2013-06-30

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グリセロールは肝臓における糖新生や脂質合成の材料であるため、肝臓へのグリセロール流入量の変化は様々な代謝経路に変調をきたす。アクアポリン9(AQP9)は、主に肝臓において発現が見られ、水分子のみならず、グリセロールや尿素などの低分子溶質をも透過させるチャネル型膜蛋白質である。AMP-activated protein kinase(AMPK)は生体内のエネルギーセンサーであり、糖・脂質代謝の恒常性維持に働くセリン/スレオニンキナーゼである。本研究では、AMPKの活性化剤である、5-aminoimidazole-4-carboxamide-1--D-ribonucleoside(AICAR)を、ヒト肝癌由来HepG2 細胞に作用させたところ、AQP9 mRNA の発現量が顕著に減少することを確認した。レポータージーンアッセイや転写因子forkhead boxa2(Foxa2)遺伝子をノックダウンさせた実験の結果から、Foxa2 は、AICAR によるAQP9 遺伝子発現抑制に関わる重要な転写調節因子であることを見出した。AICAR により活性化されたAMPK は、Akt のThr-308 残基とSer-473 残基のリン酸化を促し、それに伴いFoxa2 がリン酸化されて核内から核外へと移行することを明らかにした。したがって、肝臓でのグリセロール輸送の観点からAMPK によるコントロールのもとに、AQP9 は肝臓へのグリセロールの流入量を変化させ、糖・脂質代謝調節に寄与している可能性が示唆された。

著者

長谷川 栞 畠平 春奈 長沼 美紗 島内 あかり 笹岡 沙也加 元岡 佑美 福田 昌穂 阿部 純子 中尾 智史 加藤 大和 大森 智史 井口 和弘 中村 光浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.137, no.10, pp.1301-1311, 2017-10-01 (Released:2017-10-01)

参考文献数

36

被引用文献数

2 3

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OTC drugs play an important role in self-medication. OTC analgesic and antipyretic drugs are widely used in Japan. The present study aimed to survey the components of OTC drug package inserts for analgesic and antipyretic drugs and to evaluate the adverse event profiles using the Japanese Adverse Drug Event Report database (JADER). The JADER contains 430587 reports from between April 2004 and November 2016; a total of 750 reports of adverse events resulted from the use of OTC analgesic and antipyretic drugs. The safety signals were detected by the reporting odds ratio (ROR). The ROR values for “Skin & subcutaneous tissue disorders”, “Immune system disorders”, and “Hepatobiliary disorders” stratified by system organ class of the Medical Dictionary for Regulatory Activities (MedDRA) were 7.58 (6.56-8.76), 4.25 (3.51-5.14), and 2.35 (1.93-2.85), respectively. OTC analgesic and antipyretic drugs containing allylisopropylacetylurea (AIAU) exhibited a significantly high reporting ratio of “Skin & subcutaneous tissue disorders” compared with the drugs without AIAU. No difference in the reported incidence of “Hepatobiliary disorders” was found between the drugs with or without acetaminophen. Our results suggested that it was important to monitor patients who use OTC analgesic and antipyretic drug containing AIAU; in particular, careful attention should be paid to skin and subcutaneous tissue disorders.

著者

寺町 ひとみ 杉田 郁人 伊野 陽子 林 勇汰 吉田 阿希 大坪 愛実 上野 杏莉 勝野 隼人 野口 義紘 井口 和弘 舘 知也

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.137, no.9, pp.1177-1184, 2017 (Released:2017-09-01)

参考文献数

21

被引用文献数

4

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We analyzed impression data and the scale of communication skills of students using text mining method to clarify which area a student was conscious of in communication in practical training. The results revealed that students tended to be conscious of the difference between practical hospital training and practical pharmacy training. In practical hospital training, specific expressions denoting relationships were “patient-visit”, “counseling-conduct”, “patient-counseling”, and “patient-talk”. In practical pharmacy training, specific expressions denoting relationships were “patient counseling-conduct”, “story-listen”, “patient-many”, and “patient-visit”. In practical hospital training, the word “patient” was connected to many words suggesting that students were conscious of a patient-centered communication. In practical pharmacy training, words such as “patient counseling”, “patient”, and “explanation” were placed in center and connected with many other words and there was an independent relationship between “communication” and “accept”. In conclusion, it was suggested that students attempted active patient-centered communication in practical hospital training, while they were conscious of listening closely in patient counseling in practical pharmacy training.