著者

TAKENORI INOMATA JAEMYOUNG SUNG ALAN YEE AKIRA MURAKAMI YUICHI OKUMURA KEN NAGINO KENTA FUJIO YASUTSUGU AKASAKI AKIE MIDORIKAWA-INOMATA ATSUKO EGUCHI KEIICHI FUJIMOTO TIANXIANG HUANG YUKI MOROOKA MARIA MIURA HURRAMHON SHOKIROVA KUNIHIKO HIROSAWA MIZU OHNO HIROYUKI KOBAYASHI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.69, no.1, pp.2-13, 2023 (Released:2023-02-28)

参考文献数

63

被引用文献数

1

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During the 5th Science, Technology, and Innovation Basic Plan, the Japanese government proposed a novel societal concept -Society 5.0- that promoted a healthcare system characterized by its capability to provide unintrusive, predictive, longitudinal care through the integration of cyber and physical space. The role of Society 5.0 in managing our quality of vision will become more important in the modern digitalized and aging society, both of which are known risk factors for developing dry eye. Dry eye is the most common ocular surface disease encountered in Japan with symptoms including increased dryness, eye discomfort, and decreased visual acuity. Owing to its complexity, implementation of P4 (predictive, preventive, personalized, participatory) medicine in managing dry eye requires a comprehensive understanding of its pathology, as well as a strategy to visualize and stratify its risk factors. Using DryEyeRhythm®, a mobile health (mHealth) smartphone software (app), we established a route to collect holistic medical big data on dry eye, such as the subjective symptoms and lifestyle data for each individual. The studies to date aided in determining the risk factors for severe dry eye, the association between major depressive disorder and dry eye exacerbation, eye drop treatment adherence, app-based stratification algorithms based on symptomology, blink detection biosensoring as a dry eye-related digital phenotype, and effectiveness of app-based dry eye diagnosis support compared to traditional methods. These results contribute to elucidating disease pathophysiology and promoting preventive and effective measures to counteract dry eye through mHealth.

著者

YUKO NAKANISHI SHINOBU SAKURAI YUJIRO KAWATA YOSHIO SUZUKI MAYUMI TAKAYA SHIMPEI FUJITA KEISHOKU SAKURABA MASATAKA HIROSAWA TAKAO OKADA

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.66, no.4, pp.337-345, 2020 (Released:2020-08-31)

参考文献数

25

被引用文献数

6 5

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Objective: This study examined the prevalence of and factors affecting normal weight obesity (NWO) among women aged under 40 years old. NWO was having a normal BMI but a high body-fat percentage (BFP).Materials and Methods: We recruited 399 participants aged 18-39 during a health checkup and surveyed them about lifestyle patterns, height, weight, body composition, and girth and visceral fat area. Participants were divided into three. Those with a BMI of <25 and a BFP of <30 were classified as non-obese, a BMI of <25 and a BFP of ≥30 as NWO, a BMI of ≥25 and a BFP of ≥30 as obese. The analysis was conducted on NWO (97) and non-obese (262) groups.Results: NWO prevalence ranged from 20% to 30% across the three age groups. NWO participants had lower values for segmental lean body mass, particularly in lower limb, and higher values for abdominal girth and visceral fat area. Among participants aged 30-39, those with NWO had higher values for triglycerides and LDL cholesterol and lower values for HDL cholesterol. Regarding lifestyle factors, among those aged 30-39, NWO was associated with past weight fluctuation, respectively. In the latter age group, a gain of more than 10 kg since the age of 20 was associated with a 13-fold increase in the odds for NWO.Conclusions: Results suggest that for women under 40 years, detecting NWO early and guidance on effective lifestyle and exercise are necessary.

