著者
松野 智宣 北原 和樹 田中 正司 佐藤 田鶴子 荒井 千明
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.21, no.2, pp.53-58, 2002-08-01 (Released:2010-06-08)
参考文献数
13
被引用文献数
2

Platelet-rich plasma (PRP), separated by centrifugation of autologous blood, is a plasma containing numerous platelets. Consequently, efficient separation of PRP can provide highly concentrated autologous growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), and insulin-like growth factor-I (IGF-I), derived from α granules. However, it requires a substance to trigger platelet aggregation, in order to activate platelets to release the growth factors.In the present study, we investigated a procedure of activating platelets (aggregation) with calcium chloride alone, in the absence of thrombin, the safety of which is suspected. Prior to the investigation, we sought the optimal centrifugal conditions, i.e., centrifugal gravity and time, for separation of PRP. As a result, we discovered that a centrifugal gravity of 130 (×g) and a centrifugal time of 10 min, are the optimal conditions for separating PRP. The time required for platelet aggregation was prolonged in platelet activation by calcium chloride alone, as compared with platelet activation by thrombin. However, activation of platelets with calcium chloride alone demonstrated gelatinization of PRP indicative of sufficient fibrin formation.
著者
田中 正司
出版者
The Japanese Society for the History of Economic Thought
雑誌
経済学史学会年報 (ISSN:04534786)
巻号頁・発行日
vol.38, no.38, pp.37-44, 2000 (Released:2010-08-05)

My inquiry into John Locke's theory on the Law of Nature and Property had led me to recognize the continuity and identity of the ground and subjects between the 17th and 18th century thoughts as the theory of Law and Government. This realization opened the way for me to study the works of Adam Smith, beginning with the demonstration of the fact that the fundamental central subject of the first edition of The Theory of Moral Sentiments was the theory of justice, not prudence or beneficence. Reading “A Note” of Smith's Lectures on Jurisprudence, published in 1978, confirmed my conviction that the main themes of his moral philosophy were Moral Sentimental theorizing on the subjects of the modern natural laws, especially Francis Hutcheson's natural law system. Furthermore, inquiry into the inter-relations between Hutcheson, Hume, Lord Kames and Smith began to help me understand the theological bases of Smith's theory, provided me the key to the real meaning of the System of Natural Liberty in The Wealth of Nations and to recognize a New Adam Smith problem, which is the discrepancy between his teleological or theological assumption and his purely empirical theories.
著者
田中 正司
出版者
神奈川大学
雑誌
商経論叢 (ISSN:02868342)
巻号頁・発行日
vol.26, no.2, pp.1-51, 1991-03

論説
著者
田中 正司
出版者
神奈川大学
雑誌
神奈川法学 (ISSN:0453185X)
巻号頁・発行日
vol.27, no.2, pp.473-496, 1992