著者
岩本 淳一 本多 彰 宮崎 照雄
出版者
東京医科大学
雑誌
基盤研究(C)
巻号頁・発行日
2015-04-01

低栄養性脂肪肝の病態生理を明らかにするために,LC-MS/MSを用いた患者血清のメタボローム解析方法を開発した。それを用いて,しばしば低栄養性脂肪肝を合併するクローン病とシトリン欠損症の患者血清を分析した。クローン病ではLXRの活性化とFXRの不活性化により脂肪酸の合成亢進とβ酸化抑制が認められ,シトリン欠損症ではクエン酸の過剰供給による脂肪酸合成の亢進が観察された。以上のように,原因不明の脂肪肝の病態解明には,血液中代謝物のメタボローム解析が有効であると考えられた。
著者
佐藤 陽治 岩本 淳 久保田 秀明 道上 静香 梅林 薫
出版者
学習院大学
雑誌
学習院大学スポーツ・健康科学センター紀要 (ISSN:13447521)
巻号頁・発行日
vol.8, pp.25-34, 2000-02

Tennis used to be estimated that the exercise intencity was within the AT (Anaerobic Threshold) level formerly according to the preceding studies. There were, however, some reports which indicated that the playing load of modern tennis often overpassed the onset of blood lactate accumulation(OBLA). One of the possible explanations for exceeding the AT level in modern tennis is that the tempo of modern tennis may be rapider than before. Therfore, the present study was desighned to measure and compare the time between one ground stroke and next one in the tennis games respectively at 80's and the present, 1998-1999. The following results, statistically significant at 5% level, were obtained. 1)The rally (ground stroke) tempo at the present, 1998-1999 was rapider than 80's. without distinction of sex, 0.30(sec) in female, 0.14(sec) in male. 2)The rally (ground stroke) tempo of the net player was rapider than baseliner without distinction of sex, 0.20〜0.30(sec) in female at 80's, 0.18〜0.24(sec) in male at 80's, 0.06(sec) in male at 1999. 3)The rally (ground stroke) tempo in female at 80's was approximately 1.61 (sec) and it was 0.16(sec) slower than the tempo in male. The rally (ground stroke) tempo in female at the present, 1999 was equal to the tempo in male. The general conclusions drawn from these data is that the rally (ground stroke) tempo accelerating in modern tennis reinforces the intencity of exercise in tennis.
著者
佐藤 陽治 江口 淳一 岩嶋 孝夫 久保田 秀明 岩本 淳 梅林 薫
出版者
学習院大学
雑誌
学習院大学スポーツ・健康科学センター紀要 (ISSN:13447521)
巻号頁・発行日
vol.11, pp.1-26, 2003-03-31

According as the rally tempo is accelerated remarkablely in recent tennis the service stroke that carrys out a preemptive oppotunity to attack takes on acqire importance more than ever. The tactics on a conbination of the service in tennis consisites of two factors controling the ball that are the speed (pace) and the course (placement or direction) in order to attack and make the open court (space). The present study was designed to investigate the actual conditions of a conbination on the service speed by the male professional tennis players and to throw some light on the tactical effect of a conbination of the service speed. The service speed indicated with the apparatus set up in a corner of the court was taken note. The service speed of the all points for 6 to 9 consecutive service games by six players in three singles matches was recorded. The numerical value of service speed indicated the initial speed. Those three matches were played at the first and second round in Australia Open taken place in 2001. The courts of these three games were the center court (Rod Laver Arena) and the first court (Vodafone Arena). The numbers 8 (ATP ranking is 23 rd.), 9. (ditto 2 nd.) and 28 (ditto 6 th.) seed players were included in these three matches. The investigations yielded the following results. a) There is a significant correlationsip between the first service speed and the height of the players. b) Winners' ratio for gaining point started from the first service ratio are higher than losers. c) The maximum or mean first service speed of winners was rapider than one of lossers. d) The number 28 (ATP ranking is 6 th.)seed player (G. Rusedoski : GBR) who had a rapid first service of prominence among the players participating in the championships did not make frequent use of high speed first services, and made freely use of slow speed first services. e) The player who competed with the number 28 seed player also had high speed first services, maximum and mean speed of his firstservice were respectively 214 (km/h) and 192. 7 (km/h), he made however few use of slow first service, so that his services showed no combination and monotony of first services f) The number 8 seed and 23 rd. ATP ranking player (P. Sampras) had the rapidest mean 2 nd. service speed of significance and the amplitude of speed was also largest. g) A decline in successful ratio of first service developed a tendency to lead the game of confusion, strain and loss. h) There was no common trend in the first service speed of all six players under any point situations. Three players that had the high speed service showed however respective peculiarities of significance under some point situations. From these results mentioned above, following tactical knowledges were noted. As the point percentage from the first service is ordinarily higher than from the 2 nd. service, it is important to raise the ratio of first service for average players in first service speed, and especialy for smaller players. And it is more effectual to use a change-up first service and to make a show of the combination with various service speeds in oder to keep the service game for the players who can hit even high speed first services over 200 (km/h).