著者

大野 曜吉

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.60, no.2, pp.89-94, 1993-04-15 (Released:2009-11-13)

参考文献数

12

被引用文献数

1 1

著者

林 春雄

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.8, no.7, pp.917-920, 1937-07-15 (Released:2009-07-10)

著者

菊地 伊豆実 田沼 弘之 川名 誠司

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.1, pp.6-13, 2013 (Released:2013-03-11)

参考文献数

70

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In hyperkeratotic type tinea pedis, a sufficient curative effect is generally not obtained with topical antimycotic agents alone, because the main symptom is plantar keratosis. Oral antifungal drugs, such as itraconazole and terbinafine, are useful for treating hyperkeratotic tinea pedis in patients who can orally ingest drugs. In patients who do not respond to oral antifungal agents, we recommend the combination of an oral antifungal agent (such as itraconazole or terbinafine) and a topical antifungal agent, although problems may be encountered in obtaining reimbursement under the Japanese health insurance system. If oral administration is impossible, various topical application methods, such as concurrent use of urea ointments and the use of occlusive dressing technique, can be tried. In any case, it is important to continue treatment without losing hope. Combination therapy with oral and topical antimycotics is considered the most effective treatment. I generalized including domestic and foreign reports, and I pointed out problems, mainly regarding the cure for disease in consideration of the pharmacokinetics in the stratum corneum. In the future, we hope to see the development of more oral and topical antifungal agents that have fewer systemic adverse effects (in particular, hepatic disorders), have interactions with other drugs, and are transferred to the skin at higher concentrations. Treatment regimens (including dosage and treatment period) for existing drugs will also have to be reviewed in multicentre clinical trials.

著者

岩城 弘子 大竹 稔 飯田 和美

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.49, no.3, pp.426-432, 1982-06-15 (Released:2010-10-14)

参考文献数

13

著者

越川 昭三

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.47, no.1, pp.114-117, 1980-02-15 (Released:2010-12-22)

参考文献数

4

著者

吉村 明修

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.8, no.1, pp.18-21, 2012 (Released:2012-03-08)

参考文献数

5

被引用文献数

1 1

著者

中村 有希 四倉 寛子 加藤 雅彦 中田 淳 田中 啓治 林 宏光

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.3, no.1, pp.25-29, 2007 (Released:2007-03-23)

参考文献数

16

被引用文献数

1

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Adult autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder responsible for 8% to 10% of cases of end-stage chronic renal failure. The extrarenal complications of ADPKD kidney include cardiovascular disorders (such as mitral valve prolapse syndrome, bicuspid aortic valve, aortic coarctation, aortic aneurysm, and aortic dissection), intracranial aneurysms, diverticulum of colon, hepatic cysts, inguinal hernia, and urinary calculus. Acute aortic dissection (AAD) associated with ADPKD is life-threatening. There are few reports of ADPKD with AAD. To the best of our knowledge, only 9 cases have been found, including at autopsy, in Japan. We have treated 121 patients with AAD in the last 5 years, and 3 of these 121 patients also had ADPKD in the intensive care unit of Nippon Medical School. We report clinical features of cases of ADPKD with AAD on the basis of 12 cases, including 9 previously reported cases and our 3 cases. AAD requires urgent antihypertensive therapy, which often aggravates renal function. Priority should be given to antihypertensive therapy in emergent cases. In fact, 2 of our patients required hemodialysis owing to antihypertensive therapy for AAD. Close cooperation between cardiologists and nephrologists is essential.

著者

毛塚 淳子

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.18, no.3, pp.230-242, 2022-08-25 (Released:2022-08-27)

参考文献数

11

著者

黒澤 尚

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.61, no.1, pp.2-8, 1994-02-15 (Released:2009-07-10)

参考文献数

10

著者

阿部 正直

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.22, no.3, pp.240-242, 1955-03-15 (Released:2010-10-14)

著者

中村 哲子

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.8, no.1, pp.22-25, 2012 (Released:2012-03-08)

参考文献数

14

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Trauma studies, as consolidated in the 1990s from a trans-disciplinary perspective, have come to attach fresh significance to narrative production by trauma sufferers. William Trevor's The Story of Lucy Gault, a novel featuring a girl injured during the Irish War of Independence, describes the difficulties trauma sufferers have to face in constructing their own narrative for recovery and apprises the reader of their long suffering from a medical point of view.

著者

高橋 省一 国府田 幸夫

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.28, no.1, pp.263-265, 1961-01-15 (Released:2010-10-14)

参考文献数

2

著者

菅野 淳平

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.12, no.2, pp.61-63, 2016-04-15 (Released:2016-05-16)

参考文献数

2

著者

志村 俊郎 寺本 明 吉田 大蔵 足立 好司

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.68, no.1, pp.74-77, 2001 (Released:2001-11-30)

参考文献数

5

被引用文献数

1 1

著者

小原 洋右

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.38, no.5, pp.216-224, 1971 (Released:2010-10-14)

参考文献数

16

著者

松元 秀次

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.15, no.4, pp.201-209, 2019-10-15 (Released:2019-12-03)

