著者

野村 武夫

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.62, no.2, pp.123-129_2, 1995-04-15 (Released:2010-03-01)

著者

黒部 裕嗣 佐田 政隆

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.13, no.4, pp.210-213, 2017-10-15 (Released:2017-11-20)

参考文献数

17

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Over 190,000 patients die each year in japan due to ischemic heart disease. For these patients, percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) are done to improve the blood flow of coronary artery with stenosis. It would be better to prevent or mitigate the progress of atherosclerosis in these patients before requiring surgery. Recently, it has been reported that epicardial adipose tissue plays an important role in the progression of atherosclerosis and ischemic heart disease.This review shows the recent trends about ischemic heart disease from the clinical perspective, including its' treatment, pathology and preventive measure.

著者

杉原 仁

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.10, no.4, pp.203, 2014-10-15 (Released:2014-11-17)

著者

行徳 健助

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.2, no.6, pp.557-570, 1931-06-15 (Released:2010-01-14)

参考文献数

12

著者

叶 恵娟 勝又 聖夫 南 正康

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.67, no.5, pp.375-379, 2000 (Released:2001-11-15)

参考文献数

19

被引用文献数

2 2

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Mercury spilled from a mercurial sphygmomanometer on a hot carpet can vaporize and pollute the environment. We observed the vaporization of mercury in model experiments. Mercury (0.15g) was heated on a hot carpet and the near-by air was sampled with a midget impinger. The evaporated mercury levels were 5.0, 6.3, 8.1 and 10.0mg/m3 at 20, 40, 60 and 80 minutes, respectively at a height of 30cm from carpet. The result indicated that even if a small quantity of mercury remained on the hot carpet, it could evaporate and pollute the indoor air. Little is known about the influence on human health of low mercury exposure, especially on children. In order not to pollute the air, we need to pay attention to mercury.

著者

義沢 一孝

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.28, no.1, pp.123-134, 1961-01-15 (Released:2010-10-14)

参考文献数

64

著者

樫村 正美 野村 俊明

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.12, no.2, pp.57-60, 2016-04-15 (Released:2016-05-16)

参考文献数

12

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Several psychological and behavioral treatments have been gaining attention recently for their effectiveness in improving common diseases, such as depression and anxiety. Cognitive behavioral therapy (CBT) is particularly notable in this context, as considerable evidence of its efficacy has been presented. In this paper, we introduce the basic concept of CBT and offer evidence of its effectiveness. We believe that CBT is an effective intervention and hope that it will become widely used to deal with patient distress.

著者

中澤 秀夫

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:18802877)

巻号頁・発行日

vol.11, no.1, pp.29-36, 2015-02-15 (Released:2015-03-06)

被引用文献数

1

著者

犬竹 正雄

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.25, no.2, pp.124-144, 1958-02-15 (Released:2009-07-10)

参考文献数

43

著者

都築 茂

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.24, no.3, pp.183-205, 1957-03-15 (Released:2009-07-10)

参考文献数

22

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After Streeter begins the human arm in his horizon XIII to develop. The author's investigation begins from the. Streeter's horizon XIV upward. The author's to the youngest horizon belonging human embryo is 7 mm long which arm is only the mass of simple homogenous mesenchymal tissue, the nerve plate consisting of from the 4 th to the 8th cervical and the first thoracal nerves is protruding in the basic part of this appendage (plate 1). This nerve plate is the anlage of the brachial plexus and is beginning to divide into ventral and dorsal parts. This condition is almost the same in the next to the horizon XV belonging 6 mm long embryo, in which the central tissue of the arm is a little different from the surrounding more condensed tissue (plate 1). This central tissue may be called the beginning of the praecartilageous. The praecartilageous tissue is observed in the next to the horizon XVI belonging 9 mm long embryo, the cartilageous in the 9.5 mm long, which belongs to the Streeter's horizon XVII.The brachial plexus, which divides into ventrocranial and dorsocaudal portions without any prolongation of the branches in the 6 mm long embryo, is in the next 9 mm long well developed so that all the branches of the plexus are distinguished.In the next stage are all branches of the plexus brachialis prolonged and distinct, the precartilageous tissue of the axis of the arm is becoming cartilageous. The chondrification of the skeleton is observable in the scapula, humerus, radius, ulna and in a few carpal bones, the others yet precartilageous.A. axillaris of the 6 mm long embryo divides into A. brachialis and profunda brachii, in the 9 min long thus divided A. brachialis is prolonged to become A. interossea. The distal branch of the interossea reaches the hand plate, where it terminates as the dorsal and volar interossea. This form of the arterial branches is also in the next 9.5 mm long embryo observed, in which A. mediana from the brachialis communicates with the volar interossea.As for the venous system of the arm of these human embryos, there is no distinct change of form. The socalled Randvene or primary ulnae vein of the early stages is observed through three horizons XV, XVI, XVII, almost the same. The cranial end of the vein terminates as a venous net at the root of the arm, the caudel prolongation continues to the lateral side of the brachial plexus where it ascends and bends medialward to pour into the anterior cardinal vein.

