著者
Tohru Masuyama Takeshi Tsujino Hideki Origasa Kazuhiro Yamamoto Takashi Akasaka Yutaka Hirano Nobuyuki Ohte Takashi Daimon Satoshi Nakatani Hiroshi Ito
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.76, no.4, pp.833-842, 2012 (Released:2012-03-23)
参考文献数
30
被引用文献数
46 48

Background: Diuretics are the most prescribed drug in heart failure (HF) patients. However, clinical evidence about their long-term effects is lacking. The purpose of this study was to compare the therapeutic effects of furosemide and azosemide, a short- and long-acting loop diuretic, respectively, in patients with chronic heart failure (CHF). Methods and Results: In this multicenter, prospective, randomized, open, blinded endpoint trial, we compared the effects of azosemide and furosemide in patients with CHF and New York Heart Association class II or III symptoms. 320 patients (160 patients in each group, mean age 71 years) were followed up for a minimum of 2 years. The primary endpoint was a composite of cardiovascular death or unplanned admission to hospital for congestive HF. During a median follow-up of 35.2 months, the primary endpoint occurred in 23 patients in the azosemide group and in 34 patients in the furosemide group (hazard ratio [HR], 0.55, 95% confidence interval [CI] 0.32-0.95: P=0.03). Among the secondary endpoints, unplanned admission to hospital for congestive HF or a need for modification of the treatment for HF were also reduced in the azosemide group compared with the furosemide group (HR, 0.60, 95%CI 0.36-0.99: P=0.048). Conclusions: Azosemide, compared with furosemide, reduced the risk of cardiovascular death or unplanned admission to hospital for congestive HF. (Circ J 2012; 76: 833-842)
著者
Masao Daimon Hiroyuki Watanabe Yukio Abe Kumiko Hirata Takeshi Hozumi Katsuhisa Ishii Hiroshi Ito Katsuomi Iwakura Chisato Izumi Masunori Matsuzaki Shinichi Minagoe Haruhiko Abe Kazuya Murata Satoshi Nakatani Kazuaki Negishi Ken Yoshida Kazuaki Tanabe Nobuhiro Tanaka Kotaro Tokai Junichi Yoshikawa The JAMP Study Investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.72, no.11, pp.1859-1866, 2008 (Released:2008-10-24)
参考文献数
20
被引用文献数
73 163

Background Normal values for echocardiographic measurements and the relationship between these parameters and age in a large Japanese population are still unknown. Methods and Results A total of 700 healthy Japanese aged 20-79 years underwent 2-dimensional and Doppler echocardiography at collaborating institutions. The respective mean values obtained in men and women were as follows: septal wall thickness, 0.9±0.1 and 0.8±0.1 cm; posterior wall thickness, 0.9±0.1 and 0.8±0.1 cm; left ventricular (LV) diastolic diameter, 4.8±0.4 and 4.4±0.3 cm; LV systolic diameter, 3.0±0.4 and 2.8±0.3 cm; LV diastolic volume, 93±20 and 74±17 ml; LV systolic volume, 33±20 and 25±7 ml; LV ejection fraction, 64±5 and 66±5%; maximum left atrial (LA) volume, 42±14 and 38±12 ml. Aortic root diameter, LV wall thickness, and LV mass slightly increased with age, whereas indexed LA volume did not vary with age. Diastolic parameters assessed by mitral inflow and mitral annular velocities declined with age, as previously reported. Conclusions Normal values of echocardiographic measurements in a large Japanese population are reported for the first time; several systolic and diastolic parameters varied with age. These results provide important reference values that should be useful in routine clinical practice as well as in clinical trials. (Circ J 2008; 72: 1859 - 1866)
著者
Miwa Ono Satoshi Nakatani Keiji Hirooka Masakazu Yamagishi Kunio Miyatake
出版者
Japanese Society of Echocardiography
雑誌
Journal of Echocardiography (ISSN:13490222)
巻号頁・発行日
vol.1, no.1, pp.8-14, 2003 (Released:2005-07-08)
参考文献数
25
被引用文献数
2 2

