著者

水野 誠

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.41, no.2, pp.113-118, 2017-06-30 (Released:2018-06-30)

参考文献数

37

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Continuous use of sunscreen products prevents not only sunburn or suntan, but also signs of photo-aging such as wrinkles or pigmentation spots. In the U.S., sunscreen products are categorized as over-the-counter drugs. If certain conditions are fulfilled, statements on the preventive efficacies against skin cancer and early skin aging are allowed on the package insert. The EU commission also stated “sunscreen products can prevent the damage linked to photo-ageing.” Application of sunscreens is strongly recommended for the prevention of photo-aging or skin cancer in these countries. However, statements on the preventive effects of sunscreen cosmetics against photo-aging or skin cancer are not approved in Japan because their efficacies in Japanese people are unclear because of the lack of reliable data. This article reviews the studies that demonstrated the preventive effects of continuous application of sunscreens on photo-aging, and also describes our three-year study on sunscreen application for Japanese elderly subjects, which is probably the first long-term, interventional, clinical study conducted in Japanese people. The results of our clinical study showed that continuous application of the appropriate amount of sunscreen prevents photo-aging signs such as a change in skin color tone uniformity, similar to that seen in Caucasians. Our study investigating the relationship between efficacy and the amount of sunscreen applied, in order to examine the appropriate use of sunscreens to achieve a sufficient effect, is also introduced here.

著者

矢上 晶子

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.42, no.2, pp.104-108, 2018-06-30 (Released:2019-06-30)

参考文献数

14

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Many Japanese individuals develop gray hair with age, and thus hair dye products are useful for aesthetics and everyday life. However, there has been an increase in the number of cases of contact dermatitis following the use of hair dye. Allergic contact dermatitis has been observed in many patients and some cases develop contact urticaria as an immediate hypersensitivity reaction to hair dye. It is therefore important for individuals to perform an initial strand and allergy test before using a product, and to visit a medical institution immediately if skin symptoms are seen following the use of hair dye. In my presentation, I described the actual symptoms of skin disorders induced by using hair care products, the allergens related to hair dye use, and the efforts of administrative bodies such as the Japan Hair Color Industry Association and the Skin Safety Case Information Network (SSCI-Net) website.

著者

藤井 まき子

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.39, no.2, pp.109-113, 2015-06-30 (Released:2016-07-22)

参考文献数

16

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The skin permeation can explain with Fick's diffusion model. Skin concentration depends on partition coefficient between skin and vehicle and concentration in vehicle. However it is changed with various factors, activity of ingredient in vehicle, effect of other ingredients on skin, the change of formulation after application and so on. Thus, if the same concentration of active ingredient is in the formulation, the skin concentration or skin absorption is not always the same. It is important to know the skin penetration and permeation of cosmetic ingredient for the assessment of not only toxicity but also efficacy.

著者

都賀谷 京子

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.42, no.3, pp.162-171, 2018-09-30 (Released:2019-09-30)

参考文献数

12

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Cosmetics and medicated cosmetics are recognized as a necessity of daily life to increase the quality of life, and are used to maintain health and increase beauty. Cosmetics and medicated cosmetics are mainly regulated by The Law on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical devices. The main purpose of the Law is to improve public health, and to achieve this, securement of the quality, efficacy, and safety of cosmetics etc. is required. To fulfill the purpose, it is necessary to understand the regulation for cosmetics and medicated cosmetics accurately and to follow the Law properly. In this report, the definition of cosmetics and medicated cosmetics, regulations on ingredients and efficacy-effects, and regulations for selling cosmetics etc. are described.

著者

大谷 道輝

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.38, no.2, pp.96-102, 2014-06-30 (Released:2015-07-24)

参考文献数

17

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There are many cases where patients use ointments inappropriately. One of the reasons is that there are only few studies about ointments. Even medical package insert of ointments does not give specific instructions about usage and dosage. For moisturizers, the number of times to apply to the skin is one to a few times, but not clearly specified. There has not been many studies done on the relationship between the number of times applied to the skin and the efficacy of the moisturizers. In the past, ointments were applied after bathing. However, recent studies have shown that there is no significant difference between applying just after bathing and after few hours. There are many cases where ointments are used together with other ointments. In these cases, ointments are often mixed together. However, there are only a few studies done on the permeability of ointments which are mixed. Overglazing is also very popular, but there has been no study done on the order of application and permeability. For these reasons, further study will be needed to properly use ointments.

