著者

大野 曜吉 山本 伊佐夫

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.69, no.4, pp.320-321, 2002 (Released:2002-08-23)

参考文献数

1

著者

吉田 忠 奥貫 正雄

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.11, no.10, pp.1461-1471, 1940-10-15 (Released:2009-07-10)

参考文献数

15

著者

Tomoko Shigemori Atsushi Sakai Toru Takumi Yasuhiko Itoh Hidenori Suzuki

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.82, no.2, pp.92-99, 2015-04-15 (Released:2015-05-08)

参考文献数

54

被引用文献数

1 14

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Background and Purpose: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic basis. Although anxiety is a common major psychiatric condition in ASD, the underlying mechanisms of the anxiety are poorly understood. In individuals with ASD, evidence indicates a structural abnormality in the amygdala, a key component involved in anxiety and social behavior. Microglia, which are central nervous system-resident immune cells implicated in neurodevelopmental processes, are also reportedly altered in ASD. In the present study, we examined the involvement of microglia in the anxiety-related behaviors of ASD model mouse. Methods: Mice that have a 6.3-Mb paternal duplication (patDp/+) corresponding to human chromosome 15q11-q13 were used as an ASD model. Iba1, a microglial activation marker, was examined in the amygdala using immunofluorescence. Effects of perinatal treatment with minocycline, a microglial modulator, on anxiety-related behaviors were examined in neonatal and adolescent patDp/+ mice. Results: In patDp/+ mice, Iba1 was decreased in the basolateral amygdala at postnatal day 7, but not at postnatal days 37-40. Perinatal treatment with minocycline restored the Iba1 expression and reduced anxiety-related behaviors in patDp/+ adolescent mice. Conclusions: Perinatal microglia in the basolateral amygdala may play a pathogenic role in the anxiety observed in a mouse model of ASD with duplication of human chromosome 15q11-q13.

著者

百束 比古 水野 博司 汲田 伸一郎

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.6, no.2, pp.56-57, 2010 (Released:2010-05-06)

参考文献数

3

著者

小平 祐造

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.11, no.1, pp.41-42, 2015-02-15 (Released:2015-03-06)

著者

Ryo Yajima Yuya Ise Tetsuya Wako Shirou Katayama Junko Kizu

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.80, no.6, pp.481-485, 2013 (Released:2014-01-10)

参考文献数

11

被引用文献数

1

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Preventing infectious diseases in patients with cancer receiving palliative care is extremely important. However, little is known about the factors causing infection in these patients. The aim of this study was to clarify the factors contributing to infection in patients with cancer receiving palliative care. The medical records of each patient were reviewed, and patient characteristics were recorded. Factors that correlated significantly with infection, as revealed by univariate analysis, were performance status, the fall risk assessment score, and venous catheters. Our present study provides further evidence that the fall risk assessment score is a risk factor for infection. Critical infections might be prevented in patients with cancer receiving palliative care by monitoring the above 3 factors.

著者

斉藤 勉

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.58, no.1, pp.74-85, 1991-02-15 (Released:2010-12-22)

参考文献数

50

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内科的治療により胸痛発作が認められないST下降型狭心症93例と心筋梗塞160例の長期予後とその規定因子について, ホルター心電図, トレッドミル運動負荷試験成績および冠動脈造影所見を用い生命表法とCox型重回帰分析法にて解析し, ホルター心電図にて検出されたsilent myocardial ischemiaの臨床的および予後的意義を検討した結果, 以下の成績を得た.1) 狭心症および心筋梗塞群における心事故発生率はそれぞれ19%, 18%であり, 有意な予後規定因子は狭心症群にて多枝病変, asynergy, silent myocardialischemia, 運動負荷試験によるST下降の順であり, 心筋梗塞群ではsilent myocardial ischemia, 多枝病変の順で両群ともに, 多枝病変とsilent myocardialischemiaが独立した予後規定因子であった.2) Silent myocardial ischemiaを有する狭心症および心筋梗塞の頻度はそれぞれ30%, 38%であり, 諸家の報告とほぼ同頻度であった.3) 心事故発生率は狭心症, 心筋梗塞群ともにsilentmyocardial ischemia非出現群に比し出現群で高く, 心筋梗塞群では有意であった. また, その内訳は狭心症群では冠血行再建術が最も多く, 心筋梗塞群では再梗塞が多かった.4) Silent myocardial ischemia出現群の予後規定因子は狭心症群では多枝障害, 運動時間の短縮, asynergyの存在, 運動負荷試験による狭心症出現であるのに対し, 心筋梗塞群では左室駆出分画の低下, ホルター心電図における最大ST下降度であった.以上より, silent myocardial ischemiaは冠動脈疾患における心事故発生の重要な規定因子であり, silentmyocardial ischemia出現例の心事故発生率は非出現例に比し高かった. 心事故の内訳は狭心症群では冠血行再建術施行例が多く重症な合併症は少なかったのに対し, 心筋梗塞群では再梗塞が多く予後は不良であった. したがって, 心筋梗塞群では症状の有無にかかわらずSMI例に対し早期から積極的に冠血行再建術を施行すべきであると考える. 一方, SMI出現例における予後規定因子は心筋梗塞の既往の有無により異なることが明らかにされ, 治療対策上十分留意すべきであると結論される.