OBJECTIVES: Mitral valve closure produces a flow which propagates through the left atrium (LA) to the pulmonary vein (PV) and forms a small flow reversal (C wave) on the PV flow pattern. We examined whether propagation of mitral closure flow into LA might reflect LA compliance in patients with atrial fibrillation (AF).METHODS: We recorded PV flow velocity pattern using transesophageal echocardiography in 73 patients with AF. They were divided into 3 groups according to the estimated severity of LA damage; almost normal (Group I, 16 patients with lone AF), mildly damaged (Group II, 23 patients), and severely damaged LA function (Group III, 34 patients). C wave peak velocity (CV), the time from Q wave on ECG to the C wave peak (QC) and QC divided by LA long-axis diameter (QC/LAD) were obtained. Of the study population, in 18 patients with mitral stenosis who underwent percutaneous mitral valvotomy, mean LA compliance was calculated by dividing cardiac stroke volume by systolic rise in LA pressure.RESULTS: QC and QC/LAD proportionally prolonged as the disease severity increased (QC; 84±23 vs. 93±21 vs. 107±27 ms, p<0.01, QC/LAD; 1.44±0.32 vs. 1.47±0.32 vs. 1.79±0.55ms/mm, p<0.05 for Group I, II and III, respectively). QC and QC/LAD showed significant negative correlations with mean LA compliance (p<0.05).CONCLUSION: Propagation of a flow into LA produced by mitral closure may provide new noninvasive indexes to assess LA compliance in patients with AF.
著者
Masao Daimon Hiroyuki Watanabe Yukio Abe Kumiko Hirata Takeshi Hozumi Katsuhisa Ishii Hiroshi Ito Katsuomi Iwakura Chisato Izumi Masunori Matsuzaki Shinichi Minagoe Haruhiko Abe Kazuya Murata Satoshi Nakatani Kazuaki Negishi Ken Yoshida Kazuaki Tanabe Nobuhiro Tanaka Kotaro Tokai Junichi Yoshikawa The Japanese Normal Values for Echocardiographic Measurements Project (JAMP) Study Investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.75, no.12, pp.2840-2846, 2011 (Released:2011-11-25)
参考文献数
24
被引用文献数
22 49

Background: The purpose of the present study was to investigate gender differences in age-related changes of left ventricular (LV) and right ventricular (RV) geometries and functions throughout the entire adult age range using the Japanese Normal Values for Echocardiographic Measurements Project (JAMP) study database. Methods and Results: Seven hundred healthy volunteers (aged 20-79 years) underwent 2-dimensional and Doppler echocardiography. The subjects were stratified into 6 different age groups and then stratified by gender in each age group. LV diastolic function was assessed from pulsed wave Doppler measurements of mitral early (E) and late (A) inflow velocities and tissue Doppler measurements of mitral early (e') and late (a') annular velocities. LV volume decreased and LV mass increased with age to a similar extent in both men and women. Furthermore, for subjects <50 years, women had significantly greater E, E/A ratio and e' than men, but these parameters were similar between genders in subjects >50 years. In addition, there was a significant interaction between age and gender that affected the differences in E, e' and E/e' among the groups (P<0.03, P<0.01, and P<0.03, respectively; ANOVA). There were no gender differences in age-related changes in RV parameters. Conclusions: Gender differences were found in age-related changes in LV diastolic function in a healthy population. Gender differences should be considered for optimal diagnosis and management of cardiovascular disease. (Circ J 2011; 75: 2840-2846)
著者
Shota Fukuda Hiroyuki Watanabe Masao Daimon Yukio Abe Akihiro Hirashiki Kumiko Hirata Hiroshi Ito Masumi Iwai-Takano Katsuomi Iwakura Chisato Izumi Takayuki Hidaka Toshinori Yuasa Kazuya Murata Satoshi Nakatani Kazuaki Negishi Kazuhiro Nishigami Tomoko Nishikage Takahiro Ota Akihiro Hayashida Konomi Sakata Nobuhiro Tanaka Satoshi Yamada Kazuhiro Yamamoto Junichi Yoshikawa
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.76, no.5, pp.1177-1181, 2012 (Released:2012-04-25)
参考文献数
27
被引用文献数
27 67

Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated in a large, healthy Japanese population. Methods and Results: This study consisted of 410 healthy subjects aged from 20 to 69 years who had a RT3DE at one of the 23 collaborating institutions. All subjects had no history of cardiac disease and no risk factors. The mean values in men and women were as follows: 50±12ml/m2 and 46±9ml/m2 for left ventricular (LV) end-diastolic volume index, 19±5ml/m2 and 17±4ml/m2 for end-systolic volume index, 61±4% and 63±4% for ejection fraction, 64±12g/m2 and 56±11g/m2 for mass index, 23±6ml/m2 and 24±6ml/m2 for left atrial (LA) maximum volume index, 10±3ml/m2 and 10±3ml/m2 for minimum volume index, and 58±6% and 58±6% for percent volume change. LV sizes decreased with age, whereas LV mass index did not change. LA sizes slightly increased with age. Conclusions: This multicenter investigation determined normal reference values for LV and LA sizes, and their functional parameters on RT3DE in a large, healthy Japanese population. The results of the present study support the use of RT3DE for the diagnosis and management of cardiovascular disease. (Circ J 2012; 76: 1177-1181)