著者
伊藤 宣則 清水 弘之 吉村 健清 橋本 勉 早川 武彦 篠原 力雄 高塚 直能 徳井 教孝 笠松 隆洋 鈴木 康司
出版者
日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.71, no.9, pp.427-434, 1997-09-25
被引用文献数
5

Relationship between serum levels of lipid peroxides and carotenoids among the subjects randomly selected from the residents living in T-city, Gifu (GT), T-town, Wakayama (TW), H-city Hiroshima (HH), S-town, Fukuoka (SF), and Y-town, Hokkaido (HY) was investigated cross-sectionally. It was demonstrated that serum levels of β-carotene or cryptoxanthin were higher for GT and HY residents or for WT residents, while serum levels of lipid peroxides estimated by the thiobarbituric acid-reactive substances (TBARS) were lower for GT and HY residents, respectively. Moreover, there were some regional differences that serum levels of carotenoids such as β-carotene were inversely associated with serum TBARS levels for the residents, but not for HH residents with encumbrances of Japanese Americans. Serum TBARS levels were positively and significantly related with serum levels of n-3 unsaturated fatty acids such as icosapentaenoic acid and docosahexaenoic acid, which were high intake in Japanese, but not significantly with serum levels of n-6 unsaturated fatty acids such as arachidonic acid.
著者
近藤 寛樹
出版者
日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.78, no.12, pp.624-625, 2004-12-25

ビオチン合成の最後の段階, デスチオビオチン(DTB)への硫黄の導入, の最大の謎は活性化されていないメチル基とメチレン基にどのような仕組みで硫黄が挿入されるかという点である. この反応がbioオペロン中のbioB遺伝子の産物BioB, つまりビオチン合成酵素(モノマー分子量3.8万の二量体のタンパク質)によって触媒されること, また反応にフラボドキシン, フラボドキシン還元酵素, NADPH, S-アデノシルメチオニン(AdoMet), システイン, ジチオスレイトールが必要とされることなどがわかっていた. ビオチン合成酵素はAdoMetから還元的に生成する5'-デオキシアデノシルラジカルを利用する一群の酵素のスーパーファミリーに属し, これらには保存されたcys-X-X-X-Cys-X-X-Cys(いわゆるシステインボックス, Xは任意のアミノ酸)の配列が存在して鉄硫黄クラスターの結合部位となっている. 最近AdoMetとDTBが結合した形の大腸菌ビオチン合成酵素の立体構造が3.4Aの分解能で解かれた.
著者
上久保
出版者
日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.19, 1960
著者
佐藤 有道
出版者
日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.14, pp.457-461, 1958

The relationship between the autonomic nervous center and stress in thiamine metabolism in the organs were observed. 1) In rabbits the stimulation of sympathetic center in the hypothalamus caused a considerable decrease of total thiamine concentration in the liver (-61%) and kidney (-68%) after one hour and recovery after 24 hours. The cold stimulation caused a decrease of total thiamine in the liver after one hour (-38%) but a considerable decrease after 24 hours (-54%). Likewise the cold stimulation caused a decrease in the kidney after one hour (-27%) but a considerable decrease after 24 hours (-53%). 2) Simultaneous administration of Chlorpromazine suppressed the decrease due to stimulation. 3) Subcutaneous injection of Chlorpromazine did not show any influence in thiamine concentration, except for a slight decrease in the liver and kidney after one hour.
著者
佐藤 有道
出版者
日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.14, pp.462-469, 1958

Changes in thiamine concentration in the liver and kidneys were observed when the left ganglion caeliacum was stimulated by two different methods. 1) In rabbits a sham operation caused a decrease of total thiamine concentration in the liver (25-30%) and in the kidneys (27-36%). 2) The pharmacological stimulation by lead acetate and electric stimulation similarly caused a considerable decrease of total thiamine concentration in liver and kidneys after 1-12 hours (35-46%) . 3) Subcutaneous injection of Chlorpromazine suppressed the decrease due to sham operation and sympathetic stimulation. 4) The participation of the autonomic nervous system and pituitary adrenal system in thiamine metabolism was suggested by the above results.