著者
岡本 佳男 海田 由里子
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.51, no.1, pp.41-53, 1993-01-01 (Released:2009-11-16)
参考文献数
131
被引用文献数
12 15

Polysaccharides such as cellulose and amylose are the most accessible optically active polymers. The polysaccharides themselves show rather low chiral recognition, but their derivatives show high chiral recognition and afford useful chiral stationary phases (CSPs) for HPLC. In this review, optical resolution by cellulose esters, especially benzoates, and by various phenylcarbamates of cellulose and amylose is discussed. Chiral recognition abilities of aralkylcarbamates of cellulose and amylose are also evaluated.
著者
川合 恭平 鈴木 汎
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.37, no.6, pp.494-500, 1979-06-01 (Released:2009-11-13)

We, Toagosei Chemical Industry, have buckled down seriously to the safety problem with making the best use of our experience of plant accidents happened in the past.With an explosion accident in 1952 as a momentum, our plant operation was standardized. Then, with an explosion accident in 1972 as a momentum, an expert committee for the prevention of plant accidents was institutionalized.By the said committee, the checking for causes of accidents is done as to each stage of research, engineering, and test operation. The check list is used for this purpose. Now, we would introduce the part relating to the explosion.Differential Scanning Calorimeter is effective for the checking against explosive chemicals of which counterplan is difficult to be set.
著者
宗行 龍之祐 谷田 博
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.36, no.6, pp.454-466, 1978-06-01 (Released:2010-01-22)
参考文献数
88
被引用文献数
1 2

In relation to Friedel-Crafts acylation, complexes of (ArH·MX3), (ArH·HX·MX3), and (RCOX·MX3) were chronologically reviewed on their structual formulations up to date. Properties of their complexes and their roles in the reaction were explained in terms of their differences between π-and σ-type structure. The X-ray crystal analytical results were quoted to make clear the structual small changes between π-axial and π-edgewize complexes and between ionic and nonionic complexes of (RCOX·MX3), and also to demonstrate the characteristics of σ-complex. From the recent results obtained in nonconventional attack at ipso position, some comment was added about the difficulty of finding structual relationship between intermediate complexes and products.
著者
新森 英之 大須賀 篤弘
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.57, no.9, pp.749-762, 1999-09-01 (Released:2009-11-16)
参考文献数
64
被引用文献数
7 9

Recent advances in the synthesis of covalently linked multiporphyrin arrays are summarized with particular emphasis on those with well-defined geometries and with novel and interesting properties. Of these, 1) aromatic-group bridged porphyrin arrays have been proved to be useful for defining geometries of the porphyrin arrays without alternation of physical properties of porphyrin subunits, 2) ethynyl-group bridged porphyrin arrays that are relatively easy to make by palladium-catalyzed reactions display significant changes in their optical and electrochemical properties particularly when the ethynyl groups are attached at the meso-positions of porphyrins, and 3) meso-meso linked multiporphyrin arrays are promising in view of their unique optical properties, easy extension to higher oligomers, and relatively high solubility.
著者
近藤 忠雄 上田 実 吉田 久美
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.54, no.1, pp.42-53, 1996-01-01 (Released:2009-11-16)
参考文献数
29
被引用文献数
1 4

Various flower colors are in great part due to anthocyanins. Recently, we have elucidated two new mechanisms for blue flower color development on blue cornflower and blue morning glory. The composition of protocyanin, a blue pigment from cornflower, Centaurea cyanus, was determined to consist of six molecules of succinylcyanins (Sucy), six molecules of malonylflavones (Mafl), one ferric ion and one magnesium ion, [Sucy6Mafl6Fe3+Mg2+]. The blue color of protocyanin was due to the LMCT (Ligand to Metal Charge Transfer) interaction between Sucy and Fe3+. The structure of protocyanin was examined by using Al, Mg-protocyanin. The gross structure is much similar to that of commelinin. The pigment of blue morning glory, Ipomoea tricolor, is an triacylated anthocyanin, HBA. We measured the vacuoler pH of the petal of morning glory by using a proton selective micro electrode. The pHv of the petal of purplish red bud was 6.6 and that of blue open flower petal was 7.7. The anhydrobase anion of HBA must be stabilized by intramolecular stacking. We could solve 80 year's problems, one is about cornflower's pigment and the other is the evidence of the pH theory. In both cases hydrophobic interaction followed by formation of supra-molecule is the key of stabilization of anthocyanidin chromophore.
著者
大沢 映二
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.45, no.11, pp.1033-1043, 1987-11-01 (Released:2009-11-13)
参考文献数
94
被引用文献数
1 1

日本化学会の将来構想委員会が最近公表した報告の中に「化学におけるコンピュータの役割」と題する一章があり,その中で次のように言っている:『(コンピュータ)の役割は今後益々増え(続け),化学の将来に最も重要な分野の一つはコンピュータによる理論的な計算や論理,考察であろう』。コンピュータに向く理論計算法は大きく分けて量子化学計算と分子力学計算である。前者については本特集では別に取り上げられている。後者は一口で言えば分子模型のコンピュータ化であって,特に有機立体化学や有機合成化学への応用に適している。分子力学法の使い方や応用例については本特集では別に解説されるので,ここでは応用に入る前の導入部として,基本的な考え方や今後の動向に重きを置いて纏めてみた。
著者
長瀬 博 松本 和久 西山 久雄
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.54, no.12, pp.1055-1066, 1996-12-01 (Released:2009-11-16)
参考文献数
44
被引用文献数
6 10

