著者

山本 郁男 吉村 英敏

出版者

公益社団法人 日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.28, no.5, pp.233-248, 1982-10-30 (Released:2008-05-30)

参考文献数

117

被引用文献数

2 1

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This review is concerned primarily with our recent papers which have been published or presented since 1978. Especially, metabolic conversion of Δ8-THC to Δ8-THC-11-oic acid and to 8α, 9α-epoxyhexahydrocannabinol (8α, 9α-EHHC) and their pharmacological implications are described. Liver microsomes catalyze formation of 11-OH-Δ8-THC from Δ8-THC, 11-oxo-Δ8-THC from 11-OH-Δ8-THC, and 8α, 9α-EHHC from Δ8-THC. The involvement of cytochrome P-450 in these reactions were suggested in vivo as well as in vitro. 11-OH-Δ8-THC was detected and determined as a metabolite in vivo of Δ8-THC in the liver and brain of mice. 11-OH-Δ8-THC, when administered to mice, showed higher distribution in the brain as compared with Δ8-THC. Pharmacological activities of 11-OH-Δ8-THC, 11-oxo-Δ8-THC, Δ8-THC-11-oic acid, 8α, 9α-EHHC, 8β, 9β-EHHC, 9α, 10α-EHHC and 8β, 9α-di OH-HHC were compared with that of Δ8-THC using mice. Pharmacological effect of 11-OH-Δ8-THC, 11-oxo-Δ8-THC, 8β, 9β-EHHC and 9α, 10α-EHHC were more potent than that of Δ8-THC in the cataleptogenic, hypothermic, pentobarbital-induced sleep prolonging, and anticonvulsant effects. Daily administration of 11-OH-Δ8-THC or 11-oxo-Δ8-THC as well as Δ8-THC quickly induced tolerance to their hypothermic and pentobarbital-induced sleep-prolonging effects. The LD50s of 11-OH-Δ8-THC, 11-oxo-Δ8-THC and Δ8-THC-11-oic acid are larger than that of Δ8-THC.

著者

山本 郁男

出版者

北陸大学

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:0387074X)

巻号頁・発行日

vol.22, pp.1-16, 1998-12-31

著者

渡辺 和人 木村 敏行 宇佐見 則行 山本 郁男

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:21863989)

巻号頁・発行日

no.38, pp.37-49, 2014-12-31

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There are many novels that deal with marijuana as drug novels. Among them, the novel entitled “Kaigo-nyumon” written by Mr. Norio Mob was to win the Akutagawa Award in 2004. A marijuana user appears in the novel. We thought that a part of the novel was written by the author under the influence of marijuana. This review critically analyzes the contents of the novel from a scientific point of view.

著者

渡辺 和人 木村 敏行 舟橋 達也 山折 大 山本 郁男

出版者

北陸大学

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:0387074X)

巻号頁・発行日

no.28, pp.17-32, 2004-12-31

著者

松永 民秀 渡辺 和人 吉村 英敏 山本 郁男

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.118, no.9, pp.408-414, 1998-09-01

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△^9-Tetrahydrocannabinol (△^9-THC), cannabinol, cannabidiol and cannabichromene were detected in commercially available cannabis seeds by silica gel TLC and gas chromatography. These cannabinoids existed in rather high content (0.10-2.02mg/100g of seeds) in the feed for birds, especially bracts (82.3-441mg/100g). When the suspension prepared from the benzene washing solution of cannabis seeds, BenW, was administered at a dose of 3mg/kg corresponding to △^9-THC into a mouse, i.v., BenW caused hypothermia, catalepsy, pentobarbital-induced sleep prolongation and suppression of locomotor activity. These pharmacological activities of BenW were significantly higher than those of △^9-THC (3mg/kg, i.v.). These results may indicate the necessity to reconsider the present regulations on marihuana.

