2 0 0 0 OA 12歳で発症した若年性悪性貧血II型の1例
- 著者
- 栗山 貴久子 内藤 岳史 橋田 哲夫 大塚 拓治 日比 成美 今宿 晋作 澤田 淳
- 出版者
- 特定非営利活動法人 日本小児血液・がん学会
- 雑誌
- 日本小児血液学会雑誌 (ISSN:09138706)
- 巻号頁・発行日
- vol.12, no.5, pp.359-363, 1998-10-31 (Released:2011-03-09)
- 参考文献数
- 21
12歳で悪性貧血 (PA) を発症した男児例を報告した.患児は全身倦怠, 顔色不良を主訴に入院した.入院時, RBC 1.21×106/μl, Hb 4.7 g/dl, MCV 113.9 fl, MCH 39.2 pgと大球性高色素性貧血と好中球減少がみられた.血清のvitamin B12は低下し (190 pg/ml), 抗内因子抗体, 抗胃壁細胞抗体が陽性であった.骨髄検査では, 赤芽球の異形性と巨赤芽球性変化, 巨大後骨髄球, 好中球過分葉を認めた.胃内視鏡検査にて萎縮性胃炎が確認された.Schilling試験は57Co標識内因子, 58Coとも血中濃度が1.43%, 0.41%と著しく低値で, McIntyre II型PAと診断した. Vitamin B12の補充療法を開始したところ速やかに全身症状, 血液所見は改善したが, 萎縮性胃炎には高率に胃癌を合併する可能性があり, 定期的な内視鏡的検索が必要と思われた.
1 0 0 0 OA 焦電結晶を用いた小型元素分析装置
- 著者
- 今宿 晋 大谷 一誓 河合 潤
- 出版者
- 一般社団法人 日本鉄鋼協会
- 雑誌
- 鉄と鋼 (ISSN:00211575)
- 巻号頁・発行日
- vol.100, no.7, pp.905-910, 2014 (Released:2014-06-30)
- 参考文献数
- 23
- 被引用文献数
- 1 2
We have recently realized an electron probe microanalyzer (EPMA) and cathodoluminescence (CL) spectrometer with a palm-top size chamber including the electron source and the sample stage using a pyroelectric crystal as the electron source. In the present study, we carried out microanalysis and elemental mapping using the portable EPMA and CL spectrometer. As for the portable EPMA, the electron beam bombarded a sample and the wall of the stainless steel chamber due to using a LiTaO3 single crystal with a cuboidal shape. The electron beam was focused on the sample by setting a metal needle on the pyroelectric crystal and covering the needle holder with an insulating material. The spot size of the focused electron beam was 300 μm. We succeeded in elemental analysis in micro-scale region using the focused electron beam. The portable EPMA can also detect light elements such as Mg, Al and Si by introducing the X-ray detector into sample chamber. The portable CL spectrometer can detect ppm order of rare-earth elements in a mineral ore. The portable CL spectrometer can also perform an elemental mapping of rare-earth elements by capturing a CL image with CMOS camera.
- 著者
- 月本 一郎 塙 嘉之 高久 史麿 浅野 茂隆 上田 一博 土田 昌宏 佐藤 武幸 大平 睦郎 星 順隆 西平 浩一 中畑 龍俊 今宿 晋作 秋山 祐一 櫻井 實 宮崎 澄雄 堺 薫 内海 治郎 黒梅 恭芳 古川 利温 山本 圭子 関根 勇夫 麦島 秀雄 矢田 純一 中沢 真平 小出 亮 加藤 俊一 金子 隆 松山 秀介 堀部 敬三 小西 省三郎 多和 昭雄 筒井 孟 高上 洋一 田坂 英子 植田 浩司
- 出版者
- 一般社団法人 日本血液学会
- 雑誌
- 臨床血液 (ISSN:04851439)
- 巻号頁・発行日
- vol.31, no.10, pp.1647-1655, 1990 (Released:2009-03-12)
- 参考文献数
- 14
- 被引用文献数
- 3
Recombinant human granulocyte colony-stimulating factor (rG-CSF), produced by Chinese hamster ovary cells, was administered in 69 chemotherapy-induced neutropenic pediatric patients (pts) with malignant tumors. Each pt received two cycles of the same chemotherapy and had neutropenia with absolute neutrophil counts (ANC) <500/μl in the first cycle. Initiating 72 hours after termination of chemotherapy in the second cycle, rG-CSF (2 μg/kg/day) was given subcutaneously or intravenously to each pt for 10 days. rG-CSF significantly increased ANC at nadir; 72±14 vs. 206±40/μl (data in the first cycle vs. data in the second cycle, respectively), and reduced the period of neutropenia with ANC<500/μl; 9.7±0.6 vs. 5.1±0.6 days, and the period for restoration to ANC≥1,000/μl after initiation of chemotherapy; 25.5±0.6 vs. 17.5±0.9 days. rG-CSF did not affect other components of peripheral blood. The number of days with fever ≥38°C was significantly reduced by rG-CSF treatment. Neck pain and lumbago were observed in one pt, polakysuria in one pt, and elevation of the serum levels of LDH and uric acid in one pt, however these were mild to moderate, transient, and resolved without any specific treatment. We concluded that rG-CSF was effective in neutropenia induced by intensive chemotherapy for malignant tumors without any serious side effects.