著者
Hooi-Sean Ng
出版者
Center for Southeast Asian Studies, Kyoto University
雑誌
Southeast Asian Studies (ISSN:21867275)
巻号頁・発行日
vol.11, no.3, pp.477-514, 2022-12-22 (Released:2022-12-22)
参考文献数
125

The increasing prominence of China on the world stage has sparked scholarly interest in studying the country’s representation in the media. Also driving the enthusiasm is the global expansion of Chinese state media, which some refer to as an attempt to export Chinese propaganda. Research on the topic in Southeast Asia remains lacking despite the region’s being in China’s backyard. This qualitative study aims to narrow the knowledge gap by looking at China’s representation in Malaysia. Using content analysis and in-depth interviews, it examines specifically the coverage of former Prime Minister Najib Razak’s 2016 visit to China by the Malay, Mandarin, and English bulletins on public and private television. The results show that China’s portrayal in the coverage is positive, notwithstanding the stories indicating concerns about the implications of China’s rise. The outcome points to the dominance of the state narrative, with instances of the press breaking the authorities’ restrictions to inform the audience. It appears that the reportage was not much impacted by Chinese media’s efforts to go global. Drawing on the Hierarchy of Influences model, the study demonstrates that the representation of China in Malaysian media coverage is a product shaped by intertwined social, cultural, and political factors as complex as Malaysian society.
著者
Chika Fujisawa-Tanaka Izumi Hiratsuka Megumi Shibata Kei Kurihara Naohiro Aida Takeshi Takayanagi Yusuke Seino Taihei Ito Takashi Kenmochi Atsushi Suzuki
出版者
Fujita Medical Society
雑誌
Fujita Medical Journal (ISSN:21897247)
巻号頁・発行日
pp.2022-019, (Released:2022-12-27)
参考文献数
28

Objectives: Type 1 diabetes mellitus (T1DM) patients with diabetic kidney disease-induced kidney failure have a significantly impaired quality of life (QOL), resulting in a high level of physical, mental, and social anxiety. In this study, we evaluated the QOL of T1DM patients on the list for pancreas transplantation (PTx) at their registration, and determined whether PTx improved their QOL.Methods: There were 58 patients (men/women, 22/36; mean age, 42.8±8.0 years) with T1DM and who were registered on the waiting list for PTx. Quantitative QOL assessment was performed using the Medical Health Survey Short Form (SF-36) version 2. Changes in the QOL before and after PTx were also examined in 24 of these patients.Results: The mean value of each endpoint and the summary score of the SF-36 physical (PCS), mental (MCS), and role (RCS) components were all below the national normal level at PTx registration. No significant difference in QOL scores was observed in the intergroup comparison of 35 patients on dialysis, 13 patients without dialysis, and ten patients after kidney transplantation. The 24 patients who underwent PTx showed improvement in PCS, MCS, and most SF-36 scores.Conclusion: T1DM patients waiting for PTx had a decreased QOL, regardless of dialysis, and PTx improved their QOL.
著者
Yukihiro Sato Eiji Yoshioka Yasuaki Saijo Toshinobu Miyamoto Hiroshi Azuma Yusuke Tanahashi Yoshiya Ito Sumitaka Kobayashi Machiko Minatoya Yu Ait Bamai Keiko Yamazaki Sachiko Itoh Chihiro Miyashita Atsuko Ikeda-Araki Reiko Kishi The Japan Environment and Children’s Study (JECS) Group
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.32, no.6, pp.270-276, 2022-06-05 (Released:2022-06-05)
参考文献数
32
被引用文献数
1 3

