著者

早川 一郎

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN (ISSN:00379980)

巻号頁・発行日

vol.65, no.12, pp.1225-1226, 2007-12-01

参考文献数

9

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Halichondrin B is a polyether macrolide that exhibits an extraordinary cytotoxicity <I>in vitro</I> and antitumor efficacy <I>in vivo</I>. A structurally simplified macrolactone right half segment of harichondrin B was identified to retain the potent cell growth inhibitory activity of the natural product <I>in vitro</I>. Kishi and coworkers developed a practical, an efficient and scalable synthesis of the right half segment of harichondrin B.

著者

岩崎 成夫

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.49, no.10, pp.892-901, 1991 (Released:2009-11-16)

参考文献数

36

被引用文献数

1 3

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CLC部位に作用する化合物の構造要因は立体化学も含めて比較的単純で, STG (3) やPDT (4) のような複雑さを要しないように見える。事実, 多数の合成剤も作られている。しかし, これら薬剤の対象であるカビ, 寄生虫などに耐性が出やすく, A.nidulansのBZ剤耐性株で解析されたβ-TNの変異点が6箇所にも及ぶという事実とよく一致している。一方, 現在までに知られているVLB-MAY部位に作用する化合物は, 皆多数のキラル中心を持つ複雑な構造で, 今までは構造の部分修飾による活性の変化が調べられていた。今後は, 単純化した必須の構造要因を明らかにし, 分子認識機構を解明していくことも期待したい。この部位を標的とする薬剤の医薬・農薬としての応用では, VLB-MAY部位でのβ-TNの変異が起こりにくいことから, 耐性は出にくいという利点が予想される。以上述べてきたように, TNとこれに結合してその機能を阻害する化合物との間の相互作用について, 多くの事実は明らかになってきたが, 依然として, これら阻害剤がTNの3次元構造の何処にどのように結合しているのかは全く分っていない。そのために, 阻害剤を非可逆的に結合する (アフィニティラベル) 試みも続けられている。また, 何時か, TN-リガンド複合体の結晶解析も可能となることを願っている。

著者

原 健

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.38, no.11, pp.1105-1118, 1980-11-01 (Released:2009-11-13)

参考文献数

74

被引用文献数

1 2

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This article reviews the syntheses of 1, 4-benzodiazepines with a nitrogen atom-containing five-membered ring fused to the 1, 2-position of the diazepine ring. Recent work on this class of compounds has yielded new synthetic methodologies and compounds (potentially) useful in medicine. Descriptions are arranged according to types of structures of target tricyclic diazepines and to types of approaches in the synthesis. The activity of the compounds on the central nervous system (CNS) is also mentioned. Contents : 1. Introduction, 2. 4H-pyrrolo [1, 2-a] [1, 4] benzodiazepines, 3. 4H-imidazo [1, 2-a] [1, 4] benzodiazepines, 4. 4H-imidazo [1, 5- a] [1, 4] benzodiazepines, 5. 4H-pyrazolo [1, 5- a] [1, 4] benzodiazepines, 6. 4H-s-triazolo [4, 3- a] [1, 4] benzodiazepines, 7. 4H-s-triazolo [1, 5-a] [1, 4] benzodiazepines, 8. 4H-υ-triazolo [1, 5-a] [1, 4] benzodiazepines, 9. 4 H-tetrazolo [1, 5-a] [1, 4] benzodiazepines, 10. CNS activity, 11. Closing comment.

著者

高田 十志和 大塚 英幸

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.64, no.3, pp.194-207, 2006-03-01 (Released:2010-10-20)

参考文献数

61

被引用文献数

11 10

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Dynamic covalent chemistry relates to the utilization of chemical equilibrium systems, i.e., reversible cleavage-rebondage of covalent bond, which is effectively applicable to the molecular architectures in supramolecular chemistry and polymer chemistry. This review deals mainly with molecular integration and molecular conversion of supramolecules and polymers in order to prove significance and utility of the dynamic covalent bond by introducing the representative research studies. Equilibria of imine bond, carbon-carbon double bond, disulfide bond, trityl carbon-sulfur bond, ester bond, alkoxyamine bond, and so on are typical dynamic covalent bonds, and several important examples for the constructions of interlocked molecules and polymers are described. In the utilization of the dynamic covalent bond in polymer, utility of a few reversibly cleavable covalent bonds included in polymer main chains is also discussed for the formation and transformation of polymers and cyclic polymers.