著者

YUKA HONDA MITSUYOSHI SUZUKI YUICHI SATO KEIJI KURODA HIROMICHI SHOJI TOSHIAKI SHIMIZU

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.62, no.2, pp.153-159, 2016 (Released:2016-07-02)

参考文献数

30

被引用文献数

1

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Objective: The aim of this study was to investigate the associations of anti-Müllerian hormone (AMH) levels with physique and 25-hydroxyvitamin D (25OH-D) levels in healthy women of reproductive age based on measurements of nutritional status and physical constitution.Materials and Methods: Subjects comprised 108 non-obese women (age range, 21-39 years) who underwent examination of their physique, blood biochemistry and nutritional state. For data analysis, subjects were first divided by age. AMH levels were grouped by serum 25OH-D concentration using Holick’s classification: deficiency, <30 ng/ml; and sufficiency, ≥30 ng/ml.Results: Mean levels were 25.2±8.4 ng/ml for serum 25OH-D and 4.9±2.4 ng/ml for AMH. Overall, 76 women (70.4%) were diagnosed with 25OH-D deficiency. Serum AMH levels were significantly lower in subjects with 25OH-D deficiency (4.5±2.5 ng/ml) than in those with 25OH-D sufficiency (5.7±1.9 ng/ml; p<0.01). Significant differences were seen in the frequency of subjects with 25OH-D deficiency and sufficiency between low AMH (<2.2 ng/ml) status and normal AMH (≥2.2 ng/ml)(16/17 [94.1%] vs. 1/17 [5.9%] for low AMH status; 60/91 [65.9%] vs.31/91 [34.1%] for normal AMH status, respectively; p<0.05). Independent predictors of serum AMH levels≥2.2 ng/ml were serum 25OH-D level (p<0.05) and age (p<0.05) according to binary logistic regression analysis.Conclusions: Decreased serum AMH level is associated with vitamin D deficiency, but is unrelated to physique state in this population.

著者

山本 祐華

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.60, no.Suppl.2, pp.s42-s47, 2014 (Released:2015-02-14)

参考文献数

7

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WHOにおけるワクチン関連疾患は「preventable disease=予防可能な疾患」と表記されている.しかし風疹はワクチン関連疾患に分類されるものの,本邦では2012年に大流行し,2013年の風疹感染者は14,357人にまで上り,先天性風疹症候群(congenital rubella syndrome;CRS)を合併した児も32人出生した.日本における風疹ワクチンの歴史的背景が今回の大流行にかかわっている.風疹ワクチンの接種は1976年より定期接種として開始され,当初は中学生女子に限定されていた.1989年より男女に三種混合ワクチン(MMR)の接種が始まったものの,無菌性髄膜炎の発生により1993年にいったん中止された.1995年以降は男女ともに個別接種がされたが,ワクチン接種をすり抜けた20~40歳代の成人が風疹抗体をもたず,今回の大流行に大きく影響したと考えられる.妊娠初期に風疹に罹患した場合,かなり高率で先天性白内障,難聴,心奇形をもつCRSを発症するため,ワクチンによる抗体確保することでの集団免疫の重要性を確認する.B型肝炎は輸血後肝炎がほぼ消滅した後,母児垂直感染をいかに予防するかが注目された.2013年にB型肝炎ワクチンと免疫グロブリンの接種方法が変更され,より効果的な母児感染予防を試みている.インフルエンザは妊娠中に接種するワクチンとして最大のものといえる.妊娠全期間を通じて有益性投与を行うことができ,免疫寛容にある妊婦におけるインフルエンザワクチンの接種の重要性は新型インフルエンザ流行の際にも痛感された.最後に現在開発中のワクチンとしてサイトメガロウイルス(cytomegalovirus;CMV)ワクチンがある.妊娠中に初感染を起こすと,児に難聴,精神発達障害などをきたす先天性CMV感染症を起こす.以前はCMV抗体の保有率は90%程であったものの,現在は衛生的な改善で抗体保有率が65%にまで低下しており,妊娠中の初感染のリスクは高い.現在ワクチンは臨床治験第2段階であり,臨床応用にはまだ時間を要する.周産期にかかわるワクチンの歴史と現在の状況を確認し,今後の感染予防に役立てていく.

