著者
Tatsuo Tokeshi Ayumi Date Hiroyuki Miura Leon Kumasaka Tetsuo Arakawa Kazuhiro Nakao Shigefumi Fukui Takuya Hasegawa Masanobu Yanase Michio Nakanishi Teruo Noguchi Satoshi Yasuda Yoichi Goto
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-22-0606, (Released:2023-02-17)
参考文献数
37
被引用文献数
2

Background: Whether the magnitude and predictors of improvement in exercise capacity after cardiac rehabilitation (CR) are the same between young-old (YO) and octogenarian (OCT) patients with acute myocardial infarction (AMI) is unknown.Methods and Results: We studied 284 YO (age range 65–69 years; mean [±SD] 67±1 years) and 65 OCT (age range ≥80 years; mean [±SD] 83±2 years) patients who participated in a post-AMI CR program. After 3 months of CR, peak oxygen uptake (PV̇O2) measured during cardiopulmonary exercise testing improved significantly in both age groups (P<0.01), although the percentage increase in PV̇O2(%∆PV̇O2) was significantly smaller in the OCT than YO group (5.4±13.7% vs. 10.0±12.8%; P<0.01). Multiple regression analysis demonstrated that independent predictors of %∆PV̇O2were the number of outpatient CR (OPCR) sessions attended (P=0.015), left ventricular ejection fraction (P=0.028), and baseline PV̇O2(P=0.0007) in the YO group; and the number of sessions attended (P=0.018), atrial fibrillation (P=0.042), and the presence of nutritional risk (Geriatric Nutritional Risk Index ≤98; P=0.036) in the OCT group.Conclusions: The predictors of improvement in exercise capacity after CR differed between the YO and OCT patients with AMI. To obtain a greater improvement in PV̇O2in CR, frequent OPCR session attendance may be necessary in both groups; in addition, particularly in OCT patients, better nutritional status may be important.
著者
Kayo Misumi Michio Nakanishi Hiroyuki Miura Ayumi Date Tatsuo Tokeshi Leon Kumasaka Tetsuo Arakawa Kazuhiro Nakao Takuya Hasegawa Shigefumi Fukui Masanobu Yanase Teruo Noguchi Kengo Kusano Satoshi Yasuda Yoichi Goto
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-20-1300, (Released:2021-06-30)
参考文献数
33
被引用文献数
5

Background:In patients with chronic heart failure with reduced ejection fraction (HFrEF), cardiac resynchronization therapy (CRT) improves left ventricular ejection fraction (LVEF) and exercise-based cardiac rehabilitation (ECR) enhances exercise capacity. This study examined the relationship between the 2 responses.Methods and Results:Sixty-four consecutive HFrEF patients who participated in a 3-month ECR program after CRT were investigated. Patients were categorized according to a median improvement in peak oxygen uptake (PV̇O2) after ECR of 7% as either good (n=32; mean percentage change in PV̇O2[%∆PV̇O2]=23.2%) or poor (n=32; mean %∆PV̇O2=2.5%) responders. There was no significant difference in baseline characteristics between the good and poor responders, except for PV̇O2(51% vs. 59%, respectively; P=0.01). The proportion of good CRT responders was similar between the good and poor responders (%∆LVEF ≥10%; 53% vs. 47%, respectively; P=NS). Overall, there was no significant correlation between %∆LVEF after CRT and %∆PV̇O2after ECR. Notably, among poor CRT responders (n=32), the prevalence of atrial fibrillation (0% vs. 29%; P<0.03) and baseline PV̇O2(48% vs. 57%; P<0.05) were significantly lower among those with a good (n=15) than poor (n=17) response to ECR.Conclusions:In patients with HFrEF, good ECR and CRT responses are unrelated. A good PV̇O2response to ECR can be achieved even in poor CRT responders, particularly in those with a sinus rhythm or low baseline PV̇O2.
著者
Kazuhiro Nakao Teruo Noguchi Hiroyuki Miura Yasuhide Asaumi Yoshiaki Morita Satoshi Takeuchi Hideo Matama Keniciro Sawada Takahito Doi Hayato Hosoda Takahiro Nakashima Satoshi Honda Masashi Fujino Shuichi Yoneda Shoji Kawakami Toshiyuki Nagai Kensaku Nishihira Tomoaki Kanaya Fumiyuki Otsuka Michio Nakanishi Yu Kataoka Yoshio Tahara Yoichi Goto Kengo Kusano Haruko Yamamoto Katsuhiro Omae Hisao Ogawa Satoshi Yasuda
出版者
Japan Atherosclerosis Society
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
pp.64063, (Released:2023-09-14)
参考文献数
26
被引用文献数
1

