著者

甘利 〓一 磯貝 誠 稲生 光吉 大塚 誠之 大塚 芳郎 大塚 新太郎 河田 三治 後藤 清太郎 佐藤 豪 佐藤 忠雄 柴田 万壽太郎 栖原 豊太郎 須之部 量寛 棚沢 泰 種子島 時休 玉木 福宜 土光 敏夫 中西 不二夫 永野 治 長尾 不二夫 西脇 仁一 沼知 福三郎 林 貞助 久野 五十男 福山 勉 藤井 澄二 堀越 博 松永 陽之助 村井 等 森 糾明 矢木 栄 山内 正男 吉水 直一

出版者

一般社団法人 日本機械学会

雑誌

日本機械学會論文集 (ISSN:00290270)

巻号頁・発行日

vol.17, no.58, pp.151-174, 1951-01-30 (Released:2008-03-28)

著者

藤井澄二 著

出版者

小学館

巻号頁・発行日

1948

著者

藤井 澄二 井口 雅一

出版者

東京大学生産技術研究所

雑誌

生産研究 (ISSN:0037105X)

巻号頁・発行日

vol.13, no.5, pp.132-138, 1961-05-01

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運転者により操縦された自動車の運動特性は,自動車の運動力学的特性と,運転者の動作特性とから組み立てられる.そこでまずオーバ・ステアリング,アンダ・ステアリングで表現される自動車の静力学的特性から,さらに手放し走行などを含む動力学的特性を解説し,ついで運転者の操縦が加えられた自動車の運動特性へと論議を進め,最後に自動車の研究と平衡した運転者の研究の必要性を述べる.理解の助けとするためにアナログ計算機による計算曲線例を示す.

著者

藤井 澄子

出版者

聖カタリナ大学短期大学部

雑誌

聖カタリナ女子短期大学研究紀要 (ISSN:02869748)

巻号頁・発行日

vol.35, pp.1-17, 2002-03-10

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特別養護老人ホームにおける集団セッションでの選曲のあり方について, 筆者は各曲を5種類のジャンルに分類してそれぞれに『A』『B』『C』の好感度をつけた。この好感度は選曲の頻度などによって変化していくが, 年数を重ねるとともに『A』ランクが増え, 痴呆のセラピストにも学習効果が認められた。さらにAホームにおいては, 唱歌・童謡よりも流行歌に広がりが観られ, 選曲に双方を織り交ぜることで, 高齢者の心にある音楽を引き出すことができて, 生き生きとした活動を行えた。特に, 映画音楽の主題歌は, 青春時代の記憶を喚起させ, 情動を動かせる歌として有益性が認められ, 音楽療法の選択曲としての価値が期待される。

著者

藤井 澄二 吉本 堅一

出版者

日本ロボット学会

雑誌

日本ロボット学会誌 (ISSN:02891824)

巻号頁・発行日

vol.1, no.1, pp.4-8, 1983-04-30 (Released:2010-08-25)

参考文献数

19

被引用文献数

2

著者

藤井澄二

出版者

藤井澄二教授還暦退官記念会

巻号頁・発行日

1982

著者

K.S.ミラー著 佐藤常三 藤井澄二訳

出版者

共立出版

巻号頁・発行日

1959

著者

藤井澄二編

出版者

岩波書店

巻号頁・発行日

1967

著者

藤井澄二講師

出版者

丸善(発売)

巻号頁・発行日

1998

著者

藤井澄二著

出版者

共立出版

巻号頁・発行日

1957

著者

ステパーノフ著 白倉昌明 藤井澄二共訳

出版者

丸善

巻号頁・発行日

1956

著者

デン ハルトック著 谷口修 藤井澄二共訳

出版者

コロナ社

巻号頁・発行日

1960

著者

藤井 澄三 小川 和男 板谷 泰助 伊達 忠正 稲垣 甚一郎 野原 富士夫

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.43, no.3, pp.408-413, 1995-03-15 (Released:2008-03-31)