著者

TAKENORI INOMATA JAEMYOUNG SUNG MASAHIRO NAKAMURA MASAO IWAGAMI YUICHI OKUMURA KENTA FUJIO YASUTSUGU AKASAKI KEIICHI FUJIMOTO AI YANAGAWA AKIE MIDORIKAWA-INOMATA KEN NAGINO ATSUKO EGUCHI HURRRAMHON SHOKIROVA JUN ZHU MARIA MIURA MIZU KUWAHARA KUNIHIKO HIROSAWA TIANXING HUANG YUKI MOROOKA AKIRA MURAKAMI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.67, no.6, pp.519-529, 2021 (Released:2021-12-31)

参考文献数

67

被引用文献数

9

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Society 5.0, a visionary human-centered societal model, fuels economic development and resolves long-standing social problems. The model establishes a technological foundation and social contract to integrate cyberspace into the physical (real) space fully. The medical infrastructure outlined by the model envisions a healthcare paradigm that revolves around preventative, lifelong patient- and population- centered care that functions seamlessly within one's daily life. In satisfying this goal, cross-hierarchical integrative data-driven biological research has received attention due to medical big data and artificial intelligence (AI) technologies, capable of highly accurate and rapid data analysis. However, the collection of big data has been a bottleneck, and the capability of AI analysis is not being utilized to its full potential. In solving this obstacle, we explore mobile health (mHealth) and multi-omics as two rich sources of medical big data. Additionally, we discuss the implications of cross-hierarchical integrative analysis that encompasses all levels of cellular function, from intracellular molecular dynamics to end-phenotypes. This is to understand ocular disease pathology and implement the pillars of P4 (predictive, personalized, preventative, participatory) medicine toward human-centered healthcare. Here, we discuss notable studies in utilizing mHealth to stratify subjective symptoms, presentations of dry eye disease, and employing multi-omics machine learning targeted at elucidating immunologic mechanisms of corneal allograft rejection and ocular inflammation. We also discuss the role of cross-hierarchical integrative data-driven research in promoting future-oriented healthcare envisioned by the Society 5.0 plan.

著者

斉藤 大祐 遅野井 雄介 杉本 大介 佐藤 文彦

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.60, no.1, pp.66-68, 2014 (Released:2014-07-31)

参考文献数

4

著者

清水 梓 松村 崇 門 真起子

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.59, no.6, pp.520-522, 2013 (Released:2014-05-29)

参考文献数

5

著者

根木 治 須賀 康

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.59, no.3, pp.292-294, 2013-06-30 (Released:2014-11-26)

参考文献数

5

著者

朝蔭 直樹

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.59, no.2, pp.189-193, 2013-04-30 (Released:2014-11-26)

参考文献数

12

被引用文献数

1 1

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われわれは腹腔鏡下鼠径ヘルニア修復術をTANKO-Totally extraperitoneal repair (TEP) で行っている. その進入経路となる従来Retzius腔あるいは膀胱前腔 (以下Retzius腔) といわれているcavityに関しては諸説あるが, 必ずしも正しく理解されていないと考えるため今回検証を試みた. Retzius腔が腹膜前筋膜浅葉・深葉間の腹膜前腔 (Bogros腔) であるかのような見解があるが, Retzius腔は横筋筋膜と浅葉間に広がる疎なcavityであり, 腹膜前腔とは浅葉を境界 (boundary surface) とした非交通性の異なったcavityである. また膀胱は内胚葉由来なので腹膜前筋膜には被われていないという見解があるが, 内胚葉由来なのは膀胱上皮であって, 膀胱という「腔」は中胚葉由来の腎筋膜から連続した腹膜前筋膜である膀胱筋膜に包埋されていると理解するべきである.

著者

XUEKUN YANG JING BAI HISAMASA IMAI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.62, no.3, pp.240-247, 2016 (Released:2016-11-02)