Background: Lower respiratory tract infections (LRTIs) are a cause of inpatient and outpatient care among children. Although orofacial clefts seem to be associated with LRTIs, epidemiological studies are scarce on this topic. This study aimed to examine whether infants with orofacial clefts were associated with LRTIs.Methods: This prospective cohort study used data from the Japan Environment and Children’s Study, for which baseline recruitment was conducted during 2011–2014. This study included 81,535 participants. The number of infants with cleft lip and palate (CLP), cleft lip (CL), and cleft palate only (CP) was 67, 49, and 36, respectively. We defined history of LRTIs until 12 months’ age reported by their mothers as the dependent variable. Accumulated breastfeeding duration was used as a potential mediator.Results: The incidence proportion of LRTIs among the control group was 6.0%. The incidence proportion among infants with CLP, CL, and CP were 11.9%, 14.3%, and 5.6%, respectively. After adjusting for covariates, compared with the control group, infants with CLP and CL were associated with risk of LRTIs (incidence risk ratio [IRR] of CLP, 2.38; 95% confidence interval [CI], 1.30–4.36 and IRR of CL, 2.73; 95% CI, 1.40–5.33), but not ones with CP (IRR 1.08; 95% CI, 0.28–4.15). Accumulated breastfeeding duration decreased the IRR of CLP only (IRR of CLP, 2.16; 95% CI, 1.19–3.93).Conclusion: Infants with orofacial clefts aged 1 year have a potentially high incidence proportion of LRTIs. Accumulated breastfeeding duration might mediate the associations of CLP.
著者
Cheng-Min FENG
出版者
Eastern Asia Society for Transportation Studies
雑誌
Proceedings of the Eastern Asia Society for Transportation Studies
巻号頁・発行日
pp.13, 2011 (Released:2011-09-30)

Taiwan takes BOT approach to build and operate its high speed rail. Several issues such as the enact of new law vs. the modification of old law, tri-party agreement vs. two-party agreement, partner or regulator, refinance vs. take-over, new town vs. old town, expropriation or zonal expropriation, and plan vs. development, occurred during the planning, construction, contracting and operation periods. Taiwan learns its lessons from the process and its outcomes, which could help others to prevent the issues or adapt their plans.
著者
Makiko Sekiyama Shin Yamazaki Takehiro Michikawa Shoji F. Nakayama Hiroshi Nitta Yu Taniguchi Eiko Suda Tomohiko Isobe Yayoi Kobayashi Miyuki Iwai-Shimada Masaji Ono Kenji Tamura Junzo Yonemoto Toshihiro Kawamoto Michihiro Kamijima the Japan Environment and Children’s Study Group
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.32, no.5, pp.228-236, 2022-05-05 (Released:2022-05-05)
参考文献数
18
被引用文献数
8 26

Background: The Japan Environment and Children’s Study (JECS) is a nationwide birth cohort study investigating environmental effects on children’s health and development. A Sub-Cohort Study has begun, conducting extended exposure and outcome measurements by targeting a subgroup randomly selected from the JECS Main Study. We report the Sub-Cohort Study methodology and participants’ baseline profiles.Methods: Of 100,148 children in the JECS Main Study, children born after April 1, 2013 who met eligibility criteria ([1] all questionnaire and medical record data from children and their mothers collected from the first trimester to 6 months of age, [2] biospecimens [except umbilical cord blood] from children and their mothers collected at first to second/third trimester and delivery) were randomly selected for each Regional Centre at regular intervals. Face-to-face assessment of neuropsychiatric development, body measurement, paediatrician’s examination, blood/urine collection for clinical testing and chemical analysis, and home visits (ambient and indoor air measurement and dust collection) are conducted. Participants are followed up at 1.5 and 3 years old for home visits, and 2, 4, 6, and 8 years old for developmental/medical examination. The details of protocols after age 10 are under discussion.Results: Of 10,302 selected children, 5,017 participated. The profiles of the participating mothers, fathers and children did not substantially differ between the Main Study and Sub-Cohort Study.Conclusion: The JECS Sub-Cohort Study offers a platform for investigating associations between environmental exposure and outcomes.
著者
Nam-Hee Kim Jarvis T. Chen Ichiro Kawachi
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.32, no.5, pp.215-220, 2022-05-05 (Released:2022-05-05)
参考文献数
31
被引用文献数
2 2

