著者
櫻井 芳雄
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.50, no.2, pp.084-087, 2010 (Released:2010-03-30)
参考文献数
19
被引用文献数
1

We introduce the original and present concepts of cell assembly in the working brain and discuss the problem of dynamic size of it. A local cell assembly consisting of closely neighboring neurons was especially difficult to be detected because of spike overlapping of neighboring neurons. We developed a unique technique of spike-sorting that employed independent component analysis and showed that most of closely neighboring neurons in the monkey prefrontal cortex had dynamic and sharp synchrony of firing reflecting local cell assemblies. We propose that real features of cell assemblies could contribute to development of brain-machine interfaces and neuro-rehabilitation.
著者
青島 均
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.28, no.6, pp.296-299, 1988-11-25 (Released:2009-05-25)
参考文献数
18

Xenopus oocytes were injected with exogenous mRNA prepared from rat small intestine and kidney and their electrical responses to glucose and amino acids were measured electrophysiologically. Na+/glucose, amino acid cotransporters were expressed in the oocytes by injection of small intestine mRNA, while facilitated diffusion carrier protein(s) (uniporter) were mainly expressed by injection of kindney mRNA.
著者
今井 隆志
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.50, no.6, pp.298-299, 2010 (Released:2010-11-25)
参考文献数
8
被引用文献数
1
著者
朴 三用
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.50, no.2, pp.074-079, 2010 (Released:2010-03-30)
参考文献数
14

Influenza A virus is a major human and animal pathogen with the potential to cause catastrophic loss of life. Influenza virus reproduces rapidly, mutates frequently, and occasionally crosses species barriers. The recent emergence of swine-origin influenza H1N1 and avian influenza related to highly pathogenic forms of the human virus has highlighted the urgent need for new effective treatments. I describe two crystal structures of complexes made by fragments of PA and PB1, and PB1 and PB2. These novel interfaces are surprisingly small, yet they play a crucial role in regulating the 250 kDa polymerase complex, and are completely conserved among swine, avian and human influenza viruses. Given their importance to viral replication and strict conservation, the PA/PB1 and PB1/PB2 interfaces appear to be promising targets for novel anti-influenza drugs of use against all strains of influenza A virus. It is hoped that the structures presented here will assist the search for such compounds.
著者
吉川 雅英 八木 俊樹
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.48, no.6, pp.325-329, 2008 (Released:2008-12-02)
参考文献数
21

Eukaryotic cilia and flagella are highly specialized organelles that play important roles in generating motions and sensing flows. Here, we review recent progresses in cilia / flagella studies, focusing on their structural studies by cryo-electron microscopy.
著者
三宅 教尚 栗原 堅三
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.23, no.3, pp.135-145, 1983-05-25 (Released:2009-05-25)
参考文献数
58
被引用文献数
1 1

In the field of physiology, it has generally been Considered that changes in the phase boundary potential do not affect membrane potentials. The present review shows that the phase boundary potential directly contributes to the membrane potential of a number of cells. (1) The K+-channels of mouse neuroblastoma (N-18 cells) are open at high external K+-concentration but closed at low K+-concentration including the physiological one. Under physiological conditions, the resting membrane potentials of N-18 cells stem significantly from the phase boundary potentials. Theoretical consideration shows that changes in the phase boundary potentials directly affect the membrane potential when no selective channels are open. (2) Changes in the phase boundary potential also contribute to the receptor potentials in taste cells, olfactory cells and Tetrahymena as well as to the resting potentials of these cells: adsorption of chemical stimuli on the receptor membranes of these cells induces changes in the phase boundary potential, which leads to depolarization of the cells.

1 0 0 0 OA 海外だより

出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.55, no.2, pp.115-116, 2015 (Released:2015-03-31)

1 0 0 0 OA 書評2

出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.52, no.6, pp.312-312, 2012 (Released:2012-11-27)