著者
永井 勝次
出版者
一般社団法人 日本感染症学会
雑誌
感染症学雑誌 (ISSN:03875911)
巻号頁・発行日
vol.47, no.4, pp.111-115, 1973-04-20 (Released:2011-09-07)
参考文献数
5
被引用文献数
1 2

It has been popularly circulating in half legendary way among laymen that those who habitually eat garlic would rarely catch cold in winter time. The authors took it up rather seriously and undertook experiments to see the effects of garlic extracts against infections with influenza and Japanese encephalitis viruses in mice.Viruses used were influenza virus AO/PR 8 strain, Japanese encephalitis virus Nakayama strain and JaGAr Ol strain. Mice used in the case of influenza were ddYS strain weighed 15g, in Japanese encephalitis, the same strain weighed 8-10g regardless the sex. Garlic extracts were prepared by alcohol extraction using low percent alcohol. The extracts were administrated per os to the mice. Further, to see the effects of the combination of garlic extracts and vitamines and liver extracts, we prepared the following solutions as: Solution A-garlic extracts without any additives; Solution B-garlic extracts plus VB1; Solution C-garlic extracts plus VB12; Solution D-garlic extracts plus VB1 and VB12; Solution E-garlic extracts plus VB1, VB12 and liver extracts. Infections of influenza and Japanese encephalitis were made by pernasal and intracerebral inoculations, respectively. The inoculated mice were observed for three weeks. LD50 was measured by Reed and Muench method. Influenza infected mice were all autopsied and the consolidation of the lungs was comparatively observed.The results were summarized as follows:1. In group in which daily administrations of the solutions were begun 15 days previous to pernasal influenza virus inoculations, the effects were significant. In our data, solution A and E were best. In group in which the solutions were begun being given at the same time to the virus inoculations, the effects were hardly appreciable.2. In Japanese virus inoculated cases, the results were against our expectation. Any solution given even 15 days previously to the inoculations displayed no effect at all.
著者
永井 勝也
出版者
香川生物学会
雑誌
香川生物 = Bulletin of the Biological Society of Kagawa (ISSN:02876531)
巻号頁・発行日
no.1, pp.10-13, 1953-12-01

水耕法により培養したソラマメの根を2・4-Dで処理し, その影響を調べたのである. 植物生長素としての2・4-Dはこの実験範囲内では0.00001%より高濃度では生長抑制方向に働き, 0.00001%より低濃度では促進作用して働く, そして2.4-Dが高濃度の場合には根端細胞に傷害を起さすと共に茎の基部に異常裂開を起さして枯死に至らしめる. 0.00001%程度では根端の柔組織細胞に異常分裂さし肥大現象を起さす為, 根の作用が減退し生長が抑制されるのである. そして2・4-Dの作用が減退すると又正常な生長を続けるのである. 然しながらこの実験を今一度同一条件下で検定する必要があり, 他の?科植物についても実験を行わねばならないであろう. この実験は野口先生の御指導の下に行つた深く感謝の意を表する. なお有益な御助言を賜つた小野, 矢崎両先生に衷心より謝意を申し上げる。
著者
舘野 純子 宇賀田 裕介 永井 勝信 瀧谷 春奈 稲葉 沙央莉 猿子 美知 赤池 幸恵 坂 英里子 宮村 大治郎 門手 和義 明石 直之
出版者
社団法人 日本理学療法士協会関東甲信越ブロック協議会
雑誌
関東甲信越ブロック理学療法士学会 (ISSN:09169946)
巻号頁・発行日
vol.36, pp.182, 2017

<p>【目的】</p><p>心室性不整脈が頻発する症例に対する運動療法の効果について検討する.【症例提示】</p><p>72 歳,男性.X 年,健診にて心室性期外収縮(PVC)頻発を指摘されていた.X+1 年PVC に対してアブレーション施行するも心外膜側由来のPVC のため焼灼困難と判断し経過観察となっていた.X+3 年7 月22 日,急性心筋梗塞を発症し当院救急搬送.右冠動脈房室枝(#4AV)と後下行枝(#4PD)に完全閉塞を認め,潅流領域の広い#4PD に対して冠動脈インターベンションを施行した.#4AV は潅流領域が狭く,薬物療法継続の方針となった.退院時(7 月26 日)の心機能はEF61%,下壁の壁運動が低下しており,ホルター心電図では総拍数が88463 拍,PVC は総拍数の31%に出現,最大は3 連発であった.</p><p>【運動処方】</p><p>10 月6 日心肺運動負荷試験(CPX)施行.10 月12 日から5 ヵ月間,外来監視型心臓リハビリテーションを施行した.通院頻度は週1-2 回,運動の種類はレジスタンストレーニングと有酸素運動,運動強度は自覚的運動強度とCPX の結果に基づいて処方した。運動療法中は2 段脈が頻発,PVC ショートランの出現歴があり,自覚症状や血圧を管理しつつ介入した.</p><p>【結果】</p><p>開始時と5 ヶ月後のCPX では,PeakVO<sub>2</sub>16.1 →21.4kg/ml/min,MaxLoad84 →113W と改善を認めた.また,膝伸展筋力は体重比0.52 →0.60 と改善を認めた.さらに,週5 回程度の運動習慣がつき,非監視型運動療法への移行が可能となった.【考察】</p><p>心室性不整脈を有する患者に対する運動療法は,一定の見解が得られていない.今回,運動耐容能改善が得られた因子として,骨格筋の強化が図れたことが一要因であると考える.したがって,適切な運動処方や運動指導により,心室性不整脈を有する患者に対する運動療法は運動耐容能改善に効果的であり,非監視型運動療法への移行も可能であると考えられた.なお,本症例報告はヘルシンキ宣言に沿い対象者に同意を得たものである.</p>
著者
寺下 隆夫 永井 勝 坂井 拓夫
出版者
近畿大学農学部
雑誌
近畿大学農学部紀要 = Memoirs of the Faculty of Agriculture of Kinki University (ISSN:04538889)
巻号頁・発行日
no.34, pp.95-105, 2001-01-01