Background: In 2012, the Korean National Health Insurance extended its coverage to include denture services for older adults. We examined whether the new policy resulted in improved chewing ability in the eligible population.Methods: We used interrupted time-series (ITS) analysis, a quasi-experimental design, to analyze the effect of the policy. We used data from the Korea National Health and Nutrition Examination Survey conducted from 2007 to 2016–2018. The study population consisted of two groups: the treatment group, aged 65 years or older and eligible for the dental insurance benefit; and the control group, those younger than 65 years and ineligible. The main evaluated outcome was self-reported chewing difficulty.Results: The ITS analysis showed that chewing difficulty decreased annually by 0.93% (95% CI, −1.30 to −0.55%) and 0.38% (95% CI, −0.59 to −0.16%) after the policy extension in the older than 65 and younger than 65 groups, respectively. However, we could not conclude that the insurance extension affected chewing difficulty because there was a decrease in the control group as well.Conclusion: Chewing ability improved in both older and younger adults regardless of dental insurance coverage for older adults. Other exogenous factors probably led to the improvements in chewing ability as well as dental insurance benefits.
著者
Byoung-Seob Ko Soo Bong Choi Seong Kyu Park Jin Sun Jang Yeong Eun Kim Sunmin Park
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.28, no.8, pp.1431-1437, 2005 (Released:2005-08-01)
参考文献数
30
被引用文献数
123 140

Our preliminary study demonstrated that 70% ethanol Cortidis Rhizoma extracts (CR) had a hypoglycemic action in diabetic animal models. We determined whether CR fractions acted as anti-diabetic agent, and a subsequent investigation of the action mechanism of the major compound, berberine ([C20H18NO4]+), was carried out in vitro. The 20, 40 and 60% methanol fractions from the XAD-4 column contained the most insulin sensitizing activities in 3T3-L1 adipocytes. The common major peak in these fractions was berberine. Treatment with 50 μM berberine plus differentiation inducers significantly reduced triglyceride accumulation by decreased differentiation of 3T3-L1 fibroblasts to adipocytes and triglyceride synthesis. Significant insulin sensitizing activity was observed in 3T3-L1 adipocytes which were given 50 μM berberine plus 0.2 nM insulin to reach a glucose uptake level increased by 10 nM of insulin alone. This was associated with increased glucose transporter-4 translocation into the plasma membrane via enhancing insulin signaling pathways and the insulin receptor substrate-1-phosphoinositide 3 Kinase-Akt. Berberine also increased glucose-stimulated insulin secretion and proliferation in Min6 cells via an enhanced insulin/insulin-like growth factor-1 signaling cascade. Data suggested that berberine can act as an effective insulin sensitizing and insulinotropic agent. Therefore, berberine can be used as anti-diabetic agent for obese diabetic patients.
著者
Beladenta Amalia Marcela Fu Ariadna Feliu Olena Tigova Ranti Fayokun Kristina Mauer-Stender Esteve Fernández
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.32, no.3, pp.131-138, 2022-03-05 (Released:2022-03-05)
参考文献数
35
被引用文献数
3 8

Background: The objective of this study is to describe the legislation regulating the use of electronic cigarettes (e-cigarettes) in various places in European countries.Methods: A survey among experts from all countries of the World Health Organization (WHO) European Region was conducted in 2018. We collected and described data on legislation regulating e-cigarette use indoors and outdoors in public and private places, the level of difficulties in adopting the legislation, and the public support and compliance. Factors associated with the legislation adoption were identified with Poisson and linear regression analyses.Results: Out of 48 countries, 58.3% had legislation on e-cigarette use at the national level. Education facilities were the most regulated place (58.3% of countries), while private areas (eg, homes, cars) were the least regulated ones (39.6%). A third of countries regulated e-cigarette use indoors. Difficulty and support in adopting the national legislation and its compliance were all at a moderate level. Countries’ smoking prevalence and income levels were linked to legislation adoption.Conclusions: Although most WHO European Region countries had introduced e-cigarette use legislation at the national level, only a few of the legislation protect bystanders in indoor settings.
著者
Erika KAWASAKI Makoto HASEBE Ji-Hee HWANG Eun-Young KIM Kisup LEE Kunikazu MOMOSE Hiroki TERAOKA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.84, no.2, pp.233-237, 2022 (Released:2022-02-10)
参考文献数
17
被引用文献数
3