参考文献数

25

被引用文献数

2 3

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A full account is given of the first syntheses of 6-mercaptopurine 7-N-oxide (4) and 6-methylthiopurine 7-N-oxide (5). The synthesis of 4 followed a "phenacylamine route", which started from condensation of 4, 6-dichloro-5-nitropyrimidine (15) with N-(4-methoxybenzyl)phenacylamine to form the phenacylaminopyrimidine derivative (11) and proceeded through conversion into the mercapto derivative, intramolecular cyclization between the NO2 nitrogen atom and the phenacyl carbanion to give 6-mercapto-9-(4-methoxybenzyl)purine 7-N-oxide (12), and removal of the 4-methoxybenzyl group. S-Methylation of 12 and removal of the 4-methoxybenzyl group afforded 5. The location of the oxygen function in 4, 5, and 12 was confirmed by X-ray crystallographic analysis of 5·H2O, which was shown to exist in the N(7)-OH form (19). A UV spectroscopic approach suggested that the neutral species of 4 exists in HO as the N(7)-OH tautomer (21), whereas that of 5 exists as an equilibrated mixture of the N(7)-oxide (5) and the N(7)-OH (19) tautomers. In the in vitro bioassay of antileukemic activity against murine L5178Y cells, the N-oxides 4 and 12 were found to be weakly cytotoxic.

著者

藤井 澄三 小川 和男 斎藤 徹 板谷 泰助 伊藤 忠正 岡村 公生

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.43, no.2, pp.321-324, 1995-02-15 (Released:2008-03-31)

参考文献数

26

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Oxidation of 1-benzyladenine (12) with m-chloroperoxybenzoic acid in MeOH or in MeOH-0.5 M phosphate buffer (pH 6.6) has been found to afford 1-benzyladenine 7-oxide (13) as the main product. Nonreductive debenzylation of 13 gave adenine 7-oxide (14) in 63% yield. The structure of 13 was unequivocally established by an X-ray crystallographic analysis.

著者

/ 藤井 澄三 斎藤 徹 TOHRU SAITO

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.5, pp.2037-2043, 1986-05-25 (Released:2008-03-31)

参考文献数

28

被引用文献数

9 14

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A detailed account is given of the final step of the general 7-alkalation procedure for adenine (1), which consists of the preferential benzylation at the 3-position of 1, regioselective alkylation of the resulting 3-benzyladenine (2) to give 7-alkyl-3-benzyladenine salts (3a-c), and debenzylation of 3a-c leading to 7-alkyladenines (4a-c). Debenzylation of 3a-c (X=Cl or ClO4) has been achieved by hydrogenolysis using hydrogen and Pd-C catalyst at atmospheric pressure, producing 7-alkyladenines (4a-c) in 38-74% yields. The use of the allyl or γ, γ-dimethylallyl group at the 3-position instead of the benzyl group for the synthesis of 7-methyladenine (4a) by this procedure has no practical value. Alternatively, the salts 3a-c (X=Br, ClO4, or I) have been debenzylated efficiently by treatment with conc. H2SO4 in the presence of toluene at room temperature for 3-6h or at 60°C for 0.5-2h, giving 4a-c in 73-93% yields.

著者

藤井 澄三 小川 和男 斎藤 徹 小林 恵子 板谷 泰助 伊達 忠正 岡村 公生

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.43, no.1, pp.53-62, 1995-01-15 (Released:2008-03-31)

参考文献数

49

被引用文献数

3 4

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A detailed account is given of the first unequivocal synthesis of adenine 7-oxide (8). The synthesis started with peroxycarboxylic acid oxidation of 3-benzyladenine (6), readily obtainable from adenine (1) by benzylation, and proceeded through nonreductive debenzylation of the resulting 3-benzyladenine 7-oxide (7). The location of the oxygen function in 7 and 8 was confirmed by their chemical reactions including deamination and methylation and by X-ray crystallographic analysis. A UV spectroscopic approach suggested that the neutral species of 8 exists in H2O as an equilibrated mixture of the N(7)-oxide (8) and N(7)-OH (21) tautomers. Treatment of 6 with 30% aqueous H2O2 in MeOH in the presence of MeCN and KHCO3 at 30°C produced the N(7)-oxide 7 and 7-acetamido-3-benzyladenine (15) in 12% and 1% yields, respectively.

著者

小川 和男 西井 正廣 稲垣 甚一郎 野原 富士夫 斎藤 徹 板谷 泰助 藤井 澄三

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.5, pp.1315-1317, 1992-05-25 (Released:2008-03-31)

参考文献数

16

被引用文献数

2 7

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The synthesis of 8-methylguanine 7-oxide (3) was accomplished via a "phenacylamine route", which started from condensation of α-(4-methoxybenzylamino)propiophenone (6), prepared by coupling of α-bromopropiophenone (4) and 4-methoxybenzylamine (5), with 2-amino-6-chloro-5-nitro-4(3H)-pyrimidinone (7) and proceeded through cyclization of the resulting phenacylaminopyrimidinone (8) and removal of the 4-methoxybenzyl group. The N-oxide 3 and its 9-arylmethyl derivatives 9 and 11 showed only very weak antileukemic activity and no antimicrobial activity.

