著者
斎藤 勇哉 Peter A. Wijeratne 鎌形 康司 Christina Andica 内田 航 明石 俊昭 和田 昭彦 堀 正明 青木 茂樹
出版者
日本磁気共鳴医学会
雑誌
日本磁気共鳴医学会雑誌 (ISSN:09149457)
巻号頁・発行日
pp.2023-1790, (Released:2023-05-25)
参考文献数
28

Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) are sporadic atypical parkinsonian disorders associated with 4-repeat tauopathies. These neurodegenerative conditions closely overlap in their clinical information, pathology, and genetic risk factors ; therefore, it is difficult to accurately diagnose CBS and PSP. Recently, an unsupervised machine-learning technique, called Subtype and Stage Inference (SuStaIn), has been proposed to reveal the data-driven disease phenotypes with distinct temporal progression patterns from widely available cross-sectional data. To clarify the differences in the temporal white matter (WM) degeneration patterns between CBS and PSP, this study applied SuStaIn for fractional anisotropy (FA) in regional WM, which was sensitive to WM degeneration, based on cross-sectional brain diffusion MRI (dMRI) data. We obtained dMRI data from 15 healthy controls, 26 patients with CBS, and 25 patients with PSP. FA was calculated after fitting the diffusion tensor model to the corrected dMRI data for susceptibility and eddy-current induced geometric distortions and inter-volume subject motion. SuStaIn was applied to the cross-sectional regional WM tract FAs to identify both the disease subtypes and their trajectories with distinct WM degeneration patterns. To assess the performance of SuStaIn, the classification accuracy and sensitivity for CBS and PSP were calculated. SuStaIn revealed that the CBS degeneration started from the fornix and stria terminalis (FSTs) and corpus callosum (CC), followed by the posterior corona radiata (PCR), posterior thalamic radiation (PTR), and cerebral peduncle (CP), and subsequently extended to the cingulum. Finally, it reached the superior cerebral peduncle (SCP) and corticospinal tract (CST). In contrast, the PSP degeneration started from the SCP and cingulum, followed by the CST, and subsequently extended to the FST and CC. Eventually, it reached the PCR, PTR, and CP. Accordingly, SuStaIn classified CBS and PSP with 0.863 accuracy (sensitivity : CBS, 0.885 ; PSP, 0.840). The results suggested the utility of SuStaIn for classifying patients with CBS and PSP and identifying temporal WM degeneration patterns in patients with CBS and PSP.
著者
那須 哲夫 黒木 昭浩 浜名 克己 村上 隆之 斎藤 勇夫
出版者
宮崎大学農学部
雑誌
宮崎大学農学部研究報告 (ISSN:05446066)
巻号頁・発行日
vol.29, no.2, pp.p259-267, 1982-12