著者

林 伸和

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.40, no.1, pp.12-19, 2016-03-31 (Released:2017-05-12)

参考文献数

55

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Acne is a chronic skin condition that affects patient quality-of-life. More than 90% of the Japanese population experiences acne at some point in their lifetime. Comedones, which are caused by excess sebum secretion and hyperkeratosis in the infundibulum, appear in the first stage of acne. The second stage involves inflammatory eruptions mainly caused by Propionibacterium acnes. Benzyl-peroxide (BPO), and fixed combination products of BPO and clindamycin, became available in Japan in 2015. BPO acts on both comedones and inflammatory eruptions, and it can be used for maintenance therapy because it does not induce antibiotic-resistant P. acnes. To achieve early results and to prevent the emergence of antibiotic-resistant bacteria, the revised guidelines for the treatments of acne in Japan recommend combination therapy with adapalene, antibiotics, and BPO, including fixed-combination topical agents, in the acute inflammatory phase. Once inflammation has improved, comedones treatment should be continued with adapalene and/or BPO in the maintenance phase to achieve further improvement and to prevent recurrence. The acute phase lasts approximately 3 months, and antibiotics should not be used for maintenance therapy. Sometimes, inflammatory eruptions can result in hypertrophic and atrophic scars that cannot be treated completely. Early aggressive treatment is important to prevent scars. Skin care and cosmetics are also important in the treatment of acne as well as to avoid aggravation. The guidelines recommend twice-daily face washing with a suitable cleanser. Non-comedogenic moisturizers should be used by patients who have dry skin and by those who need to avoid the adverse effects of adapalene and BPO. There is no reliable evidence connecting certain foods and acne, and we should not uniformly restrict specific foods. There is compelling evidence demonstrating the efficacy of azelaic acid and chemical peels with glycolic acids in the treatment of acne. Camouflage also helps acne patients improve their quality of life. To improve acne treatments, more evidence is needed regarding the integration of treatments and skin care.

著者

中邨 智之

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.43, no.1, pp.14-17, 2019-03-31 (Released:2020-03-31)

参考文献数

22

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Elastic fibers are extracellular matrix components that confer resilience on tissues such as skin, lung, and arteries. Deterioration of elastic fibers by elastase secreted from macrophages or neutrophils induced by UV or smoking, together with aging directly causes loose skin, emphysema, and arteriosclerosis. The turnover rate of elastic fibers is very slow, and it has been believed to be difficult to regenerate elastic fibers. There are several steps required in elastogenesis: (1) formation of microfibril meshwork or bundles, (2) micro-aggregation of tropoelastin (elastin monomer), (3) deposition of elastin on microfibrils, and (4) cross-linking of elastins by lysyl oxidase. We have identified several secreted proteins, Fibulin-4, -5, and LTBP-2, -4 that are necessary for each step. Elucidating the function of these elastogenic proteins may lead to novel clinical application of elastic fiber regeneration.

著者

宮本 久喜三

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.41, no.3, pp.188-195, 2017-09-30 (Released:2018-09-30)

参考文献数

2

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It is well known that excess sun UV exposure accelerates skin damage and aging. However, there are few studies to understand the impact on the skin aging under mild daily sun exposure in general life style such as office workers and/or housekeeping wives. Also, it is not well understood the longitudinal progression of chronic skin aging and its variation of individuals. Two clinical research trials were carried out to quantify and characterize chronic skin photodamage and longitudinal skin aging under general life style among Japanese women in Japan. First, we investigated chronic photodamage on the facial skin among totally 602 Japanese women who permanently lived in two different locations between Akita (low annual sun UV exposure) and Kagoshima (high UV exposure), and observed there were statistically significant worse in visible signs of skin aging such as skin darkness, wrinkles and hyperpigmented spots among the subjects who lived in Kagoshima than those of lived in Akita, especially age over 45. Second, we have trucked longitudinal facial skin aging over 11 years among 108 Japanese women who permanently lived in Akita. We found facial skin aging appearances and its longitudinal progression were not equally to all individuals, and variation of chronic skin aging appearances became larger by age, even over age 70. It was also demonstrated that their skin care habits and practice influenced on the variation of skin aging. For example, subjects who frequent used sun-screen and/or skin whitening formula over 11 years showed better visible appearances of facial skin such as hyperpigmentation and wrinkles.

