著者
渡邊 徹
出版者
養賢堂
雑誌
畜産の研究 (ISSN:00093874)
巻号頁・発行日
vol.64, no.6, pp.623-628, 2010-06

酪農現場における飼料給与を中心とする飼養管理方法についての一考察。外的要因の主なものとして、気候や牛舎環境の影響、管理の不具合があります。具体的には、暑熱や寒冷の影響、牛床、飼槽、繋ぎ方等いわゆるカウコンフォートの項目としてあげられているものです。また、飼料の変動、牛の入れ替え、牛群内でのイジメ、近所での工事等も飼料摂取に影響を与えます。これら外的要因は牛に負担をかけ、ストレスが生じ、その結果飼料摂取量が低下します。ストレスとは物理的、精神的に外部から力が加わっている状態で、寒冷、暑熱、筋肉疲労、炎症、感染、怒り、不安などの物理的、化学的、精神的な負荷は全てストレスの要因となり得ます。また、ストレスが加わると副腎皮質からコルチゾール(糖質コルチコイドの一種)が分泌され、ストレスを緩和しようとしますが、コルチゾールは繁殖ホルモンやカルシウムの代謝などに大きな影響を与え、乳牛の生乳生産をマイナス方向に導きます。乳牛がストレスを感じるのは、行動に制約がある時、不快な時、不安な時等です。
著者
永澤 正哉 渡邊 徹
出版者
公益社団法人 日本都市計画学会
雑誌
都市計画論文集 (ISSN:09160647)
巻号頁・発行日
vol.26, pp.133-138, 1991-10-25 (Released:2020-05-01)
参考文献数
11

RECENTLY, THE THIRD-SECTOR ORGANIZATIONS PLAY AN IMPORTANT ROLE IN DEVELOPMENT OF THE THREE PROJECTS, NAMELY, (MAKUHARI-SHINTOSHIN, MINATO-MIRAI 21, TOKYO-RINKAI-FUKUTOSIN), IN THE TOKYO BAY AREA.THE PURPOSE OF THIS PAPER IS TO ANALYZE THE DIFFERENT CHARACTER OFTHE THRID-SECTOR ORGANIZATIONS IN THE ABOVE AREAS AND ALSO TO EXPLAIN THE DIFFERENCE IN TERMS OF HISTORICAL, SOCIAL AND GEOGRAPHICAL BACKGROUNDS. THE FINDINGS INCLUDE THE CHARACTER OF ROCAL GOVERNMENTS AND THE CHARACTER OF DEVELOPMENT PROJECTS.
著者
渡邊 徹 野村 行雄
出版者
公益社団法人 日本心理学会
雑誌
心理学研究 (ISSN:00215236)
巻号頁・発行日
vol.11, no.4, pp.329-361, 1936
被引用文献数
2

As the thyroid gland, as any other endocrine organs, is responsible for the mental as well as the bodily development, it has, been advocated by E. Kretschmer, G. Eward, W. Jaensch, M. R. Berman, O. Klieneberger and other psychologists and characteologists that the thyroidhas a great effect upon the human character. Above all, Berman insisted in his <I>The Glands Regulating Personality</I> upon that the thyroid internal secretion has a very definite controlling relation to intelligence and the complexity of the convolutions of the brain, and that when the chemical reactions which depend upon the thyroid go faster, more oxygen and food materials are burned up or oxidized, more energy is liberated, the metabolic wheel rotates More quickly, the individual senses, feels, thinks and acts more quickly. But his theory is imaginative and speculative, lacks the exact psychological experimental ground.<BR>We began this study for the purpose of detecting the effect of the thyroid gland upon the behavi6ur and learningabilityof animals. For this purpose, we used 32 albino rats and 12 mice and we sorted them into pairs of the same breeding according to their age, sex and weight?\one group for experimental and the other for control animals. To ah experilnental albino rat, we administered the desiccated thyroid gland every day successively 0.005 gm. per 100gm. of its bodily weight and to an experimental mouse 0.0006gm. for some days. Then after about ten days, we experimented on the albino rats by the Obstruction Method, the Maze Learning Method, the Choice Box Method and on the mice by the Revolving Wheel Method. The results of the observations and experiments are as follows:<BR>1) The behaviour of the hyperthyroid rats was more stimulating, more smart ahd more active than that of control rats.<BR>2) The former crossed over the water funk in the obstruction box sooner than the latter. See Fig. 6 in the Japanese Text, pp.344 & 345)<BR>3) In the maze learning, the former eliminated the blinds more readily and reached to the goal sooner than the latter. (See Fig. 8 and Fig 9 in the Japanese Text, pp. 350-1 and 353)<BR>4) The hyperthyroid mice revolved the wheel in the revolving wheel cage more than 10,000 times in six hours in the first trial day in spite of the fact that the control revolved only a few hundred times. But the former hardly improved in revolving the wheel by learning, while the latter revolved more and more times till they surpassed the former in revolving times by above 2,000 times after one week's learning. (See Fig. 12 in the Japanese Text p.359)<BR>5) The above mentioned changes in the behaviour and learning ability of the hyperthyroid animals seemed to appear from five to ten days after the beginning of administrating the desiccated thyroid gland.<BR>6) When we discontinued to administer the desiccated thyroid gland, the animal became less active and less stimulating. We could not make clear whether the improved learning ability would change afterwards again or not.<BR>7) We could not know how these changes happened. In order to find out: whether these changes came from the hunger of the hyperthyroid animals, we tried an experiment, but could not get to any conclusion.
著者
岡﨑 敬之介 渡邊 徹 齋藤 勲 村山 純一郎
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.132, no.2, pp.231-236, 2012 (Released:2012-02-01)
参考文献数
10
被引用文献数
2 2

Our aim was to clarify the side effects of irinotecan which occurred in patients admitted to Showa University Hospital to investigate whether the UGT1A1 genetic polymorphism status was reflected in the discontinuation or dose reduction of irinotecan. We retrospectively investigated UGT1A1 genetic polymorphisms, irinotecan dosage, dose discontinuance or reduction, and laboratory results from May 1 2009 to April 30 2010. The analysis of UGT1A1 genetic polymorphisms in 23 patients showed that frequencies of the UGT1A1*6 and UGT1A1*28 polymorphisms were 35% (eight patients) and 22% (five patients), respectively, and 17% (three patients) were UGT1A1*6/UGT1A1*28 compound heterozygotes. Of all patients who received irinotecan, dose reduction occurred in six patients (38%) and discontinuance in two patients (13%) due to neutropenia and other factors. Of these eight patients, seven (88%) had the UGT1A1*6 and/or *28 polymorphism. The most common irinotecan dose reduction was about 25% of the initial dose. Grade 4 neutropenia was observed in two patients who had the UGT1A1*6 and/or *28 mutation (13%), and one patient was a compound heterozygote. Our investigation confirmed that the UGT1A1 genetic polymorphism status of the patients was reflected in the discontinuance or dose reduction of irinotecan. Our results suggest that Grade 4 neutropenia may occur in patients who are compound heterozygotes and that these patients may need careful selection of treatment regimens possibly involving discontinuance or reduction in irinotecan dosage.
著者
渡邊 徹
巻号頁・発行日
2013

筑波大学博士 (工学) 学位論文・平成25年3月25日授与 (甲第6422号)