著者

Shoji Matsune

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.79, no.3, pp.170-175, 2012 (Released:2012-07-05)

参考文献数

28

被引用文献数

6 13

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Vascular endothelial growth factor (VEGF) was identified in 1980s as a protein that increases vascular permeability and induces endothelial cell-specific mitosis. VEGF plays an important role in angiogenesis during the embryonic stage and in angiogenesis and in increasing vascular permeability during postnatal life, both physiologically and pathologically. Great progress has been made in studies of VEGF, mainly in the field of oncology, and VEGF-targeted therapy has been successfully used to treat patients with cancer. In research related to chronic inflammation, several reports concerning rheumatoid arthritis or retinopathy and VEGF have been published. In the lower respiratory tract, increased levels of VEGF have been detected in biological samples from patients with asthma. However, VEGF has not been studied in detail in upper-airway diseases, such as rhinosinusitis. This review article focuses on VEGF and allergic rhinitis to advance studies of VEGF in chronic inflammation of the upper respiratory tract. VEGF levels in nasal secretions and nasal lavage fluid were higher in perennial allergic rhinitis than in nonallergic rhinosinusitis, after, rather than before, the antigen provocation test. The major VEGF isoforms were confirmed to be VEGF121 and VEGF165 in allergic rhinitis. Expression of VEGF mRNA was higher in serous versus mucous acini. In allergic rhinitis, serous acini produced significant quantities of VEGF, which was hypersecreted after antigen provocation. VEGF seems to play an important role in the pathophysiology of allergic rhinitis. Modulation of VEGF function seems to contribute to the successful treatment of conditions with airway inflammation such as allergic rhinitis.

著者

岩切 勝彦 田中 由理子

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.6, no.1, pp.4-6, 2010 (Released:2010-03-05)

被引用文献数

1

著者

山崎 峰雄

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.8, no.4, pp.274-279, 2012 (Released:2012-12-28)

参考文献数

4

著者

石渡 明子 北村 伸 野村 俊明 根本 留美 石井 知香 若松 直樹 片山 泰朗 川並 汪一

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.1, pp.14-19, 2013 (Released:2013-03-11)

参考文献数

11

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Aim: Community Consultation Center was established in 2007 as a core facility of a project entitled "Community Support Network for Citizens with Mild Cognitive Impairment and Dementia" subsidized by the Ministry of Education, Culture, Sports, Science and Technology. This study reports the activity within the facility and users' outcome. Methods: At the facility, users consulted their memory problem, and a screening tool with a touch-panel type computer (TP) was used to check their memory loss. Dementia was suspected when the TP score was 12 or less points, and clinical psychotherapist implemented Mini-Mental state examination. All the results were summarized in reports, and we prompted users to see their primary doctors, or nearby medical institutes that we offered. In this study, we asked these medical institutes of their outcome. Informed consent was obtained from all users. Results: A total of 2,802 people visited the Center, and 1,565 people registered (male/female=519/1,046; mean age, 74 years). 561 people used the center twice or more. Among 1,354 who had TP, 722 users got a score under 12 (46.1%). A total of 409 responses from medical institutes were collected. The data revealed that Mild cognitive impairment (MCI) was 11.2%, Alzheimer's disease was 37.1%, and vascular dementia was 8.00%. Conclusion: These results indicate that approximately half of the users of the Center was suspected dementia, and a prevalence of both MCI and dementia reached to about 60%. This Center has proven to be useful for early detection and diagnosis.