著者

小川 和男 西井 正廣 稲垣 甚一郎 野原 富士夫 斎藤 徹 板谷 泰助 藤井 澄三

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.2, pp.343-350, 1992-02-25 (Released:2008-03-31)

参考文献数

47

被引用文献数

8 10

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A full account is given of the first chemical synthesis of the antitumor antibiotic guanine 7-oxide (5) and its 9-substituted derivatives (24a-k and 26). Coupling of appropriate primary amines (17a-e, g-k) with phanecyl bromide (16) produced, after treatment with HCl, the corresponding N-substituted phenacylamine hydrochlorides (18a-e, g-k). A similar phenacylation of 4-amino-1-butanol (21) failed to give the desired compound 18f, so that 21 was heated with 2-bromomethyl-2-phenyl-1, 3-dioxolane (20) at 150-155°C for 3h to furnish, after treatment with HCl, the amino ketal hydrochloride 22 in 40% yield. Deketalization of 22 with hot 2N aqueous HCl afforded 18f in 96% yield. Condensations of the free bases, generated in situ from the hydrochlorides 18a-l and 1N aqueous NaOH, with the chloropyrimidinone 6 were effected in aqueous EtOH at the boiling point for 20 min or at 25-30°C for 3-24h, giving the 6-phenacylamino-4-pyrimidinones 19a-l in 54-90% yields. On treatment with 2N aqueous NaOH at room temperature for 10-60 min, the nitropyrimidinones 19a-k cyclized to provide the 9-substituted guanine 7-oxides 24a-k in 61-98% yields. A similar alkali-treatment of 19l failed to yield guanine 7-oxide (5). However, removal of the 9-(arylmethyl) group from 24i-k was effected with conc, H2SO4 at room temperature for 1-3h in the presence of toluene, producing the target N-oxide 5 in 56-89% yields. In the in vitro bioassay of antileukemic activity against murine L5178Y cells, none of the 9-substituted guanine 7-oxides (24a-k and 26) was more effective than the parent, natural N-oxide 5. Within this series, however, the benzyl analogues 24g-k with or without alkoxy functions were more cytotoxic, with IC50's of 13.0-48.0μg/ml, than the alkyl analogues 24a-f.

著者

藤井 澄三 高田 泰孝 小川 和男 板谷 泰助 松原 聰

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.43, no.2, pp.325-327, 1995-02-15 (Released:2008-03-31)

参考文献数

20

被引用文献数

2

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Treatment of N6-benzyladenine (2) with 15% aqueous H2O2 in trifluoroacetic acid at 65-70°C for 1 h was found to give the N(3)-oxide (3) and the N(7)-oxide (4) in 4% and 4% yields, respectively. The structure of 3 was established by its identity with a sample prepared from 6-chloropurine 3-oxide (6) and benzylamine, and the structure of 4 by its identity with a sample obtained from 1-benzyladenine 7-oxide (8) by Dimroth rearrangement. The N-oxides 3 and 4, together with previously reported N6-benzyladenine 1-oxide (1), were tested for cytokinin activity in the tobacco callus bioassay. Each of the three N-oxides was active at 4 μM concentration, being less active than the parent base 2 by a factor of 40.

著者

小川 和男 西井 正廣 野原 富士夫 斎藤 徹 板谷 泰助 藤井 澄三

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.3, pp.612-616, 1992-03-25 (Released:2008-03-31)

参考文献数

46

被引用文献数

2 8

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A detailed account is given of the first chemical synthesis of hypoxanthine 7-N-oxide (5), which started from coupling of 6-chloro-5-nitro-4(3H)-pyrimidinone (7) with N-(4-methoxybenzyl)phenacylamine, generated in situ from the hydrochloride (8), and proceeded through cyclization of the resulting phenacylaminopyrimidinone (9) and removal of the 4-methoxybenzyl group. The results of catalytic hydrogenolysis, methylation followed by catalytic hydrogenolysis, and rearrangement under acidic conditions of 5 supported the correctness of the assigned structure. An ultraviolet spectroscopic approach suggested that the neutral species of 5 exists in H2O mainly as the N(7)-OH tautomer (21). In the in vitro bioassay of antileukemic activity against murine L5178Y cells, 5 was weakly cytotoxic, with IC50 of 100μg/ml. It did not show any antimicrobial activity even at 1000μg/ml. None of the 9-(4-methoxybenxyl) (11) and O-methyl (12, 13, and 14) derivatives was found to be antiieukemic or antimicrobial.