著者

黒田 広生 小川 紀雄 貫名 至 太田 善介

出版者

一般社団法人 日本老年医学会

雑誌

日本老年医学会雑誌 (ISSN:03009173)

巻号頁・発行日

vol.20, no.6, pp.500-505, 1983-11-30 (Released:2009-11-24)

参考文献数

25

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Alzheimer 病に代表される痴呆を主徴とする疾患や Huntington 病, Parkinson 病などの不随意運動を伴う疾患において, 脳内γ-アミノ酪酸 (GABA) 代謝の異常が指摘されている. 近年の人口の高齢化に伴い, 軽度の不随意運動や知的レベルの低下を呈する老齢者の増加が認められ, これらの老年者においても脳内GABA代謝に何らかの異常の存在することが予想される. そこで今回, 脳内GABA代謝に与える加齢の影響について研究する目的で, 脳内のGABA代謝異常を鋭敏に反映すると考えられている脳脊髄液中GABA (CSF-GABA) 濃度を各年代について測定し, 比較検討を行った.対象は健常人ボランティアおよび神経・精神疾患を有さね患者, 総計34名 (内訳: 男19名, 女15名). 年齢は21歳から81歳におよび, 平均年齢は49歳であった. CSF-GABA濃度測定にはGABA radioreceptor assay (GABA-RRA) 法を用いた.その結果, コントロール群 (20代および30代) のCSF-GABA濃度131±7.5pmoles/ml (mean±SEM) に比し, 50代, 60代, 70代, 80代の対象群のCSF-GABA濃度は有意な低下を認め, 特に70代ではコントロール群の50%, 80代では30%と著しい低値を示した. しかし, 40代では有意差は認めなかった. CSF-GABA濃度と年齢との間にも有意な負の相関関係が認められた (p<0.01). しかもこの関係は男性群, 女性群ともに成立し, 女性群においてより著明であった.これらの結果は, 年齢が進むにつれて脳内GABA代謝に著しい変化が起こることを示しており, 高齢者ほど脳内GABA代謝異常に伴う種々の症状が発現しやすい状態にあることを予測させるものであった.

著者

平田 敏彦 高橋 香代 鈴木 久雄 太田 善介 金重 哲三

出版者

日本体力医学会

雑誌

体力科學 (ISSN:0039906X)

巻号頁・発行日

vol.40, no.6, 1991-12-01

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陸上競技長距離選手が良い成績をあげるためには高い全身持久力が必要である。一方、過度の体脂肪は走運動の効率を低下させることから効果的なトレーニングの指導のためには、選手の持久性体力と身体組成の経時的な情報が必要であると考える。今回、我々は陸上協議長距離選手の持久性体力ならびに、DPXE法による身体組成を径時的に測定したので報告する。

著者

平木 潔 太田 善介 入野 昭三 三好 勇夫 瀬崎 達雄 原田 英雄 鈴木 信也 大里 尚司 永森 俤一郎 守屋 純一郎 六車 昌士 高杉 潔 駄場崎 浩 池田 一彦

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.77, no.5-6, pp.795-835, 1965-06-30 (Released:2009-03-30)

参考文献数

229

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Morphologic characteristics of most of known oncogenic viruses, some of which were investigated by us, were described in relation to their oncogenicity and their localizations in tumor tissues.Oncogenic viruses were classified into six groups: type A, B, C, D, E and F. Viruses pertaining to type A were presumably not mature virus particles. Some of them could, however, be immature form or incomplete form of oncogenic virus particles. Viruses belonging to type B, C, D, E, and F were represented by mammary tumor virus of mice, leukemia viruses of mice and chickens, polyoma virus, Shope fibroma virus and Lucké renal adenocarcinoma virus, respectively. They were different in size and shape, and in the mode of development.It was presumed that type B and C viruses were members of the Myxovisus group and type D viruses belonged to Adenovirus and the Papova virus group. It was also believed that type E and F viruses had in general the feature of the Pox virus group and Herpes virus group, respectively.

著者

平木 潔 太田 善介 三好 勇夫 原田 英雄 鈴木 信也 六車 昌士

出版者

日本ウイルス学会

雑誌

ウイルス (ISSN:00426857)

巻号頁・発行日

vol.16, no.1-2, pp.6-12, 1966-04-30 (Released:2010-03-16)

参考文献数

21

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Spontaneous mammary carcinoma of AKR mice and Xray-induced mammary carcinoma of C58 mice, both known as low-cancer strains, were investigated by electron microscopy.In AKR mammary carcinoma, intracytoplasmic type A and extracellular type B particles were present. In C58 mammary carcinoma, extracellular type C particles were observed. In both tumors, mature virus particles, i.e. type B and type C particles, were formed by the process of budding of cytoplasmic membrane of carcinoma cells and present in the lumina of the milk ducts. Aberrant form of type C particles, which contained a filamentous structure instead of a nucleoid was also seen in C58 mammary carcinoma.In serial in vivo transplantation of those carcinoma cells to the same strain mice, these virus particles were always present and formed from carcinoma cells, although the number of virus particles reduced almost successively with transplantations in AKR mammary carcinoma.In tissue culture of C58 mammary carcinoma cells, type C particles similar to those in the original tumor were observed extracellularly. On the contraty to the presence of type B particles in the original AKR mammary tumor, however, two tissue culture strains derived from in vivo transplanted AKR carcinoma cells contained type C particles. These type C particles were conceivable to be the leukemia virus that naturally harbored in AKR mice and happened to have been tranferred to the tissue culture probably through its latent infection in carcinoma cells.

著者

守田 吉孝 槇野 博史 太田 康介 和田 淳 四方 賢一 柏原 直樹 池田 修二 小倉 俊郎 太田 善介

出版者

社団法人 日本腎臓学会

雑誌

日本腎臓学会誌 (ISSN:03852385)

巻号頁・発行日

vol.36, no.7, pp.832-838, 1994 (Released:2011-07-04)

参考文献数

16

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Effect of heparin and low-molecular-weight heparin (LMWH) were evaluated on 15 patients with proliferative glomerulonephritis with various degrees of sclerosing legion. Five cases were subcutaneously administered with 7000 to 11000 units of heparin for 4 weeks. Ten cases were administered with 60 unit/kg of LMWH by drip infusion for 4 weeks. Eleven cases were treated with prednisolone and all cases were treated with anti-platelet agent as well. Urinary protein excretion reduced from 3.0±1.8 to 1.8±0.6g/day in the heparin-treated group and from 2.4±1.9 to 1.8±1.4g/day in the LMWH-treated group, respectively. There were no remarkable changes in the renal functions of both groups. In one case, both heparin and LMWH brought about reduction of proteinuria. Therefore, LMWH reduced urinary protein excretion by the same mechanism as heparin. The LMWH has an advantage over heparin in that the former has less risk of causing bleeding. We conclude that heparin and LMWH reduce proteinuria in some patients with proliferative glomerulonephritis. The LMWH is beneficial in the treatment of proliferative glomerulonephritis with a sclerosing lesion.