著者

辻 勉

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.45, no.6, 2009-06-01

著者

蜂須賀 暁子

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.47, no.7, pp.672-677, 2011-07-01

著者

小林 哲幸

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.47, no.4, pp.317-321, 2011-04-01

著者

大野 勝行

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.192, pp.95-118, 1898-02-26

被引用文献数

1

著者

Hiroshi Fukasawa Madoka Nakagomi Naoko Yamagata Hiroshi Katsuki Kohichi Kawahara Kazuyoshi Kitaoka Takami Miki Koichi Shudo

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.8, pp.1206-1212, 2012-08-01 (Released:2012-08-01)

参考文献数

69

被引用文献数

17 75

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Tamibarotene (Am80), a synthetic retinoid approved in Japan for treatment of acute promyelocytic leukemia (APL), is a retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. Am80 is considered to be a promising candidate drug for treatment of Alzheimer’s disease (AD) because of its transcriptional controls of multiple target genes involved in etiology and pathology of AD. In APP23 AD model mice, administration of Am80 decreased the deposition of insoluble amyloid-β(42). In senescence-accelerated mice (SAMP8), Am80 ameliorated the decrease of cortical acetylcholine, as well as reducing anxiety in behavioral tests and improving the sleep deficit. Am80 also effected a significant improvement of memory in the rat scopolamine-induced memory deficit model. Like other retinoids, Am80 also has an immunomodulatory effect and reduces secretion of proinflammatory cytokines and chemokines by astrocytes and microglia surrounding amyloid-β plaques. In a rat experimental autoimmune encephalomyelitis model, Am80 reduced inflammatory cytokines and showed significant efficacy. Retinoids also promote differentiation of neural stem cells, and Am80 improved the recovery of spinal cord-injured rats. Am80 may also improve vascular factors involved in onset and/or progression of AD. Am80 has been in clinical use for treatment of APL in Japan since 2005, and has been reported to have fewer side effects than other retinoids. We have recently started a clinical study to evaluate the efficacy and safety of Am80 for the treatment of Alzheimer’s disease.

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.306, pp.928-929, 1907-08-26

著者

林 信一

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.10, no.9, 1974-09-15

著者

三橋 博 佐々木 希吉 清水 譲

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.11, no.11, pp.1452-1455, 1963-11-25

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The whole plant of Perugularia extensa N. E. Br. was proved to contain a glycoside mixture which showed strong Keller-Kiliani reaction, suggesting the presence of a 2-deoxy-sugars in the sugar part. The sugar fraction obtained by acid hydrolysis was found to contain D-cymarose, D-sarmentose, L-oleandrose, and D-glucose by a paper chromatographic comparison with authentic specimens. Uzarigenin and a new glycoside (m.p. 244〜248°) were found.

著者

Noriaki Nagai Atsushi Takeda Yuri Itanami Yoshimasa Ito

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.12, pp.2230-2237, 2012-12-01 (Released:2012-12-01)

参考文献数

42

被引用文献数

3 8

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Non-steroidal anti-inflammatory drugs (NSAIDs) comprise one of the most frequently used classes of medicines in the world; however, NSAIDs have significant side effects, such as gastroenteropathy, and rheumatoid arthritis patients taking NSAIDs are more susceptible to NSAID-induced gastric lesions as compared to patients with other diseases. In Asian countries, loxoprofen has been used clinically for many years as a standard NSAID. We demonstrate the preventive effect of the co-administration of water containing magnesium ion (magnesium water, 1–200 µg/kg) on the ulcerogenic response to loxoprofen in adjuvant-induced arthritis (AA) rats. Oral administration of loxoprofen (100 mg/kg) caused hemorrhagic lesions in the gastric mucosa of AA rats 14 d after adjuvant injection, and, following loxoprofen administration, the lesion score of AA rats was significantly higher than that of normal rats. The expression of inducible nitric oxide synthase (iNOS) mRNA and nitric oxide (NO) production in the gastric mucosa of AA rats were also increased by the administration of loxoprofen, and the increase in lesions and NO were prevented by the administration of aminoguanidine, an iNOS inhibitor. The co-administration of magnesium water decreased the ulcerogenic response to loxoprofen in AA rats. In addition, the co-administration of magnesium water attenuated the increase in iNOS mRNA expression and NO production in AA rats receiving loxoprofen. These results suggest that the oral co-administration of magnesium water to AA rats has a potent preventive effect on the ulcerogenic response to loxoprofen, probably by inhibiting the rise in iNOS and NO levels in the gastric mucosa.

著者

寒川 裕士

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.20, no.3, pp.237-241, 1984-03-01

著者

Takayoshi Mamiya Takamasa Asanuma Mitsuo Kise Yukihiko Ito Aya Mizukuchi Hiromichi Aoto Makoto Ukai

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.27, no.7, pp.1041-1045, 2004 (Released:2004-07-10)

参考文献数

21

被引用文献数

30 44

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We evaluated the effects of pre-germinated brown rice (hatsuga genmai, PGR) on learning and memory and compared them with those of polished rice or cornstarch. In mice that were fed pellets of polished rice or PGR for two weeks, the learning ability in the Morris water maze test was significantly enhanced compared with mice that were fed cornstarch pellets. In the Y-maze test, the intake of food pellets for two weeks failed to affect spontaneous alternation behavior. β-Amyloid25—35 (Aβ25—35: 3 nmol/mouse, i.c.v.) protein impaired spontaneous alternation behavior in mice that were fed pellets of cornstarch or polished rice. In contrast, PGR pellets prevented the Aβ25—35-induced impairment of spontaneous alternation behavior. These results suggest that polished rice and PGR have facilitating effects on spatial learning. In particular, it is surmised that PGR may prevent Alzheimer's disease associated with Aβ.