著者

入戸野 文夫

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.26, no.8, pp.769-778, 1959-08-10 (Released:2010-10-14)

参考文献数

70

被引用文献数

1 1

著者

井上 哲夫

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.2, pp.69-76, 2013 (Released:2013-05-08)

著者

馬場 俊吉

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.2, pp.54-60, 2013 (Released:2013-05-08)

著者

Tatsuya Suzuki Kenzo Oba Yoshimasa Igari Noriaki Matsumura Kentaro Watanabe Shoko Futami-Suda Hiroko Yasuoka Motoshi Ouchi Kazunari Suzuki Yoshiaki Kigawa Hiroshi Nakano

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.74, no.5, pp.338-343, 2007 (Released:2007-10-26)

参考文献数

20

被引用文献数

45 75

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Background: Colestimide has been reported to lower blood glucose levels in patients with type 2 diabetes complicated by hypercholesterolemia. Aim: To examine the mechanism by which colestimide decreases plasma glucose levels in the above patients. Methods: A total of 16 inpatients with type 2 diabetes complicated by hypercholesterolemia received colestimide for 1 week after their plasma glucose levels stabilized. We measured plasma glucose, serum immunoreactive insulin (IRI), serum lipid, plasma glucagon, and plasma glucagon-like peptide-1 (GLP-1) levels. These variables at baseline and 1 week of colestimide administration were compared. Results: Preprandial plasma glucose levels (baseline: 132 ± 33 mg/dL vs. completion: 118 ± 43 mg/dL, P=0.073) tended to decrease after colestimide administration, while 1-hr postprandial plasma glucose levels (baseline: 208 ± 49 mg/dL vs. completion: 166 ± 30 mg/dL, P<0.001) and 2-hr postprandial plasma glucose levels (baseline: 209 ± 56 mg/dL vs. completion: 178 ± 39 mg/dL, P=0.015) decreased significantly at 1 week of colestimide administration. The 2-hr postprandial plasma GLP-1 level was significantly (P=0.015) higher at 1 week of colestimide administration as compared with the baseline level, while there were no significant changes in preprandial and 1-hr postprandial plasma GLP-1 levels. Conclusions: The GLP-1-increasing activity of colestimide may explain, at least in part, the mechanism of its blood glucose-lowering activity in patients with type 2 diabetes complicated by hypercholesterolemia.

著者

福尾 勉

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.27, no.2, pp.294-323, 1960-02-15 (Released:2010-10-14)

参考文献数

26

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1. The lunate sulcus is present in 69 Japanese brains among 90, in 101 hemispheres among 180; the percentage is 76.7 for individuals, 56.1 for hemispheres.2. As for the side of the appearance of the lunate, the left side (25 among 90 individuals, 27.7%) is far more frequent than the right (12, 13.3%). Among 101 hemispheres with the lunate sulcus 57 are left (56.4%), 44 are right (43.5%) As for the sexual difference the lunate sulcus is present more frequent in the female brain (17 among 24 hemispheres, 70.8%).3. The site of the lunate sulcus is on the same hight with the occipital pole (66.3%), when it deviates, it is more frequent lower (28.7 %) than higher (5.4%).4. The form of the lunate sulcus is almost half circle in 50.4%(type I-V), the others (type VI-XI) are more flat or bent down, the chord of the arc runs almost always from up and medial to down lateral.5. The greatest distance from the occipital pol to the lunate sulcus is 2.6-3.5cm long in total, it is longer (3.1-3.5cm) by the half circle form, shorter (2.6-3.0cm) by the flat form.6. The depth of the lunate sulcus is pretty deep, it's length is 3.1-5.0cm.7. The situations of the lunate sulcus is up and lateral to the outer part of the retrocalcarine sulcus, except this retrocalcarine the upper and lower occipital sulci are surrounded by the arc of the lunate. A part of the upper occipital may situate out of the arc, the lateral occipital comes always lateral and out of the lunate.8. The retrocalcarine sulcus is present in 135 among 180 hemispheres, its prolongation to the lateral side is observed in 88 among 135. The lunate sulcus comes in 61 among these 88, the remaining 40 hemispheres with the lunate are without retrocalcarine.9. As for the anastomosing sulcus with lunate the upper occipital is more frequent than the lower occipital. The number of the anastomose is one in 45.5% among lunate hemispheres. The site of the anastomose is at the middle part of the sulcus, less frequent at the lower end and scanty at the upper end.10. The lunate sulcus is almost always accompanied by the prelunate, , the number of the latter is one, less frequently two. Except this prelunate there are 2 or 3 collateral short accompanying sulci.11. The dimensions of the cuneus on the medial surface are inclined to be a little broader by the lunate specimens. The angles between the calcarine and parieto-occipital sulci oscilate between 70° and 89°. It seems that there is no correlative relation between this angle and lunate.12. By the lunate specimens are the intraparietal sulci not straight and run nearer to the mantle rim. At their caudal end the medial branch of the transverse occipital sulcus is longer than the lateral.13. When a circumscript elevation on the outer surface of the occipital lobe may be called as operculum, there are 126 examples among 180 hemispheres. In the 101 lunate specimens there are 55 distinct, 24 not so much distinct operculum, 79 in total.14. The sulci which limit the operculum at the upper margin are almost always the transverse occipital, at the lateral margin are the lunate, and when the latter deficient the lateral occipital.15. The lateral occipital sulcus is distinct in 168 among 180 hemispheres, and when the lunate is present it lies always medial to the lateral occipital and horizontal. The anastmosis with the lateral occipital comes to the temporalis medius frequently (62 among 180).16. The upper and lower occipital sulci are less marked by the lunate brains.

