著者

佐田 文宏 福岡 秀興 尾崎 貴視 伊藤 善也 吉池 信男 瀧本 秀美

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.72, no.1, pp.15-19, 2017 (Released:2017-02-02)

参考文献数

26

被引用文献数

2

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There are two major nationwide birth cohort studies in Japan, namely, the Longitudinal Survey of Newborns in the 21st Century conducted by the Ministry of Health, Labor and Welfare (MHLW) and the Japan Environment and Children’s Study (JECS) conducted by the Ministry of Environment. The former was a longitudinal questionnaire survey focusing on environmental and socioeconomic factors for descriptive epidemiology conducted every year since 2001 by mail. The latter was based on 15 unit centers nationwide with environmental measurements and collection of biological samples for environmental risk evaluation. Both are prospective birth cohort studies whose findings will be expected as the basis for establishing health policies. The data obtained in the former study can be used for research with permission from MHLW. To date, there have been more than ten published studies using those data. We have reviewed these studies and introduced our preliminary findings on factors affecting infant growth. Employment before delivery, educational background of parents, household income, and smoking habit of both parents have been suggested to affect infant growth. We will analyze the associations between socioeconomic factors and infant growth trajectory to elucidate the most adequate intervention for children.

著者

福岡 秀興 佐田 文宏

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.3, pp.185-187, 2016 (Released:2016-09-30)

参考文献数

12

被引用文献数

7

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Epigenetic modification takes place in many types of environment. Undesirable epigenetic changes for the postnatal life at the developmental stage are induced in utero by exposure to harsh environment such as endocrine disruptors, severe psychological stress and insufficient or excessive nutrition. Some of these changes continues even for a long time after birth from womb to tomb. Under these circumstances with an unhealthy life style, such as higher caloric intake, insufficient exercise, or stress, there is a higher risk of developing various illnesses including lifestyle-related diseases, such as essential hypertension, type 2 diabetes mellitus, dyslipidemia, psychological disorders and cancers. An illness goes through these two steps, first having origins in the early stage of life and secondary exposure of unhealthy life. In addition, some of these modifications have a tendency to be transmitted to the next generations, (transgenerational effect). This is the concept of Developmental Origins of Health and Disease theory (DOHaD). The incidence of noncommunicable diseases (NCDs) have been markedly increasing, especially in developing countries, and the prevention of these diseases is a high-profile objective for world economic growth. In addition to birth weight, specific epigenetic modifications are expected to be good marks for developing illness in later life. With analysis of these makers, even for the individuals with a higher risk, the illness development will be expected to be effectively controlled through intervention in the early stage. Research on predicting markers, and intervention supplements, and pharmacological materials for higher risk individuals has been progressing considerably. This DOHaD theory is expected to be highly beneficial for the prevention of many illnesses.

著者

馬 明月 梅村 朋弘 森 ゆうこ 貢 英彦 西條 泰明 佐田 文宏 岸 玲子

出版者

公益社団法人日本産業衛生学会

雑誌

産業衛生学雑誌 (ISSN:1349533X)

巻号頁・発行日

vol.47, 2005-04

著者

馬 明月 梅村 朋弘 森 ゆうこ 貢 英彦 西條 泰明 佐田 文宏 岸 玲子

出版者

公益社団法人日本産業衛生学会

雑誌

産業衛生学雑誌 (ISSN:13410725)

巻号頁・発行日

vol.47, no.2, 2005-03

著者

佐田 文宏

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.1, pp.41-46, 2016 (Released:2016-01-30)

参考文献数

38

被引用文献数

5 21

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Japan has the highest proportion of low-birth-weight infants among OECD countries for over 20 years. In 2011, the proportion of low-birth-weight infants in Japan was 9.6%, whereas the mean proportion in OECD countries was only 6.8%. In particular, young Japanese women’s strong desire to be thin has been pointed out as the underlying cause. Indeed, the frequencies of unhealthy thinness among third-year female junior and senior high school Japanese students have been increasing since the start of “Healthy Parents and Children 21”, and both groups have reached about 20%. The hypothesis of the fetal origins of adult disease (Barker’s theory) was proposed by Professor David J. Barker of Southampton University, who had conducted descriptive epidemiological studies in England and Wales and birth cohort studies in Hertfordshire, for example. In early 21st century, it became the wider theory known as the “Developmental Origins of Health and Disease (DOHaD)”, which was composed of developmental plasticity and the mismatch concept. Birth cohort studies are believed to be suitable for epidemiological studies to demonstrate the DOHaD theory. These studies and their collaborations are very popular in European countries, whereas such collaborations lagged behind in Japan. Recently, a new paradigm, “preemptive medicine”, has been proposed in Japan. The importance of interdisciplinary studies focusing on fetal and childhood periods was also recommended as a political strategy. We just expect the realization of nationwide large-scale interdisciplinary research projects based on DOHaD and preemptive medicine and the establishment of a central research institute of these studies.

著者

岸 玲子 吉岡 英治 湯浅 資之 佐田 文宏 西條 泰明 神 和夫 小林 智

出版者

北海道大学

雑誌

萌芽研究

巻号頁・発行日

2007

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いわゆる化学物質過敏症を疑って札幌市内1医院を受診した患者全員(30人)に基本調査票の記入を依頼し、男性2名を含む26名から回答を得た。平均年齢は44.5歳、発症からの経過年数は2-5年が10人、発症時と比べて症状が悪化した11名、症状頻度が増加した13名だった。ドイツのBeilerらが開発した化学物質過敏症尺度(IEI尺度)を用いた結果、主訴は「においを強く感じる、頭痛、集中力の低下、疲労感、眠気」であり、原因物質は「ある種の香水、塗料または希釈液、タバコや葉巻、ガソリンのにおい、整髪料、マニキュア」だった。化学物質曝露による「健康状態、職場や学校での能力、余暇、家庭生活、身体的能力」への影響の有訴が高かった。この結果、先行研究同様に本研究対象者にとってもいわゆる化学物質過敏症は複数の身体症状が長く続く状態であるといえた。このうち同意が得られた18名(内男性1名)に芳香療法(アロマセラピー)の介入を、無作為化クロスオーバー比較試験として実施した。IEI尺度、および不安尺度については、介入期間前後と対照期間前後の得点差には統計学的有意差は見られなかったが(p>0.05)、各回のアロマセラピー前後では気分尺度の6つ全ての下位尺度に有意な改善が認められた(p<0.05)。化学物質過敏症は臨床的な疾病概念が定義されていない。しかし患者にとって身体症状は事実であり、症状コントロールが必要であるにもかかわらず、現在までに有効性が示された療法はない。本研究は化学物質過敏症へのアロマセラピーの効果を初めて検討した。対象者数が少なく、アロマセラピー介入による症状改善効果は本研究では明らかにならなかったものの短期には気分の改善が認められ、対象者の多くは機会があればこれからもアロマセラピーを受けたいと答えたことから、本研究の課題を改善することでさらなる研究の可能性が示唆された。