著者

田村 龍一

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.43, no.9, 2007-09-01

著者

中川 昌子 木内 みどり 小尾 道子 殿塚 雅克 小林 和美 日野 亨 舟越 和久

出版者

公益社団法人日本薬学会

雑誌

CHEMICAL & PHARMACEUTICAL BULLETIN (ISSN:00092363)

巻号頁・発行日

vol.23, no.2, pp.304-312, 1975

被引用文献数

17

---

The reaction of tryptamine with &delta;-valerolactone in tetralin gave &delta;-hydroxyamide (3) as the main product and the lactam (4) as the minor product. However, the reaction of 5, 6-dihydro-2-pyrone with tryptamine or aniline afforded a mixture of the corresponding &alpha;&beta;- and &beta;&gamma;-unsaturated lactams, whereas, 2-pyrone did not react with either tryptamine or aniline to give the corresponding pyridone. Cyclization of 3 or 4 by Bischler-Napieralski reaction and followed NaBH<SUB>4</SUB> reduction provided a convement synthesis of 1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-&alpha;] quinolizine (23).

著者

岡山 松久 杉山 博夫 〓谷 阜子 津田 豊彦 小川 正夫

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.7, no.1, pp.70-71, 1960-03-30

著者

木下 潔

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.34, no.7, 1998-07-01

著者

佐々木 琢磨 新井 祥子 池川 哲郎 千原 呉郎 福岡 文子

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.19, no.4, pp.821-826, 1971-04-25 (Released:2008-03-31)

被引用文献数

24 39

---

Antitumor polysaccharide preparations G-Z and P-Z were fractionated from the water soluble extracts of Ganoderma applanatum (PERS.) PAT and Phellinus linteus (BERK. et CURT) AOSHIMA, basidiomycetes of Polyporaceae, respectively, by fractional precipitation with ethanol and cetyltrimethylammonium hydroxide. The structures of G-Z and P-Z consist of β-(1→3), (1→4) linked D-glucose residue, and β-(1→3) linked D-glucose residue, respectively. These polysaccharide preparations have marked antitumor activity against transplanted sarcoma 180 in mice, and a complete regression of tumors was observed in more than half of animals with no sign of toxicity. Some derivatives of P-Z were synthesized and their antitumor effects were also examined.

著者

Hideyuki Konishi Fumika Hoshino Kei Manabe

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.64, no.10, pp.1438-1441, 2016-10-01 (Released:2016-10-01)

参考文献数

35

被引用文献数

13

---

We have developed a safe and practical synthetic method for preparing axially chiral diphenyl dicarboxylates using Pd-catalyzed external-CO-free carbonylation with phenyl formate as a CO surrogate. Optimized conditions consisted of axially chiral [1,1′-binaphthalene]-2,2′-diyl ditriflate and its congeners, each easily prepared from commercially available enantiomerically pure diols, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane, ethyldiisopropylamine, and no solvent. To demonstrate the potential utility of these products, this method was conducted on gram-scale and the phenyl ester products were converted to other useful compounds, and both processes were carried out without difficulty.

著者

久万 楽也

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.11, no.2, pp.126-127, 1965-06-30

著者

浮島 美之 成田 弘子 増井 俊夫 杉井 邦好 鈴木 由利子 奈良 正人

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.30, no.4, pp.216-221, 1984-08-31

---

The sale of escolar (Lepidocybium flavobrunneum) and castor oil fish (Ruvettus pretiosus) is prohibited in Japan, because their muscles are rich in wax which may cause a food poisoning. The identification of these fishes was therefore investigated by wax analysis. The analytical procedure was as follows : lipids were extracted from fish meats, and the presence of wax in the lipids was examined by thin-layer chromatography (TLC). The compositions of these waxes were examined by gas chromatography with FID (FID-GC). In order to investigate the composition of higher alcohols included in the waxes, the lipids separated from fishes were saponified and the extracted unsaponifiable matters were subjected to FID-GC after acetylation. The results obtained from the analysis on 28 fish species showed that the lipids of john dory (Zeus faber) in addition to escolar and castor oil fish contained wax. The gas chromtogram of waxes showed that the molecular formular of waxes of escolar and castor oil fish were C_<34>H_<66>O_2,whereas that of john dory was C_<40>H_<76>O_2 as their main ingredient. Furthermore, it was shown that the alcohols of escolar and castor oil fish were of C 16 : 0,whereas that of john dory was of C 22 : 1 as their main ingredient. These results indicate that it is possible to distinguish sale-prohibited fishes from edible fishes by wax analysis, even if they are sliced.

