著者

粕谷 志郎 後藤 千寿 大友 弘士

出版者

一般社団法人 日本感染症学会

雑誌

感染症学雑誌 (ISSN:03875911)

巻号頁・発行日

vol.62, no.12, pp.1152-1156, 1988-12-20 (Released:2011-09-07)

参考文献数

8

被引用文献数

1 3

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アニサキス幼虫に対する殺虫効果のあるなしを13の食品もしくはその抽出液について検討した.それぞれ乾燥重量に対し5%となるよう生理食塩水にて抽出液を作成し, これにスケトウダラ内臓より採取したアニサキス幼虫を入れ24時間観察した.その結果, アオジソ, ショウガ, ワサビ, ニンニクの4食品の抽出液で完全に虫体の運動を消失 (死亡と推定) させることができた.エタノールは8%以上の=濃度で強い致死効果が認められた.シソ, ワサビの2.5%抽出液ではそれぞれの5%溶液に比し致死率が低下したが, ショウガの2.5%溶液はなお完全な効果を示した.運動停止 (1分間の観察中動きが認められない) までの平均時間はシソ3.1時間, ショウガ3.2時間, ワサビ5.6時間, ニンニク10.8時間であった.ネギ, パセリ, ダイコン, キャベツ, ホウレンソウ, ミツイシコンブ, トウガラシ, チャ (茶) には致死効果は認められなかった.強力な殺虫効果を示したシソ, ショウガの若干の既知成分についてもこのような効果があるか検討し,[6]-shogao1,[6]-gingerol (以上ショウガ), perillaldehyde, perillylalcoho1 (以上アオジソ) のそれぞれが100%致死効果を発揮する最少濃度が62.5μg/ml, 250μg/ml, 125μg/ml, 250μg/mlであることが判明した.一方, 陽性対照に使用したthiabendazoleでは10mg/dlでも死亡虫体を認めなかった.

著者

坪井 謙之介 寺町 ひとみ 葛谷 有美 水井 貴詞 後藤 千寿 土屋 照雄

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.8, pp.522-533, 2012-08-10 (Released:2013-08-10)

参考文献数

24

被引用文献数

18 18

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An important aspect of medicinal treatment is having the patient take the medicines prescribed by the doctor. However, a previous questionnaire about medication compliance and adherence showed that approximately 50% of patients forget to take their medicines. In this study, the status of patient medication-taking behavior and factors affecting adherence were investigated through a survey involving 226 patients who presented at Gifu Municipal Hospital from November 2009 to February 2010. The survey items included patient characteristics (age, sex, occupation, side effects, allergies, etc.), medication status (dosing time, medicine formulations), and factors affecting medication adherence (awareness of taking medication, awareness of illness and medicines, life rhythm, character, relationship of trust with doctor or pharmacist, use of medicine information leaflets). Overall, 73% of patients took medicines as directed. Evaluation by medication adherence status revealed that patients with poor adherence most frequently forgot to take their medicines after lunch and between meals. A separate factor analysis of good and poor medication adherence groups showed significant differences between the groups for 18 of 30 factors. Then, using Customer Satisfaction analysis and excluding factors related to personality, 4 factors for improvement were selected from the remaining 16 factors. These findings suggest that patient medication adherence increases when the factors of “regularity of life rhythm”, “regularity of meals”, “trust in pharmacists”, and “use of medicine information leaflets” are improved.

著者

林 剛 舘 知也 野口 義紘 杉岡 まゆ子 青山 智 田中 和秀 安田 昌宏 後藤 千寿 山田 浩司 水井 貴詞 寺町 ひとみ

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.47, no.9, pp.464-476, 2021-09-10 (Released:2022-09-10)

参考文献数

15

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In this study, we evaluated the effect of risk minimization activities in a risk management plan (RMP) formulated for sodium-glucose cotransporter-2 (SGLT2) inhibitors using both the Japanese Adverse Drug Event Report database (JADER) and real-world clinical data. We extracted data from the JADER, which is maintained by the Pharmaceuticals and Medical Devices Agency, from the first quarter of 2004 to the second quarter of 2020. We also used real-world clinical data of the patients who took SGLT2 inhibitors among those who visited or were admitted to Gifu Municipal Hospital from June 2014 to January 2018. We conducted a comparison before and after implementing the risk minimization activities. We compared the reported rate of clinical trials with the reported rate after marketing using the JADER. In addition, we compared the prevalence rate of the clinical trials of SGLT2 inhibitors with that in real clinical data. Furthermore, we compared the onset of side effects (in days) reported in clinical trials recorded in the JADER with that in real clinical data. The pre/post comparison showed a significant increase in the reported rates of increased ketone body, volume depletion, urinary tract infections, and genital infections. A significant decrease in the prevalence rates for hypoglycemia and increased ketone body was also observed. Moreover, the time to onset of side effects was significantly shortened in volume depletion. In conclusion, the risk minimization activities in RMP would contribute to the increased reported rate, decreased prevalence rate, and early detection of side effects.