Red-crowned cranes Grus japonensis, which are an endangered species, have two separate populations, a mainland population in the Eurasian continent and an island population in eastern Hokkaido, Japan. Island cranes showed three haplotypes (Gj1, Gj2 and Gj13), whereas ten haplotypes (Gj3–Gj12) were confirmed in captive cranes and stray cranes. We found Gj5 haplotype in feathers of two cranes as well as four new haplotypes in seven wild crane feathers collected in South Korea. We also found feathers in the nest in Sarobetsu Wetland in northwestern Hokkaido. While the haplotype of female-derived feathers was Gj2, that of male-derived feathers was Gj5. The results suggest that there has been crossbreeding between cranes in the island population and cranes in the mainland population.
著者
Chikage Umeda-Hara Hidekazu Iwakawa Misato Ohtani Taku Demura Tomoko Matsumoto Jun Kikuchi Koji Murata Masaaki Umeda
出版者
Japanese Society for Plant Biotechnology
雑誌
Plant Biotechnology (ISSN:13424580)
巻号頁・発行日
pp.22.0716a, (Released:2022-09-17)
参考文献数
28

Somatic polyploidization often increases cell and organ size, thereby contributing to plant biomass production. However, as most woody plants do not undergo polyploidization, explaining the polyploidization effect on organ growth in trees remains difficult. Here we developed a new method to generate tetraploid lines in poplars through colchicine treatment of lateral buds. We found that tetraploidization induced cell enlargement in the stem, suggesting that polyploidization can increase cell size in woody plants that cannot induce polyploidization in normal development. Greenhouse growth analysis revealed that radial growth was enhanced in the basal stem of tetraploids, whereas longitudinal growth was retarded, producing the same amount of stem biomass as diploids. Woody biomass characteristics were also comparable in terms of wood substance density, saccharification efficiency, and cell wall profiling. Our results reveal tetraploidization as an effective strategy for improving woody biomass production when combined with technologies that promote longitudinal stem growth by enhancing metabolite production and/or transport.
著者
Jun-Ichi Sasaki Satoshi Imazato
出版者
Japan Prosthodontic Society
雑誌
Journal of Prosthodontic Research (ISSN:18831958)
巻号頁・発行日
vol.64, no.3, pp.239-242, 2020 (Released:2020-08-07)
参考文献数
40
被引用文献数
18

Purpose: The present review aimed to investigate autoclave sterilization of dental handpieces based on available studies.Study selection: The sterilizing efficiency of dental handpieces with autoclave is mainly affected by the types of apparatus (N, B, and S), the packaging with sterilizing pouch, cleaning, and lubrication. These subjects were reviewed based on the in vitro experimental studies.Results: Dental handpieces can be sterilized, including inactivation of heat-resistant bacterial spores, with type B or type S sterilizers, regardless of the use of a sterilization pouch. In contrast, although type N autoclaves are capable of sterilization of general bacteria such as Streptococcus salivarius even in a sterilization pouch if instruments are washed beforehand, complete sterilization of the wrapped handpiece is not always achieved. Therefore, to achieve sterilization efficiency with type N autoclaves, processing without any packaging is recommended. As regards cleaning of handpiece, although contamination decreases with irrigation and wiping of handpieces, all reports concluded that these treatments alone do not achieve complete decontamination of reusable handpieces.Conclusion: Although type B and type S autoclaves allow us to sterilize the dental handpieces, it is important to realize that complete sterilization of the handpiece is not always achieved by type N autoclave. Understanding autoclave processing of handpieces is essential for dental practice to deliver the safe dental care.
著者
Megumi Ueno Sayaka Shibata Ikuo Nakanishi Ichio Aoki Ken-ichi Yamada Ken-ichiro Matsumoto
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
雑誌
Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
巻号頁・発行日
pp.22-57, (Released:2022-12-08)
参考文献数
42

