- 著者
- Mayumi Matsuda Yu Funakubo Asanuma Kazuhiro Yokota Sakon Sakai Hiroaki Yazawa Takashi Maruyama Takuma Tsuzuki Wada Yasuto Araki Toshihide Mimura
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.0590-22, (Released:2022-11-09)
- 参考文献数
- 41
- 被引用文献数
- 11
Since December 2020, coronavirus disease 2019 (COVID-19) vaccines have been distributed in most countries to prevent the onset and aggravation of COVID-19. There is little information regarding the long-term safety of the vaccines. We report three cases and a literature review of new-onset adult-onset Still's disease (AOSD) that occurred following COVID-19 vaccination. Our cases include moderate to severe AOSD, and two were complicated with macrophage activation syndrome. Seventeen cases of new-onset or relapse of AOSD following COVID-19 vaccination, including 14 identified in the literature review and our 3 patients, were all treated successfully with glucocorticoid therapy, immunosuppressive drugs, or biologic agents.
- 著者
- 土居 隆秀 中村 智幸 横田 賢史 丸山 隆 渡邊 精一 野口 拓史 佐野 祐介 藤田 知文 TAKAHIDE DOI TOMOYUKi NAKAMURA MASASHI YOKOTA TAKASHI MARUYAMA SEIICHI WATANABE HIROFUMI NOGUCHI YUSUKE SANO TOMOFUMI FUJITA 栃木県水産試験場 (独)水産総合研究センター 東京海洋大学海洋生物資源学科 東京海洋大学海洋環境学科 東京海洋大学海洋生物資源学科 東京海洋大学海洋環境学科 東京海洋大学海洋環境学科 東京海洋大学海洋生物資源学科 Tochigi Prefectural Fisheries Experiment Station Freshwater Fisheries Research Division National Research Institute of FIsheries Science Department of Aquatic Biosciences Department of Marine Environmental Sciences Tokyo University of Marine Science and Technology Department of Aquatic Biosciences Department of Marine Environmental Sciences Tokyo University of Marine Science and Technology Department of Marine Environmental Sciences Tokyo University of Marine Science and Technology Department of Aquatic Biosciences
- 出版者
- 日本水産學會
- 雑誌
- 日本水産学会誌 (ISSN:00215392)
- 巻号頁・発行日
- vol.70, no.5, pp.706-713, 2004-09-15
- 参考文献数
- 28
- 被引用文献数
- 2 3
イワナ・ヤマメ養殖魚の小型魚と大型魚の釣獲放流後の死亡率と成長を実験池において調査した。餌釣り, 毛鈎釣りともに, 口腔にかかった鈎を除去した場合, いずれの魚種においても死亡率は低かった。餌釣りで口腔より奥にかかった鈎を除去した場合, イワナ小型魚とヤマメ大型魚では死亡率は高かった。口腔にかかった毛鈎を残留させた場合, イワナ大型魚では死亡率は高かった。死亡のほとんどが釣獲放流後14日以内に観察された。釣獲方法, 鈎がかりの部位, 鈎の処理方法は成長と肥満度に影響しなかった。
- 著者
- Takashi MaruYama Hiroyuki Yamakoshi Yoshiharu Iwabuchi Hiroyuki Shibata
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.46, no.6, pp.756-763, 2023-06-01 (Released:2023-06-01)
- 参考文献数
- 59
- 被引用文献数
- 1
Curcumin has long been recognized for its anti-inflammatory properties. An antitumor effect has been recently reported in curcumin and clinical trials are being conducted. However, a large amount of required intake to obtain the antitumor effect of curcumin has been regarded as a problem. Therefore, curcumin analogs have been created by many researchers to enhance the effects of curcumin. We have synthesized >50 curcumin analogs and revealed greater growth suppression of various tumor cells with mono-carbonyl analogs than curcumin. Mechanistically, mono-carbonyl analogs inhibited transcriptional activity (e.g., nuclear factor kappa B, signal transducer, and activator of transcription 3) or activated caspase-3. Additionally, mono-carbonyl analogs of curcumin control tumor cell metabolism. Herein, we summarize the current knowledge about mono-carbonyl curcumin analogs and discuss their potential clinical applications.
