著者

木村芥舟 著

出版者

交詢社

巻号頁・発行日

1892

著者

Jun SATO Yasuhito YAMAMOTO Tsuneaki NAKAMURA Shigeru ISHIDA Yutaka TAKAGI

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.30, no.4, pp.339-347, 2005 (Released:2006-01-11)

参考文献数

14

被引用文献数

3 3

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We evaluated the toxicity of tetradecanoic acid methyl ester sodium salt (C14-MES), a major component of fabric detergents, following the test guidelines of the Organization for Economic Cooperation and Development. The rat acute oral LD50 was 1,000 mg/kg in males and 500 mg/kg in females. Applying the combined repeated dose and reproductive/developmental toxicity screening test (ReproTox), we exposed groups of Crj:CD (SD) IGS rats to C14-MES in the diet at concentrations of 0, 0.3, 0.6, or 1.2%. We observed decreases in fibrinogen levels and longer prothrombin time at the 1.2% treated level in females and decreases in serum triglyceride levels in both sexes at the 0.6% and 1.2% treatment levels, but the effects were not clinically significant. The no-observed-effect-level (NOEL) for repeated dose toxicity was 0.3% (175 mg/kg body weight/day for males, 249 for females). The NOEL for reproduction/developmental toxicity was 1.2% (740 mg/kg for males, 1039 for females). C14-MES was negative in the reverse gene mutation assay and the chromosomal aberration test and did not induce skin sensitization in the guinea pig maximization test. These data confirm that C14-MES is of low hazard potential.

著者

Toshiharu TAKEI Hiroshi ODAKE Kazuaki MIURA Yutaka TAKAGI

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.55, no.3, pp.121-126, 2006 (Released:2006-02-11)

参考文献数

21

被引用文献数

3 4

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This paper reports the ecotoxicological study of “tetradecanoic acid, 2-sulfo-, 1-methylester, sodium salt (C14MES)”. This salt was synthesized by sulfonating 1-methyl tetradecanoic acid derived from palm oil and coconut oil with sulfur trioxide. The tests were attempted in accordance with the OECD (Organization for Economic Cooperation and Development) Guidelines for the Testing of Chemicals. The 72 h ErC50 exceeded 100 mg/L in the alga growth inhibition test. In the daphnia acute immobilization and reproduction tests, 17.2 mg/L of 48 h EC50 and 4.10 mg/L of NOEC were derived, respectively. These ecotoxicities of C14MES were equivalent to or lower than that of other similar anionic surfactants, such as LAS (linear alkylbenzene sulfonate) or AOS (alpha olefin sulfonate).

著者

榊原 正幸 上原 誠一郎

出版者

一般社団法人 日本鉱物科学会

雑誌

岩石鉱物科学 (ISSN:1345630X)

巻号頁・発行日

vol.35, no.1, pp.3-10, 2006 (Released:2006-03-01)

参考文献数

29

被引用文献数

2 1

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The term asbestos is a generic designation given to six types of naturally occurring mineral fibers that are or have been used in commercial products. These fibers belong to two mineral groups: serpentines and amphiboles. The serpentine group contains a single asbestiform variety: chrysotile. The amphibole group contains five asbestiform amphibole varieties: anthophyllite, grunerite (amosite), riebeckite (crocidolite), tremolite and actinolite.     These fibrous minerals share several properties which qualify them as asbestiform fibers. They are bundles of fibers which can be easily cleaved into thinner fibers. Several properties that make asbestos so versatile and cost effective are high tensile strength, chemical and thermal stability, high flexibility, and low electrical conductivity.     Asbestos fibers have been used in a broad variety of industrial application; some 3000 applications such as roofing products, gaskets, and friction products. 80% of imported asbestos is used for cement products such as asbestos boards and slates which are used for building materials, 7% for friction materials, and less than 3% for asbestos textile. Nearly all of the asbestos produced worldwide is chrysotile. Historically, chrysotile has accounted for more than 90% of the world’s asbestos production, and it presently accounts for over 99% of the world production. Two types of amphiboles, commonly designated as amosite and crocidolite are no longer mined. With the onset of the health issues concerning asbestos in the late 1960s and early 1970s, world production and consumption began to decline during the 1980s. Japan used approximately 6.7 million tons between 1974 and 2004. About 67% of this amount was used since 1930.     The relationship between workplace exposure to airborne asbestos fibers and respiratory diseases is one of the most widely studied subjects of modern epidemiology. The research efforts resulted in significant consensus that asbestos fibers can be associated with diseases of asbestosis, lung cancer and mesothelioma. Its carcinogenic nature, an overall lack of knowledge of minimum safe exposure levels, and the long latency for the development of lung cancer and mesothelioma are the main contributing factors to these controversies.

著者

逸見 勝亮

出版者

教育史学会

雑誌

日本の教育史学:教育史学紀要 (ISSN:03868982)

巻号頁・発行日

vol.33, pp.112-132, 1990-10-27