著者
小谷 広子 阪下 裕子 林 和加子 吉田 君子 松田 実 植松 邦夫
出版者
特定非営利活動法人日本臨床細胞学会
雑誌
日本臨床細胞学会雑誌 (ISSN:03871193)
巻号頁・発行日
vol.19, no.2, pp.226-230, 1980-04-25
被引用文献数
1

A case of mesothelioma of the peritoneum with asbestosis of the lung was reported. Cytological examination of the peritoneal effusion was performed in this case, which was histologically diagnosed to have malignant mesothelioma. Characteristic findings of malignant cells are as follows: Tumor ceils appeared singly or as groups consisting of a few〜 many cells. Some of these cells were overlapping each other. The cytoplasm was abundant and its perinuclear area was staind lightly pale or sometimes appeared to be eosinophilic, with a gradual transition to a deep stain at the periphery. Cytoplasmic rims were distinct and sometimes blister-like protrusions appeared after application of the Giemsa' stain. Nuclei were round or oval and mainly central in location. Their borders were smooth. The chromatin content was increased and chromatin was finely granular with occasional prominent clumps of chromatin. There could be seen 1〜4 small nucleoli and, sometimes, 1〜2 large irregular-shaped nucleoli. Single tumor cells were large and often multinucleated. Mitoses occured in a small number of tumor cells. Thick strand-like, dark clumping or finely granular PAS-positive substances were irregularly distributed in the cytoplasm, sometimes the whole of the cytoplasm was stained as a ring. Vacuolated cytoplasm gave a negative reaction to staining. Vacuolated cytoplasm and a part of the cytoplasmic border were stained positive by alcian blue staining.
著者
秋保 信彦 遠藤 希之 井沢 路世 熊谷 勝政 長嶋 真紀 武山 淳二 八重樫 弘 渡辺 みか 森谷 卓也
出版者
特定非営利活動法人日本臨床細胞学会
雑誌
日本臨床細胞学会雑誌 (ISSN:03871193)
巻号頁・発行日
vol.46, no.6, pp.323-331, 2007-11-22
参考文献数
30
被引用文献数
2 4

目的:乳腺における「細胞診および針生検の報告様式(日本乳癌学会)」に従った細胞診成績を導入前と比較し,導入の意義を検討した.方法:15470検体を新報告様式導入前後で2期に区分し,(1)診断区分ごとの比率,(2)新報告様式の数値目標,(3)英国乳腺スクリーニング基準(QA)による感度・特異度などの係数,を比較検討し,(4)癌例において,細胞診で初回に悪性判定できなかった症例の診断確定までの追跡を行った.成績,(1)新報告様式導入により悪性疑い症例の比率が増加し,検体不適正率・鑑別困難率が低下した.(2)新報告様式の目標値では悪性疑い症例中のがん症例の割合と,(3)QAの基準値では偽陰性率(Fls-)が,導入前後を通じ目標に到達しなかった.(4)診断確定のための追加検査のうち,再度の細胞診で悪性判定されたのは18.5%だった.結論:数値変化の原因として,新報告様式の導入効果(組織型推定と根拠となる細胞所見の記載・臨床への判定理由フィードバック)が考えられた.新報告様式の数値目標は精度管理上有益で,QAや文献データとの比較が可能となった.