参考文献数

17

被引用文献数

1 2

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Objective: We aimed to reveal the declining status of autopsy rate in Japanese university hospitals during the last 34-year period, to draw attention to the importance of autopsy.Methods: Autopsy related data from 1979 to 2012 in all Japanese university hospitals were collected and analyzed on annual basis under categories of Juntendo University Hospital, Japanese university hospitals, public university hospitals and private university hospitals separately. Trends of changes in autopsy rate from 1979 to 2012 were plotted and compared between the groups.Results: The autopsy rate in Juntendo University Hospital was maintained at the levels of 50-60% until 1986, then started to decline steadily and reached to 9.7% in 2012. Regression coefficient of the autopsy rate during the 34-year period was -0.0173. The mean autopsy rate of all university hospitals in Japan was maintained at 45% until 1983, then started declining steadily and reached to 6.8% in 2012. Of these hospitals, the mean autopsy rate in public hospitals was still kept at 45% in 1985 but continued declining to 9.3% in 2012, while in private hospitals it reached to 45% in 1983 and kept declining to only 5.6% in 2012.Conclusion: The steady decline of the autopsy rate in university hospitals in Japan began early 1980’; this trend still continues, and the autopsy rate declined to 6.8% in 2012. We should work to prevent the decline of autopsy rate furthermore in Japanese university hospitals.

著者

TAKAHIRO WATANABE

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.66, no.Suppl.1, pp.83-87, 2020 (Released:2020-09-30)

参考文献数

4

被引用文献数

2

著者

浦尾 正彦

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.60, no.1, pp.16-24, 2014

被引用文献数

1

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便秘とは,排便の頻度が週2回以下で,便が硬く,排便困難,残便感がある状態といわれている.実際には放置されていたり自己流の対処をされていることが多い.が,便秘患者では労働生産性が障害されたり,肛門疾患や結腸癌などの様々なリスクも増加することが知られており,しっかり取り組むべき疾患である.<br>慢性便秘は,症候性,薬剤性,器質性,機能性便秘などに分類される.症候性便秘は神経疾患,内分泌疾患の症状の一部としてみられるもの,薬剤性便秘は薬剤によって誘発されるもので薬剤の中止変更で改善する.器質性便秘は結腸などの器質的変化によるもので時として手術を必要とする.特に排便時出血,50歳以上,大腸癌の家族歴,急激な体重減少がある場合は専門医に相談する必要がある.<br>ほとんどの慢性便秘は機能性便秘であり,生活習慣の改善でコントロールできることが多い.すなわち,①睡眠を十分にとる,②1日の生活リズムを整える,③朝食を食べる,④軽い運動を行う.また腸内環境を整えるために,⑤食物繊維を摂る,⑥1日2<i>l</i> の水分摂取,⑦ヨーグルトや整腸剤を摂取する.またスムーズな排便のために,⑧排便マッサージ,⑨排便姿勢の調整,⑩リラックスできる環境づくりなどがあげられる.機能性便秘を放置することで,さらにひどい便秘となり手術を要する疾患に発展することもあるので,重症化を予防するための日々の努力が重要である.

著者

MICHIKO MOCHIZUKI SUDO AKITO AZUMANE MOCHIZUKI EIJI KIRINO KENJI ITOH

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ19-OA21, (Released:2020-02-18)

参考文献数

36

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Objective: Research has demonstrated the positive effects of physical activities on social cognition. The purpose of the present study was to find out whether coordination exercises have a beneficial effect on enhancing social functioning. We investigated the activation of the brain areas associated with doing one-person coordination exercises, as compared to doing two-person coordination exercises. We were interested in testing the hypothesis that two-person coordination exercises activate those brain areas underlying communication abilities, empathy in “theory of mind” (ToM), and working memory in social cognition. Materials: Thirty-four Japanese college students served as subjects. Methods: In the MRI system, the subjects carried out block-designed cognitive tasks containing affective visual stimuli (pleasant, unpleasant, and neutral stimuli). Then they got out of the MRI system and performed both one-person coordination and two-person coordination exercises. Just after the exercises, they were retested using the same types of the affective stimuli in the MRI system. We examined social abilities in terms of empathizing and memory span. Results: The present study provided evidence that coordination exercises activate language, working memory, and theory of mind functions. One of the fMRI results to be noted is that the right, but not the left, anterior cingulate correlated with the working memory function. Conclusions: We provided evidence for the effect of performing coordination exercises on the activation of the left frontal gyrus related to social functioning. We could also provide support for the hypothesis that two-person coordination exercises activate both the working memory function and the ToM function.

