出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.103, no.3, pp.760-779, 2014-03-10 (Released:2015-03-10)

著者

Shuwa Minami Tomotaka Kawayama Masao Ichiki Mamoru Nishiyama Yoshiko Sueyasu Rumi Gohara Masaharu Kinoshita Hideyuki Koga Tomoaki Iwanaga Hisamichi Aizawa

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.47, no.6, pp.503-509, 2008 (Released:2008-03-17)

参考文献数

21

被引用文献数

2 2

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Background There is insufficient evidence for the efficacy of a transdermal tulobuterol patch (TP), although combination therapy with bronchodilators is recommended for chronic obstructive pulmonary disease (COPD). Objective A randomized, controlled crossover study was conducted to evaluate the clinical efficacy and safety of the TP in 16 patients with COPD. Slow-release theophylline was used as a control drug. Methods Following a 2-week run-in period, patients were randomly allocated to two groups by the envelope method; they then received the TP and theophylline for 4 weeks each by the crossover method. Pulmonary function tests, peripheral blood examination, and electrocardiography were performed before and after each treatment period. Patients recorded in diaries their symptom scores, numbers of administrations of inhaled β2 agonists, and presence/absence of adverse reactions. Results Patients receiving TP exhibited significant improvement in the number and ease of sputum expectorations and in cough frequency score and wheezing severity score compared with baseline (p<0.05); the corresponding improvement in patients receiving theophylline was non-significant. Assessment of quality of life by the St. George's Hospital Respiratory Questionnaire revealed that treatment with TP was associated with significant improvement in symptoms, impact, and total scores compared with baseline (p<0.05); theophylline gave only a non-significant improvement in total score. Neither drug caused significant changes in the results of physiological examinations or in pulse or blood pressure. There was no difference in safety between the treatments. Conclusion Treatment of COPD patients with TP is more effective than with theophylline.

著者

Kazutoshi Fujibayashi Hirohide Yokokawa Toshiaki Gunji Noriko Sasabe Mitsue Okumura Kimiko Iijima Tomomi Haniu Teruhiko Hisaoka Hiroshi Fukuda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.7, pp.717-723, 2015 (Released:2015-04-01)

参考文献数

27

被引用文献数

1 5

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Objective The aim of this study was to investigate the associations between the incidence of diabetes and the accumulation of markers of impaired glucose metabolism; i.e., pre-diabetes. Methods This retrospective cohort study recruited 1,631 men without diabetes at baseline who attended more than two routine health check-ups at our institution between 2006 and 2012. The participants were divided into four groups based on the number of markers of impaired glucose metabolism exhibited at the initial examination. The following markers of impaired glucose metabolism were defined as risk factors for diabetes: a fasting plasma glucose level of ≥110 mg/dL, 2-hour plasma glucose level of ≥140 mg/dL and glycated hemoglobin (HbA1c) value of ≥6.0% (42 mmol/moL). The risk of developing diabetes was assessed using a multivariate analysis. Results The median examination interval was 1,092 days. The incidence of diabetes rose in association with the number of markers. The subjects with two markers displayed a multivariate-adjusted odds ratio (OR) for diabetes of 19.43 [95% confidence interval (CI): 9.70-38.97] and the subjects with three markers displayed an OR of 48.30 (95% CI: 20.39-115.85) compared with the subjects with one or no markers. Conclusion The present results demonstrate the impact of accumulating markers of impaired glucose metabolism on the risk of developing diabetes. Anti-diabetes intervention strategies should aim to comprehensively assess an individual's risk of developing diabetes at the pre-diabetes stage.

著者

服部 信孝

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.103, no.3, pp.637-644, 2014-03-10 (Released:2015-03-10)

参考文献数

5

著者

渋江 公尊 原島 伸一 中本 裕士 浜崎 暁洋 稲垣 暢也

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.102, no.7, pp.1794-1796, 2013-07-10 (Released:2014-07-10)

参考文献数

5

被引用文献数

1

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水様下痢と嘔吐を繰り返し,膵尾部原発ガストリノーマの診断にて膵体尾部・脾臓・肝外側区域切除術および胆嚢摘出術を受けた.術後2年を経過した頃から低血糖発作が頻発.血清インスリン値高値でありインスリノーマの併発が疑われた.局在診断に68Ga標識DOTATOCを用いたPET/CTを施行し,アログリセムによる治療を試みた症例を経験したので報告する.