著者

渡辺 和人 山本 郁男

出版者

公益社団法人 日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.38, no.5, pp.385-396, 1992-10-31 (Released:2008-05-30)

参考文献数

133

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Marihuana is a complex mixture containing various biologically active compounds in which cannabinoids are major components. The drug interaction of marihuana with other drugs is a serious problem in some cases since marihuana is often taken with other centrally-acting drugs. Tetrahydrocannabinol (THC), which is a main component responsible for most of the psychomimetic effects of marihuana, can potentiate the effects of many depressants, such as alcohol, barbiturates, anesthetics, morphine and anticonvulsants, in the central nervous system. The drug interaction of THC with other drugs is a functional mechanism in the central nervous system. THC has biphasic effects (stimulant and depressant) depending on, maily, doses. THC, therefore, interacts with stimulants as cocaine and phencyclidine in a complicated manner. Cross-tolerance in some effects of the components of marihuana and of other drugs has been recognized. Cannabidiol (CBD), which is another major component in marihuana but lacks psychomimetic activity, potentiates the effects of some specified drugs that terminates their effects through metabolic inactivation. The interaction of CBD with other drugs is considered to be metabolic in origin since the cannabinoid can suppress the gepatic microsomal drugmetabolizing enzymes. Drug interaction can also occur among cannabinoids, indicating the complexity of the combined effect of marihuana and other drugs. These are additives, synergistic or antagonistic, depending on the conditions used. This review describes the interactions of marihuana components with centrally-acting drugs in relation to their pharmacological and toxicological significance.

著者

山本 郁男

出版者

北陸大学

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:0387074X)

巻号頁・発行日

vol.16, pp.1-20, 1992-12-31

著者

山本 郁男

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.125, no.1, pp.73-120, 2005-01-01 (Released:2005-01-01)

参考文献数

91

被引用文献数

2 3

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Thirty-six allyl substituted oxopyrimidine analogues such as barbituric acid (BA), barbiturates, uracil, thymine, and related derivatives including 13 new compounds were synthesized and their pharmacologic effects ([hypnotic activity, anticonvulsant activity against pentylentetrazol (PTZ)-induced seizures, and LD50]) and interactions with the barbiturates were evaluated in mice and rats. The results are briefly and parially summarized as follows. BA prolonged pentobarbital (PB)-induced sleep and had some central depressant effects. N,5,5-Triallyl-BA exhibited some hypnotic and anticonvulsant activities, although the other 5,N-allyl-compounds did not show any activity except for allobarbital (AlloB). N-Allyl-BA, 5-allyl-BA, N1,N3,5-triallyl-BA, N,5,5-triallyl-BA, and N1,N3,5,5-tetraallyl-BA also prolonged PB-induced sleep. Interestingly, N,5,5-triallyl-BA was the most potent in the interaction with AlloB, phenobarbital (PheB), amobarbital (AB), PB, and thiopental (TP) but not barbital (B). N1,N3,5,5-Tetraallyl-BA prolonged AlloB-, PB-, and AB-induced sleep but not B-, PheB-, and TP-induced sleep. N1,N3,5-Triallyl-B prolonged only PB- and TP-induced sleep. 5,5-Diallyl-BA prolonged PheB- and TP-induced sleep. N,5-Diallyl-BA prolonged only TP-induced sleep. In contrast, BA and N1,N3,5-triallyl-AB tended to antagonize AlloB, AB, and B. N1,N3,5,5-Tetraallyl-BA also slightly antagonized B, PheB, and TP. 5,5-Diallyl-BA antagonized only AB. The prolonging effects of BA, N,5,5-triallyl-BA, and N1,N3,5,5-tetraallyl-BA on PB-induced sleep were dose dependent. These results indicate that the position and number of allyl groups substituted on the structure of BA play an important role in their depressant activities. This review deals with the structure-activity relationship of allyl-substituted oxopyrimidines as part of our search for antagonists and agonists of barbiturates as well as their mechanisms of action.

著者

山本 郁男

出版者

北陸大学

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:0387074X)

巻号頁・発行日

vol.14, pp.1-15, 1990-12-31

著者

渡辺 和人 木村 敏行 宇佐見 則行 山本 郁男

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:21863989)

巻号頁・発行日

no.38, pp.37-49, 2014-12-31

---

There are many novels that deal with marijuana as drug novels. Among them, the novel entitled "Kaigo-nyumon" written by Mr. Norio Mob was to win the Akutagawa Award in 2004. A marijuana user appears in the novel. We thought that a part of the novel was written by the author under the influence of marijuana. This review critically analyzes the contents of the novel from a scientific point of view.

