著者
金井 将昭 中村 敏一 船越 洋
出版者
日本ペット栄養学会
雑誌
ペット栄養学会誌 (ISSN:13443763)
巻号頁・発行日
vol.14, pp.Suppl_69-Suppl_70, 2011

21世紀に入り、ヒトの情動障害や伴侶動物の行動異常は、社会活動に影響を与える疾患として益々重要性を増している。古くから、トリプトファン (Trp) 代謝が情動に影響することが知られているが、その分子機序の詳細は不明である。私達はTrp代謝からみた精神神経機能の解析を行うため、Trp代謝の中心酵素であるTryptophan 2,3-dioxygenase (TDO) の遺伝子欠損マウスを作製し、Trp代謝ならびに情動行動におけるTDOの役割を解析した。その結果、TDOは全身ならびに脳内Trp代謝の中心酵素として働き、不安行動ならびに海馬等の神経新生を修飾する生理的な調節因子であることが明らかになった。
著者
中村 隆之
出版者
The Japanese Society for the History of Economic Thought
雑誌
経済学史学会年報 (ISSN:04534786)
巻号頁・発行日
vol.41, no.41, pp.58-70, 2002 (Released:2010-08-05)
参考文献数
45

Harrod's Dynamics represented a methodological revolution because his trade cycle theory not only connects multiplier and relation (acceleration) with each other, but also rejects the explanation of trade cycle by sequence of temporary equilibrium. Harrod showed the originality of his dynamics as the difference between lag theory of Samuelson, Hicks, Tinbergen etc. and antinomy theory of his own. But few number of economist understood the essence of his antinomy theory.Baumol, Alexander and many others regarded Harrod's theory as imperfect because his fundamental equation is merely identical equation, therefore it does not determine the behavior of the next moment. They thought the behavioral equation must be added in order to complete Harrod's model.Shackle insisted Harrod's ‘one point in time’ approach excluded the essential uncertainty in decision-making. Okishio insisted that difference-differential equation is essential for the completion of Harrod's instability principle. Although Besomi, scholar of Harrod's economics, introduces the Harrod's methodology, he also regards the fundamental equation in Harrod's Essay as missing the consideration of expectations.All critics above did not understand that his dynamics represents a direction of the movement at the very moment in time and need not have a behavioral equation. Harrod thought the moment analysis is more important than locus in the time sequence. But they held that the opposite of his intention was true.Despite these critiques I insist that Harrod's antinomy theory is valid and his methodology is very useful. For my conclusion I criticize Okishio model, which is representative interpretation of Harrod's instability principle so far. The model has two behavioral equations for product-decision and investment-decision.Harrod's fundamental equation expresses the antinomy of economic structure, which always exists, by the form of identical equation. Identical equation is objective, valid for qualitative analysis. His objective approach is similar to Keynes's approach which uses the fundamental equation in A Treatise on Money and the instantaneous multiplier in General Theory.Harrod's antinomy theory has been lost because the objective approach to dynamics was not understood. It is to emphasize that the ultimate cause of misunderstandings is a strong leaning toward the micro foundation of modern economics. We incline to start with individually subjective decision-making, not objective structure.