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1 0 0 0 OA 川崎病 update 病理学的解析を中心に

著者: 髙橋啓
出版者: 帝京大学アジア国際感染症制御研究所
雑誌: ADC Letter for Infectious Disease Control (ISSN:21895171)
巻号頁・発行日: vol.6, no.1, pp.25-27, 2019 (Released:2020-03-10)

Kawasaki disease (KD) is a systemic vasculitis that affects mainly children under 5 years of age. Although over 50 years have passed since Dr. Tomisaku Kawasaki first reported KD, its cause remains unclear. We have been performing a histopathological study on vasculitis of KD. In addition, we established a murine model of systemic arteritis by injecting a Candida albicans cell wall polysaccharide. The arteritis that develops in the model shows a predilection for manifesting in the coronary artery and aortic root. Careful observation of human and experimental model is important to understand the pathogenesis of the vasculitis of KD.

2021-10-18 16:41:35
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1 0 0 0 OA Effects of Products Containing Bacillus subtilis var. natto on Healthy Subjects with Neck and Shoulder Stiffness, a Double-Blind, Placebo-Controlled, Randomized Crossover Study

著者: Yoichi Sunagawa Nobuko Okamura Yusuke Miyazaki Kana Shimizu Mai Genpei Masafumi Funamoto Satoshi Shimizu Yasufumi Katanasaka Eriko Morimoto Hajime Yamakage Maki Komiyama Noriko Satoh-Asahara Hiromichi Wada Mika Suzuki Koji Hasegawa Tatsuya Morimoto
出版者: The Pharmaceutical Society of Japan
雑誌: Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日: vol.41, no.4, pp.504-509, 2018-04-01 (Released:2018-04-01)
参考文献数: 24
被引用文献数: 2 7

Neck and shoulder stiffness is a typical subjective symptom in developed countries. This stiffness is caused by factors such as muscle tension and poor blood flow, leading to reduce work efficiency and diminish QOL. NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F, has antithrombotic, fibrinolytic, and blood viscosity-lowering effects. Here, we investigated the effect of NKCP® on neck and shoulder stiffness in a double-blind placebo-controlled randomized crossover study. Thirty subjects with neck and shoulder stiffness were randomly divided into 2 groups and ingested 250 mg of NKCP® or placebo daily for 4 weeks. Headache score significantly improved in the NKCP® group compared to the placebo group. Moreover, NKCP® significantly improved the score of visual analogue scale for neck and shoulder stiffness and pain, reduced muscle stiffness of the neck, and increased the skin surface temperature of neck and shoulders, compared to before ingestion. No adverse effects were observed during this study. These results suggest that NKCP® may alleviate headaches and chronic neck and shoulder stiffness and pain.