著者

日下部 吉男 中村 康宏 谷川 和也 唐澤 健 丸山 桂司

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.143, no.7, pp.607-616, 2023-07-01 (Released:2023-07-01)

参考文献数

13

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In today’s world, where clinical options are ever increasing and patients’ needs are more diverse, it is not possible to conclude that simply practicing medical care based on pathophysiological data and medical evidence is sufficient for patients, particularly in terms of seeing each patient as an individual. Medical professionals must maintain a close relationship with their patients and seek treatment and care methods that reflect the patient’s values and views on life and death, based on their own ethics in medical care. Ethics education should be provided on a continuing basis from the beginning of medical/pharmacy school. However, ethics education in pharmacy departments is often delivered in a lecture format attended by many students and/or as group training using case studies and hypothetical situations, i.e., “paper” patients. With these teaching methods, there are limited opportunities for the students to foster a sense of ethics or to think deeply about their values and views on life and death with respect to the patients they care for. Therefore, in this study, we conducted ethics exercises for pharmacy students in a group study format using a documentary film of real patients who were facing death. By retrospectively analyzing the results of the questionnaires collected before and after the assignments and exercises, we verified the educational effects and changes in the students’ sense of ethics from participating in the group learning exercise; moreover, our results revealed the insight gained by the students in examining the experiences and challenges faced by terminally ill patients.

著者

長谷川 和也 熊坂 崇

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.64, no.4, pp.294-299, 2022-12-15 (Released:2022-12-17)

参考文献数

34

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Cryo-crystallography is usually used at synchrotron macromolecular crystallography(MX)beamlines in order to mitigate radiation damage. However, the structures determined at cryogenic temperatures sometimes hide conformational states observed at room temperature. Serial femtosecond crystallography(SFX)developed at XFELs demonstrated that room temperature structure analysis is possible even using micro-crystals. Following these successes, serial crystallography is also performed at synchrotron MX beamlines aiming at room temperature structure determination and time resolved structure analysis. In this review, synchrotron serial crystallography(SSX)performed at synchrotron MX beamlines in worldwide is summarized, and development of SSX at SPring-8 MX beamlines is introduced together with ongoing project toward time resolved experiments.

著者

梶並 知記 長谷川 和也

雑誌

情報処理学会論文誌デジタルコンテンツ(DCON) (ISSN:21878897)

巻号頁・発行日

vol.6, no.1, pp.17-27, 2018-02-28

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本稿では,対戦型格闘ゲームの初心者観戦者を対象とした,試合の観戦支援システムを提案する.対戦型格闘ゲームは,プレイヤが格闘家を模したキャラクタを操作し,対戦相手のプレイヤが操作するキャラクタと闘うゲームであり,近年国際的な競技会も開催されているデジタルゲーム競技(e-Sports)のジャンルの一種である.従来研究で,キャラクタの相対位置や,ゲームフィールド上の絶対位置がプレイヤの意思決定に及ぼす影響について考察されている.本稿ではゲームキャラクタの相対位置や絶対位置に基づき,対戦型格闘ゲームのプレイ中に現れる典型的な3つの状況である,近距離状況,遠距離状況,画面端状況を定義し,状況に応じた文字アノテーションと図形アノテーションを提示する観戦支援システムを構築する.文字アノテーションは,プレイヤにとっての各状況の意味を端的に観戦者に示しつつ,攻防が行われそうなタイミングを観戦者に伝達する.図形アノテーションは,矩形や矢印といった基本図形で,攻防が行われそうな場所を観戦者に伝達する.対戦型格闘ゲームにあまり詳しくない初心者観戦者を被験者とした評価実験を行い,提案システムの有効性を検証する.実験の結果,提案システムを用いた被験者が,試合中の攻防が行われるタイミングや場所をより容易に理解・予測できるようになることを示す.

著者

山本 雅貴 平田 邦生 長谷川 和也

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.64, no.1, pp.2-9, 2022-02-28 (Released:2022-03-04)

参考文献数

37

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Since the first crystal structure determination of protein by J. C. Kendrew in 1959, protein crystallography has been playing the leading role in the structural biology by various technology developments. Especially the utilization of synchrotron radiation from the 1990s brought innovative progress in this field on the data quality and the phasing method and had expanded the sample targets including membrane proteins and supra-molecular complexes. Here we will describe the outline and the future prospects of the protein crystallography from the role of synchrotron radiation and SPring-8.

著者

石井 則久 鵜殿 俊史 藤澤 道子 伊谷 原一 谷川 和也 宮村 達男 鈴木 幸一

出版者

日本ハンセン病学会

雑誌

日本ハンセン病学会雑誌 = Japanese journal of leprosy (ISSN:13423681)

巻号頁・発行日

vol.80, no.1, pp.29-36, 2011-02-01

参考文献数

25

被引用文献数

1

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&nbsp;&nbsp;Leprosy is suspected to develop after a long period of latency following infection with <i>Mycobacterium leprae</i> (<i>M. leprae</i>) during infancy, but definitive proof has been lacking. We found a rare case of leprosy in a chimpanzee (<i>Pan troglodytes</i>) born in West Africa (Sierra Leone) and brought to Japan around 2 years of age. At 31, the ape started exhibiting pathognomic signs of leprosy. Pathological diagnosis, skin smear, serum anti-phenolic glycolipid-I (PGL-I) antibody, and by PCR analysis demonstrated lepromatous leprosy. Single-nucleotide polymorphism (SNP) analysis verified the West African origin of the bacilli. This occurrence suggests the possibility of leprosy being endemic among wild chimpanzees in West Africa, potentially posing a zoonotic risk.