著者
高畑 尚之 颯田 葉子
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.32, no.2, pp.1-5, 1992-03-25
参考文献数
3

Life, it seems, really is a lottery. &hellip;Once we grasp how improbable our existence is, once we realize that we have won the jackpot in the lottery of life, and once we sense how precarious this precious existence is when nature does not care whether our imaginations and feelings survive or not, perhaps we shall learn to cherish human life more carefully ourselves. (Nigel Calder)<SUP>1)</SUP>
著者
張 岩 今井 清博 小林 道頼
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.47, no.3, pp.167-173, 2007-05-25
参考文献数
13

The slope of the oxygen equilibrium curve (OEC) of mammalian-hemoglobin (Hb) is maximized at <i>S</i> (oxygen saturation) value of 0.38, and the slope of the <i>S</i> vs. <i>P</i>/<i>P</i><sub>50</sub> (<i>P</i> is partial oxygen pressure; <i>P</i><sub>50</sub> is <i>P</i> at <i>S</i> = 1/2) plot at a <i>P</i>/<i>P</i><sub>50</sub> value of 1 is one-forth that of the Hill-coefficient (<i>n</i>). OECs of mammalian Hbs are designed to have an identical optimal <i>P</i><sub>50</sub> value for O<sub>2</sub> delivery and the effectiveness of the Bohr shift (shift of OEC upon pH changes) at O<sub>2</sub> loading site. This fact is favorable for uptake and delivery of maximum amount of O<sub>2</sub> for fetal blood. To have the identical optimal <i>P</i><sub>50</sub> value for O<sub>2</sub> delivery and for the efficiency of the Bohr shift, the relationship, <i>P</i>aO<sub>2</sub>/<i>P</i>vO<sub>2</sub> = ((<i>n</i> + 1)/(<i>n</i> &minus; 1))<sup>2/n</sup>, is required to hold, where <i>P</i>aO<sub>2</sub> and <i>P</i>vO<sub>2</sub> are <i>P</i> for arterial and venous bloods, respectively.<br>
著者
中垣 俊之 山田 裕康
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.41, no.5, pp.244-246, 2001-09-25
参考文献数
7
被引用文献数
1
著者
金子 智行
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.41, no.6, pp.312-314, 2001-11-01
参考文献数
6
被引用文献数
1
著者
四釜 慶治 松岡 有樹 菅原 芳明
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.41, no.2, pp.74-79, 2001-03-25
被引用文献数
4

The reversible and stable binding of dioxygen to the heme iron (II) is the basis of myoglobin and hemoglobin functions. During reversible oxygen binding, however, the oxygenated form of myoglobin or hemoglobin is oxidized easily to the ferric (III) met-form with generation of the superoxide anion. Thus, stability property of each oxygenated form is of particular importance in vivo, since the iron (III) species cannot bind dioxygen and is therefore physiologically inactive. With special emphasis on the possible roles of the distal histidine, this overview represents a compendium for the molecular mechanism of autoxidation for myoglobin and hemoglobin molecules.
著者
水谷 泰久
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.47, no.5, pp.288-294, 2007-09-25
参考文献数
25
被引用文献数
3 1

In numerous biological processes, the ensuing protein structural changes accompanying a reaction at a specific site must spatially extend to the mesoscopic dimensions of the protein to achieve a biological function. The molecular mechanism of cooperativity in oxygen binding of hemoglobin is one of the classical problems in this aspect. This review describes our recent works on protein dynamics of myoglobin and hemoglobin by using time-resolved resonance Raman spectroscopy.<br>
著者
赤松 友成
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.38, no.4, pp.147-150, 1998-07
参考文献数
8

Dolphins have bio-sonar ability called echoiocation. Clicks, echolocation signals, provide various biological information, such as, species, target range and acoustical survey effort of dolphins. Acoustical measurement is anewly developed method to observe underwater behavior of vocalizing animals.