著者

鎌田 為夫 綿貫 恵太郎 海野 泉 円野 要 益子 保男 小川 一彦 吉田 一郎 池田 弘志 石田 文太 石沢 整 阿達 英次郎 本田 信義 鑓田 義男 中路 一 大森 暢久 戸塚 武彦 原田 誠一 長堀 篤二 永井 三生 那珂 治和 畔高 善行 船津 清 岩沢 貞 藤波 浩 奥村 和夫 伊藤 英雄 斉藤 正雄 岸田 隆 栗田 広 近藤 恒夫 本間 誠 藤沢 浩 入山 伸 桜井 啓介 岩城 保仁 赤木 勝雄 河瀬 澄男 小口 昌美 山田 記道 市川 靖夫 阿部 恒保 河西 正隆 梅津 光司 高井 英世 大田 豊穂 大矢 裕庸 斎藤 達雄 渋谷 嘉三 冨山 元次郎 村上 勝美 大藤 敏三 大河原 孫一他 山中 太郎 角谷 広男 大島 博 坪井 栄孝 黒河 内三郎 吉田 弘平 清野 友三郎 盤若 博司 佐藤 美好 松兼 雄三 右田 省之 作道 皓 渋谷 彰一 大屋 剛 加藤 正三 緒方 知三郎

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.26, no.1, pp.91-105, 1959-01-15 (Released:2010-10-14)

著者

酒井 義雄

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.33, no.5, pp.327-336, 1966-10-15 (Released:2010-10-14)

参考文献数

40

著者

永山 寛

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.12, no.3, pp.78-85, 2016-06-15 (Released:2016-07-13)

参考文献数

48

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Depression is found in about 40% of patients with Parkinson's disease (PD). The main characteristics of depression in PD is inability to experience pleasure, however, the symptoms such as severe anxiety, suicidal idea, daily fluctuation of mood, depression associated hallucination and delusion are relatively rare. In more than half of these patients, the cause of depression is closely linked the pathophysiology of PD itself. The feature of depression in PD is limited and is equivalent for the words of anhedonia/apathy, although the feature of "depression" is also occasionally found in PD. Indeed, recent studies suggested the features of depression, apathy (anhedonia) and dementia were independent in PD. As the mechanism of anhedonia/apathy in PD, the disturbance of acetylcholine and other monoamine system such as noradrenaline as well as dopaminergic system is indicated. The dopamine system that concerns with anhedonia/apathy is considered to be originated from ventral tegmental area in the midbrain project to nucleus accumbens, amygdala and mesolimbic system. Malfunction of these neurons cause the inactivation of emotion and motivation as the disruption of frontostriatal circuits, and this is related to the anhedonia/apathy in PD. Moreover, recent studies have shown that the dysfunction of amygdala and the disruption of its connectivity in the brain is suggested to the etiology of depression in PD. In the treatment of depression, at first, the sufficient medication for motor symptoms is needed, because depression in PD is linked the pathophysiology of PD. In the next step, anti-depressants are used. Some dopamine agonist such as pramipexole is also effective.

著者

藤田 繁実

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.39, no.2, pp.120-135, 1972-02-15 (Released:2010-12-22)

参考文献数

33

著者

小林 茂樹

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.8, no.2, pp.134-142, 2012 (Released:2012-05-30)

参考文献数

22

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Many drugs for glaucoma treatment have recently been developed, but prostaglandin (PG) analogs, which are PGF2α derivatives, are used most frequently. In particular, PG analogs with a stem name of "-prost" have become first-line therapies. When using PG analogs, it is important to understand their chemical structures and characteristics. These PG analogs are biologically active in carboxylate forms and are formulated as prodrugs by esterifying the terminal carboxyl to reduce side effects. The effect of PG analogs on glaucoma is determined by the degree of affinity to prostaglandin FP receptors. the structural formulae of PG analogs and our experimental results suggest that a 15-difluoro PG analog (tafluprost), which has a 13, 14 double bond, would have greater affinity for prostaglandin FP receptors and greater stability than 15-hydroxy PG analogs. Furthermore, 15-difluoro PG analogs containing a 13, 14 double bond were effective in clinical studies. Experimental results have shown that 15-difluoro PG analogs could help improve blood flow in the eye and might reduce the side effect of pigmentation. Tafluprost has been considered the best PG analog for first-line therapy, but a series of new glaucoma eye drops containing 2 active ingredients were launched in Japan in 2010. Each eye drop has advantages and disadvantages, and further studies are necessary to evaluate their clinical usefulness.

著者

斎藤 致司 前島 豊

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.26, no.11, pp.1270-1272, 1959-11-15 (Released:2010-10-14)

著者

戸田 茂樹 喜多村 孝幸 寺本 明

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.4, no.1, pp.36-40, 2008 (Released:2008-03-17)

参考文献数

3

被引用文献数

1 1

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We present a case of bilateral chronic subdural hematoma due to spontaneous intracranial hypotension. This patient complained of postural headache. Computed tomography of the brain showed bilateral chronic subdural hematomas, and radioisotope cisternography showed leakage of cerebrospinal fluid at the lumbar level. We placed an epidural blood patch at the lumbar level and a few days later performed irrigation of the bilateral hematomas. The patient recovered completely and was discharged.