[Author Abstract]The ectomycorrhizal fungi Tricholoma matsutake and Lyophyllum shimeji are famous and delicious edible mushrooms from Japan. Since they form mycorrhiza on the fine roots of living plants, their growth depends facultatively on living plants. To cultivate these fungi for in a pure culture, glucose and a few other monosaccharides must be used as carbon sources. In 1994,it was reported that L.shimeji can form mature fruit-bodies on a medium that consists mainly of barley grains ; in addition, they form without a host plant. These observations indicate that some mycorrhizal mushroom fungi have the ability to utilize barley starch. When fungi form fruit-bodies, large amounts of mycelia may be needed either to store nutrients or to transport nutrients to the fruit-bodies, or for both purposes. However, it is very difficult to cultivate large amounts of mycelia using monosaccharides in a pure culture. The addition of low molecular weight substances in high concentrations increases the osmotic pressures of a medium, which in this case would suppress the growth of the mycelium. Then, amylase productions during the vegetative mycelial growth of T.matsutake (No.114 and Z-1 strain), which hydrolize starch as a substrate for the growth of the fungi were examined using a somewhat modified matsutake liquid medium. Amylase activity (α-and gluco-amylase) in the culture filtrates had relatively high values at 40 days after the inoculation. Maximum activity was attained 80 days after inoculation. α-Amylase showed more activity than glucoamylase in both strains. Amylase activity in the culture filtrate of T.matsutake was assayed by using several kinds of starch as the substrate ; the starches were purified from barley (5 kinds), corn, sweet potato, and potato. The enzyme was most active in the presence of the starch prepared from the "Amagi" and "Ichibanboshi" strains in the "Nonwaxy" barley group among the starches. This activity was were observed at a circa 2.0-fold higher value than that of the control (potato). The addition of potato and yam to the culture medium increased the dry weight of mycelia 4.8-5.6 times, as compared to the control (without addition) ; moreover, the value of amylase activity was 1.9-2.6 times that of the control. A positive correlation between vegetative mycelial growth and amylase activity was detected. To elucidate the properties of extracellular amylases in the T.matsutake Z-1 strain, the amylase fractions obtained from the DEAE-Toyopearl column chromatography were identified. One type of α-amylase, glucoamylases and α-glucosidases showed activity upon analysis by thin layer chromatography using hydrolyzates.[JST抄録]菌根形成食用担子菌,ホンシメジ(Lyophyllum shimeji)およびマツタケ(Tricholoma matsutake)の子実体形成研究についてレビューした。最初に,菌根形成きのこ類の人工栽培が難しい理由の一端を説明した。次に,ホンシメジが人工栽培化に至った過程,また,マツタケの人工的な子実体形成研究の現状について,これらの菌根菌類の生育生理の面から成育基質として重要な澱粉の利用性に注目して,アミラーゼなどの生成酵素との関連で述べた。マツタケ「シロ」中にどの程度の澱粉が含まれ,マツタケ菌がアミラーゼを生成してその澱粉をどの程度利用しているかなど今後解明すべき点は多い。
著者
島田 達朗 永井 勝一郎
出版者
日経BP社
雑誌
日経systems (ISSN:18811620)
巻号頁・発行日
no.307, pp.48-55, 2018-11

Dockerに代表されるコンテナ技術に注目が集まっている。従来の仮想マシンに比べて、起動が速い、仮想化環境の再現性が高いなどのメリットがある。ママ向けサービス「ママリ」を運営するコネヒトは3ステップを踏み、既存システムをDockerに手堅く移行した。一連の作業の勘所を解説してもらう。
著者
木方 正 永井 勝幸 宮本 郁夫 渡辺 利明 鵜飼 茂夫
出版者
公益社団法人日本薬学会
雑誌
藥學雜誌 (ISSN:00316903)
巻号頁・発行日
vol.110, no.4, pp.286-288, 1990-04-25
被引用文献数
4

