著者

本間 清一 リディア マレロ 五十嵐 脩

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.65, no.3, 1991-03-25

著者

神谷 真太郎

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.18, pp.396-400, 1959

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In the previous papers, it was reported that L-ascorbic acid decomposing enzymes of bacteria were produced adaptively only in the cells grown in a medium containing L-ascorbic acid, but not in the unadapted cells even when they were in contact with L-ascorbic acid for a long time. In this paper, it was shown that the unadapted cells became able to metabolize L-ascorbic acid when a small quantity of glucose and casein hydrolyzate were given. Both D-araboascorbic acid and D-glucoascorbic acid too were decomposed by L-ascorbic acid decomposing cells, but other reductones such as reductic acid, dihydroxymaleic acid, and 5-methyl-3,4-dihydroxytetrone were not. On the other hand, some properties of L-ascorbic acid oxidase found in the unadapted cells were studied. Its optimum pH was about 5.0 and the optimum concentration of the substrate was 800μM. It was found, too, that endiol compounds such as D-araboascorbic acid, reductic acid and 5-methyl-3,4-dihydroxytetrone, etc. were not decomposed by this enzyme.

著者

田中 英彦 木本 英治

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.64, no.4, 1990-04-25

著者

阿部 皓一 石橋 恭子 大前 雅彦 河部 靖 勝井 五一郎

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.51, no.3, pp.111-117, 1977-03-25

被引用文献数

2

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A Method for the determination of ubiquinone homologues (UQ) in serum and liver is described. Serum or liver homogenate was saponified with methanolic alkaline solution after addition of 2,3,6-trimethyl-5-nonaprenyl-1,4-benzoquinone (TQ-9) as an internal standard and then extracted with n-hexane. The n-hexane extract was evaporated under N_2 gas at 30℃, and the residue was dissolved in dioxane. The sample solution was applied to the high-speed liquid chromatography (HSLC) using a Permaphase ODS column and ethanol・water (80 : 20) as a mobile phase. The peaks of UQ and TQ-9 were not disturbed by other fat-soluble substances when an on-line high-sensitive multiple wavelength detector set at 275 nm (absorption maximum of UQ) was used as a detector. The proposed HSLC method was found to be more simple and specific than the other conventional determination methods.

著者

滕 飛 美藤 友博 竹中 重雄 薮田 行哲 渡邉 文雄

出版者

日本ビタミン学会

雑誌

ビタミン = Vitamins (ISSN:0006386X)

巻号頁・発行日

vol.90, no.7, pp.341-347, 2016-07

著者

山本 あい子

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.85, no.8, pp.423-425, 2011-08-25

参考文献数

4

著者

増田 桓一 奥村 和男

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.6, 1953

著者

勝井 五一郎

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.51, no.4, 1977-04-25

著者

八木 年晴

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.85, no.11, pp.611-612, 2011-11-25

著者

山田 幸子 石坂 博信 石田 博基 山本 恵子

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.68, no.7, 1994-07-25

著者

松浦 知和 白井 美佐子 永妻 啓介 横山 寛 鷹橋 浩幸 池上 雅博 古庄 律 小嶋 聡一

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.89, no.4, 2015-04-25

著者

池川 雅哉 木村 美恵子

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.83, no.8, pp.453-460, 2009-08-25

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Lithium (Li) is the smallest of the alkali metals. Medical application of Li for treating mood disorders was preceded to the studies on its actions for human health. Traces of Li were detected in human organs and fetal tissue. Li is found in variable amounts in our environment and in foods. In some areas, the drinking water also provides significant amounts of the element. Animal experiments on rats and goats maintained on low-lithium rations showed to exhibit higher mortalities as well as reproductive and behavioral abnormalities; however, it is still debatable that Li is essential as an ultra trace nutrient. The biochemical mechanisms of action of Li appear to be multi-factorial and are inter-correlated with the functions of several enzymes, hormones, vitamins and minerals. Here we reviewed lithium occurrence, dietary intakes, and nutritional essentiality as well as pharmacological properties with special references to cancer and stem cell biology.