牛(ホルスタイン種,雌, 8カ月齢)の単蹄肢(左右前肢)について解剖学的観察を行った.得られた結果は次のとおりである.### 1. 中手骨の遠位中手管は右肢で完全に閉鎖していた.第四中手骨の外側遠位部に第五中手骨が遺残し,またそれに関節する指骨(基節骨)の遺残を認めた.中手骨の滑車は右肢に1個,左肢に2個存在し,左肢の滑車間切痕は浅くなっていた.### 基節骨,中節骨および末節骨は左右両肢とも第三,四指のものがそれぞれ完全に癒合していた.### 近位種子骨は右肢に2個,左肢に3個存在し,遠位種子骨は左右肢とも各1個が存在した.### 2. 右肢において第三指伸筋,第四指伸筋および総指伸筋の腱は中手・指節関節部で合一し,幅広い腱を形成して中節骨および末節骨の前面に停止していた.左肢では総指伸筋のみは独自の腱を形成して,基節骨の近位端に停止していた.### 浅指屈筋と深指屈筋の腱は中手・指節関節部で分岐することなく,単一のまま走行し,浅指屈筋腱は中節骨後面に,深指屈筋腱は末節骨後面に停止していた.### 3. 正中動脈と橈骨動脈は中手骨の掌側面を下行し,中手骨中間部において深掌動脈弓を形成する.この動脈弓から指骨の外側および内側へ分布する2本の枝が出ており,これらの枝は指骨背側面で互に吻合していた.### 前骨間動脈は細い枝となり中手骨の背面に分布していたが,指骨にまで達していなかった.### 4. 正中神経は中手骨の掌側面を下行し,中手骨近位端1/3のところで分岐し指骨の外側および内側へ分布していた.### 尺骨神経掌側枝は骨間筋の外側を下行し指骨の外側へ分布していた.### 中手骨背側面を下行する外側前腕皮神経は途中で消失しており,それより遠位部では確認できなかった.A pair of forelimbs of 8-month-old Holstein-Freisean cow which had solid hoof was dessected to be description. The details were reported as follows.### 1. The distal perforating canal was absent from the right metacarpus. On the lateral-distal part of the metacarpal bone there were vestiges of the fifth metacarpus and the first phalanx which were jointed earch other. The right metacarpus had one distal trochlea and the left had two trochleas. The intertrochlear notch of the left metacarpus was relatively shallow. All the phalanges of front feet were completely fused. The left foot had three proximal sesamoid bones and a distal sesamoid bone, but the right had only two proximal sesamoid bones and a distal sesamoid bone.### 2. The lateral, medial and common digital extensor tendons of right forelimb fused into a wide aponeurotic plate at the fetlock joint and inserted on the extensor surfaces of the second and the third phalanx. The tendon of the left "common digital extensor did not fuse but inserted into the proximal end of the first phalanx. The superficial and deep digital flexor tendons coursed normally but did not divide into two branches at the level of the fetlock joint, the former inserted on the palmar surface of the second phalanx and the latter inserted on that of third phalax.### 3. The median and the radial arteries descended on the volar side of the metacarpus and anastomosed each other to form the deep palmar arch.### Arising from the deep palmar arch, two branches terminated by entering the lateral and the medial volar surfaces of the digit, where they formed an anastomosing arches.### The small cranial interosseus artery which descended the dorsal surface of the metacarpus did not reach the digital bone.### 4. The median nerve descended on the mediovolar side of the metacarpus. At the proximal third of the metacarpus, this nerve divided into two branches which innervated the medial and the lateral volar sides of the digit.### The palmar branch of the ulnar nerve descended along the lateral side of the interosseus muscle to the laterovolar side of the digit. The lateral cutaneous antebrachial nerve which was a slender branch of the radial nerve disappeared during its course on the volar surface of the metacarpus.
著者
村上 隆之 斎藤 勇夫 望月 公子
出版者
宮崎大学農学部
雑誌
宮崎大学農学部研究報告 (ISSN:05446066)
巻号頁・発行日
vol.33, no.1, pp.p1-8, 1986-10

鳥類19種の冠状動脈を肉眼的に観察した.### 一般に,左・右大動脈洞から起始し,深枝と浅枝に分岐する2本の冠状動脈が認められたが,これらに加え197例中5例に別の細い動脈が大動脈洞から直接起始している所見がえられた.### 右冠状動脈は一般に左冠状動脈と同大か,やや太かったが,フクロウ目では逆に左大動脈の方が太い傾向が認められた.### 右深枝は右浅枝より太いのが一般的であるが,ゴイサギの9例中3例に両者の太さの等しいものが見られた.### キジ目,ツル目, ミズナギドリ目,チドリ目,フラミンゴ,スズメ目では左深枝が左冠状動脈の主幹をなしていたが,ガンカモ目,フクロウ目,ゴイサギ,シュバシコウでは左浅枝の旁円錐室間枝が主幹をなしていた.ワシタカ目とヘラサギでは左深枝と旁円錐室間枝が同大であった.### 鳥類心臓の動脈分布様式を比較検討した結果,観察した19種の鳥類のそれらは8型に分類された.The coronary arteries were macroscopically investigated in 19 species of aves.### There were usually two coronary arteries arising from the left and right aortic sinuses, each dividing into a deep and a superficial branch. However, in five of 197 specimens examined, other small arteries arose directly from the aortic sinus.### In general, the right and left coronary arteries were of equal size or the former was slightly larger than the latter. However, in the hearts of Strigiformes the left artery was larger than the right.### The right deep branch was larger than the right superficial branch, but in 3 of 9 hearts of Nycticorax nycticorax they were equally developed.### In the hearts of Galliformes, Anseriformes, Procellariiformes, Charadriiformes, Phoenicopterus###ruber chilensis and Passeriformes the main trunk of the left coronary artery was formed with the left deep branch, but was formed with the paraconal branch of the left superficial branch in Anseriformes, Strigiformes, Nycticorax nycticorax and Ciconia ciconia. In the Falconiformes and Platalea leucorodia the deep and the paraconal interventricular branches were equally developed.### Eight patterns of arterial distribution were thus recognized in the hearts of 19 species of aves.