著者

Yasuhiro Kiyonaga Keisuke Maeshima Chiharu Imada Miwa Haranaka Koji Ishii Hirotaka Shibata

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.11, pp.1209-1213, 2014 (Released:2014-06-01)

参考文献数

39

被引用文献数

1 11

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We herein report the case of an 84-year-old man with steroid-dependent adult-onset Still's disease (AOSD) whose daily steroid dose was successfully tapered after etanercept treatment. The corticosteroids worked well initially, and the patient went into remission promptly; however, he suffered a relapse due to steroid tapering. Because treatment with cyclosporine and methotrexate was ineffective, reducing the steroid dose was difficult, and the corticosteroids induced myopathy and diabetes. However, steroid tapering was accomplished in combination with etanercept therapy, and the patient's steroid-induced side effects disappeared. Etanercept should therefore be considered as a steroid-sparing treatment option in patients with steroid-responsive, steroid-dependent AOSD.

著者

Yoshiro Sakai Tetsuya Naito Chiyoko Arima Miho Miura Liang Qin Hidenobu Hidaka Kenji Masunaga Tatsuyuki Kakuma Hiroshi Watanabe

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.5, pp.459-464, 2015 (Released:2015-03-01)

参考文献数

12

被引用文献数

4 10

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Objective Warfarin is known to interact with many drugs; however, there are currently no descriptions of an interaction with linezolid in the literature. It was recently brought to our attention, however, that several warfarin-medicated patients have experienced an increase in the prothrombin time international normalized ratio (PT-INR) following the administration of linezolid. We therefore performed a retrospective survey in order to investigate the possibility of an interaction between warfarin and linezolid. Methods The survey items included age, gender, underlying disease, type of surgery, type of infectious disease, duration of linezolid administration, laboratory values and the dose of warfarin. The PT-INR was observed over time before treatment and at days 4 or 5 and 10, completion and one week after the end of concomitant therapy. Patients The subjects included six patients who were recovering from recent heart-related surgery. Results The PT-INR increased from 1.62±0.32 before concomitant linezolid administration to 3.00±0.83 at day 4 or 5 after concomitant administration (p<0.01) and significantly decreased from 1.65±0.45 at the completion of the regimen to 1.26±0.1 one week later (p<0.05). With respect to the relationship between the dose of warfarin and the PT-INR in five cases, the PT-INR increased following concomitant linezolid treatment in all cases. Conclusion Although it has been reported that linezolid does not influence the metabolism or protein binding of warfarin, our data showed potential drug interactions between warfarin and linezolid. Our data suggest that PT-INR monitoring after the completion of concomitant warfarin and linezolid therapy is important.

著者

大里 後吾 渡部 佳吉

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.13, pp.879-884, 1925 (Released:2008-06-12)

著者

瀬川 文徳 黒岩 義之

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.89, no.4, pp.608-616, 2000-04-10 (Released:2008-06-12)

参考文献数

5

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不随意運動は,主にその運動の出現が安静時か動作・姿勢時か,律動性の有無,運動の速さ,律動性があれば動きの周波数に注目し分類していくことが有用である.近年,基底核の神経回路への知見の集積とともに,錐体外路性の不随意運動に対する新たな理解が深まり,不随意運動などの運動異常に対して,定位脳手衛や電気刺激療法も行われるようになってきた.近年の基底核回路への考え方を図示し,不随意運動の病態,分類について解説する.