著者

古川 治平

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.6, no.5, pp.557-579, 1935-05-15 (Released:2009-07-10)

参考文献数

20

著者

横山 和子

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.45, no.4, pp.223-228, 1978-08-15 (Released:2010-10-14)

参考文献数

15

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This review of clinical preanesthetic assessment of surgical patient was designed to help not only the anesthesiologist but also all medical colleagues.Today, many kinds of assessment technique for all organ are available, but often neglected. The present papar is a discussion of some of practical point which should be done as a preanestheticassessment of respiratory, cardiac, liver and kidney functions.Practical points of preanestheticevaluation are includ:(1) family history, past history and present history.(2) physical examination.(3) laboratory tests.Laboratory test should include:(1) blood: type, WR, WBC, RBC, Hb, Hct, Platlet, bleeding time, clotting time and HBantigen and antibody.(2) urine: urine volume/day, SG, protein and glucose.(3) blood chemistry: serum glucose, TP, A/G, BUN, Na, K, Cl, SGOT, SGPT, LDH, BSP, Al-P and CPK.(4) lung function test: VC, VT, FEV1 RR and blood gas if necessary.(5) chest X-ray.(6) ECG.It should be emphasized that a precise assessment of all organ function is not alway possiblebecause of the uncertainties of intra-anesthetic management as a result of unanticipated surgicalproblems that may adversely affect all organ functions.

著者

薩田 清明 真壁 明子 小川 真利子 黒川 顕 大塚 敏文

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.51, no.3, pp.385-389, 1984-06-15 (Released:2009-07-10)

参考文献数

10

著者

金子 勝治 桑原 利彦 磯部 茂 谷家 章五 源田 信博

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.35, no.2, pp.84-87, 1968-04-15 (Released:2010-10-14)

参考文献数

16

著者

内藤 善哉

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.5, no.3, pp.159-166, 2009 (Released:2009-07-15)

参考文献数

4

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The confocal laser scanning microscope (CLSM) is a device for obtaining high-resolution optical images of immunofluorescent staining. The CLSM can produce in-focus images of thick specimens, a process known as optical sectioning. The images are reconstructed with a computer, using 3-dimensional image software, allowing 3-dimensional reconstructions of topologically complex objects. On the same tissue sections, the CLSM can obtain the images of differential interference contrast. Recently, a special inverted CLSM-the multimode microscopy system-has been used to examine the morphology and functions of cells. A multimode microscopy system can be used to obtain images of CLSM, total internal reflection fluorescence, time-lapse, and micromanipulation. In the present study, we show images of pancreatic cancer cells as an example.

著者

揖斐 孝之 稲毛 道憲 浅川 光夫

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.1, no.4, pp.185-188, 2005 (Released:2005-11-09)

参考文献数

17

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Double inferior vena cava is a congenital venous anomaly that is found at about 1% to 3% of routine autopsies and has been described in numerous reports over the years. According to Adachi (1940), it has an incidence of 1.4±0.34%. More recently, diagnostic imaging has revealed that double inferior vena cava tends to be found in patients with hydronephrosis and various other conditions. During routine anatomical practice at Nippon Medical School in 2000, a case of double inferior vena cava was observed in a Japanese woman who had died of subarachnoid hemorrhage at 66 years of age. Bilateral inferior venae cavae, left renal vein, and transiliac vein were found through dissection. These findings are supplemented by a discussion of the literature with respect to embryological studies, morphological classifications, and disease correlations.

著者

工藤 翔二 慶長 直人

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.66, no.5, pp.336-339, 1999-10-15 (Released:2000-04-12)

参考文献数

12

被引用文献数

1

著者

平澤 博之

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.60, no.6, pp.406-410, 1993-12-15 (Released:2010-03-01)

参考文献数

12

著者

三輪 正人

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.11, no.4, pp.215, 2015-10-15 (Released:2015-11-26)

著者

洲鎌 秀永 柿沼 由彦

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.12, no.2, pp.42-43, 2016-04-15 (Released:2016-05-16)

参考文献数

3

著者

峯 克也 明樂 重夫 近藤 幸尋 竹下 俊行

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.6, no.3, pp.147-151, 2010 (Released:2010-06-28)

参考文献数

5

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A 33-year-old woman was referred to us by the department of urology because of cyclic bladder pain during menstruation. Cystoscopy showed a 3.5-cm-diameter tumor in the bladder mucosa, and a biopsy showed chronic cystitis. Transvaginal ultrasound and pelvic magnetic resonance imaging revealed a left endometrial ovarian cyst. Although a biopsy did not prove bladder endometriosis, we diagnosed bladder endometriosis on the basis of the characteristic clinical findings. Laparoscopic partial cystectomy for bladder endometriosis and left ovarian endometrial cyst resection were performed. The bladder was closed in one layer using Z sutures with #3-0 polyglactin 910. Indigo carmine dye was then used to check for any leakage. The procedure lasted 4 hours, and the estimated blood loss was 10mL. There were no technique problems or complications. The Foley catheter was removed after 7 days. The symptoms had resolved by 4 weeks after surgery, and the patient was released to routine follow-up. The patient had complete resolution of bladder symptoms and cyclic pelvic pain and was delighted with the absence of pain and the cosmetic result.

著者

丸野 広

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.34, no.3, pp.179-187, 1967-06-15 (Released:2010-10-14)

参考文献数

15

著者

山寺 博史 中村 秀一 鈴木 英朗 遠藤 俊吉

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.64, no.1, pp.53-56, 1997-02-15 (Released:2009-07-10)

参考文献数

10

被引用文献数

1 1

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We experienced a 49 years old female SAD patient who showed a good response the next day after alprazolam 1.2 mg administration. The back ground EEG of the patient showed a abnormal EEG with slow waves. The personality was colored with histerical features. The nadir of body core temperature from rectum slightly delayed in remission phase compared with depressive phase. The patient became hypomania and calmed down gradually. Alprazolam tratment is seemed to be available for SAD patients. (J Nippon Med Sch 1997; 64: 53-56)