著者

井上 正康

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.78, no.9, pp.458-460, 2004-09-25

被引用文献数

1

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通常, "疲労"と言えば"肉体疲労"と"精神疲労"に分類されるが, 風邪や慢性炎症などでも強く疲労を感じ, いずれの場合も"しんどい"と感じる. このことは, 筋肉病態, 感染病態, あるいは精神病態が誘起した変化を同じ病態情報として認識する脳の"疲労検知中枢"が存在することを意味する. UVAは体表組織の葉酸を破壊して成長不良を誘起するが, 遺伝子毒性の強いUVBはコレステロールからビタミンD前駆体を合成してクル病を予防する. アフリカ大地溝帯で産まれた人類の祖先は, 紫外線のプラスとマイナスの効果がちょうど折り合うニッチで, 黒人, 黄色人種および白人として環境に適応分布してきた. しかし, 大航海時代以後, 移動システムの進歩, 植民地政策, 奴隷貿易などにより, 肌の色や紫外線感受性とは無関係に人種の分布が混ざり合ってきた. オーストラリアの珊瑚礁などで1時間ほど太陽光を浴びると皮膚細胞の遺伝子に約10万個もの傷がつきメラノーマが生じる. このため, オーストラリアの70歳以上の白人男性の約半数は皮膚癌に悩まされている. 皮膚をUVBで照射すると日焼けすることは常識であるが, 実は「眼に紫外線を当てても皮膚が黒くなる」という驚くべき現象がみつかった.

著者

斎藤 純逸

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.28, no.3, pp.248-252, 1963-09-25

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In the course of study on the biological effect of AICA, it was recognized that the pyruvate decarboxylation by yeast apocarboxylase and cocarboxylase system was accelerated by addition of AICA to the reaction system. This effect was not observed in the yeast carboxylase extracted without cocarboxylase elimination. It was shown that this effect was different from the mechanism of Ochoa's effect based on thiamine addition and of the prevention of heavy metal inhibition. The effect of AICA is supposed to be concerned in the formation of apo- and coenzyme complex.

著者

宮本 恵美 橘高 博美 足達 理子 渡辺 文雄

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.79, no.7, pp.329-332, 2005-07-25

被引用文献数

1

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To verify whether edible bamboo shoots contain vitamin B_<12> or not, vitamin B_<12> was assayed by the microbiological method authorized in the standard tables of food composition in Japan (5th Edition), and by a reversed-HPLC. The results indicate that edible bamboo shoots do not contain vitamin B_<12>, but some compounds showing the vitamin B_<12>-like activity (known as the alkali-resistant factor).

著者

宮本 恵美 橘高 博美 足達 理子 渡辺 文雄

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.79, no.7, pp.329-332, 2005

参考文献数

7

被引用文献数

1

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To verify whether edible bamboo shoots contain vitamin B_<12> or not, vitamin B_<12> was assayed by the microbiological method authorized in the standard tables of food composition in Japan (5th Edition), and by a reversed-HPLC. The results indicate that edible bamboo shoots do not contain vitamin B_<12>, but some compounds showing the vitamin B_<12>-like activity (known as the alkali-resistant factor).

著者

平原 文子 小池 佳子 沼野 富子

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.69, no.9, pp.495-501, 1995-09-25