著者

朝比奈

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.319, pp.934-935, 1908-09-26

著者

Jung-Sub Shin Hee-Won Park Gyo In Hyun Kyu Seo Tae Hyung Won Kyoung Hwa Jang Byung-Goo Cho Chang Kyun Han Jongheon Shin

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

pp.c16-00240, (Released:2016-07-05)

参考文献数

17

被引用文献数

14

---

Panax ginseng C.A. Meyer is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination of four- and six-year-old red ginseng using ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed clear discrimination between extracts of red ginseng of different ages and suggest totally six discrimination markers (two for four-year-old and four for six-year-old red ginseng). Among these, one marker was isolated and the structure determined by NMR spectroscopic analysis was 13-cis-docosenamide (marker 6-1) from six-year-old red ginseng. This is the first report of a metabolomic study regarding the age differentiation of red ginseng using UPLC-QToF-MS and determination of the structure of the marker. These results will contribute to the quality control and standardization as well as provide a scientific basis for pharmacological research on red ginseng.

著者

迫 和博

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.37, no.5, pp.403-405, 2001-05-01

著者

畝山 寿之 竹内 孝治

出版者

公益社団法人日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.12, pp.1675-1676, 2011 (Released:2011-12-01)

参考文献数

8

著者

村上 隆 佐野 元治

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.16, no.11, pp.1087-1092, 1980-11-01

---

"プロパー"と言えば, 薬の売り込み要員としての印象が強かった.開業医さんのもろもろの御用聞きやゴルフのお相手なども仕事の大事な部分であった.今や, 医薬品の有効性・安全性の確保の第一線におけるにない手として, "医薬情報担当者"という名に変った.西ドイツにおいてはその資格化が行われた.現在わが国では, このような業務にたずさわる薬学出身者は全体の25%を占めるにすぎない.本来このような仕事は, 薬学領域の中で極めて重要な位置にあること, それにふさわしい人材を養成することは薬学の使命であることなどをよく考えてみたい.

著者

塚本 佐知子

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.31, no.12, 1995-12-01

著者

小川 和男 寺田 忠史 本那 隆次

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.32, no.3, pp.930-939, 1984-03-25

---

As a part of our search for new potent analgesic agents, novel fused pyrazole derivatives were synthesized. The reaction of 2-substituted-5-hydroxypyrazole (I) with ethyl 2-substituted (for example COCH_3 or CO_2C_2H_5) acylacetates (II) gave mainly pyrazolo [1,2-a] pyrazole-1,5 (1H, 5H)-diones (III). On the other hand, similar reaction of I with diethyl benzoylmalonate gave mainly pyrazolo [5,1-b] [1,3] oxazin-5 (5H)-one (V) but did not give III at all. Thermal and photochemical isomerization of III gave V. Methanolysis of IIIa in the presence of LiOH occurred with retention of the 4-ethoxycarbonyl-5-pyrazolone ring and similar products (VIa and VIf) were obtained by methanolysis of Va and Vf, respectively. Analgesic activities of the present new compounds were all inferior to that of aminopyrine.

著者

木村 雄四郎 滝戸 道夫 中野 紘一 滝下 満之

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.86, no.12, pp.1184-1186, 1966-12-25

被引用文献数

1

---

From the petroleum ether extracts of rhizomate of Alpinia speciosa K. SCHUMANN and A. kumatake MAKINO (A. formosana K. SCHUMANN), dihydro-5,6-dehydrokawain (I) and 5,6-dehydrokawain (II) were isolated. The latter was isolated for the first time from Zingiberaceae plants and the former, from a natural source.