著者

横山 聡

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.59, no.3, pp.234-246, 1992-06-15 (Released:2010-10-14)

参考文献数

17

被引用文献数

2 2

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Fast Fourier Transform (FFT) analysis method. The subjects who had mastered a “rapid-reading” method, were classified into two groups according to theirrapid-reading achievement level: the “under-trained readers” (male 5, female 2) had already acquired the ability of smooth eye movement, but continued to use the mental phonetic process while reading. The “well-trained readers” (male 6, female 2) could understand the contents of the text without resorting to such phonetic process. All subjects were righthanded.The tasks were designed to eliminate the artifact of the eye movement and the electromyogram as much as possible. The EEGs were recorded with twelve channels of the international standard 10-20 electrode system. The relative power value (R. P. V.) was calculated as follows:RPV (%) = {(X. C) IN} X 100(%)where X is the beta 1 or beta 2 power value by FFT analysis while doing tasks, C is the power value while doing control tasks, and N is the value in the resting state with the eyes open. The results were statistically analyzed by paired I-test.The following results were obtained: In both groups; (a) the left angular gyrus was usually activate during the rapid-reading; (b) the Wernicke's center was activated only during reading with the phonetic process; (c) in the well-trained readers the activation of the right visual cortex was associated with some visual imaging during the rapid-reading; (d) in the under-trained readers, the association between the activation of the central frontal area and the rapid-reading was observed.Thus, the following model for “reading” was obtained: Two parallel pathways seem important in the processing of the verbal information presented visually; one relates only to the left angular gyrus where the visual-verbal information is processed directly, and the other relates to the interactive pathway between the left angula gyrus and the Wernicke's center. Moreover, the visual cortex of the non-verbal hemisphere seems to play some role in understanding verbal information.

著者

松倉 則夫 恩田 昌彦 山下 精彦

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.62, no.4, pp.313-319, 1995-07-15 (Released:2010-03-01)

参考文献数

22

著者

大塚 茂

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.10, no.2, pp.121-122, 2014 (Released:2014-05-08)

著者

東 直行

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌

巻号頁・発行日

vol.13, no.1, pp.8-21, 2017

被引用文献数

1

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<p>Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease. Both abnormal barrier function and abnormal immune function are closely involved in the etiology of AD. Patients with AD have been subdivided into abnormal filaggrin, normal filaggrin, high immunoglobulin E, normal IgE groups, and so on. Regarding local cytokine profiles in the skin of patients with AD, the involvement of Th2, Th22, and Th17 cells at the acute stage, and the involvement of Th2, Th22, and Th1 cells at the chronic stage have been suggested. The IL-9 level has been reported to be higher in patients with AD than in healthy individuals, but it has also been reported that there are no differences in IL-9 levels between patients with AD and normal individuals. Thus, the role of IL-9 is unclear. The serum IL-18 level is high and induces Th2 reactions in patients with AD. IL-21 is thought to suppress IgE formation, but its activity in relation to AD remains unknown. IL-22 is involved in hyperplasia, increased antimicrobial peptide formation, and reduced filaggrin in patients with AD. IL-25, IL-33, and thymic stromal lymphopoietin are produced in epidermal cells and activate type 2 innate lymphoid cells or premature dendritic cells, resulting in the induction of Th2 reactions. IL-31 is produced by Th2 cells, causing an itching sensation and scratching behavior. A correlation has been reported between serum IL-32 levels and the severity of dermatitis. IL-34 is an element of the control system that suppresses inflammation, but its activity in cases of AD is unknown. One published report describes a correlation between serum IL-37 levels and the severity of dermatitis, but this relationship has not been sufficiently clarified to date, and requires further analysis. In this review, the author has attempted to summarize reports on cytokine expression in patients with AD. The author expects that important cytokines and cells involved in the pathophysiology of AD will be revealed, contributing to strategies for treating AD.</p>