著者

渡辺 和人 木村 敏行 舟橋 達也 山本 郁男

出版者

北陸大学

雑誌

北陸大学紀要 = Bulletin of Hokuriku University (ISSN:0387074X)

巻号頁・発行日

no.25, pp.15-26, 2001-12-31

著者

山本 郁男 岩井 勝正 井本 真澄 宇佐見 則行 ヤマモト イクオ イワイ カツマサ イモト マスミ ウサミ ノリユキ Ikuo YAMAMOTO Katsumasa IWAI Masumi IMOTO Noriyuki USAMI

雑誌

九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare

巻号頁・発行日

vol.6, pp.277-285, 2005-03-25

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The School of Pharmaceutical Sciences, Kyushu University of Health and Welfare located in Nobeoka City, Miyazaki Prefecture wa founded in April, 2003. This place (Nobeoka) wa famous to be called Himuka(Hyuga), an ancient name, since several handred years ago. Himuka is still used in the historical and sightseeing books. However, it was no reasons why the School of Pharmaceutical Sciences did start at this place, Nobeoka. So, we searched all over the place(Himuka) for some people related to Pharmaceuticla Sciences. As results, Kitsumon AKIZUKI(1989-1981) who lived in Nobeoka during Edo period was picked out among several persons. Although he stayed in Nobeoka only for two years, he had done many great things concerned tin the education, medicine, botany, herbalism, philology and political events. Especially, Kitsumon AKIZUKI invited Hika KAKU, a famous herbalist, from Azimu, Usa (Oita prefecture) and let him investigate and herborize the local herbs near Nobeoka. This paper deals with Kitsumon AKIZUKI and his achievement in his life.

著者

山本 郁男 宇佐見 則行 井本 真澄 岸 信行

出版者

九州保健福祉大学

雑誌

九州保健福祉大学研究紀要 (ISSN:13455451)

巻号頁・発行日

vol.8, pp.187-192, 2007-03-25

被引用文献数

1

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Shouan Watanabe (1613-1699) was one of the most famous men in the history of Hyuga (Nobeoka, Miyazaki). He was a physician during the Edo period, often called the father of medicine in Nobeoka. He was born in Nobeoka and studied both medicine and Jugaku in Kyoto. After his return to Nobeoka, he practiced medicine and opened a private school for young people. Watanabe was ordered by Yasuzumi Arima, then leader of the Nobeoka-Han, to be a teacher for his son, Kiyozumi Arima. Watanabe had over one hundred students. He was not only a physician and teacher, but also a politician. His grave is still in Zenseiji temple in Yamashita-machi, Nobeoka, with writings by Jinsai Ito and Tougai Ito on it. This paper deals with Watanabe himself, the people around him, and the events of his life.

著者

山本 郁男

出版者

日本毒性学会

雑誌

Journal of toxicological sciences (ISSN:03881350)

巻号頁・発行日

vol.20, no.5, pp.App.119-App.124, 1995-11-25

著者

塚田 司郎 出村 礼子 山本 郁男

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.30, no.2, pp.85-90, 1984-04-30

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Fluorometric determination for hydrogen peroxide based on the formation of thiochrome was studied. Thiochrome is oxidation product of thiamine and gives intense fluorescence. Though bromine cyanide or pottasium ferricyanide has been generally used as oxidizing agent of thiamine, it was proved that hydrogen peroxide was useful as oxidizing agent. Then, hydrogen peroxide can be determined from the quantity of produced thiochrome. The analytical procedure was as follows ; to a sample solution containing a proper quantity of hydrogen peroxide, 1 ml of thiamine (30μg/ml), peroxidase (10 units/ml), and sodium hydroxide solution (20%) were added. The mixture was stood for 30 minutes at room temperature and saturated with sodium sulfate. Ten ml of isobutanol was further added and shaken to extract thiochrome produced here. Fluorescence intensity of the separated isobutanol after treatment with sodium sulfate was measured (λEx ; 375 nm, λEm ; 430 nm). The calibration curve was linear up to H_2O_2 0.2μg/tube. On the basis of the proposed method, remaining hydrogen peroxide in Japanese noodle (udon) could be determined with the recovery of 90.6% and coefficient of variation of 1.1%.