著者
Gerard B. Remijn Emi Hasuo Haruna Fujihira Satoshi Morimoto
出版者
一般社団法人 日本音響学会
雑誌
Acoustical Science and Technology (ISSN:13463969)
巻号頁・発行日
vol.35, no.5, pp.229-242, 2014-05-01 (Released:2014-09-01)
参考文献数
109
被引用文献数
11

In 1939, Pauline Davis reported the first study on event-related potentials (ERPs) performed on awake humans. ERPs are time-locked brain potentials that occur in response to cognitive, motor or perceptual events. The events used by Davis were sounds, and in the decades that followed her landmark study ERP research significantly contributed to the knowledge of auditory perception and neurophysiology we have today. ERPs are very well suited to study neural responses to sound stimuli, since the researcher can monitor the brain's registration of sound edges and spectral changes in sound on a millisecond-by-millisecond basis. In this overview we will introduce basic concepts of auditory ERP research. The overview includes descriptions of typical ERP components, experimental paradigms, sound stimuli, research methodology, and ways to analyze data.
著者
Yoshimi K Kaneko T Voigt B Mashimo T
出版者
Nature Publishing Group
雑誌
Nature communications (ISSN:20411723)
巻号頁・発行日
vol.5, 2014-06-26
被引用文献数
152

CRISPR/Casシステムを用いたアレル特異的ゲノム編集とラット毛色突然変異の修復!.京都大学プレスリリース. 2014-06-27.
著者
Howard B Abrams
出版者
日本プライマリ・ケア連合学会
雑誌
General Medicine (ISSN:13460072)
巻号頁・発行日
vol.15, no.1, pp.5-13, 2014-06-20 (Released:2014-06-27)
被引用文献数
1 1

Our Health Care Systems, especially our hospitals, were designed primarily to provide episodic care for acute occurrences of single diseases. With our aging population and the predominance of chronic diseases, highly integrated and coordinated care is required. This demands a “systems re-design”, not just making the old system better. Additionally, higher expectations of patients and families to be involved in and co-direct their care, and the advent of rapidly evolving mobile information technology (mHealth), requires an innovative and “agile” approach to this re-design process. To be sustainable, innovation must improve the experience of care for both patients and health care providers, as well as produce clinical and financial outcomes that are at least as good as or better than current care. Health Systems Centres of Innovation can be provide “new ways of thinking” about health care, and the creativity to sustainably re-design our Health Care Systems.

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著者
b
出版者
acc
著者
藤田 景子 目黒 あかね 久能 均 Carver T.L.W. Thomas B.
出版者
日本植物病理学会
雑誌
日本植物病理學會報 (ISSN:00319473)
巻号頁・発行日
vol.69, no.1, 2003-02-25

オオムギ子葉鞘に接触したオオムギうどんこ病菌,コムギうどんこ病菌,エンドウうどんこ病菌分生子の直下に液状物質が(ECM)が出現する.それぞれの胞子(inducer)をオオムギ子葉鞘の1細胞に接種し,1時間以内にinducerを取り除き,細胞をECMに1時間だけ接触させた.別の子葉鞘で培養したオオムギうどんこ病菌(challenger)の発芽胞子1個をその細胞に移植した.19時間培養後,challengerの吸器形成を観察した.ECMと予め接触していない細胞では吸器形成率は約50%であったが,オオムギうどんこ病菌ECMに1時間接触した細胞では約63%に増加した.しかし,非病原菌であるコムギうどんこ病菌,エンドウうどんこ病菌ECMに接触した細胞では,それぞれ約29%,約7%に減少した.これらの結果は,子葉鞘細胞が病原菌,非病原菌のECMを接触後1時間以内に認識すること,challengerが侵入する移植後5,6時間目までに,受容性または拒否性状態に変化することを示している.
著者
Ivan Sandi Darma Takafumi Sugiyama Michael Angelo B. Promentilla
出版者
公益社団法人 日本コンクリート工学会
雑誌
Journal of Advanced Concrete Technology (ISSN:13473913)
巻号頁・発行日
vol.11, no.10, pp.266-281, 2013-10-09 (Released:2013-10-09)
参考文献数
35
被引用文献数
10 53

This paper demonstrates the application of microfocus X-ray computed tomography (CT) to study solute transport in cracked concrete. Cracks in a cylindrical specimen of ordinary Portland cement (OPC) and fly ash mortar were induced using a splitting tensile test. Cesium Carbonate (Cs2CO3) was then used as a tracer in the in-situ diffusion test with the aid of X-ray CT. Image analysis was also employed to measure the 3D crack geometry and tracer diffusivity from these CT images. The geometric tortuosity of the crack was approximately 1.25 irrespective of the crack opening width and whether fly ash was added or not. On the other hand the constrictivity increased for the fly ash mortar having roughly the equivalent crack opening width. The measured diffusivity in the crack was controlled by both crack opening width and constrictivity. Results obtained from microtomographic images suggest that the entire crack space may not always be filled with the tracer. The diffusive transport of solute in cracks thus can be restricted from microstructure’s point of view. Smaller crack opening would increase such restricted diffusion. Indications also suggest that the addition of fly ash would lead to the reduction of diffusivity through uncracked body of the mortar.
著者
Makita Tomohiro Katsuyama Yoko Tani Shuji SUZUKI Hayato KATO Naoki TODD Richard B. HYNES Michael J. TSUKAGOSHI Norihiro KATO Masashi KOBAYASHI Tetsuo
出版者
Japan Society for Bioscience, Biotechnology, and Agrochemistry
雑誌
Bioscience, biotechnology, and biochemistry (ISSN:09168451)
巻号頁・発行日
vol.73, no.2, pp.391-399, 2009-02-23
被引用文献数
3 35

AmyR is a Zn(II)<SUB>2</SUB>Cys<SUB>6</SUB> transcriptional activator that regulates expression of the amylolytic genes in <I>Aspergillus</I> species. Subcellular localization studies of GFP-fused AmyR in <I>A. nidulans</I> revealed that the fusion protein preferentially localized to the nucleus in response to isomaltose, the physiological inducer of the amylolytic genes. The C-terminal domains of AmyR, designated MH3 (residues 419–496) and MH4 (residues 516–542), were essential for sensing the inducing stimulus and regulating the subcellular localization. The MH2 domain (residues 234–375) located in the middle of AmyR was required for transcriptional activation of the target genes, and the nuclear localization signals were identified within the N-terminal Zn(II)<SUB>2</SUB>Cys<SUB>6</SUB> DNA binding motif.