Just after the discovery of PGI2, we started to find chemically and metabolically stable PGI2 derivatives with longer duration of action. Extensive studies led us to a new class of stable PGI2 analogue, 5, 6, 7-trinor-4, 8-inter-m-phenylenePGI2 that has a phenol moiety instead of enol-ether linkage in PGI2. In order to accomplish synthesis of the m-phenylenePGI2, novel synthetic methods were developed, for instance, ortho-selective metal-halogen exchange reaction of bromoanisoles by means of Grignard reagent, copper-catalyzed SN2' cyclization to prepare dihydrocyclopenta [b] benzofuran, and regioselective and stereo-selective elongation of ω-side chain by Prins reaction. Further efforts were devoted to synthesize derivatives of m-phenylenePGI2 with enhanced pharmacological activity and less adverse reaction. Finally, we attained to Beraprost sodium which is the first launched drug as an orally active PGI2. This paper will focus on the study of total syntheses of m-phenylenePGI2.
著者
岡 希太郎 原 昭二
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.37, no.1, pp.25-39, 1979-01-01 (Released:2010-01-22)
参考文献数
105
被引用文献数
1

This review involves the synthetic studies on the salamander alkaloids isolated from an animal venom in the skin gland of Salamandra maculosa Laurenti. Syntheses of three groups of the alkaloids, one with a bicyclo-oxazolidine system, one with a carbinolamine system, and another with a pure 3-aza-A-homo steroid system, are discussed separately. It will be emphasized that the synthetic works described herein made a considerable contribution to the structure analyses of this field of alkaloids and earlier proposed structures based on X-ray and spectroscopic analyses have been changed step by step. Regio and stereospecific syntheses of the alkaloids are mainly discussed in connection with the construction of the bicyclo-oxazolidine system of the major alkaloids and with Beckmann rearrangement of steroid 3-ketoximes for the syntheses of the other alkaloids.
著者
前田 満和
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.49, no.11, pp.1021-1031, 1991-11-01 (Released:2009-11-16)
参考文献数
54
被引用文献数
1 3

Cisplatin [cis-dichlorodiammineplatinum (II)] has been widely used for clinical cancer chemotherapy though the complex has severe side effect such as renal toxicity. This article is summarized synthetic method, reactivities, and mechanism of action against target molecules of cisplatin. And a part of newly synthesized cisplatin analogs including our liposoluble or water miscible platinum (II) complexes are summarized with their antitumor activities against experimental tumors.
著者
金子 正勝
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.49, no.11, pp.989-1001, 1991-11-01 (Released:2009-11-16)
参考文献数
87
被引用文献数
3 8

Recent development in the synthetic chemistry of the antitumor antimetabolites of nucleic acid related compounds has been reviewed. In addition to the methodology of the synthesis of antimetabolites from the point of synthetic chemistry, the antitumor activities and the mechanisms of them have also been mentioned.
著者
蒲地 保子 工藤 忠宏
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.52, no.4, pp.285-294, 1994-04-01 (Released:2010-01-28)
参考文献数
14
被引用文献数
10 16

Recent study in this laboratory is reviewed The single electron donor ability of samarium diiodide (SmI2) can be enhanced with ligands around of Sm (II) when a sufficient electron is supplied from ligands. Mechanistic consideration of this enhancement led us to find that carboxylic acid, ester, amide, nitrile and the other functionalities were rapidly reduced with SmI2 in the presence of base, acid and water as ligands at room temperature in good yields. Particularly, these systems reduced directly carboxylic acid into alcohol and SmI2-85% phosphoric acid system reduced aromatic primary amide to aldehyde in good yield Pyridines were similarly reduced to piperidines with SmI2-base or water system and aromatic nucleus of phenol derivatives was rapidly reduced with SmI2-base system Furthermore, carboxylic acid, ester, amide and nitrile were rapidly reduced with Sm or Yb metal-hydrochloric acid system.The striking characteristic of these reduction is mild conditions, short reaction time (within a few secondsminutes), high yield of reductive products and one pot reaction with facile method.
著者
安達 直義 萩原 昭二
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.11, no.1, pp.2-28, 1953

色彩を科学的に数値を以つて表示することは比較的近年の発達であり照明, 天然色寫眞並に印刷を始め染料, 顔料, 染色加工品, その他色を取り扱う分野に極めて重要な役割を占めるに至つた. 既にアメリカその他の国ではこの表示法は実用化された今日海外貿易の立場からも極めて大切であり我国においても日本工業規格の「色の表示方法」が昭和27年制定された。本綜説は色彩表示に関し大体1941年頃から最近に至る発展を成るべく李易に解説したものであり, 下記の図書の内容程度については既に充分の理解を有していることを前提として書いた. 色彩に関係する人々に寄与し且つ前記工業規格の具体的応用の進展に段立ち得れば幸である.<BR>1. Arthur O. Hardy; <I>Handbook of Colorimetry</I> (1936) 邦訳吉城肇蔚訳測色学 (昭和19年)<BR>本書は1935年頃迄の測色学の発展程度である. 乳財団法人日本色彩研究所著色の標準 (昭和26年) 本書中の色の標準解説は1943年頃迄の発展程度である.