著者

大野 乾 大野 翠

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.24, no.6, pp.555-560, 1988-06-01

著者

門伝 亀久郎

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.12, no.6, pp.331-334, 1967

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The ethanol content in blood was determined by gas-liquid chromatography using solid sampler and hydrogen flame ionizing detector. To 1 ml of blood specimen, 1∼2 mg of isopropyl alcohol was accurately added as an internal standard, and about 0.1 ml of the mixture was applied to gas chromatograph equipped with a column containing 5% glycerol coated on Celite 545. Calibration of ethanol content was performed by comparing the peak area of ethanol with that of internal standard. Recovery was almost quantitative. Change of ethanol content in blood was determined by this method and Conway method, and the results were compared.

著者

Shigeyuki Ohta Sayaka Sakaguchi Yuki Kobayashi Norikazu Mizuno Kenji Tago Hiroshi Itoh

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.38, no.4, pp.594-600, 2015-04-01 (Released:2015-04-01)

参考文献数

26

被引用文献数

1 24

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GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) and is highly expressed in parts of tumor cells. The involvement of GPR56 in tumorigenesis has been reported. We generated agonistic monoclonal antibodies against human GPR56 and analyzed the action and signaling pathway of GPR56. The antibodies inhibited cell migration through the Gq and Rho pathway in human glioma U87-MG cells. Co-immunoprecipitation analysis indicated that the interaction between the GPR56 extracellular domain and transmembrane domain was potentiated by agonistic antibodies. These results demonstrated that functional antibodies are invaluable tools for GPCR research and should open a new avenue for therapeutic treatment of tumors.

著者

兒島

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.155, pp.21-22, 1895-01-26

著者

Manabu Murakami Hidetoshi Niwa Tetsuya Kushikata Hiroyuki Watanabe Kazuyoshi Hirota Kyoichi Ono Takayoshi Ohba

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.37, no.5, pp.834-839, 2014-05-01 (Released:2014-05-01)

参考文献数

20

被引用文献数

7 34

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The effects of inhalation anesthesia (2% isoflurane, sevoflurane, or enflurane) and intraperitoneal anesthesia with pentobarbital (65 mg/kg) were compared in rats using an electrocardiogram (ECG) and determination of blood oxygen saturation (SPO2) levels. Following inhalation anesthesia, heart rate (HR) and SPO2 were acceptable while pentobarbital anesthesia decreased HR and SPO2 significantly. This indicates that inhalation anesthesia is more preferable than pentobarbital anesthesia when evaluating cardiovascular factors. Additionally, pentobarbital significantly increased HR variability (HRV), suggesting a regulatory effect of pentobarbital on the autonomic nervous system, and resulted in a decreased response of the baro-reflex system. Propranolol or atropine had limited effects on ECG recording following pentobarbital anesthesia. Taken together, these data suggest that inhalation anesthesia is suitable for conducting hemodynamic analyses in the rat.

著者

久田 末雄 安野 爽子 稲垣 勲

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.91, no.6, pp.687-689, 1971-06-25

被引用文献数

1

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Rhizomes of Dryopteris bissetiana C. CHR. (Aspidiaceae) were examined for phloroglucinol derivatives and margaspidin was isolated. This is the first time that margaspidin was isolated from Japanese ferns. Margaspidin was also detected by thin-layer chromatography from the rhizomes of D. pacifica TAGAWA, D. saxifraga H. ITO, and D. sacrosancta KOIDZ.

著者

上田 亨

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.14, no.4, 1978-04-01

著者

狐塚 寛

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.115, no.3, pp.157-169, 1995-03-25

被引用文献数

8

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"Toxicology"includes a broad range of application such as environmental, clinical and forensic toxicology. These several kinds of applied toxicology forms a mutually connected ring. This ring is supported by a column called as deductive and detective analysis by the author."Deductive toxicology"is a way of thinking to solve toxicological problems more multidimensionally. In this paper, an application of this way to the study of bone lesions observed in Itai-itai diseased patients is described. In cultured embryonic chick bone, both cadmium and copper induced an atrophic change of the osseous tissue. However, zinc induced an osteomalacic change as a result of strong inhibition of calcification. These histological changes were supported by investigation using a culture system of osteoblastic MC3T3-E1 cells. Cadmium stimulated bone resorption in a neonatal parietal bone. In addition, cadmium stimulated the formation of osteoclast-like cells in bone marrow cell culture. It is thus suggested that cadmium and copper are factors of osteoporosis whereas zinc is a factor of osteomalacia when they directly act on bone tissues. A simultaneous exposure of cadmium and zinc to cultured bones resulted in an osteomalacic change with or without inhibition of bone matrix formation. Copper caused an atrophic change in the absence or the presence of zinc. A combination of cadmium and copper induced a severe damage of osteoblasts and osteogenic mesenchymal cells. These results suggested that an interactive exhibition of heavy metal toxicity can cause various bone lesions such as osteomalacia, osteoporosis and osteoporomalacia. The idea that heavy metals can directly act on bone tissues and their interaction can induce various histological changes in the tissue will help an understanding of bone lesions in Itai-itai disease.

著者

関谷 剛男

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.26, no.3, pp.209-212, 1990-03-01