著者
Xiang-Lin Chi Yong-Peng Yu Ke-Ping Bi
出版者
Japan Brain Science society
雑誌
脳科学誌 (ISSN:13415301)
巻号頁・発行日
vol.41, pp.17-36, 2013-09-30 (Released:2017-06-01)

The purpose of this study was to examine whether group intensive rehabilitation (GIR) can significantly improve lower limb functional outcome in patients early after stroke compared to routine rehabilitation (RR). Ninty-four patients were enrolled in this study who received GIR, individual intensive rehabilitation (IIR) or RR. Lower limb motor function was assessed using the Fugl-Meyer Assessment of Motor Recovery (FM). Dependence was recorded using the Modified Barthel Index (MBI), which is an index of daily living activities (ADL). Measures were taken before treatment and 3 weeks later respectively. Socioeconomics significance was assessed using rehabilitation cost-effectiveness ratio (CER). GIR and IIR produced greater gains than RR both in lower limb FM (p<0.01, p<0.01, respectively) and MBI (p=0.007, p=0.026, respectively) at 3 weeks after intervention. There were no significant differences both in FM and MBI score changes of lower limb between GIR and IIR (p=0.365, p=0.782, respectively). GIR had lower CER than IIR and RR (p<0.01, p<0.01, respectively). There were significant differences in CER between the three groups. Subjects in GIR had lower CER compared with those in IIR and RR (p<0.01, p<0.01, respectively). Patients receiving GIR or IIR could make greater gains than those receiving RR in lower limb motor function and ADL early after stroke, while there were no differences between those receiving GIR and IIR, which indicated that this beneficial effect was attributed to higher intensity of therapy, but had nothing to do with group factors. GIR may be a pragmatic, effective and economical method for patients early after stroke allowing for the optimal utilization of resources.
著者
Mika Kimura Ryuzo Hanaie Ikuko Mohri Kuriko Kagitani-Shimono Masaya Tachibana Junko Matsuzaki Norihiko Fujita Yoshiyuki Watanabe Masako Taniike
出版者
Japan Brain Science society
雑誌
脳科学誌 (ISSN:13415301)
巻号頁・発行日
vol.42, pp.21-42, 2013-09-30 (Released:2017-06-01)

Autism spectrum disorder (ASD) is a neuro-developmental disorder characterized by a number of functional abnormalities including disruptions to language. Recently, abnormal connectivity in the brain has been reported as a neuronal basis of functional impairments in ASD. Using tractographical analysis of the arcuate fasciculus (AF) by Diffusion Tensor Imaging (DTI), we attempted to clarify the neuropsychological basis for the language impairment in ASD by investigating thirteen school-aged children with ASD and eleven age- and IQ-matched control subjects. As a result of the DTI examination, no statistically significant differences in the values of fractional anisotropy (FA), axial diffusivity, radial diffusivity, and mean diffusivity were found. In both TD and ASD groups, the FA score of the AF was higher in the left hemisphere than it was in the right. We revealed that in children with ASD, the FA values of the left AF showed a positive correlation between age, verbal intelligence quotient (VIQ), and full-scale intelligence quotient (FSIQ). In addition, a negative correlation was found between RD values on the left AF with VIQ, FSIQ, and age in children with ASD. This is the first report to reveal a correlation between microconnectivity of the AF and VIQ in children diagnosed with ASD. Therefore, these findings suggest that the altered microstructural integrity of the AF may be related to verbal ability in ASD.
著者
Fumiyo Nagatani Junko Matsuzaki Moe Eto Kuriko Kagitani-Shimono Ikuko Mohri Masako Taniike
出版者
Japan Brain Science society
雑誌
脳科学誌 (ISSN:13415301)
巻号頁・発行日
vol.39, pp.5-21, 2012-10-30 (Released:2017-06-01)
参考文献数
33

Attention deficit/hyperactivity disorder, predominantly inattentive subtype (AD/HD-I) is one of subtypes of AD/HD. Previous studies found that poor academic performance was the most common problem of children with AD/HD-I. Moreover a higher prevalence of substance dependence/abuse disorders and higher percentage experienced neurological disorders were reported in adults with this disorder. However AD/HD-I has a high risk of being overlooked due to the lack of objective measurement. To avoid these problems, it is necessary to find out children with AD/HD-I and start to intervene them early in life. AD/HD is reported to have deficits in executive function (EF), however, there have been no consistent findings regarding the presence and the characteristics of EDF in ADHD-I to date. To clarify EDF of AD/HD-I, we analyzed EF in children with AD/HD-I by using two tests designed to evaluate inhibition and working memory from CANTAB together with the BRIEF, a parent-rated scale. We found significant differences in many outcome measures of these CANTAB tests and most scales of the BRIEF between AD/HD-I and control children, indicating the presence of EDF in AD/HD-I. In addition, correlations between these tools were identified, especially in scales for working memory. We also examined predictors that distinguish AD/HD-I from controls by using discriminant analysis. In summary, outcome measures of CANTAB and the BRIEF are considered to be useful for determining AD/HD-I in young children. Short title as a running head: Assessment of executive function in children with AD/HD-I
著者
Zhao-qiang Zhang Xiao Sun Xiang-lin Chi Xian-chang Sun Hong Jiang
出版者
Japan Brain Science society
雑誌
脳科学誌 (ISSN:13415301)
巻号頁・発行日
vol.40, pp.54-65, 2013-03-30 (Released:2017-06-01)
参考文献数
11

Objective Modeling a stable and reproducible animal model of Parkinson's disease by rotenone intraperitoneal injection for further pathogenesis study of PD. Methods Twenty-seven male Wistar rats were used, which were randomly divided into three groups on average (Rotenone Injection, Vehicle Injection and Normal group). Rats of rotenone injection group (RIG) were administered rotenone (3.0 mg/kg/day) in a specialized vehicle through daily intraperitoneal injection; rats of vehicle injection group (VIG) were administered only special vehicle in the same way, rats of normal group (NG) didn't receive any injection. Checked the changes of its behavior and numbers of SNpc neurons to determine the model successful or not. Results Six rats of RIG developed part of Parkinson's symptoms at different time. All rats of RIG emerged behavioral deficits through rearing behavior testing and square bridge testing, and the mean number of SNpc neurons showed significant reduction. There were no behavioral deficits and changes of the mean number of SNpc neurons in rats of NG and VIG. Conclusion Model of Parkinson's disease by rotenone intraperitoneal injection was successfully established. This form of the rotenone model is stable and easy to reproduce, and may provide a new excellent supporter to related studies.