著者

田中 浩

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.43, no.1, pp.39-43, 2019-03-31 (Released:2020-03-31)

参考文献数

28

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In Japan, there are values that prefer the state where the skin is white and has no spots or dullness. Therefore, spots and freckles are becoming one of the skin troubles for many consumers. The term “skin whitening” is used as a term referring to skin care for skin troubles such as spots and freckles. Products used for skin whitening purposes, so-called whitening products, generally refer to quasi-drugs containing skin whitening active ingredients. Various mechanisms of action for skin whitening have been elucidated so far, and various skin whitening active ingredients have been developed accordingly. In this article, the functional mechanism of skin whitening active ingredients blended in skin whitening quasi-drugs and the effects on human skin were outlined.

著者

松永 佳世子

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.39, no.2, pp.103-108, 2015-06-30 (Released:2016-07-22)

参考文献数

21

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Recently we have experienced two outbreaks of health hazard from cosmetics that were voluntary recalled. One is an outbreak of immediate wheat allergy due to epicutaneous sensitization to a hydrolyzed wheat protein, contained in a facial soap. A total of 2,111 patients have been registered. Most of the patients are females, and half of them had anaphylaxis after eating wheat. The other is an outbreak of Rhododenol-induced leukoderma, and more than 19,000 patients were reported. Rhododenol is a quasi-drug ingredient for lightening cosmetics, and is a phenol compound. The Patch Test Material Research Committee of the Japanese Society for Dermaoallergology and Contact Dermatitis was set up in 2007, and has been performing two nation-wide studies. One of them is an epidemiological study on allergic contact dermatitis, which was done first as the paper-based case-registration questionnaire study started in 2010. Cosmetics were the most responsible products of allergic contact dermatitis, 67% of all, and the common causative items were hair dyes, skin lotions, and shampoos. The cases from the facial soap containing the hydrolyzed wheat protein and cosmetics for lightening skin including Rhododenol were reported in our study. We have made ‘Skin Safety Case Information Network of Cosmetics and Other Products: SSCI-Net.' The aim of this network is to get real-time information of skin health hazards from cosmetics and decrease the risk and hazard as soon as possible by the industry–academic–government information network.

著者

高野 勝弘

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.39, no.1, pp.17-22, 2015-03-31 (Released:2016-05-11)

参考文献数

22

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There are various types of side effects caused by cosmetics; mostly they are believed to be not serious. Further, there are not a few cases at present that it is difficult to identify which ingredients in cosmetic products caused; even it was certainly caused by cosmetics which had been used. It herewith refers the actual cases which were implemented some measures by MHLW (Ministry of Health, Labour and Welfare of Japan) under the jurisdiction of Pharmaceutical Affairs Law or JCIA (Japan Cosmetic Industry Association) as a representative of cosmetic industries, taking into account the cases must be caused by cosmetics (including quasi-drugs such as medicated cosmetics). It also covers the background and history of cosmetic regulation under the Pharmaceutical Affairs Law in considering the safety of cosmetics.

著者

中谷内 一也

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.38, no.4, pp.244-249, 2014-12-31 (Released:2016-01-22)

参考文献数

4

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Conventionally, in social psychology research, “perceived competence” that is rooted in a specialized technique and knowledge, and “perceived motivation” that is rooted in the attitude to carry out one's duty have been targeted, as important factors for earning trust. Today, attention is being drawn to the salient value similarity (SVS) model whose viewpoint differs from that of these two factors. In the SVS model, trust is assumed not only to be dependent on characteristics of the trusted party but also to be determined by the commonality of both the trusting and trusted parties, in particular, by sharing salient values. That is to say that the SVS model insists that “we can trust in and entrust something to a person who has the same viewpoint and shares similar feelings.” Studies related to trust in recent years have clarified that all of the perception of competence, motivation, and value sharing are significant defining factors of trust. In addition, it is reported that the weight of trust in value-sharing perception increases and the weight of competence perception decreases relatively, in the event that the problem someone faces is important to the individual, in the event that there exists an argument in the society concerning the pros and cons of the problem, and in the event that trust in the risk management organization subject to assessment is reduced.