著者

李 鍾酷

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.26, no.11, pp.1173-1185, 1959-11-15 (Released:2010-10-14)

参考文献数

75

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Experiments have been done on the vital reactions in acute and chronic exposure to the lowered barometric pressure using rabbits and high altitude chamber, and new approaches were undertaken for the elucidation of the mechanism of altitude adaptation from the analyses of blood viscosity and plasma proteins using 8 female rabbits exposed to 18, 000 feet for nine weeks.Those findings in acute and chronic hypoxci hypoxia were sammarized in Table 21. Shortly speaking, in acute hypoxia the organism can reveal its homeostatic mechanism through only physical method (i.e. hyperpnea), and on the contrary, for biological or chemical adaptation, it takes considerable time.Hypoxic respiratory acidosis is different from normoxic respiratory acidosis in its reduced CO2-combining capacity.In chronic hypoxia, namely, acclimatization to 18, 000 feet for nine weeks, hemoglobin concentration, hematocrit, circulating blood volume, circu lating plasma volume, and cell volume increased 20, 23, 78, 36 and 116%, respectively. Plasma protein amount increased about 33 Albumin-globulin ratio was elevated, but serum γ-globulin decreased.In short, the vital responses in acclimatization to hypoxia is the increase of oxygen carrying capacity due to increased circulating hemoglobin. This increase was accomplished by the increase of erythrocytes. However, when hematocrit increa ses over 60%, blood viscosity becomes very high and consequently circulatory disturbances result. The organism prevents increase in hematocrit by increasing circulating blood volume to minimize such disturbances. In reality, the circulating hemoglobin amount increased to twice normal. In order to prevent high hematocrit, plasma volume also increased. To compensate for increased blood viscosity due to somewhat increased hematocrit, plasma viscosity was lowered by decreased plasma protein concentration and higher albumin-globulin ratio. Moreover, nutritional disturbances and the plasma colloid osmotic pressure functions were completely compensated by increased total circulating plasma protein amount and by relative increase of the albumin fraction.Reasonable and physiologic compensatory vital functions of the organism were shown in these phenomena exhibited by the acclimatized animals.

著者

Takuma Iwai Hiroshi Yoshida Tadashi Yokoyama Hiroshi Maruyama Seiji Suzuki Takeshi Matsutani Akira Matsushita Atsushi Hirakata Koji Sasajima Eiji Uchida

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.78, no.3, pp.189-193, 2011 (Released:2011-06-30)

参考文献数

17

被引用文献数

3 5 3

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We describe a patient in whom a fish bone penetrated the duodenum and migrated into the right renal vein. The bone was successfully removed with surgery. The 75-year-old man was admitted to Nippon Medical School Tama Nagayama Hospital because of right upper abdominal pain persisting for 7 days. The patient's medical history was not relevant to the current disorder. Plain radiography showed no abnormalities. Computed tomography revealed a linear object of high intensity that had penetrated the duodenum and migrated into the right renal vein with thrombus. The object was surrounded by a low-density area, suggesting severe inflammation. The patient had eaten fish 1 day before the onset of abdominal pain. We diagnosed duodenal penetration caused by an ingested fish bone. Endoscopic examination showed erosion, but no fish bone or ulceration was detected in the duodenum. The patient was treated conservatively with fasting, peripheral parental nutrition, and intravenous antibiotics. Three days after admission, non-contrast-enhanced computed tomography showed no movement of the foreign body. The patient continued to have pain, and the decision was made to surgically explore the abdomen. Intraoperative ultrasonography showed that the foreign body had migrated completely into the right renal vein with thrombus. Severe inflammation of the right renal vein was observed. Because we could not remove the foreign body without seriously injuring the right renal vein, right nephrectomy was performed. Macroscopic examination of the surgical specimen confirmed the presence of a fish bone with thrombus in the right renal vein. The patient was discharged 9 days after operation, with no complications.

著者

松倉 則夫

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.69, no.2, pp.200-204, 2002 (Released:2002-04-26)

参考文献数

22

被引用文献数

1 1

著者

澤 芳樹

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.5, no.1, pp.22-26, 2009 (Released:2009-04-15)

参考文献数

7