著者

瀬野 信子

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.35, no.5, pp.388-393, 1977-05-01 (Released:2009-11-13)

参考文献数

42

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Typical ester sulfates found in nature are sulfated mucopolysaccharides from animal sources and sulfated glycans from seaweeds. This article deals with the distribution, variation of chemical structures and functions of sulfated mucopolysaccharides, such as chondroitin sulfates A, C, D, E, K, dermatan sulfate and dermatan polysulfates, heparin, heparan sulfate and keratan sulfates.

著者

松浦 輝男

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.30, no.Special, pp.83-97, 1972-12-15 (Released:2009-11-13)

参考文献数

80

著者

大谷 文章

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.55, no.5, pp.460-465, 1997-05-01 (Released:2009-11-16)

参考文献数

35

被引用文献数

1 1

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Principle and recent development of photochemical reactions which are applicable to organic syntheses are interpreted. Special emphasis is placed on the new types of heterogeneous photoinduced reactions, e.g., semiconductor photocatalytic reactions, photoreactions of solid, and those of incorporated or intercalation compounds. Some industrialized photoreactions, e.g. photonitrosation of cyclohexane, or photochlorination of pyridines are also reviewed in order to see the perspective for application of photoreactions.

著者

谷 久也 山下 伸典

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.24, no.11, pp.997-1012, 1966-11-01 (Released:2010-06-28)

参考文献数

99

著者

平井 功一

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.38, no.2, pp.97-114, 1980-02-01 (Released:2010-01-22)

参考文献数

163

被引用文献数

11 13

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Recent advances in the field of the β-lactam ring syntheses are reviewed. All the methods are classified according to the notation of m±n_??_4 cyclization (m and n=0, 1, 2, 3, …), which is first proposed by the author. Each reaction is briefly commented.

著者

関屋 実

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.34, no.2, pp.67-81, 1976-02-01 (Released:2009-11-13)

参考文献数

71

被引用文献数

3 3

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In an abundance of the previous papers formic acid has been exhibited as a versatile reducing agent for diverse organic compounds. This article is an attempt to review its reduction reactions, but does not exhaustively cover every paper in the literature. Attention has been made, in the main, to a consideration of studies in the reduction induced by formic acid or formate itself. Therefore, the reductions which seem likely to depend upon its prior decomposition are left out of consideration. Particularly, emphasis in this article is laid upon the works in recent decade on the reductions by the use of the formic acid-trialkylamine azeotropes as reducing agents, which have been devoted to developing several fields of the reduction.

著者

山本 亮

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.18, no.8, pp.531-542, 1960-08-01 (Released:2010-10-20)

参考文献数

31

著者

高橋 英一

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.39, no.11, pp.1114-1123, 1981-11-01 (Released:2009-11-13)

参考文献数

57

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Many of the elements in the soil circulate through the ecosystem : soil (source) →plant (assimilator) →animal (predator) →microorganism (decomposer) →soil. In this circulation of elements, plant occupies a special and important position that the elements in the lithosphere firstly enter into the biosphere. Since 1900, the information on the existence and roles of trace metals in the plant has been much accumulated. These knowledges enable us not only to increase the crop yield but also to cure the disorders of crop, cattle and human caused by deficiency and excess of trace metals in the soil. In this paper such topics of essential (Cu, Zn, Mo, Mn, Fe) and non-essential (Cd, Al, Ge, Cr, Co, Ni, ) trace metals are briefly presented.

著者

山根 英人 真崎 光夫

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.35, no.11, pp.926-934, 1977-11-01 (Released:2009-11-13)

参考文献数

27

被引用文献数

2 2

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The manufacture of ε-caprolactam is carried on by means of three processes at present. The first process was developed by IG Farben, at which the first industrial production of ε-caprolactam was begun in 1943. The starting material is phenol, from which cyclohexanone is produced, and then converted to the corresponding oxime. Hydoxylamine is produced by Raschig method. The oxime is transformed into ε-caprolactam by Beckmann rearrangement in oleum. Major amount of ε-caprolactam in the world is manufactured still by this process, which is, however, somewhat modified. The modifications differ with manufacturers. Phenol may be replaced with cyclohexane which is converted to cyclohexanone by air oxidation. Hydroxylamine can be produced also by reduction of either nitrogen monoxide or nitric acid. The second process was developed by Snia Viscosa in 1962. The starting material is toluene, which is converted into cyclohexane carboxylic acid. The treatment of the acid with nitrosyl sulfuric acid in oleum yields ε-caprolactam. The third process was developed by Toyo Rayon (now, Toray) in 1963. The method consists of the photo-reaction of cyclohexane with nitrosyl chloride giving cyclohexanone oxime hydrochloride, which is rearranged in oleum to ε-caprolactam.The ε-caprolactam manufacture is historically reviewed.