Biological activities of two galactomannans (CI-P and CI-A) isolated from the insectbody portion of Chan hua (fungus : Cordyceps cicadae) were studied. CI-P having low affinity for concanavalin A (Con A) exhibited potent carbon-clearance activity in mouse, although both polysaccharides had little antitumor activity against sarcoma 180 in mice. Furthermore, CI-P and CI-A was found to have potent hypoglycemic activity in normal mice, and CI-A having high affinity for Con A showed slightly higher activity than CI-P.
著者
寺下 隆夫 永井 勝 坂井 拓夫
出版者
近畿大学
雑誌
近畿大学農学部紀要 (ISSN:04538889)
巻号頁・発行日
vol.34, pp.95-105, 2001-03-31

[Author Abstract]The ectomycorrhizal fungi Tricholoma matsutake and Lyophyllum shimeji are famous and delicious edible mushrooms from Japan. Since they form mycorrhiza on the fine roots of living plants, their growth depends facultatively on living plants. To cultivate these fungi for in a pure culture, glucose and a few other monosaccharides must be used as carbon sources. In 1994,it was reported that L.shimeji can form mature fruit-bodies on a medium that consists mainly of barley grains ; in addition, they form without a host plant. These observations indicate that some mycorrhizal mushroom fungi have the ability to utilize barley starch. When fungi form fruit-bodies, large amounts of mycelia may be needed either to store nutrients or to transport nutrients to the fruit-bodies, or for both purposes. However, it is very difficult to cultivate large amounts of mycelia using monosaccharides in a pure culture. The addition of low molecular weight substances in high concentrations increases the osmotic pressures of a medium, which in this case would suppress the growth of the mycelium. Then, amylase productions during the vegetative mycelial growth of T.matsutake (No.114 and Z-1 strain), which hydrolize starch as a substrate for the growth of the fungi were examined using a somewhat modified matsutake liquid medium. Amylase activity (α-and gluco-amylase) in the culture filtrates had relatively high values at 40 days after the inoculation. Maximum activity was attained 80 days after inoculation. α-Amylase showed more activity than glucoamylase in both strains. Amylase activity in the culture filtrate of T.matsutake was assayed by using several kinds of starch as the substrate ; the starches were purified from barley (5 kinds), corn, sweet potato, and potato. The enzyme was most active in the presence of the starch prepared from the "Amagi" and "Ichibanboshi" strains in the "Nonwaxy" barley group among the starches. This activity was were observed at a circa 2.0-fold higher value than that of the control (potato). The addition of potato and yam to the culture medium increased the dry weight of mycelia 4.8-5.6 times, as compared to the control (without addition) ; moreover, the value of amylase activity was 1.9-2.6 times that of the control. A positive correlation between vegetative mycelial growth and amylase activity was detected. To elucidate the properties of extracellular amylases in the T.matsutake Z-1 strain, the amylase fractions obtained from the DEAE-Toyopearl column chromatography were identified. One type of α-amylase, glucoamylases and α-glucosidases showed activity upon analysis by thin layer chromatography using hydrolyzates.[JST抄録]菌根形成食用担子菌,ホンシメジ(Lyophyllum shimeji)およびマツタケ(Tricholoma matsutake)の子実体形成研究についてレビューした。最初に,菌根形成きのこ類の人工栽培が難しい理由の一端を説明した。次に,ホンシメジが人工栽培化に至った過程,また,マツタケの人工的な子実体形成研究の現状について,これらの菌根菌類の生育生理の面から成育基質として重要な澱粉の利用性に注目して,アミラーゼなどの生成酵素との関連で述べた。マツタケ「シロ」中にどの程度の澱粉が含まれ,マツタケ菌がアミラーゼを生成してその澱粉をどの程度利用しているかなど今後解明すべき点は多い。記事区分:原著
著者
尾上 哲治 永井 勝也 上島 彩 妹尾 護 佐野 弘好
出版者
日本地質学会
雑誌
地質學雜誌 (ISSN:00167630)
巻号頁・発行日
vol.110, no.4, pp.222-236, 2004-04-15
被引用文献数
5 22

九州・四国のジュラ紀新世〜白亜紀古世付加体である三宝山付加コンプレックスから産出する玄武岩の産状・岩相及び岩石学的特徴を記載し,化学組成(主成分元素,微量元素)を検討した.玄武岩類は,主に泥質岩および玄武岩質火山砕屑岩基質中に岩塊として産出し,interpillow limestoneを伴う枕状溶岩と塊状溶岩,玄武岩角礫岩,ハイアロクラスタイトから構成される.玄武岩の産状からは陸源砕屑物の堆積場で噴出した証拠は認められない.変質による移動が少ないと考えられている元素(Ti,Zr,Nb,Y)を用いた地球化学的判別図では,多くの玄武岩がTi,Nbに富む海洋島玄武岩(OIB)に類似する.したがって,三宝山付加コンプレックスの玄武岩は,太洋域でのプレート内火成活動によって形成された海山に起源を持つと考えられる.