著者

木村 俊三

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.35, no.1, pp.17-25, 1968-02-15 (Released:2010-10-14)

参考文献数

62

著者

Yuri Kinoshita Hidehisa Saeki

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.83, no.6, pp.216-222, 2016-12-15 (Released:2017-01-27)

参考文献数

47

被引用文献数

18

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Toxic epidermal necrolysis (TEN) is a rare skin condition, most often drug-induced, known for its skin detachment and high mortality. In general, acute TEN is considered a T-cell mediated, type IV hypersensitivity disorder. It mostly results from a cumulative effect of risks from the drug structure, drug metabolism, HLA alleles and T cell clonotypes. However, the precise mechanism of TEN is still unknown. Apoptosis or necroptosis causes keratinocytes to lose their shape and adhesion, and necrosis predominates within a few days. Total epidermal necrosis separates the epidermis from the dermis. TEN is regarded as an immune reaction with predominantly CD8+ T lymphocytes, monocytes/macrophages, and natural killer cells. Impaired regulatory T-cells, T-helper 17 cells, cytotoxic granules such as perforin-granzyme and granulysin, tumor necrosis factor α, annexin, microRNA-18a-5p, and drug metabolites are all thought to be involved. From what is known, it can be assumed their mechanism is complex, and there is still much to be investigated. New findings will contribute to the identification of effective active methods of intervention.

著者

風間 たね

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.8, no.6, pp.679-720_2, 1937-06-15 (Released:2009-12-04)

参考文献数

40

著者

野村 俊明

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.7, no.4, pp.166-168, 2011 (Released:2011-12-22)

参考文献数

14

著者

Koichi Yoneyama Atsuko Sekiguchi Takashi Matsushima Rieko Kawase Akihito Nakai Hirobumi Asakura Toshiyuki Takeshita

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.83, no.1, pp.6-14, 2016-01-15 (Released:2016-03-09)

参考文献数

19

被引用文献数

2

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Aim: The aim of the present study was to elucidate the clinical characteristics of pregnancy-associated maternal deaths. Methods: We performed a retrospective analysis with medical records and autopsy reports of cases of pregnancy-associated deaths. We collected information on all maternal deaths related to pregnancy that occurred in 3 hospitals affiliated with Nippon Medical School in Japan from January 1, 1984, to December 31, 2014. Data analyzed were maternal age, past medical history, parity, gestational age, clinical signs and symptoms, cause of death, and maternal autopsy findings. Results: A total of 26 maternal deaths occurred during the 31-year study period. Autopsies were performed for 16 patients (61.5%). The 26 deaths included 19 (73.1%) classified as direct maternal deaths and 7 (26.9%) classified as indirect maternal deaths. The mean maternal age at death was 33.1±4.3 years (range, 26-41 years). The highest percentage of women was aged 35 to 39 years (38.5%). Of the 26 maternal deaths, 69% occurred at 32 to 41 weeks of gestation. In cases of direct maternal death, the leading causes were amniotic fluid embolism (7 cases, 27.0% of all deaths) and hemorrhage (6 cases, 23.1% of all deaths). In cases of indirect obstetric deaths, the causes included cardiovascular disorders, cerebrovascular disorders, sepsis due to group A streptococcal infection, and hepatic failure of unknown etiology. Conclusions: Amniotic fluid embolism was the leading cause of maternal deaths and was followed by obstetric hemorrhage. To prevent and reduce the number of maternal deaths in Japan, further basic and clinical research on amniotic fluid embolism is required.

著者

室岡 一 須藤 董穂 田中 聡 小田原 耕三

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.29, no.5-9, pp.45-50, 1962-09-15 (Released:2010-10-14)

参考文献数

53