著者

MINORU KUNII SUSUMU S. SAWADA NAOFUMI YAMAMOTO YUKO GANDO HISASHI NAITO

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ19-OA04, (Released:2019-12-13)

参考文献数

20

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Objective: The purpose of this study was to evaluate the relationship of freestyle swimming performance between adolescence and adult Japanese top-class swimmers.Methods: The 234 males and 134 females ranked in the top 100 records of 50, 100, 200 and 400 m freestyle short-course performances of over 22 years old during 2016 to 2018 (latest TIME), and their season best performances during 2006 to 2017 were analyzed. All data were collected from the public database “Swimrecord.com” by Japan Swimming Federation. Performance maturity status was determined by the ratio of each age record to the latest TIME and the relationship between the latest TIME and each age record was evaluated. Also, the subjects were divided into the upper or lower group with reference to the latest TIME and the developmental changes of performance were compared between the groups.Results: The performance maturity status was higher in females than males at each age. The correlation between the latest TIME and each age record became gradually stronger from males aged 17 years and females aged 14 years, but there was no clear correlation in the previous records. There was no difference in developmental changes in performance between the upper and lower groups in both males and females.Conclusions: The longitudinal analysis of the swimming performance in the growth period reveals that the Japanese top-class swimmers show high performance before 12 years old and that the time to approximate peak performance appeared earlier in females than in males and the relationship is different depending on swimming distance.

著者

TOMOHIRO NAKAMURA RYO KAKIGI NORIKO ICHINOSEKI-SEKINE TAKAMASA TSUZUKI HIROYUKI KOBAYASHI KAZUHIKO SAKUMA HISASHI NAITO

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ19-OA08, (Released:2019-09-25)

参考文献数

21

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Objective: Alpha-actinin (ACTN) 3 R577X polymorphisms have three genotypes: RR, RX and XX. Only RR and RX genotypes express ACTN3 protein in type II fibers. The purpose of this study was to clarify whether there are differences in ACTN3 protein expression levels and myosin heavy chain (MyHC) composition between RR and RX genotypes in Japanese college-level male sprinters.Materials and Methods: Forty-three Japanese college-level male sprinters participated in this study. Subjects were genotyped for ACTN3 R577X using a real-time polymerase chain reaction assay. Furthermore, muscle biopsies from the vastus lateralis muscle were obtained from a subset of subjects who had R allele and gave their consent (4 RR and 9 RX). ACTN3 protein expression levels were assessed by western blotting. MyHC composition was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis.Results: There was no difference in 100-m sprint performance among RR, RX and XX genotypes in all 43 subjects. In 13 biopsy-sampled subjects, there was also no difference in 100-m sprint performance between RR and RX and ACTN3 protein expression levels tended to be higher in RR genotype than in RX genotype. Although there were no differences in the proportion of type I and II MyHC isoforms between both genotypes, RR genotype had a significantly higher proportion of type IIx MyHC isoform and a significantly lower proportion of type IIa MyHC isoform than RX genotype.Conclusions: ACTN3 protein expression levels and the proportion of type IIx MyHC isoform are higher in RR genotype compared with RX genotype in Japanese college-level male sprinters.

著者

OKIO HINO

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.60, no.6, pp.588, 2014 (Released:2015-06-03)

著者

植木 理恵

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.59, no.4, pp.327-330, 2013-08-31 (Released:2014-11-26)

参考文献数

5

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皮膚科に求められるアンチエイジングは, しみ, しわ, 白髪, 薄毛である. 薄毛は髪が抜けて数が少なくなる場合と, 毛が細くなる場合と両方の場合がある. 脱毛には (1) 生理的脱毛 (成長と休止を繰り返す毛周期があり, 1日100本以内の脱毛は正常範囲である), (2) 病的脱毛 (1日100本以上の脱毛や, 一部分だけ抜けて生えてこない場合など) の2つに大きく分かれる. 病的脱毛の原因は, 1. 加齢変化, 2. 男性型脱毛症, 3. 先天性脱毛症, 4. 円形脱毛症, 5. 内臓疾患に随伴する脱毛, 6. 皮膚病に伴う脱毛, 7. 薬物や放射線治療などの医原性脱毛, など様々である. 病気ではないが, 薄毛の原因で多いのは加齢変化と男性型脱毛症である. 女性では原因がはっきりしない, 髪の成長が休んでしまう休止期脱毛も少なくない. 正常な髪について知って, 様々な脱毛があることを理解して, 健康で美しい髪で過ごすコツを実践していただきたい.

