2 0 0 0 OA 官報
- 著者
- 大蔵省印刷局 [編]
- 出版者
- 日本マイクロ写真
- 巻号頁・発行日
- vol.1885年08月24日, 1885-08-24
2 0 0 0 IR 福沢諭吉の中津像 : 『 福翁自伝』の記述に込められた"意図"
- 著者
- 堀 和孝
- 出版者
- 慶應義塾福沢研究センター
- 雑誌
- 近代日本研究 (ISSN:09114181)
- 巻号頁・発行日
- no.31, pp.203-221, 2014
研究ノートはじめに一 島津祐太郎宛書簡と「中津留別の書」二 中津市学校への支援と耶馬渓競秀峰の景観保全おわりに
2 0 0 0 スポ-ツ指導と根性論<特集>
- 出版者
- 杏林書院
- 雑誌
- 体育の科学 (ISSN:00398985)
- 巻号頁・発行日
- vol.34, no.2, pp.p82-106, 1984-02
- 著者
- Daishu Miura Kimiyasu Yoneyama Yoshiaki Furuhata Kazuo Shimizu
- 出版者
- 日本医科大学医学会
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.81, no.4, pp.211-220, 2014 (Released:2014-09-03)
- 参考文献数
- 26
- 被引用文献数
- 5 18
Introduction: An important mechanism by which trastuzumab inhibits the growth of human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells is the activation of a host tumor response via antibody-dependent cell-mediated cytotoxicity (ADCC). Although paclitaxel has a synergistic effect in combination with trastuzumab, whether ADCC is enhanced by paclitaxel is not known. In the present study we examined whether adding paclitaxel to trastuzumab enhances ADCC and also investigated the kinetics of effector cells in ADCC. Materials and Methods: The subjects were 20 patients with HER2-positive breast cancer: 9 received the combination of trastuzumab (4 mg/kg as a loading dose and 2 mg/kg weekly) and paclitaxel (80 mg/m2 weekly) and 19 received monotherapy with trastuzumab. In blood samples (mononuclear cells) obtained before and 10 minutes after administration of chemotherapy, ADCC and the number of effector cells, including natural killer (NK) cells, monocytes, and CD64+ cells, were compared in each case. The ADCC was analyzed with a 51Cr releasing assay using the SK-BR-3 cell line, and the fractions of NK cells (both CD16+ [FcγRIII] and CD56+) and CD64+ (FcγRI) cells were analyzed with flow cytometry. Results: The mean ADCC level increased 20% after trastuzumab monotherapy and 126% (p<0.05) after combination therapy with trastuzumab and paclitaxel. All 9 patients receiving combination therapy had increased ADCC levels. The number of NK cells increased 51% after trastuzumab monotherapy and 112% (p<0.05) after combination therapy. No significant changes were found in monocytes (39% increase) or CD64+ cells (53% increase) after trastuzumab monotherapy, but monocytes decreased 40% (p<0.05) and CD64+ cells decreased 24% after combination therapy. Conclusions: Adding paclitaxel to trastuzumab significantly enhances ADCC, with levels twice as great as with trastuzumab monotherapy, through a rapid recruitment of NK cells. This finding suggests that the combination of trastuzumab and paclitaxel has a stronger-than-expected synergistic effect in HER2-positive breast cancer.
2 0 0 0 IR 原典研究 フサイン・ムルーワ著『アラブ・イスラーム哲学における唯物論的諸傾向』
- 著者
- 栗田 禎子
- 出版者
- 早稲田大学イスラーム地域研究機構
- 雑誌
- イスラーム地域研究ジャーナル (ISSN:1883597X)
- 巻号頁・発行日
- vol.5, pp.137-142, 2013
2 0 0 0 イスラム黎明期の詩について
- 著者
- ターハー・フサイン [著] 高井清仁訳
- 出版者
- ごとう書房
- 巻号頁・発行日
- 1993
2 0 0 0 OA 面白く出来る化学の実験
2 0 0 0 OA 一立斎広重一世一代江戸百景
2 0 0 0 OA 国際ネットワーク新出史料によるドイツ兵俘虜のスポーツ活動の全体構造の解明
本研究は、中国の山東半島・青島(チンタオ)における敗戦の結果、第一次世界大戦中に日本に抑留されていたドイツ兵捕虜のスポーツ・レクリエーション活動の全体構造を明らかにしようとした。インターネット時代に相応した迅速かつ確実な史料収集と、それではできない現地調査の両面から研究を推進した。主たる新たな知見は、以下の4点である。(1)ドイツ兵捕虜のスポーツ活動の素地は、青島(チンタオ)時代にすでにあった。(2)ドイツ兵捕虜の日本到着直後、スポーツ施設が不十分だった時期においては、スポーツに代わる体力づくりや「格闘遊戯」が、運動不足解消のために工夫されていた。(2)ドイツ兵捕虜の学校(主として中学校、師範学校)・地域とのスポーツ交流には、俘虜収容所見学やスポーツ行事の際だけでなく、実際に、学校で体操を示範したり、地域のチームとサッカーの試合をしたりもあった。(3)戦争の長期化が確定的になってからの各俘虜収容所における「スポーツ管理の軟化」から見ると、板東俘虜収容所だけが際立った優遇であったかどうかは疑問である。
- 著者
- Myrtille Méricam-Bourdet
- 出版者
- Voltaire Foundation
- 巻号頁・発行日
- 2012
2 0 0 0 OA 日本郵船株式会社創立満三十年記念帖
- 著者
- 日本郵船株式会社 編
- 出版者
- 日本郵船
- 巻号頁・発行日
- 1915
2 0 0 0 Handbook of information for passengers and shippers by the steamers of the Nippon Yusen Kaisha
- 出版者
- Nippon Yusen
- 巻号頁・発行日
- vol.1920, 1894
- 著者
- 丸山(山本) 愛子
- 出版者
- 広島大学大学院教育学研究科
- 雑誌
- 広島大学大学院教育学研究科紀要 第一部 学習開発関連領域 (ISSN:13465546)
- 巻号頁・発行日
- no.58, pp.73-80, 2009
This research investigated developmental changes in self-regulation, which is divided into two categories: self-assertion and self-inhibition, in comparison of four periods i.e., infancy, childhood, adolescence and youth. Japanese university students (N=132), 21 years old, evaluated their self-assertive behavior and self-inhibitive behavior in each of the periods. The results were as follows: (1) The scores of self-evaluation of self-inhibition gradually increases from infancy to youth. (2) As to self-evaluation of self-assertion, the score in childhood is the highest and that in adolescence is the lowest. (3) Each score of all four periods shows significant correlations with its closest periods. (4) As to the scores of self-evaluation of either self-assertion or self-inhibition, there is no significant relation between the period of infancy and that of youth.
