著者
富山 健一 舩田 正彦
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.140, no.2, pp.179-192, 2020-02-01 (Released:2020-02-01)
参考文献数
31

In most countries marijuana is regulated by the Single Convention on Narcotic Drugs. In Japan marijuana use is illegal under the Marijuana Control Law. In USA, marijuana is also classified as a schedule I drug, which is the most stringent regulation category under federal law. On the other hand, California became the first state to legalize marijuana for medical uses in 1996. Since then, several other US states have approved marijuana for medical or recreational use. However, marijuana remains completely illegal in most states, while some allow only cannabidiol (CBD) extracted from marijuana for medical use. In June 2018, the US Food and Drug Administration approved Epidiolex, the first marijuana-derived drug, containing purified CBD, to treat certain rare childhood seizure syndromes. Therefore the situation surrounding control of marijuana in USA is complex. Recently, a definite trend toward reconsidering marijuana regulation has been seen around the world, which could have a major impact on marijuana policy in Japan. In this review, we investigated existing medical and recreational marijuana laws in various US states, with a focus on California, which approved recreational use in 2018. Here, we describe the current state of marijuana regulation in terms of both medical and recreational use. In addition, we discuss public safety issues associated with marijuana, including crime, traffic accidents, and emergency department visits from possible marijuana exposure, as well as generated tax revenues, from official marijuana-related reports in Colorado, which legalized marijuana use in 2012.
著者
菅野 翔平 宮治 裕 富山 健
出版者
日本感性工学会
雑誌
日本感性工学会論文誌 (ISSN:18840833)
巻号頁・発行日
vol.14, no.2, pp.315-323, 2015 (Released:2015-04-30)
参考文献数
19

Kawaii is one of the representative concepts of Japan-original Kansei. In this paper, we categorized Kawaii motion of Roomba and investigated the correlation between physical properties of motions and Kawaii-ness. First, we classified motions of Roomba into 10 types. Impressions of those motions were investigated and three of them were found to be Kawaii by subjects. Based on the findings, we formed a hypothesis that variations in acceleration, namely the jerk, affect Kawaii-ness. Second, we evaluated parameters of seven physical properties (position, velocity, acceleration, angle, angular velocity, angular acceleration, and time) of three Kawaii motions of Roomba. Then, we created 24 types of robot motions and evaluated impressions of them. The physical features of created motions were correlated with the Kawaii-ness of them. The result indicated that the jerk certainly affects the Kawaii-ness of motion but not always. It clearly indicated that the Kawaii-ness of motion is multifaceted.
著者
舩田 正彦 富山 健一
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.140, no.2, pp.205-214, 2020-02-01 (Released:2020-02-01)
参考文献数
58

Cannabis use among the younger population in Japan has been steadily increasing. The aim of the present review is to highlight recent knowledge regarding the molecular mechanisms of action and health risks associated with cannabis and synthetic cannabinoid consumption. We investigated the effects of Δ9-tetrahydrocannabinol (THC) and synthetic cannabinoids on place conditioning in ICR mice. Both Δ9-THC and synthetic cannabinoids produce a significant conditioned place preference. These rewarding effects were completely suppressed by the cannabinoid CB1 receptor type antagonist AM251. The cytotoxicological effects of Δ9-THC and synthetic cannabinoids were also characterized in the limbic forebrain of mice in primary culture in vitro. Δ9-THC and synthetic cannabinoids caused cell death in a dose-dependent manner. The rank order of cytotoxicological potency was synthetic cannabinoids>Δ9-THC and related to the agonistic activities of the CB1 receptor. A recent review on the harmful effects of cannabis use in humans reported that behavioral impairments, especially in terms of attention, memory, and complex information-processing ability, can last for many weeks after cessation of cannabis use among heavy users. In addition, cannabis use could be a risk factor for drug dependence and later psychosis among adolescents. The results of animal and human studies suggest that CB1 receptors play an important role in the expression of harmful effects of cannabis and synthetic cannabinoid use. Moreover, concern regarding increasing concentrations of Δ9-THC in cannabis in many countries has been noted, because more potent cannabis may be associated with worse adverse effects.
著者
大和 秀彰 古田 貴之 富山 健
出版者
一般社団法人 日本機械学会
雑誌
日本機械学会論文集C編 (ISSN:18848354)
巻号頁・発行日
vol.77, no.776, pp.1441-1453, 2011 (Released:2011-04-25)
参考文献数
27