Aim: Omega-3 fatty acids have emerged as a new option for controlling the residual risk for coronary artery disease (CAD) in the statin era. Eicosapentaenoic acid (EPA) is associated with reduced CAD risk in the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention trial, whereas the Statin Residual Risk with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridemia trial that used the combination EPA/docosahexaenoic acid (DHA) has failed to derive any clinical benefit. These contradictory results raise important questions about whether investigating the antiatherosclerotic effect of omega-3 fatty acids could help to understand their significance for CAD-risk reduction. Methods: The Attempts at Plaque Vulnerability Quantification with Magnetic Resonance Imaging Using Noncontrast T1-weighted Technic EPA/DHA study is a single-center, triple-arm, randomized, controlled, open-label trial used to investigate the effect of EPA/DHA on high-risk coronary plaques after 12 months of treatment, detected using cardiac magnetic resonance (CMR) in patients with CAD receiving statin therapy. Eligible patients were randomly assigned to no-treatment, 2-g/day, and 4-g/day EPA/DHA groups. The primary endpoint was the change in the plaque-to-myocardium signal intensity ratio (PMR) of coronary high-intensity plaques detected by CMR. Coronary plaque assessment using computed tomography angiography (CTA) was also investigated. Results: Overall, 84 patients (mean age: 68.2 years, male: 85%) who achieved low-density lipoprotein cholesterol levels of <100 mg/dL were enrolled. The PMR was reduced in each group over 12 months. There were no significant differences in PMR changes among the three groups in the primary analysis or analysis including total lesions. The changes in CTA parameters, including indexes for detecting high-risk features, also did not differ. Conclusion: The EPA/DHA therapy of 2 or 4 g/day did not significantly improve the high-risk features of coronary atherosclerotic plaques evaluated using CMR under statin therapy.
著者
Kazufumi KITAGAKI Rei ONO Harumi KONISHI Michio NAKANISHI Hiroyuki MIURA Tatsuo AOKI Teruo NOGUCHI
出版者
Japanese Society of Physical Therapy
雑誌
Physical Therapy Research (ISSN:21898448)
巻号頁・発行日
pp.E10199, (Released:2022-09-14)
参考文献数
22