2 0 0 0 人工臓器は、いま : 暮らしのなかにある最先端医療の姿
2 0 0 0 OA 各種リドカインテープ製剤の粘着特性,薬物放出性及び皮膚透過性に及ぼす粘着基剤の影響
- 著者
- 杉野 雅浩 三上 充宏 石原 智樹 細谷 治 從二 和彦
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.135, no.8, pp.977-985, 2015 (Released:2015-08-01)
- 参考文献数
- 23
- 被引用文献数
- 2
A generic drug is defined as a drug product that is comparable to a brand name drug in terms of dosage, form, strength, route of administration, quality, performance characteristics, and indicated use. Generic drugs for topical use, in the case of sheet-like products, are required to be the same as the original drug in terms of application area and dosage form. The composition of such generic drug formulations may differ from that of the original product. The adhesive of any pharmaceutically-active tape that directly contacts the skin plays a role in delivering the active ingredient into the skin, and affects the sensation and ease of handling. Therefore, adhesives are an important ingredient in these products. Thus, the aim of this study was to characterize original and generic lidocaine tape products, and to evaluate the adhesive properties of each. The tack force, peel strength and shear adhesion were measured as adhesive properties. In addition, in vitro drug releasing profiles and skin permeation profiles of the products were evaluated. In vivo transdermal absorption was also evaluated to predict the possibility of adverse effects. Adhesive properties differed among the three analyzed products. These differences may have been caused by differences in the adhesives. Drug-releasing profiles and skin permeation profiles also differed among the three products, even though the pharmacokinetics were not significantly different. By obtaining an adequate understanding of the characteristics of original and generic products, we will be able to provide better tailor-made medications for drug therapies for patients.
2 0 0 0 OA メディチ家の彫玉コレクション
- 著者
- 松本典昭(訳)/マリアリータ・カザローザ・グァダーニ(原著) まつもとのりあき
- 雑誌
- 阪南論集. 人文・自然科学編
- 巻号頁・発行日
- vol.44, no.2, pp.73-91, 2009-03
- 著者
- Syed Ghulam Sarwar Shah Alexandra Farrow
- 出版者
- (公社)日本産業衛生学会
- 雑誌
- Journal of Occupational Health (ISSN:13419145)
- 巻号頁・発行日
- vol.56, no.5, pp.323-331, 2014 (Released:2014-11-22)
- 参考文献数
- 41
- 被引用文献数
- 14
Objectives: To review empirical research on adverse health and pregnancy outcomes associated with physiotherapists' occupational exposure to radiofrequency electromagnetic fields (RF EMFs) from shortwave (SWD) and microwave (MWD) diathermy devices. Methods: A systematic review of peer reviewed literature published from 1990 to 2010 in the English language searched in eight online bibliographic databases: CINAHL, EBSCOhost, ISI Web of Knowledge, Medline, OSH UPDATE, PubMed Central, ScienceDirect, and Scopus. Results: Findings suggest that physiotherapists' occupational exposure to SWD was statistically significantly associated with delayed time to pregnancy (>6 months), still birth, altered gender ratio (low ratio of boys to girls), congenital malformations and low birth weight (<2,500 g) among physiotherapists' offspring. Physiotherapists' exposure to MWD was also found to be statistically significantly associated with spontaneous abortion. However, causal mechanisms for these statistical associations are unknown. The present systematic review has found these adverse reproductive outcomes and health effects associations with RF EMFs from therapeutic diathermy devices to be inconsistent. Conclusions: A number of studies did not find statistically significant results to replicate associations with such adverse outcomes, and therefore further research, preferably prospective studies of cohorts of physiotherapists, is warranted.(J Occup Health 2014; 56: 323-331)