参考文献数

18

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Stroke is clinically characterized by hemiplegia and exercise intolerance, both of which not only interfere with the ability to perform activities of daily living (ADL), but also significantly reduce quality-of-life (QOL). Neurological and functional recovery occurs mainly within the first 6 weeks after onset of stroke, but the process continues for several months, with maximal functional recovery usually achieved within 6 months. In Japan, convalescent rehabilitation wards play an important role in the rehabilitation of post-stroke patients who have impaired ADL and health status after the acute phase. Various physiotherapies have been developed to improve functional recovery in patients with hemiplegia due to stroke, including the facilitation technique with proprioceptive neuromuscular facilitation, and constraint-induced movement therapy. A novel facilitation technique is repetitive facilitative exercises (RFE), which promote the functional recovery of the hemiplegic limbs to a greater extent than conventional rehabilitation sessions.Functional electrical stimulation (FES) is a technique used to produce contractions in paralyzed muscles by the application of small pulses of electrical stimulation to the nerves that supply the paralyzed muscle. FES is used as an orthosis to assist walking, and also as a means of practicing functional movements for therapeutic benefit. New training technologies involving the use of robots have recently been developed to help in the rehabilitation of post-stroke patients.Robot-assisted rehabilitation therapy provides functional training of the upper and lower limbs in an effective, easy and comfortable manner. Furthermore, the robot-assisted training paradigm offers intensive, repetitive, sufficient, and accurate kinematic feedback along with symmetrical practice while reducing the workload for the therapist, thus reducing the cost of post-stroke rehabilitation. Exoskeleton-type robotic devices have robot axes aligned with the anatomical axes of the wearer. These robots provide direct control over individual joints, which can minimize abnormal posture or movement. Robot-assisted gait training is effective in the long term in improving balance and walking ability, and it has a positive impact on patients' QOL. Several well-designed studies have provided evidence that robot-assisted training promotes motor recovery and functional improvement in post-stroke patients. However, the evidence is insufficient to draw conclusions about the effectiveness because of small samples sizes, methodological flaws, and heterogeneous training procedures. More well-designed randomized controlled trials are needed.

著者

亀山 元帥

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.63, no.2, pp.127-139, 1996-04-15 (Released:2010-03-01)

参考文献数

45

被引用文献数

1 1

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Locus control region (LCR) is known to occur 5′-upstream of the globin gene clusters in humans and a number of other animals. It comprises four DNase I hypersensitive sites, HS 1-4, and has been considered to play a key role in regulating the globin gene expression in tissue- and developmental stage-specific manners. The occurrence of LCR in the rat genome, however, has not been documented so far. In the present study, the author intended to identify and analyze the rat β-LCR HS 1 and HS 2, in order to further facilitate studies on the regulatory mechanism involved in globin gene expression. The results obtained in this study are summerized as follows:1. A DNA region of about 700 bp on the rat genome was amplified by polymerase chain reaction (PCR) using synthetic primers derived from portions of the mouse β-LCR HS 2. The nucleotide sequence of the PCR product (R 700) shows 67% and 83% homologies with those of the human and mouse HS 2, respectively, indicating that R 700 represents β-LCR HS 2 of rats.2. In order to locate β-LCR HS 2 on the rat genome, a 7 kb DNA fragment (R 7, 000) harboring a region between β-LCR HS 2 and the ε 1-globin gene was obtained by PCR. Restriction endonuclease mapping of R 7, 000 revealed that the rat β-LCR HS 2 is located 6.0kb 5′-upstream relative to the cap site of the ε 1-globin gene.3. The rat β-LCR HS 1 was then located 4.2 kb 5′-upstream of the ε 1-globin gene by Southern blot hybridization of R 7, 000 using a human HS 1 probe. Nucleotide sequencing revealed that the rat HS 1 has 83% homology to the mouse HS 1.4. Comparisons of the structures of the rat β-LCR HS 1 and HS 2 with those of other animal species indicate that several motifs and consensus sequences for binding of transcription factors, such as NF-E 2/AP-1 and GATA-1, are well conserved during evolutional periods, indicating an indispensable role of LCR in globin gene expression

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.6, no.4, pp.204-206, 2010 (Released:2012-10-12)

著者

秋元 勇治

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.36, no.1, pp.1-19, 1969-02-15 (Released:2010-12-22)

参考文献数

43

被引用文献数

2

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1) The “waxing and waning”(w-w) was studied on 479 normal healthy subjects and 2, 264 patients with mis-cellaneous neuro-psychiatric disorders. All the subjects were over 16 years of age.2) The w-w has been considered as the rhythmicity of normal cerebral activity, but this is uncertain. The auth-or attempts to examine it's properties in this report. The characteristics of the w-w represented at least 40μV of it's maximum amplitude, ca. 1-2 sec. of it's duration, and two or three times difference between maximum and minimum amplitude, and the w-w is mo-re clear and typical by biporal than monoporal recording.3) The w-w can be seen more clearly and typically at the stage of drowsiness or relaxation, and it is more pro-minent in hyperventilation than in bemegride or pentetrazol provocation.4) There is no specificity of age. The w-w was observed in 11.3% of normalhealthy subjects.5) The w-w was markedly observed in the subjects with miscellaneous autonomic disturbances, migraine, arter-iosclerosis, neurotic states and brain damage or posttraumatic complaints.But with statistical procedures, es-pecially, it had much more dominance in the subjects with migraine, miscellaneous autonomic disturbances and posttraumatic complaints at the level of X2<0.01.6) In almost all the cases with posttraumatic complaints, the w-w may decrease or diminish during continuous observation, but in other cases (ex. neurotics, with miscellaneous autonomic disturbances) it may be contin-uous at all times whether symptoms are remaining or not.7) There were no significant changes of the w-w produced by any medications.8) Therefore the w-w is not an abnormal sign, but the “significant sign”, indicating the relationship between the “certain cerebral function” and some clinical conditions.

著者

金田 誠

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.18, no.1, pp.113, 2022-02-20 (Released:2022-03-15)