著者

清水 幸雄 柚原 亜美 矢野 勝子 北川 佳奈子 飯田 純一 五十嵐 信智 伊藤 清美 落合 和 折井 孝男 杉山 清

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.36, no.1, pp.31-36, 2010 (Released:2011-12-24)

参考文献数

17

被引用文献数

6 4

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There is concern about the possibility of degradation of the active substance as a result of pH changes when making suspensions of several drugs together by the simple suspension method.However,this has been investigated by few researchers.In the present study,we focused our attention on aspirin since it is known to be hydrolyzed at high temperatures or with elevation in pH.In this study,a Bufferin® 81 mg Tablet was suspended alone or together with alkaline drugs by the simple suspension method,and its stability evaluated.When in the suspension alone,the Bufferin® 81 mg Tablet was stable for 5 hours and the amount of salicylic acid (hydrolyte of aspirin) produced was negligible.On the other hand,when it was suspended together with alkaline agents (magnesium oxide tablet/powder,or lithium carbonate tablet),the residual content of aspirin decreased to 77-84% in ten minutes.The pH of the suspensions containing both the Bufferin® 81 mg Tablet and alkaline agents ranged from about 9 to 10 showing that alkalinity had been enhanced as compared with the suspension of Bufferin alone whose pH was 4.It has been reported that in low-dose aspirin therapy,platelet aggregation inhibition is unstable if the daily aspirin dosage is reduced to less than 75 mg.However for Bufferin® 81 mg Tablet,the results of the present study suggested that the beneficial effect of low-dose aspirin therapy might not be fully achieved it were suspended together with alkaline agents by the simple suspension method.

著者

石井 敬 戸田 雄大 五十嵐 信智 落合 和 杉山 清

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.3, pp.301-310, 2012 (Released:2012-03-01)

参考文献数

36

被引用文献数

2 14

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Living organisms eliminate foreign low-antigenic substances, such as drugs and environmental pollutants, by detoxification mediated by metabolizing cytochrome P450 (CYP). We have examined the possible regulation of CYP expression by enteric bacteria. Cyp mRNA expression levels, Cyp3a protein expression level, and the activity of Cyp3a in hepatic microsomal fractions were compared in germ-free (GF) and specific pathogen-free (SPF) mice. We evaluated hepatic Cyp3a11 mRNA expression levels and Cyp3a metabolic activity in GF and SPF mice after five days of antibiotic administration. The fecal levels of lithocholic acid (LCA)-producing bacteria and hepatic taurolithocholic acid (TLCA) were also measured. Cyp mRNA expression levels, Cyp3a protein expression level, and the activity of Cyp3a in SPF mice were higher than those in GF mice, indicating that enteric bacteria increases hepatic Cyp3a expression. The effects of enteric bacteria-reducing antibiotics on Cyp3a expression were examined. We observed that decreasing enteric bacteria with antibiotics in SPF mice caused a significant decrease in the hepatic Cyp3a11 mRNA expression, TLCA, and fecal LCA-producing bacteria compared to the group that did not receive antibiotics. No change in Cyp3a11 expression was observed in GF mice that were treated with antibiotics. Administration of LCA to GF mice showed an increase in Cyp3a11 expression similar to that of SPF mice. The enzymes of the enteric bacteria are believed to metabolize and detoxify drugs by either reduction or hydrolysis. The results of this study indicate that changes in enteric bacteria may alter the expression and activity of hepatic drug metabolizing enzymes and pharmacokinetics. Therefore, enteric bacteria should be closely monitored to ensure the safe use of drugs.