著者

高田 俊彦 生坂 政臣

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.102, no.12, pp.3261-3263, 2013-12-10 (Released:2014-12-10)

参考文献数

5

著者

渡辺 守 土屋 輝一郎

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.98, no.9, pp.2152-2156, 2009 (Released:2012-08-02)

参考文献数

12

著者

森瀬 敏夫

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.97, no.11, pp.2822-2825, 2008 (Released:2012-08-02)

著者

Takeshi Yoshida Natsumi Fujisaki Ryo Nakachi Takeshi Sueyoshi Shugo Suwazono Masahito Suehara

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.20, pp.2373-2376, 2014 (Released:2014-10-15)

参考文献数

10

被引用文献数

8

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A 76-year-old man came to our hospital complaining of hiccups and vomiting lasting for five days. A neurological examination showed dysfunction of cranial nerves V, VII, VIII, IX and X on the left side. Cerebrospinal fluid polymerase chain reaction for varicella zoster virus-DNA was positive. The patient responded well to treatment with intravenous acyclovir and steroids. To the best of our knowledge, this is the first case report of zoster sine herpete presenting with persistent hiccups and vomiting. It is important to keep in mind that herpes zoster can present with symptoms that closely resemble those of intractable hiccups and nausea of neuromyelitis optica. Early detection of the virus is critical for making appropriate treatment decisions.

著者

今村 顕史

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.102, no.11, pp.2816-2822, 2013-11-10 (Released:2014-11-10)

参考文献数

12

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HIV感染症の予後は,抗HIV薬による治療(ART)によって劇的に改善した.その一方で,近年は様々な長期合併症が問題となってきている.長期合併症の回避,ARTによる感染予防効果などによって,より早期の治療開始も推奨されるようになった.今後は,さらなる早期診断への努力や,長期療養へ向けた医療体制の整備なども求められている.

著者

野川 茂 福内 靖男

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.91, no.8, pp.2289-2295, 2002-08-10 (Released:2008-06-12)

参考文献数

42

著者

味澤 篤

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.98, no.11, pp.2767-2773, 2009 (Released:2012-08-02)

参考文献数

5

被引用文献数

1 12

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HIV感染症は,抗体+抗原による第4世代のスクリーニングキットが使用されるようになって,感染後2~3週間で陽性が判明するようになった.しかしスクリーニング検査では必ず偽陽性が生じるので,確認検査としては,WB法+RT-PCR法が用いられている.WB法は急性感染期には陰性となってしまうために,RT-PCR法でのHIV-RNA量測定が必要となる.一方AIDSは,HIV感染者が,エイズ動向委員会で定められた23の疾患もしくは状態と判定された場合に診断される.

著者

日比野 進

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.60, no.13, pp.14-15, 1971-12-31 (Released:2011-02-22)

被引用文献数

7

著者

Kayo Harada-Shirado Kazuhiko Ikeda Miki Furukawa Masumi Sukegawa Hiroshi Takahashi Akiko Shichishima-Nakamura Hiroshi Ohkawara Hideyoshi Noji Kinuyo Kawabata Shun-ichi Saito Hitoshi Ohto Kazuei Ogawa Yasuchika Takeishi

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.20, pp.2369-2371, 2014 (Released:2014-10-15)

参考文献数

18

被引用文献数

4 8

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A 44-year-old man whose platelet count had been at the lower limit of the normal range for years visited the urgent care department of our hospital for treatment of a high fever and severe fatigue. The influenza A virus was detected, and the patient therefore received the intravenous antiviral agent, peramivir. One week later, he developed systemic petechial rashes. A peripheral blood examination showed a markedly decreased platelet count (3.0×109 cells/L), and the bone marrow findings were compatible with a diagnosis of immune thrombocytopenia (ITP). Furthermore, a drug-induced lymphocyte-stimulating test was positive for peramivir. The thrombocytopenia slowly responded to treatment with oral prednisolone. This case suggests that neuraminidase inhibitors, including peramivir, can elicit or worsen ITP.

著者

Toshio Naito Nagako Kudo Akihiro Inui Naomi Matsumoto Naoto Takeda Hiroshi Isonuma Takashi Dambara Yasuo Hayashida

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.45, no.13, pp.833-834, 2006 (Released:2006-08-01)

参考文献数

5

被引用文献数

9 16 17

著者

川上 和義

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.98, no.9, pp.2365-2371, 2009 (Released:2012-08-02)

参考文献数

17