著者

谷本 能文 藤原 好恒

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.53, no.5, pp.413-422, 1995-05-01 (Released:2009-11-16)

参考文献数

17

被引用文献数

17 18

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Effects of high magnetic field (<14 T) on the primary process of organic photochemical reactions and related phenomena are reviewed. With increasing a magnetic field, lifetimes of triplet radical pairs in micellar solution and triplet biradicals in homogeneous solution increase significantly, reach their maximum values at ca. 2 T, and then decrease gradually up to 14 T. These results are interpreted in terms of the radical pair mechanism. The effects at low field are attributable to the reduction of spin transitions due to the isotropic and anisotropic hyperfine interaction. The inversion of the lifetime is attributable to the enhancement of spin relaxation induced by the anisotropic g-value.

著者

功刀 泰碩 酒井 朝也

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.20, no.5, pp.426-434, 1962-05-01 (Released:2010-06-28)

参考文献数

39

著者

山本 為親

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.41, no.6, pp.570-576, 1983-06-01 (Released:2009-11-13)

参考文献数

9

被引用文献数

2 2

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Fuel methanol made of natural gas or coal in large scale under adequate conditions can be substitute of petroleum products. In Japan now the fuel methanol is mainly considered as the fuel of internal combustion engines, however, the most profitable use of fuel methanol is the raw materials of petrochemicals industry. Ethylene and propylene can be made from by far higher yield than that from naphtha under mild conditions. Gasoline from methanol by MTB process contains about 30% of aromatic hydrocarbons. Against hydrocarbon steam reforming to make hydrogen carried out at 800-900°C, methanol can be steam reformed at 250300°C with more simple installation.If the cost of calorific value of fuel methanol and petroleum products are same, the use of methanol as raw material is profitable far away than use of petroleum naphtha in Japan.

著者

伊藤 正雄

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.34, no.7, pp.505-511, 1976-07-01 (Released:2009-11-13)

参考文献数

32

被引用文献数

2 4

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Maleic Anhydride is produced through an oxidation in a catalytic vapor phase of various hydrocarbons, and Benzene and C4 Hydrocarbons are usually its feedstock in commercial production.A catalyst having vanadium oxides as an active component acts an important role in the process of oxidating hydrocarbons into Maleic Anhydride. In order to find out a catalyst having a higher selectivity against Maleic Anhydride, a study on the oxigen transfer mechanism over the surface of catalyst in the course of oxidation procedure was first carried out, and the oxidation kinetics was also developed for determing the optimum conditions for reation.Process for commercial purpose employs two types of reactor ; one being a fixed bed type and the other a fluidized bed type. In the following, comparison of these two types and characteristic features of several commercial processes for Maleic Anhydride production are also dealt with.

著者

近藤 美欧 正岡 重行

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.80, no.11, pp.1055-1064, 2022-11-01 (Released:2022-11-05)

参考文献数

90

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Artificial photosynthesis mimics natural photosynthesis and involves oxidation and reduction half-reactions, both of which are small-molecule transformations. Given that the realization of artificial photosynthesis may alleviate the energy and environmental problems faced by humankind, the development of catalysts for such transformations is a task of great practical significance. Our analysis of the natural photosynthetic system suggests that efficient small-molecule conversion requires the related catalysts to have (1) an active center with good reactivity, (2) charge-transporting sites close to the active center, and (3) substrate-transporting channels. Herein, we describe our recent progress in the development of small-molecule conversion catalysts based on this consideration and our original concept of function integration.

著者

今本 恒雄

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.56, no.6, pp.511-520, 1998-06-01 (Released:2009-11-16)

参考文献数

65

被引用文献数

2 5

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This review deals with new optically active phosphine ligands which appeared in the literature during past eight years. Emphasis is laid on the utility of these ligands in transition metal-catalyzed asymmetric reactions. New methods for the synthesis of chiral phosphine ligands are also described.

著者

平野 康次

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.64, no.4, pp.416-417, 2006-04-01 (Released:2010-10-20)

参考文献数

10

被引用文献数

1 1

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This mini review focuses on current topics on the following two reactions with azido compounds, which have been recently developed in the field of chemical biology; I) triazole synthesis by copper-catalyzed cycloaddition of an azide with an alkyne, II) modified Staudinger reaction, that is, Staudinger ligation.