This paper presents a new methodology of attitude estimation for cost-effective and small-size inertial measurement units, consisting of tri-axial gyroscope sensors, accelerometers and geo-magnetometers. Introduced for the algorithm development is a quaternion feedback structure, where bias terms in the gyroscope rate information, appearing in the phase-locked loop, are identified with the theoretical guarantee of the global and asymptotical stability. The bias-term identification and modification process is performed continuously without the influence of the disturbance by applying the proposed disturbance detection scheme and a conventional vector matching method. Practical validity of the presented framework is fully evaluated by experiments. The evaluation result shows that the approach in this paper can offer superior drift-free performance with property of disturbance rejection under arbitrary high-frequency test motion of spatial rotation and translation.
著者
菅野 翔平 宮治 裕 富山 健
出版者
日本感性工学会
雑誌
日本感性工学会論文誌 (ISSN:18840833)
巻号頁・発行日
vol.14, no.2, pp.315-323, 2015

Kawaii is one of the representative concepts of Japan-original Kansei. In this paper, we categorized Kawaii motion of Roomba and investigated the correlation between physical properties of motions and Kawaii-ness. First, we classified motions of Roomba into 10 types. Impressions of those motions were investigated and three of them were found to be Kawaii by subjects. Based on the findings, we formed a hypothesis that variations in acceleration, namely the jerk, affect Kawaii-ness. Second, we evaluated parameters of seven physical properties (position, velocity, acceleration, angle, angular velocity, angular acceleration, and time) of three Kawaii motions of Roomba. Then, we created 24 types of robot motions and evaluated impressions of them. The physical features of created motions were correlated with the Kawaii-ness of them. The result indicated that the jerk certainly affects the Kawaii-ness of motion but not always. It clearly indicated that the Kawaii-ness of motion is multifaceted.
著者
舩田 正彦 富山 健一
出版者
公益社団法人 日本薬学会
雑誌
薬学雑誌 (ISSN:00316903)
巻号頁・発行日
vol.140, no.2, pp.205-214, 2020

<p>Cannabis use among the younger population in Japan has been steadily increasing. The aim of the present review is to highlight recent knowledge regarding the molecular mechanisms of action and health risks associated with cannabis and synthetic cannabinoid consumption. We investigated the effects of Δ<sup>9</sup>-tetrahydrocannabinol (THC) and synthetic cannabinoids on place conditioning in ICR mice. Both Δ<sup>9</sup>-THC and synthetic cannabinoids produce a significant conditioned place preference. These rewarding effects were completely suppressed by the cannabinoid CB<sub>1</sub> receptor type antagonist AM251. The cytotoxicological effects of Δ<sup>9</sup>-THC and synthetic cannabinoids were also characterized in the limbic forebrain of mice in primary culture <i>in vitro</i>. Δ<sup>9</sup>-THC and synthetic cannabinoids caused cell death in a dose-dependent manner. The rank order of cytotoxicological potency was synthetic cannabinoids>Δ<sup>9</sup>-THC and related to the agonistic activities of the CB<sub>1</sub> receptor. A recent review on the harmful effects of cannabis use in humans reported that behavioral impairments, especially in terms of attention, memory, and complex information-processing ability, can last for many weeks after cessation of cannabis use among heavy users. In addition, cannabis use could be a risk factor for drug dependence and later psychosis among adolescents. The results of animal and human studies suggest that CB<sub>1</sub> receptors play an important role in the expression of harmful effects of cannabis and synthetic cannabinoid use. Moreover, concern regarding increasing concentrations of Δ<sup>9</sup>-THC in cannabis in many countries has been noted, because more potent cannabis may be associated with worse adverse effects.</p>