Objective: This study aimed to investigate whether longitudinal changes in exercise capacity in patients with acute myocardial infarction (AMI) differ by sex and clarified what contributed to these differences. Methods: We retrospectively examined the differences in each variable between men and women in 156 patients with AMI (mean age: 65 ± 12 years; 82.0% male) who participated in a 3-month cardiac rehabilitation (CR) program and could be followed-up for exercise capacity 12-months after AMI onset. Sex-related differences in the change in peak oxygen uptake (peak VO2) at baseline, 3-months, and 12-months after AMI were analyzed. Results: Male patients with AMI were younger and had higher body mass index and employment rate than women. The attendance of the CR program was higher in women (men vs. women; 10 [3–15] vs. 14 [11–24] sessions, p = 0.0002). Women showed a significant lower %change in peak VO2 after 12 months (men vs. women; 7.8% [–0.49% to 14.6%] vs. 1.3% [–5.7% to 7.5%], p = 0.013). In multiple linear regression analysis, age (β = –0.76, 95% confidence interval [CI] = –1.0 to –0.50, p <0.0001) and female sex (β = –6.3, 95% CI = –9.1 to –3.5, p <0.0001) were negative independent predictors of change in peak VO2 over 12 months, while CR attendance (β = 0.21, 95% CI = 0.0032–0.42, p = 0.047) and recommended exercise habit after the CR program (β = 2.1, 95% CI = 0.095–4.1, p = 0.040) were positive independent predictors of change in peak VO2 over 12 months. Conclusion: In female patients, exercise capacity improved during the CR program but decreased to AMI onset levels after 12 months.
著者
Wataru Komada Tasuku Inagaki Yoji Ueda Satoshi Omori Keiichi Hosaka Junji Tagami Hiroyuki Miura
出版者
Japan Prosthodontic Society
雑誌
Journal of Prosthodontic Research (ISSN:18831958)
巻号頁・発行日
vol.61, no.1, pp.73-80, 2017 (Released:2017-03-22)
参考文献数
26
被引用文献数
5

Purpose: The purpose of this study was to evaluate the influence of water immersion on the mechanical properties of three kinds of glass fiber posts and the fracture resistance of structures using resin composites with glass fiber posts.Methods: Each post was divided into three groups; a control group and two water immersion groups (30 and 90 days). Flexural strength was determined by three-point bending test. Each structure was divided into two groups; a control group and a water immersion group for 30 days. The fracture strength of structures was determined by a static loading test.Results: In the flexural strength, two kinds of post in water immersion groups showed lower values than control groups. In the fracture strength, two kinds of structures in water immersion group showed lower values than control groups.Conclusion: The prefabricated glass fiber posts and structures using resin composites with glass fiber posts were affected by water immersion.
著者
Ken Takahata Hiroyuki Miura
出版者
一般社団法人 園芸学会
雑誌
The Horticulture Journal (ISSN:21890102)
巻号頁・発行日
pp.MI-110, (Released:2016-05-28)
被引用文献数
5

In the tomato (Solanum lycopersicum), the position of the inflorescence on the stem is known to affect the number of days to first anthesis and has commonly been characterized by the leaf-number (ordinal number from the oldest leaf) of the leaf just below the inflorescence (LEAF-BI) only by the appearance after extension of the stem near the inflorescence. Some examples showing that this evaluation was not suitable were observed by the authors. To confirm the reproducibility of the observation, experiments were conducted in which 4 cultivars were sown in a greenhouse 12 times from Oct. 2008 to Aug. 2010. Based on the vertical positional relationship between the base of the first, second, or third inflorescence and the base of the last initiated leaf before inflorescence primordium on the growing point (L-LEAF, the true guide for determining the inflorescence position), the L-LEAFs of ‘My Lock’ plants in all growth periods and ‘House Momotaro’, ‘Momotaro 8’, and ‘Super Fast’ plants in the non-high-temperature growth periods were always just above the inflorescences, that is, the LEAF-BIs were always the leaves below the L-LEAFs. In contrast, the L-LEAFs of all cultivars except ʻMy Lockʼ in the high-temperature growth periods were often just below the inflorescence, that is, the LEAF-BIs were often the L-LEAFs. Comparing the leaf-number of LEAF-BI and that of L-LEAF demonstrated that the former often overestimated the inflorescence positon among growth periods and cultivars. In temperature treatments with ‘House Momotaro’, such a positional switch of the L-LEAF was reproducible. External observation indicated that the stem on the L-LEAF side and the stem on the inflorescence side extended non-uniformly and the position of the L-LEAF was determined by which side extended faster. Collectively, the LEAF-BI is not a leaf identified morphogenetically, and to identify the position of the inflorescence, the leaf-number of L-LEAF, not LEAF-BI, should be used.