The impact of radiation-induced hydrogen peroxide (H2O2) on the biological effects of X-rays and carbon-ion beams was investigated using a selenium-deficient (SeD) mouse model. Selenium is the active center of glutathione peroxidase (GSH-Px), and SeD mice lack the ability to degrade H2O2. Male and female SeD mice were prepared by feeding a torula yeast-based SeD diet and ultrapure water. Thirty-day survival rates after whole-body irradiation, radiation-induced leg contracture, and MRI-based redox imaging of the brain were assessed and compared between SeD and normal mice. Thirty-day lethality after whole-body 5.6 Gy irradiation with X-rays or carbon-ion beams was higher in the SeD mice than in the normal mice, while SeD did not give the notable difference between X-rays and carbon-ion beams. SeD also did not affect the maximum leg contracture level after irradiation with carbon-ion beams, but delayed the leg contraction rate. In addition, no marked effects of SeD were observed on variations in the redox status of the brain after irradiation. Collectively, the present results indicate that SeD slightly altered the biological effects of X-rays and/or carbon-ion beams. GSH-Px processes endogenous H2O2 generated through mitochondrial respiration, but does not have the capacity to degrade H2O2 produced by irradiation.
著者
Sho Takeda Taisuke Togawa Kei-ichiro Mishiba Katsuyuki T. Yamato Yuji Iwata Nozomu Koizumi
出版者
Japanese Society for Plant Biotechnology
雑誌
Plant Biotechnology (ISSN:13424580)
巻号頁・発行日
vol.39, no.3, pp.303-310, 2022-09-25 (Released:2022-09-25)
参考文献数
37
被引用文献数
2

The unfolded protein response (UPR) or the endoplasmic reticulum (ER) stress response is a homeostatic cellular response conserved in eukaryotes to alleviate the accumulation of unfolded proteins in the ER. In the present study, we characterized the UPR in the liverwort Marchantia polymorpha to obtain insights into the conservation and divergence of the UPR in the land plants. We demonstrate that the most conserved UPR transducer in eukaryotes, IRE1, is conserved in M. polymorpha, which harbors a single gene encoding IRE1. We showed that MpIRE1 mediates cytoplasmic splicing of mRNA encoding MpbZIP7, a M. polymorpha homolog of bZIP60 in flowering plants, and upregulation of ER chaperone genes in response to the ER stress inducer tunicamycin. We further showed that MpIRE1 also mediates downregulation of genes encoding secretory and membrane proteins in response to ER stress, indicating the conservation of regulated IRE1-dependent decay of mRNA. Consistent with their roles in the UPR, Mpire1ge and Mpbzip7ge mutants exhibited higher sensitivity to ER stress. Furthermore, an Mpire1ge mutant also exhibited retarded growth even without ER stress inducers, indicating the importance of MpIRE1 for vegetative growth in addition to alleviation of ER stress. The present study provides insights into the evolution of the UPR in land plants.
著者
Zhe-Yu Liu Jiao-Jiao Ji Feng Jiang Xing-Rui Tian Jian-Kuan Li Jian-Ping Gao
出版者
Japanese Society for Plant Biotechnology
雑誌
Plant Biotechnology (ISSN:13424580)
巻号頁・発行日
vol.39, no.3, pp.251-257, 2022-09-25 (Released:2022-09-25)
参考文献数
33
被引用文献数
4