著者

五十嵐 信智 入野 真規子 篠原 泰友 篠原 久仁子 杉山 清 杉本 奈緒子 高橋 則篤 高崎 文香 伊藤 清美 平野 智子 黒木 由香 大井 文子 小川 聡子

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集

巻号頁・発行日

vol.16, 2006

著者

五十嵐 信智 齋藤 景子 伊藤 清美 杉山 清

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集 17 (ISSN:24242470)

巻号頁・発行日

pp.281, 2007-09-01 (Released:2019-01-19)

著者

五十嵐 信

出版者

一般社団法人 資源・素材学会

雑誌

資源と素材 (ISSN:09161740)

巻号頁・発行日

vol.110, no.9, pp.679-688, 1994-08-25 (Released:2011-01-27)

参考文献数

5

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Akabira Colliery has been opend since 1938. The mine has many minable coal seams and is recentry extracting six seams, of them. The seams incline steeply toward syncline axis which runs across the central part of the mine from south to north. The mine has continued to product annualy washing coal from 1Mt to 2Mt since 1960's on a condition that there were mining trouble and safty caused by many faults and a lot of methane gas flow.In 1986, a change of coal situation that a demand of domestic coal took a sudden turn for the decrease because on an amendment of coal policy in Japan made Akabira Colliery determine to improve the basic structure of mining and safty. As the result, the structure of ventilation and transportation was simplified and made more efficient. And mining inside the shaft saftypillar has become a necessity. Heavy mechanised mining system replaced manual one. Akabira Colliery has become a new mine and come to be able to continue production in spite of severe situiation of domestic coal. Since the shaft is apt to be influenced or possibly damaged by ground movements, the prediction of shaft behavior due to mining, the monitoring of shaft deformations, and the repair of shaft damage should be executed as precisely as possible.This report shows experience of a drastic remodeling of mining structure and safty one which was carried out at Akabira Colliery from 1986 to 1994.

著者

佐伯 英明 三浦 邦夫 五十嵐 信寛 小川 弘良 清水 世紀 和田 郁生 鈴木 隆志 原田 忠 森田 隆 加藤 哲郎

出版者

社団法人日本泌尿器科学会

雑誌

日本泌尿器科學會雜誌 (ISSN:00215287)

巻号頁・発行日

vol.73, no.8, pp.1058-1062, 1982-08-20

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症例は妊娠第15週の36歳の女子で,肉眼的血尿を主訴として当科を受診した。膀胱鏡を施行したところ,膀胱左側壁に巨大な腫瘤を認めたので生検を行ない,移行上皮癌と判明した。患者は既に3子を有しているので,人工流産を施行し,泌尿器科的精査および治療を進めていつた。膀胱造影では左側半分を占める巨大た陰影欠損を認め,骨盤部動脈造影で腫瘍血管に富む腫瘍を認めた。術前に,マイクロカプセル化されたマイトマイシンCを合計40mg使用して2度にわたつて腫瘍支配動脈の化学塞栓を行ない,化学塞栓後の膀胱造影で腫瘍が中等度縮小した時点で膀胱全摘除術および回腸導管造設術を施行した。肉眼的には大小2個の腫瘍が認められ,組織学的にはgrade I, stage Aの移行上皮癌であつた。術後5ヵ月という短い経過ではあるが,転移や再発の徴候はない。妊娠に悪性腫瘍が合併することは稀れであり,殊に尿路悪性腫瘍が合併することは極めて少ない。妊娠に合併した膀胱癌の症例は欧米の文献に7例を認めるが,本邦では最初の報告ではないかと思われた。血尿が認められれば妊娠の有無にかかわらず即時にしかも適切な検索が行なわれなけれぼならないことを強調し,かつ,妊娠中の膀胱癌の治療法および妊娠と悪性腫瘍との関係について若干の考察を加えた。

著者

柳 勝幸 村松 佳孝 五十嵐 信哉 鈴木 庸介 福田 滋夫 加藤 直樹

出版者

一般社団法人日本建築学会

雑誌

学術講演梗概集. B-2, 構造II, 振動, 原子力プラント (ISSN:13414461)

巻号頁・発行日

vol.2008, pp.303-304, 2008-07-20