著者
西山 雅祥 樋口 秀男
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.44, no.2, pp.75-80, 2004 (Released:2004-03-23)

Kinesin is an ATP-driven molecular motor that moves processively along a microtubule in a stepwise manner. The steps occur not only in the forward direction, but also in the backward. Here, we have studied the bidirectional stepping mechanism of kinesin motors. The stepping mechanism of the forward and backward movements was well characterized by Feynman's thermal ratchet model. The driving force of the stepwise movement is essentially Brownian motion, but it is biased in the forward direction by utilizing the free energy released from the hydrolysis of ATP.
著者
上岡 龍一 市原 英明 古水 雄志
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.54, no.1, pp.005-010, 2014 (Released:2014-01-29)
参考文献数
26

We have produced hybrid liposomes (HL) which can be prepared by sonication of a mixture of vesicular and micellar molecules in a buffer solution. Some interesting results are as follows; HL remarkably inhibited the growth of cancer cells along with apoptosis in vitro and in vivo. Anticancer effects increased with a growth in membrane fluidity of HL and fluidity of plasma membranes of cancer cells. In clinical applications, prolonged survival and remarkable reduction of neoplasm were attained in patients with lymphoma after the treatment with HL without any side effects after the approval of the bioethics committee.
著者
金子 智行
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.41, no.6, pp.312-314, 2001-11-01
参考文献数
6
被引用文献数
1
著者
藤崎 久雄
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.40, no.3, pp.195-198, 0001-01-01 (Released:2001-04-26)
参考文献数
10