文献一覧: 中西弘 (著者)

1 0 0 0 OA 抗がん剤による職業的曝露回避のためのバイアル包装の耐破損性能評価-オンコテイン™の耐破損性について-

著者: 小林由佳岩根裕紀中西弘和
出版者: 一般社団法人日本医療薬学会
雑誌: 医療薬学 (ISSN:1346342X)
巻号頁・発行日: vol.40, no.6, pp.352-359, 2014-06-10 (Released:2015-06-10)
参考文献数: 12

Onco-TainTM Vial, which was developed to prevent occupational exposures to hazardous drugs such as antineoplastic drugs, is a vial preparation equipped with sheathings (a PVC reinforced base and a shrink wrapping of a protective PET sleeve on the vial). The shatter-resistance of the Onco-Tain™ vial was evaluated with a free fall test. Four types (9 strengths in total) of Onco-Tain™ vials, which contain antineoplastic agents and are available worldwide, were used in the test. Vials with the PVC bases and PET sleeves removed from the Onco-Tain™ vial were used as the control. Mimicking the fall of vials in the medical setting, the falling heights were set at 70, 135 and 180 cm, and the breakage ratios of vials and the scattering area of contents were measured.In the control group (Non-OT group), 3.5, 9.4 and 8.9 percent of vials were broken at the heights of 70, 135 and 180 cm, respectively, and the scattering of contents was observed in all broken vials. The breakage ratios of vials in the Onco-Tain™ vial group (OT group) were statistically significantly lower (0.0 and 2.4%) at the heights of 70 and 135 cm, and tended to be lower (3.3%) at the height of 180 cm. No leakage was observed in vials broken in the OT group. The significant improvement of shatter-resistance of vials was confirmed by applying the protection sleeves to the surface of the vials. By applying these concepts in the future, a decrease of occupational exposures to hazardous drugs caused by the breakage of containers is expected.

2019-03-13 11:36:43
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1 0 0 0 OA 記号過程を内包した動的適応システムの設計論

著者: 椹木哲夫土屋和雄門内輝行冨田直秀横小路泰義尾形哲也青柳富誌生水山元中西弘明堀口由貴男青井伸也谷口忠大
出版者: 京都大学
雑誌: 学術創成研究費
巻号頁・発行日: 2007

複雑なシステムの中におかれたヒトや生体は,自らを取り巻くところの環境や社会を能動的に意味づけ,価値づけ,自らの棲む世界として秩序化していくことができる.本研究課題では,このような自律的主体の「多様性の生成と選択」の機構を「記号過程」に求め,記号の生成・利用のダイナミズムの観点から,生体細胞から環境適応機械(ロボット),社会組織に亘る様々なレベルにおける適応システムの同型性を見いだし,個々のシステム要素が外部・内部の物理的環境との相互作用を介して機能が形成される一般的過程について追究した. 5カ年の成果により,目的をもって生きる存在としての自律的な主体(人,ロボット,細胞)が, 他者主体を含む環境との相互作用を通して,意味の世界を創出して伝達する仕組み(記号過程)を解明し,システムが人を育て,人がシステムを育てる相互主導性を担保できるシステムの設計論を確立することができた。