- 著者
- Shunsuke TSUZUKI Yoshihiro MURAGAKI Masayuki NITTA Taiichi SAITO Takashi MARUYAMA Shunichi KORIYAMA Manabu TAMURA Takakazu KAWAMATA
- 出版者
- The Japan Neurosurgical Society
- 雑誌
- Neurologia medico-chirurgica (ISSN:04708105)
- 巻号頁・発行日
- pp.2022-0340, (Released:2024-01-10)
- 参考文献数
- 36
Neurosurgery is complex surgery that requires a strategy that maximizes the removal of tumors and minimizes complications; thus, a safe environment during surgery should be guaranteed. In this study, we aimed to verify the safety of brain surgery using intraoperative magnetic resonance imaging (iMRI), based on surgical experience since 2000. Thus, we retrospectively examined 2,018 surgical procedures that utilized iMRI performed in the operating room at Tokyo Women's Medical University Hospital between March 2000 and October 2019. As per our data, glioma constituted the majority of the cases (1,711 cases, 84.8%), followed by cavernous hemangioma (61 cases, 3.0%), metastatic brain tumor (37 cases, 1.8%), and meningioma (31 cases, 1.5%). In total, 1,704 patients who underwent glioma removal were analyzed for mortality within 30 days of surgery and for reoperation rates and the underlying causes within 24 hours and 30 days of surgery. As per our analysis, only one death out of all the glioma cases (0.06%) was reported within the 30-day period. Meanwhile, reoperation within 30 days was performed in 37 patients (2.2%) due to postoperative bleeding in 17 patients (1.0%), infection in 12 patients (0.7%), hydrocephalus in 6 patients (0.4%), cerebrospinal fluid (CSF) leakage in 1 patient, and brain edema in 1 patient (0.06%). Of these, 14 cases (0.8%) of reoperation were performed within 24 hours, that is, 13 cases (0.8%) due to postoperative bleeding and 1 case (0.06%) due to acute hydrocephalus. Mortality rate within 30 days was less than 0.1%. Thus, information-guided surgery with iMRI can improve the safety of surgical resections, including those of gliomas.
- 著者
- Mayumi Matsuda Kazuhiro Yokota Takaya Ichimura Sakon Sakai Takashi Maruyama Takuma Tsuzuki Wada Yasuto Araki Yu Funakubo Asanuma Yuji Akiyama Atsushi Sasaki Toshihide Mimura
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.9793-22, (Released:2022-10-26)
- 参考文献数
- 30
We encountered a 57-year-old Japanese woman with encapsulating peritoneal sclerosis (EPS) in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis. The patient was admitted to our hospital because of ascites retention. Administration of tocilizumab, an anti-interleukin-6 (IL-6) receptor antibody, for her RA reduced the refractory ascites remarkably; however, she developed sudden acute gastrointestinal bleeding and died a year later. On autopsy, sclerotic thickening of the peritoneum showed diffuse infiltration of podoplanin-positive fibroblast-like cells, and a diagnosis of EPS was made. EPS rarely occurs in SLE, and tocilizumab may be a new treatment candidate for EPS.
- 著者
- Masanori Abe Noriaki Maruyama Takashi Maruyama Kazuyoshi Okada Masayoshi Soma
- 出版者
- Japan Atherosclerosis Society
- 雑誌
- Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
- 巻号頁・発行日
- vol.22, no.12, pp.1235-1247, 2015-12-01 (Released:2015-12-01)
- 参考文献数
- 32
- 被引用文献数
- 4 5
Aim: To determine the lipid lowering effectiveness, cost effectiveness, and safety of rosuvastatin compared with pitavastatin in dyslipidemic patients with concurrent renal disorders.Methods: This single-center, prospective, open-label, randomized, 12-month study evaluated rosuvastatin (2.5 mg) and pitavastatin (1 or 2 mg) in 134 dyslipidemic patients with concurrent chronic kidney disease (CKD; rosuvastatin group, n=68; pitavastatin group, n=66). Lipid parameters [i.e., low density lipoprotein cholesterol (LDL-C), etc.], renal function parameters [i.e., estimated glomerular filtration rate (eGFR), etc.], glycated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured at enrollment (baseline), month 6, and month 12.Results: The mean daily dose of rosuvastatin and pitavastatin was 2.5 mg and 1.4 mg, respectively. All lipid parameters were significantly more improved in the rosuvastatin group. eGFR improved from baseline in the rosuvastatin group (p<0.0001) and showed no tendency to worsen in the pitavastatin group (p=0.2232). In multiple regression analysis (n=134), it was significantly associated with a percent change in total cholesterol (β=0.2296; p=0.0112), smoking (β=0.1927; p=0.0224), and HbA1c (β=-0.1606; p=0.0585). Hs-CRP was significantly improved in both groups. An analysis eliminating the influence of antidiabetic medication showed a significant difference between groups in the change of HbA1c at month 6 from baseline (p=0.0016). No subjects in either group had new onset of diabetes mellitus. The cost of statin medication required to reduce LDL-C by 10 mg/dL was significantly lower for 2.5 mg of rosuvastatin (p=0.0116).Conclusions: Rosuvastatin 2.5 mg had superior lipid lowering and cost effectiveness in dyslipidemic patients with concurrent CKD.(UMIN ID: UMIN000005812)
- 著者
- Kazuyoshi Nishijima Takashi Maruyama Mathias Graf
- 出版者
- Japan Society of Hydrology and Water Resources (JSHWR) / Japanese Association of Groundwater Hydrology (JAGH) / Japanese Association of Hydrological Sciences (JAHS) / Japanese Society of Physical Hydrology (JSPH)
- 雑誌
- Hydrological Research Letters (ISSN:18823416)
- 巻号頁・発行日
- vol.6, pp.23-28, 2012 (Released:2012-03-13)
- 参考文献数
- 11
- 被引用文献数
- 17 27
This paper performs a quantitative impact assessment of the climate change on typhoon wind risk, focusing on residential buildings in Japan. The risk is assessed based on (1) the typhoon event set extracted from the simulation by the super-high resolution atmospheric general circulation model developed within the KAKUSHIN program; (2) the probabilistic typhoon modeling scheme developed by our group; (3) a fragility model empirically estimated on the basis of the damage report of typhoon Songda in 2004 and the reproduced wind field by a mesoscale meteorological model; JMA-NHM. The main results are that in the future (2075–2099) at most locations of Japan: (1) extreme wind events (10-minute sustained wind speed exceeding 30 m/s) are more likely to occur; (2) the median of the annual maximum wind speed decreases; (3) the expected number of damaged residential buildings decreases, assuming that the profile of the building portfolio remains unchanged. Based on these results, the assumptions and inputs to the assessment are critically reviewed. Thereby, the needs of further research efforts toward more credible and comprehensive assessment are addressed.