著者

横山 和正 服部 信孝

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.60, no.2, pp.s53-s59, 2014

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ワクチンというと皆さんはエドワードジェンナーについて学生時代に学んだかもしれません.当時経験的に知られていたのは,牛痘にかかったヒトは天然痘にかからないですむ,もしくは天然痘にかかったとしても死に至らず天然痘感染による症状が軽くすんでいたことから治療への応用が検討されました.他の医師が行った実験治療では多くの死亡事故もあったようです.それを踏まえてジェンナーが行ったのは,天然痘予防のためのウシ天然痘(牛痘)のヒトへの接種実験でした.現在ワクチンという呼び名で一般化したこの試みは見事に成功し数多くの人命が救われ,184年後の1980年5月,WHO(世界保健機関)は天然痘の根絶を宣言しました.<br>このようにワクチンは正しく使用すれば効果も高く,社会に貢献するのはあきらかですが例外もあります.本日参加された皆さんはワクチンの適応,時期,その限界や副作用についてもよく知っておく必要があると思います.繰り返しになりますが,ワクチンに限らず万人に対して同じ作用・効果を起こす薬剤は存在しませんし,個々のワクチン接種時の免疫状態によって効果や副作用が変化する可能性もあるのです.またご自身,家族,友人,会社,村,市,地方,県,国,世界と接種対象のスケールアップに伴いワクチンの主たる目的も変わってきます.<br>ワクチンはもともと個人の体内に存在していない異物(非自己)を,皮下,筋肉注射,静脈注射,経鼻,経口ルートから投与し,個人のもつ免疫能を強制的に賦活させるものです.よって,場合によっては死に至るような重篤な副作用を起こす可能性が常にあります.<br>今回の公開講座は広くワクチンの特集であり,他の演者からすでにそれぞれの分野における最新の報告が行われてきたかと思いますが,私の講演ではインフルエンザワクチンにより起こりうる神経系の副作用についてまずお話をします.また,最近話題になっている子宮頸癌ワクチンと神経系への副作用,さらには私の主たる研究である多発性硬化症のワクチンを利用した免疫治療が歴史的にどのように行われてきたかについて述べ,日本でも増加しているアルツハイマー病に対してのワクチンによる免疫治療とその誤算,最後に今後日本でもますます増えるであろう様々なワクチンにどう向き合うかの基本姿勢についてまとめて述べます.自己を病気から守るためには非自己である感染のみならず,自己に対しての過剰反応である免疫現象を理解することが必要不可欠なのです.

著者

佐久間 俊郎 海老原 伸行

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.59, no.6, pp.513-515, 2013 (Released:2014-05-29)

参考文献数

4

著者

NORIYUKI FUKU ERI MIYAMOTO-MIKAMI NAOKI KIKUCHI HIROFUMI ZEMPO HISASHI NAITO

出版者

順天堂医学会

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.62, no.Suppl.1, pp.22-28, 2016 (Released:2017-07-27)

参考文献数

41

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A number of familial and twin studies have assessed the relative contribution of genetic and environmental factors to physical performance or its-related traits, and a significant genetic component has been predicted to affect phenotypes. A twin study indicated that the heritability of athletic status is 66%. Thus, genetic factors appear to be important for determining elite sporting performance. To date, over 200 genes in both nuclear DNA and mitochondrial DNA (mtDNA) have been reported to be associated with physical performance and health-related fitness. However, most studies have been reported in European populations. In the Asian population, only 3 genetic loci have been linked to physical performance, including angiotensin I-converting enzyme and α-actinin-3 genetic polymorphisms and mtDNA polymorphisms (mitochondrial haplogroups). In this review, we discuss the genetics of elite sporting performance, particularly in Asian populations, and their effects on lifestyle-related diseases such as type 2 diabetes and age-related muscle wasting (i.e., sarcopenia).