著者

佐藤 純

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.41, no.3, pp.226-228, 2005-03-01

著者

小林 正

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.31, no.3, pp.156-170, 1985-06-30

被引用文献数

4

---

It is well known that the antirachitic activity of sunlight is due to the photochemical conversion of 7-dehydrocholesterol as provitamin D_3 to vitamin D_3 via previtamin D_3 in skin exposed to ultraviolet rays in sunlight (Dorno ray). On the other hand, it is documented that the major circulating metabolite of vitamin D in the plasma is 25-hydroxyvitamin D (25-OH-D) of which concentration directly reflects the repletion status of vitamin D nutrition. Therefore, we assayed the concentrations of 25-OH-D_2 and 25-OH-D_3 in the plasma samples obtained from about 1000 subjects including adults, mothers, infants and children. The mean and standard deviation of the assayed values of endogenous 25-OH-D_3 in the plasma of healthy adults was 23.0±10.1 ng/ml, which clearly showed the seasonal variation that the levels in summer were significantly higher than those in winter. On the other hand, the levels of mothers were about two times higher than the respective data of newborn infants and there was a highly significant correlation between mothers and newborns. On the basis of these data, the nutritional problems of vitamin D are discussed in this review.

著者

平塚 祥子 熊野 宏昭 片山 潤 岸川 幸生 菱沼 隆則 山内 祐一 水柿 道直

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.120, no.2, pp.224-229, 2000-02-01

被引用文献数

1

---

The failure of patients to comply with treatment regimens recommended by their physicians is a significant clinical problem. Researches on the assessment of compliance have, however, been precluded by methodological difficulties such as lack of adequate measures. The purpose of this study was to develop a self-administered questionnaire to evaluate drug compliance. First, questionnaire containing a 52-items complied by two doctors, a pharmacist and a nurse, was tested on 81 outpatients, all volunteers, attending the departments of psychosomatic medicine and internal medicine. Four items were temporarily removed for later analysis because they directly inquired about drug compliance (drug compliance items). The other 48 items were analyzed and three factors consisting of 26 items were further studied : expectation on taking medicine, rejection to taking medicine and seeking knowledge of drugs. Chronback's alpha coefficients representing internal consistency of the three factors were sufficiently high (ranging from .75 to .84). Furthermore, we preformed a simplified pill count to validate the 4 drug compliance items. There was a weak to moderate correlation between the result of pill count and each of 4 drug compliance items. A new self-administered questionnaire of 30 items was thus developed and named the Drug Compliance Scale.

著者

青山 豊彦 塩入 孝之

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 = Journal of the Pharmaceutical Society of Japan (ISSN:00316903)

巻号頁・発行日

vol.115, no.6, pp.446-459, 1995-06-25

参考文献数

22

被引用文献数

5

---

Tilivalline (1a), a metabolite isolated from Klebsiella pneumoniae var. oxytoca, belongs to a group of pyrrolo [2, 1-c] [1, 4] benzodiazepines, a characteristic skeleton of anthramycin-type antitumor antibiotics. We have accomplished a completely stereoselective, efficient and convenient synthesis of 1a utilizing a new Mannich type intramolecular cyclization as a key step. Further, a computational chemical analysis clarified the effect of zinc chloride on the high stereoselectivity in the tilivalline synthesis. To aim both the extension of the scope of the new Mannich type intramolecular cyclization and the studies on the structure-biological activity relationship, we further extended the method to the synthesis of tilivalline derivatives and 2-(3'-indolyl)-1, 4-benzodiazepines (50). Investigation on the cytotoxicity of 1a and its analogs has revealed that 1a shows the strong cytotoxicity toward mouse leukemia L 1210 cells and the replacement of the indole function of 1a with cyano one increases the cytotoxicity of 1a about 100 times (IC<SUB>50</SUB>=0.05 &mu;g/ml).