- 著者
- Takashi Maruyama Eriko Tomokiyo Junji Maeda
- 出版者
- 水文・水資源学会/日本地下水学会/日本水文科学会/陸水物理研究会
- 雑誌
- Hydrological Research Letters (ISSN:18823416)
- 巻号頁・発行日
- vol.4, pp.40-44, 2010 (Released:2010-04-09)
- 参考文献数
- 4
- 被引用文献数
- 1 4
The strong wind field caused by Typhoon Songda, which passed through Kyushu in Japan in 2004, was simulated numerically. A non-hydrostatic mesoscale model was used for the numerical simulation. The simulated wind field was compared with the observed wind field in terms of wind speeds and directions, which were measured by the wind observation network, NeWMeK. It was found that the temporal variation of the calculated wind speeds at 1 km hori-zontal mesh grids correspond to the average of the observed wind speeds over a ten to fifteen minute time period. The temporal variation of the calculated wind directions showed good agreement with the observations. The maximum values of the calculated wind speeds were highly correlated to the maximum values of the observed wind speeds. The applicability of the mesoscale model for the wind hazard assessment of buildings was examined, and it was found that the maximum values of the calculated wind speeds at higher altitudes showed higher correlations with the rates of damaged houses caused by Typhoon Songda.
- 著者
- 久保田 仁志 中村 智幸 丸山 隆 渡邊 精一 Hitoshi Kubota Tomoyuki Nakamura Takashi Maruyama Seiichi Watanabe 栃木県水産試験場 独立行政法人水産総合研究センター中央水産研究所水面利用部 東京水産大学海洋環境学科 東京水産大学資源育成学科 Tochigi Prefectural Fisheries Experiment Station Freshwater Fisheries and Environment Division National Research Institute of Fisheries Science Department of Ocean Sciences Tokyo University of Fisheries Department of Aquatic Biosciences Tokyo University of Fisheries
- 出版者
- The Japanese Society of Fisheries Science
- 雑誌
- 日本水産学会誌 = Bulletin of the Japanese Society of Scientific Fisheries (ISSN:00215392)
- 巻号頁・発行日
- vol.67, no.4, pp.703-709, 2001-07-15
- 参考文献数
- 19
- 被引用文献数
- 5 12
1993年6月∿1995年11月にかけて, 利根川水系鬼怒川の小支流において, イワナ, ヤマメの生息数, 当歳魚の移動分散, 成長の季節変化を調査した。3ヶ年の総採捕個体のうち, イワナは81.4%(1073個体中873個体), ヤマメは98.8%(244個体中241個体)が当歳魚であった。ヤマメ当歳魚は2月から採捕され, 8月以降はほとんど採捕されなかった。これに対して, イワナ当歳魚は3月から採捕され, 6月以降は1回の調査あたりの採捕数の変化はなかった。一方, 1995年に鬼怒川本流で採捕調査を行ったところ, 採捕された当歳魚のうちイワナが8.0%, ヤマメが92.0%を占め, ヤマメ当歳魚が優占した。以上の結果から, 小支流は特にイワナ当歳魚にとって重要な成育場所であると考えられた。We investigated the seasonal changes in number, dispersal and growth of juvenile Japanese charr Salvelinus leucomaenis and masu salmon Oncorhynchus masou masou in the Karatakisawa Stream, a small tributary of the Kinu River in central Japan. 873 (81.4%) of a total 1073 charr caught by monthly sampling from 1993 to 1995 were age-0,and 241 (98.8%) of a total 244 salmon were age-0. Most of the newly emerged age-0 salmon were caught in the spring of 1995. They shifted downstream, and the number of fish decreased markedly by early summer. The number of the age-0 charr caught at any sampling from any month did not decrease until the end of autumn, although the distribution of the age-0 charr shifted downstream. In contrast, of a total 387 age-0 fish captured by samplings in the adjacent Kinu River in 1995,356 (92.0%) were salmon, whereas only 31 (8.0%) were charr. These results suggest that small tributaries play an important role as nursery habitats, especially for Japanese charr.