著者

上出 良一

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.41, no.2, pp.124-131, 2017-06-30 (Released:2018-06-30)

参考文献数

31

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Sun exposure induces acute and chronic skin damage. In an aging society, life-long protection against ultraviolet rays starting from childhood is important in order to suppress the increase of skin cancer in sun exposed areas. On the other hand, some women tend to over-protect their exposed skin from sun light to prevent pigmentation such as blotches, freckles and wrinkles. Such an attitude like photophobia in daily life might induce vitamin D insufficiency and consequently damage their health. Vitamin D can be produced by sub-erythematous doses of UVB and excess vitamin D is destroyed by UV to maintain a proper level. In general, applications of sunscreen are incomplete, so that people receive a certain amount of UV exposure on the face and dorsum of hands, which produces a necessary amount of vitamin D. In addition to biosynthesis, vitamin D is safely taken orally through proper foods and supplements. Accordingly, there is no reason to recommend sun bathing to avoid vitamin D insufficiency.

著者

萩野 亮

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.43, no.2, pp.119-127, 2019-06-30 (Released:2020-06-30)

参考文献数

25

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Makeup cosmetics have been used in ancient times for the purpose of religious acts or expression of user’s authorities. The meaning of makeup changes with the times, and nowadays it is mainly used for the expression of personal beauty and tidy appearance. The main function of the makeup products are visual effects such as hiding of skin troubles, modifying the skin color and texture, and making users look more attractive with color and brilliance. In addition, recent makeup products also offer protective function such as moisturization or UV protection. Furthermore, research about the psychological effects by using makeup products is also in progress such as gaining confidence, satisfaction and sociality. There are various makeup products with different application area, and their usage method and required finishing state differ depending on each product. Therefore, in order to use makeup products safely and effectively, it is important to understand the composition of each product and usage method including the package and the applicator. In this article, I explain the formulation composition and several essential raw materials of each makeup product, and outline the molding technology and usage.

著者

佐藤 潔

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.41, no.1, pp.44-48, 2017-03-31 (Released:2018-03-31)

参考文献数

6

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When our skin is exposed to the solar light, perceptible skin reactions are induced by ultraviolet A ray (UVA) and ultraviolet B ray (UVB). UVB causes erythema after several hours followed by pigmentation called delayed tanning after a few days. On the other hand, the skin exposed to UVA exhibits grayish brown colored pigmentation immediately after UVA exposure without causing erythema. The pigmentation persists more than several hours and the color gradually changes to brown. This persistent pigmentation is called persistent pigment darkening (PPD) reaction. To indicate the UV protection level of sunscreen, SPF and PA labeling are used. SPF stands for “Sun Protection Factor” and PA stands for “Protection Grade of UVA.” The number of SPF means the number of times longer that you will be protected from getting erythema, which is mainly induced by UVB, with sunscreen than you will be without sunscreen. PA grade is determined based on the protection level of PPD reaction induced by UVA. In the case of PA labeling, the degree of protection is labeled as PA+, PA++, PA+++ or PA++++ on a sunscreen product. The more plus (+) mark means the more protection level against UVA. The current test methods related to UV protection are harmonized globally. Global standard ISO24444 is adopted as Japanese standard test method for SPF measurement and ISO24442 is adopted as Japanese standard test method for UVA protection measurement.

著者

仲谷 正史

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.44, no.2, pp.123-128, 2020-06-30 (Released:2021-06-30)

参考文献数

18

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Sense of touch is fundamental perceptual modality that most people experience in their daily life. Although we tend to pay little attentions to touch modality, recent study showed that our cognitive behaviors such as the preference to warm materials and decision makings were affected by the haptic impressions obtained in our daily life. This article introduces several examples about human behaviors which are associated with haptic impressions, and provides basic knowledge on how we can elucidate such perceptual and cognitive phenomena based on multiple research aspects concerning sense of touch and bodily sensation.

著者

小池 都 村上 泉子 丹野 修

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.37, no.2, pp.81-89, 2013-06-30 (Released:2014-07-16)

参考文献数

27

被引用文献数

1

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We determined skin properties and morphological characteristics in the neck and décolleté in 90 Japanese women aged 22–76 years old, then analyzed age-related changes and differences in those areas as compared to skin of the face. Our results showed that skin in the décolleté had higher water content, as well as lower TEWL and sebum levels as compared to the cheek, with the same tendency seen in the neck, e.g., the sebum-water balance in the skin of the neck and décolleté areas was greatly different from that in the skin of the cheek. Furthermore, in subjects aged 40 years and older, sebum levels and skin color lightness were significantly decreased in the neck and décolleté areas, while wrinkle morphology was also markedly different, suggesting that these areas showed marked alterations in women in their 40s, which may be attributed to the effects of ultraviolet (UV) to change skin elasticity and color. The shape of the neck and lower jaw area was also markedly changed in subjects aged 60 years older, indicating that subcutaneous tissue might exert varying age-dependent effects on lower jaw morphology.

