- 著者
- 植田 章夫 後藤 一輔 福原 篤 森 亮太 小松 史 達谷 英文 千野 武廣
- 出版者
- (公社)日本口腔インプラント学会
- 雑誌
- 日本口腔インプラント学会誌 = Journal of Japanese Society of Oral Implantology (ISSN:09146695)
- 巻号頁・発行日
- vol.11, no.4, pp.521-533, 1998-12-30
- 参考文献数
- 21
HAP implants bond directly with bone, the load and distribution of occlusal force differs from that of natural teeth, which have physiological motility. More specifically, we considered the occlusal force is a key measure of the restoration of chewing ability. We performed a clinical investigation of the restoration of chewing ability and changes over time in peripheral gingiva in patients that had received HAP-coated dental implants (SUMICIKON®)The results and implications can be summarized as follows:
- 著者
- 植田 章夫 後藤 一輔 福原 篤 森 亮太 小松 史 達谷 英文 千野 武廣 Ueda Akio Goto Kazusuke Fukuhara Atsushi Mori Ryota Komatsu Fuhito Tatsuya Hidefumi Chino Takehiro
- 出版者
- (公社)日本口腔インプラント学会
- 雑誌
- 日本口腔インプラント学会誌 = Journal of Japanese Society of Oral Implantology (ISSN:09146695)
- 巻号頁・発行日
- vol.11, no.4, pp.521-533, 1998-12-31
HAP implants bond directly with bone, the load and distribution of occlusal force differs from that of natural teeth, which have physiological motility. More specifically, we considered the occlusal force is a key measure of the restoration of chewing ability. We performed a clinical investigation of the restoration of chewing ability and changes over time in peripheral gingiva in patients that had received HAP-coated dental implants (SUMICIKON®)The results and implications can be summarized as follows:
1 0 0 0 OA 座談会 -2020年東京オリンピック・パラリンピックと超高齢少子社会に向けて-
- 著者
- 山本 雅康 久保 博子 西口 宏美 蜂須賀 知理 森 亮太 山田 泰行
- 出版者
- 一般社団法人 日本人間工学会
- 雑誌
- 人間工学 (ISSN:05494974)
- 巻号頁・発行日
- vol.51, no.3, pp.167-173, 2015-06-15 (Released:2016-07-14)
- 参考文献数
- 20
1 0 0 0 OA ダウン症患者における早期アルツハイマー病発症メカニズムの解明
- 著者
- 浅井 将 川久保 昂 森 亮太郎 岩田 修永
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.137, no.7, pp.801-805, 2017 (Released:2017-07-01)
- 参考文献数
- 18
- 被引用文献数
- 12
Down syndrome (DS) patients demonstrate the neuropathology of Alzheimer's disease (AD) characterized by the formation of senile plaques and neurofibrillary tangles by age 40-50 years. It has been considered for a number of years that 1.5-fold expression of the gene for the amyloid precursor protein (APP) located on chromosome 21 leading to overproduction of amyloid-β peptide (Aβ) results in the early onset of AD in adults with DS. However, the mean age of onset of familial AD with the Swedish mutation on APP which has high affinity for β-secretase associated with a dramatic increase in Aβ production is about 55 years. This paradox indicates that there is a poor correlation between average ages of AD onset and the theoretical amount of Aβ production and that there are factors exacerbating AD on chromosome 21. We therefore focused on dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), since overexpressing transgenic mice show AD-like brain pathology. The overexpression of DYRK1A caused suppression of the activity of neprilysin (NEP), which is a major Aβ-degrading enzyme in the brain, and phosphorylation at the NEP cytoplasmic domain. NEP activity was markedly reduced in fibroblasts derived from DS patients compared with that in fibroblasts derived from healthy controls. This impaired activity of NEP was rescued by DYRK1A inhibition. These results show that DYRK1A overexpression causes suppression of NEP activity through its phosphorylation in DS patients. Our results suggest that DYRK1A inhibitors could be effective against AD not only in adults with DS but also in sporadic AD patients.
- 著者
- 森 亮太 成岡 優 土屋 武司 鈴木 真二
- 出版者
- 一般社団法人日本機械学会
- 雑誌
- 年次大会講演論文集 : JSME annual meeting
- 巻号頁・発行日
- vol.2006, no.5, pp.469-470, 2006-09-15
A neural network modeling approach has been developed to analyze human pilots' control by utilizing the recorded time history of visual cues and pilot control inputs. An experimental method is developed to record the time histories of visual cues and pilot control inputs by analyzing recorded video data at a real flight. The developed method makes it possible to obtain neural network model of a pilot at a real landing case. In this research, the reliability of this method is confirmed by comparing the video data with GPS/INS data. The obtained results of the contribution ratios and sensitivities reveal the characteristics of the pilot's control.
- 著者
- 森 亮太 鈴木 真二
- 出版者
- 一般社団法人日本機械学会
- 雑誌
- 交通・物流部門大会講演論文集
- 巻号頁・発行日
- vol.2006, no.15, pp.273-276, 2006-12-13
A neural network modeling approach has been developed to analyze human pilots' landing control at visual approach by utilizing the recorded time history of visual cues and pilot control. In real flight analysis, we develop the new method to obtain the necessary data by analyzing recorded video data. In this research, the accuracy of the obtained data is confirmed by comparing the video data with GPS/INS data. Moreover, several real flight experiments with various flight conditions are carried out and the characteristic of each pilot control method for each flight condition is revealed by contribution ratios analysis and sensitivity analysis.