著者

後藤 千寿 梅田 道 大澤 友裕 甲田 明英 池上 遼 勝野 隼人 大野 佑城 安田 昌宏 水井 貴詞

雑誌

日本薬学会第140年会(京都)

巻号頁・発行日

2020-02-01

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【目的】ボノプラザンは、カリウムイオン競合型アシッドブロッカーとも呼ばれる、新たな作用機序を有する新しいカテゴリーのプロトンポンプ阻害薬(PPI)である。既存のPPIは、低マグネシウム血症を引き起こすことが報告されているが、ボノプラザンについては報告されていない。今回、ボノプラザンの投与が、既存のPPIと同様に低マグネシウム血症を引き起こすリスク因子であるかについて検討を行ったので報告する。【方法】2016年11月~2018年10月に、岐阜市民病院において血清マグネシウム(S-Mg)の測定がされた患者を対象に、遡及的に調査を行った。調査期間内におけるS-Mgの最低値が施設基準下限値(1.8mg/dL)未満を「未満群」、以上を「以上群」とし、2群間の差の検定にはFisher’s exact testを使用した。さらに、単変量解析においてp<0.2であった因子を独立変数とし、多重ロジスティック回帰分析を行った。なお、いずれもp<0.05の場合を有意差ありと判定した。【結果】対象患者は384名(男性:207名、女性177名)、平均年齢(±SD)は69.4(±17.0)歳であった。多変量解析の結果、「ボノプラザン投与」(オッズ比(OR):2.26、95%信頼区間(CI):1.17 – 4.37、p=0.02)および「マグネシウム製剤投与」(OR:0.42、CI:0.18 – 0.97、p=0.04)において有意差が見られた。【考察】既存のPPIと同様に、ボノプラザンの投与がS-Mg値低下のリスク因子である可能性が示唆された。そのため、新規PPIであるボノプラザンを投与されている患者においても、S-Mg値の低下に注意する必要があると考えられた。

著者

舘 知也 加藤 未紗 大澤 友裕 甲田 明英 福田 聖啓 田中 和秀 青山 智 安田 昌宏 水井 貴詞 後藤 千寿 寺町 ひとみ

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.11, pp.1223-1233, 2013 (Released:2013-11-01)

参考文献数

19

被引用文献数

3 5

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Since April 2011, a dosage adjustment program has been implemented at Gifu Municipal Hospital. In this program, upon receiving a prescription for renally eliminated drugs, pharmacists verify patients' serum creatinine concentrations by using a computerized medical record system to evaluate the patient's kidney function and suggest the appropriate dosage to doctors, if necessary. In our study, we used questionnaires that were administered to pharmacists and doctors at the hospital to investigate their respective working times and the cost of the program, in order to comprehensively analyze the clinical resource costs of the hospital and evaluate the economic burden of the program for levofloxacin. In addition, we studied the pharmacists' and doctors' attitudes toward the program and the circumstances of prescriptions for patients with renal dysfunction. The questionnaire comprised items such as time required for the program; attitude toward the program, including satisfaction; and attitude toward the circumstances of prescriptions for patients with renal dysfunction. The pharmacists' and doctors' working times and cost of the program were obtained from the questionnaire responses. For cost estimation, we used data from this study as well as those of our previous study that suggested that the levofloxacin program was economically beneficial. Furthermore, their attitudes toward the program and circumstances of prescriptions for patients with renal dysfunction were clarified. Regarding the pharmacists' tasks and interventions, we need to not only investigate attitudes toward them but also perform a cost analysis by the method of the economic evaluation of the medical techniques used in our study.

著者

吉田 阿希 舘 知也 兼松 勇汰 杉田 郁人 野口 義紘 大澤 友裕 安田 昌宏 水井 貴詞 後藤 千寿 寺町 ひとみ

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.44, no.1, pp.49-53, 2018-01-10 (Released:2019-01-10)

参考文献数

19

被引用文献数

1

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Recently, the use of complementary alternative medicine (CAM) has been increasing in Japan. There are few reports on the use of CAM such as health foods and supplements in cancer patients despite the high interest in it. In this study, we performed a retrospective research to elucidate factors influencing the use of health foods and supplements in cancer patients. The objectives were inpatients diagnosed with cancer at Gifu Municipal Hospital between October 1, 2014 and March 31, 2015. Survey items were age, gender, information on cancer, history of chemotherapy and operation, prescription drugs, and health foods and supplements at admission. A multiple logistic regression analysis was conducted to evaluate the influence of survey items on the use of health foods and supplements. Statistical significance was set at P < 0.05. Patients using health foods and supplements were 5.8% (59/1,012). The use rate of health foods and supplements is significantly high in recurrent patients [odds ratio (OR), 4.83; 95% confidence interval (CI), 2.55-9.15; P < 0.001] and is significantly low in patients receiving operation [OR, 0.363; 95% CI, 0.197-0.667; P = 0.001]. In this study, it was clarified that recurrent cancer patients more frequently use health foods and supplements, and that cancer patients undergoing surgery use them less frequently.