著者

富永 真琴

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.36, no.4, pp.296-302, 2012-12-31 (Released:2013-12-20)

参考文献数

18

被引用文献数

1

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Sensing temperature is essential for organismal survival and efficient metabolism, and now we know that TRP (transient receptor potential) channels are important for detecting ambient temperatures in many species. TRP channels were first described in Drosophila in 1989, and in mammals, TRP channels comprise six related protein families (TRPC, TRPV, TRPM, TRPA, TRPML, TRPP). One subunit of the TRP channel is composed of six transmembrane domains and a putative pore region with both amino and carboxyl termini on the cytosolic side. TRP channels are best recognized for their contributions to sensory transduction, responding to temperature, nociceptive stimuli, touch, osmolarity, pheromones and other stimuli from both within and outside the cell. Among the huge TRP super family of ion channels, some have been proven to be involved in thermosensation detecting ambient temperatures from cold to hot. There are now nine thermosensitive TRP channels (TRPV1, TRPV2, TRPV3, TRPV4, TRPM2, TRPM4, TRPM5, TRPM8 and TRPA1) with distinct temperature thresholds for their activation. Thermosensitive TRP channels work as ‘multimodal receptors’ which respond to various chemical and physical stimuli. TRPV1, the first identified thermosensitive TRP channel, was found as a receptor for capsaicin in 1997, and later was found to have thermosensitivity. I would like to describe the physiological significance of the thermosensitive TRP channels.

著者

佐藤 隆

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.40, no.1, pp.8-11, 2016-03-31 (Released:2017-05-12)

参考文献数

30

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Sebum production and secretion in sebaceous glands play important roles in the formation of a thin lipid layer as a physiological barrier on the skin's surface. The secretion of sebum is considered to be controlled in concert with the regulation of sebum production, in which insulin/insulin-like growth factor 1, 5α-dihydrotestosterone, corticotrophin-releasing hormone, and eicosanoids are involved under physiological and pathological conditions. In addition, environmental stimuli such as ultraviolet (UV) irradiation and temperature change have been reported to influence sebum secretion as well as its production. Furthermore, the abnormalities of sebum production and secretion are likely to disrupt the skin barrier functions and to cause sebaceous gland disorders such as acne, seborrhea, and xerosis. On the other hand, the regulation of sebum secretion has been generally defined to be due to a holocrine mechanism, which may contain apoptosis of sebaceous gland cells (sebocytes). In contrast, the apoptosis-independent sebum secretion by polymethoxy flavonoids and UVB has been reported in differentiated hamster sebocytes. Therefore, in addition to sebocyte-specific lipogenetic mechanisms, another unique sebum secretion pathway distinct from the holocrine mechanism is likely to exist in sebaceous glands.

著者

平尾 哲二

出版者

日本香粧品学会

雑誌

日本香粧品学会誌 (ISSN:18802532)

巻号頁・発行日

vol.37, no.2, pp.95-100, 2013-06-30 (Released:2014-07-16)

参考文献数

23

被引用文献数

1

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The skin is the largest tissue surrounding our body, and is essential for maintenance of our life. The epidermis, including stratum corneum, plays a pivotal role in barrier function, which is essential for terrestrial living organisms, as well as retaining in moisture to keep itself supple. In addition to these biological functions, the skin locates the outermost layer affecting its appearance and tactile perception. Moisturized skin is supple and beautiful. This review summarizes molecular and structural mechanisms in skin moisturization and recent advances in skin moisturization. Free amino acids are major component of natural moisturizing factors in the stratum corneum, which are derived from degradation of filaggrin protein. Recent studies have revealed that several proteases are involved in degradation of filaggrin into free amino acids. Other constituents of natural moisturizing factors include organic acids and mineral ions, which are derived, at least in part, from sweat and sebum. In addition to these low molecular natural moisturizing factors, properties of structural protein such as keratins may affect moisture retention activity in the stratum corneum. Thus, skin moisturization is composed of heterogeneous factors and its improvement can be achieved by various skincare approaches.