Codonopsis pilosula, a traditional Chinese medicinal and edible plant, contains several bioactive components. However, the biosynthetic mechanism is unclear because of the difficulties associated with functional gene analysis. Therefore, it is important to establish an efficient genetic transformation system for gene function analysis. In this study, we established a highly efficient Agrobacterium-mediated callus genetic transformation system for C. pilosula using stems as explants. After being pre-cultured for 3 days, the explants were infected with Agrobacterium tumefaciens strain GV3101 harboring pCAMBIA1381-35S::GUS at an OD600 value of 0.3 for 15 min, followed by co-cultivation on MS induction medium for 1 day and delayed cultivation on medium supplemented with 250 mg l−1 cefotaxime sodium for 12 days. The transformed calli were selected on screening medium supplemented with 250 mg l−1 cefotaxime sodium and 2.0 mg l−1 hygromycin and further confirmed by PCR amplification of the GUS gene and histochemical GUS assay. Based on the optimal protocol, the induction and transformation efficiency of calli reached a maximum of 91.07%. The establishment of a genetic transformation system for C. pilosula calli lays the foundation for the functional analysis of genes related to bioactive components through genetic engineering technology.
著者
Amr Almaz Abdel-aziem Elsadat Saad Soliman Dalia Mohammed Mosaad Amira Hussin Draz
出版者
The Society of Physical Therapy Science
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.30, no.2, pp.307-312, 2018 (Released:2018-02-28)
参考文献数
45
被引用文献数
6 18

[Purpose] To examine the effect of physiotherapy rehabilitation program on moderate knee osteoarthritis in patients with different pain intensities. [Subjects and Methods] Sixty subjects (37 men and 23 women) with moderate knee osteoarthritis participated in the current study. Randomization software was used to select the participating subjects’ numbers from the clinic records. They were classified into three groups according to pain intensity: mild, moderate, and severe pain groups. All groups underwent a standard set of pulsed electromagnetic field, ultrasound, stretching exercises, and strengthening exercises. Pain intensity, knee range of motion, knee function, and isometric quadriceps strength were evaluated using the visual analogue scale, universal goniometer, Western Ontario and McMaster Universities osteoarthritis index, and Jamar hydraulic dynamometer, respectively. The evaluation was performed before and after a 4-week rehabilitation program. [Results] All groups showed significant differences in pain intensity, knee range of motion, isometric quadriceps strength, and knee function. The score change in moderate pain group was significantly greater than those in mild and severe pain groups. [Conclusion] Pain intensity is one of the prominent factors that are responsible for the improvement of knee osteoarthritis. Consequently, pain intensity should be considered during rehabilitation of knee osteoarthritis.
著者
Satomi YOSHIDA Masato TAKEUCHI Sachiko TANAKA-MIZUNO Kayoko MIZUNO Masayuki NAKASHIMA Toshiki FUKASAWA Koji KAWAKAMI
出版者
The Japan Academy
雑誌
Proceedings of the Japan Academy, Series B (ISSN:03862208)
巻号頁・発行日
vol.98, no.10, pp.517-528, 2022-12-09 (Released:2022-12-09)
参考文献数
104
被引用文献数
7

Hospital-based registry data, including patients’ information collected by academic societies or government based research groups, were previously used for clinical research in Japan. Now, real-world data routinely obtained in healthcare settings are being used in clinical epidemiology and pharmacoepidemiology. Real-world data include a database of claims originating from health insurance associations for reimbursement of medical fees, diagnosis procedure combinations databases for acute inpatient care in hospitals, a drug prescription database, and electronic medical records, including patients’ medical information obtained by doctors, derived from electronic records of hospitals. In the past ten years, much evidence of clinical epidemiology and pharmacoepidemiology studies using real-world data has been accumulated. The purpose of this review was to introduce clinical epidemiology and pharmacoepidemiology approaches and studies using real-world data in Japan.
著者
Jean-Pierre ANTONIO
雑誌
鈴鹿国際大学紀要Campana = Suzuka International University journal campana (ISSN:13428802)
巻号頁・発行日
vol.10, pp.61-70, 2004-03-20

In this assignment five student profiles are presented. The profiles are based on interviews conducted with students at a private university. The students are long term foreign residents of Japan who entered the Japanese educational system at various ages and as such all share the experience of having learned Japanese as a second language. In the first part of this project a brief description of the students' present educational environment and a description of the interview process is given. In the second part the students' profiles are presented. Finally, using students' educational experiences and self-evaluations of their Japanese language proficiency an attempt is made to draw some conclusions concerning the role the Japanese education system has played in the various degrees of success each student has achieved in acquiring Japanese language proficiency and cultural adjustment to life in Japan