被引用文献数

1

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The nutrition survey of infants at day care center in Tokyo, on 8 healthy boys and 7 girls, aged 13 to 34 months, 74.8 to 91.3cm body height and 9.6 to 14.3 kg body weight was examined by the method based on the national nutrition survey of Japan. The nutritional status was estimated by calculation using the standard tables of food composition in Japan, 4th revised edition and supplementary table of for fatty acids, cholesterol and vitamin E. The mean values of energy, lipids, protein, retinol, thiamine, riboflavin and ascorbic acid in model menu exceeded the recommended dietary allowance(RDA) for infants of the age. The mean intakes of lipid, energy and polyunsaturated fatty acids, protein in boys and girls were almost the same as those in the RDA. The mean intakes of retinol, riboflavin and ascorbic acid exceeded the RDA for infants of the age. A great difference was found in the lipids, thiamine and vitamin E intake between infants, the mean intake value in 2 years old was lower than those of 1 year olds. The daily cholesterol intake was from 147mg to 235mg. The ratio of E/PUFA was higher than 0.6. The ratios of vitamin E intake per 100 kcal energy and per 1 kg in body weight, were from 0.44 to 0.62mg and from 0.30 to 0.60mg, respectively. As a conclusion, the finding of a smaller intake of principal nutrients in 2 years old infants compared with 1 year old infants, involves many nutritional problems. These results suggest that these infants should be required nutritional advice about a well balanced diet and an available selection of proper foods.

著者

森内 幸子 志村 二三夫 梨本 光太郎 細谷 憲政 小林 正

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.49, no.5, pp.225-232, 1975-06-25

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1α-OH-D_3の十二指腸における^<45>Ca輸送能並びに血清Ca濃度に対する効果を, 腎臓摘出D欠乏シロネズミを用いて観察した.312pmolの1α-OH-D_3を投与して24時間後の十二指腸における^<45>Ca輸送能の増大は, 腎臓摘出動物においても観察されたが, 血清Caの増大は擬似手術を施した群では観察されたが, 腎臓摘出動物においては観察されなかった.1α-OH-D_3の投与量を6,250pmolにして, はじめて血清Caに対する効果が腎臓摘出動物においても観察された.すなわち, 1α-OH-D_3は骨からのCaの溶出作用は弱いが, 小腸からのCaの吸収に対する作用は大きい.それ故, 1α-OH-D_3はDの代謝異常によるD不応性くる病の治療に有効な物質と考えられる.また, 小腸に対する作用と骨に対する作用に差異の観察されたことは, まだ発見されていない1α-25-(OH)_2-D_3以外の最終活性物質が腎臓で生成されて骨に対して作用することを示唆するものと思われる.

著者

渡邉 文雄

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.86, no.8, pp.451-452, 2012-08-25

著者

柴田 克己

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.61, no.2, pp.39-56, 1987-02-25

被引用文献数

4

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Four NAD biosynthetic pathways have been known ; (I), NiANH_2→NMN→NAD pathway (II), NiA→NaMN→NaAD→NAD pathway (III), NiANH_2→NiA→NaMN→NaAD→NAD pathway (IV), QA→NaMN→NaAD→NAD path-way. So, the functional pathway in each organ of rats was investigated. It was found that all the four 'NAD biosynthetic pathways exist in the liver. Among the four pathways, (IV) is presumed to be the functional pathway as judged by the results that the levels of NAD and niacin in liver increased with the content of dietary Trp and that exogenous QA had a 1/9 niacin activity of NiA. In kidney, (I), (II), and (IV) were found to exist. In the three pathways, (I) was supposed to be the functional pathway as judged by the results that NiANH_2 was the main precursor supplied and that the activity of kidney aminocarboxy-muconate-semialdehyde decarboxylase was much higher than the liver enzyme activity. In heart, (I) and (II) were found but (I) was seemed to be the functional pathway as judged by the result that NiANH_2 was a main precursor sup-plied. In other organs, e,g., the small intestine, spleen, lung, pancreas, brain and muscle, only (I) was found. Thus, the pathway found in all the organs tested was (I). Although the reaction of NAD→NiANH_2 was found to occur in all organs, the reaction of NiANH_2→MNA→2-Py was found to occur mainly in liver. In the view of complexicity of the metabolic pathways of NAD and existence of the questionable bioavailability of the bound forms of nicotinic acid in foods, a straight forward method to determine blood NAD for assessing the nutritional status of niacin was established. Using this method, it was proved that blood NAD level was useful for assessing the nutritional status of niacin. NAD level of healthy human blood was about 30 nmol/ml.