著者

Ishitsuka Yosuke Kawachi Yasuhiro Taguchi Shijima Maruyama Hiroshi Fujisawa Yasuhiro Furuta Junichi Nakamura Yasuhiro Otsuka Fujio

出版者

Nature Publishing Group

雑誌

Journal of investigative dermatology (ISSN:0022202X)

巻号頁・発行日

vol.132, no.7, pp.1775-1784, 2012-07

被引用文献数

14 4

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The epidermis is a self-renewing tissue, the homeostasis of which is dependent upon the tight balance between proliferation and differentiation based on appropriate regulation of the cell cycle. The cell cycle regulation is dependent on the interactions among a number of cell cycle regulatory molecules, including the pituitary tumor-transforming gene 1 (PTTG1), also known as securin, a regulator of sister chromatid separation and transition from metaphase to anaphase. This study was conducted to clarify the less-known functions of PTTG1 in the epidermis by the use of keratinocytes cultured under two-dimensional (2D) or three-dimensional (3D) conditions. Forced overexpression of PTTG1 caused upregulation of cyclin B1, cyclin-dependent kinase 1 (CDK1), and c-Myc, resulting in enhanced proliferation and suppression of early differentiation without apparent alterations in terminal differentiation, and the exogenous PTTG1 was downregulated in association with cell cycle exit. In contrast, depletion of PTTG1 caused their downregulation and constrained proliferation with retention of differentiation capacity. These findings suggested that PTTG1 could alter the proliferation status by modulating the expression levels of the other cell cycle regulatory proteins, and excess PTTG1 primarily affects early differentiation of keratinocytes under the stability regulation associated with cell cycle exit.

著者

鈴木 弘之

巻号頁・発行日

2011

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科学研究費補助金研究成果報告書:基盤研究(A)2008-2010

著者

Hayashi Hitoshi Wang Aohan Kawabata Kohsuke Goto Hiromasa

出版者

Elsevier

雑誌

Materials chemistry and physics (ISSN:02540584)

巻号頁・発行日

vol.137, no.3, pp.816-824, 2013-01

被引用文献数

11

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A series of chiral three-ring type compounds with rigid shape was employed as chiral inducers for induction of chiral cholesteric liquid crystal (cholesteric LC) from achiral nematic LC. Helical twisting power of the chiral compounds was estimated with the Cano wedge method. Cholesteric LC electrolyte solution was prepared by adding the chiral compounds. Subsequently, polymerization in the cholesteric LC was carried out to produce chiroptically active polymer films. This method is different from conventional methods for synthesizing chiral polymers because neither chiral monomers nor asymmetric catalysts are employed. Surface structure and optical properties of the polymer thus prepared were examined.

著者

高野 晋吾

巻号頁・発行日

2012

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011

著者

Ogasawara Yui Murai Yuta Sakihama Yasuko Hashidoko Yasuyuki Hashimoto Makoto

出版者

Japan Institute of Heterocyclic Chemistry

雑誌

Heterocycles (ISSN:03855414)

巻号頁・発行日

vol.86, no.1, pp.735-743, 2012-12-31

被引用文献数

1

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The click reaction is one of the latest techniques for the chemical modification of bioactive compounds. Chemical modifications of α-amino acid side chains are gaining significance as useful and important tools for biochemical research. Biotinylation at side chain of propargylglycine using click reaction was examined. The detail quantitative analysis of Cu(I) concentration are performed to proceed the click reaction effectively.

著者

山口 廸彦

出版者

[出版者不明]

巻号頁・発行日

2007-01

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制度:新 ; 文部省報告番号:甲2359号 ; 学位の種類:博士(学術) ; 授与年月日:2007/2/8 ; 早大学位記番号:新4432

著者

Nakahara Shinji Ichikawa Masao

出版者

日本疫学会

雑誌

Journal of epidemiology (ISSN:09175040)

巻号頁・発行日

vol.23, no.1, pp.70-73, 2013-01

被引用文献数

50

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Introduction: On 11 March 2011, a magnitude 9.0 earthquake caused a huge tsunami that struck Northeast Japan, resulting in nearly 20 000 deaths. We investigated mortality patterns by age, sex, and region in the 3 most severely affected prefectures.Methods: Using police data on earthquake victims in Iwate, Miyagi, and Fukushima prefectures, mortality rates by sex, age group, and region were calculated, and regional variability in mortality rates across age groups was compared using rate ratios (RRs), with the rates in Iwate as the reference.Results: In all regions, age-specific mortality showed a tendency to increase with age; there were no sex differences. Among residents of Iwate, mortality was markedly lower among school-aged children as compared with other age groups. In northern Miyagi and the southern part of the study area, RRs were higher among school-aged children than among other age groups.Conclusions: The present study could not address the reasons for the observed mortality patterns and regional differences. To improve preparedness policies, future research should investigate the reasons for regional differences.

著者

安永 守利

巻号頁・発行日

2012

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011

著者

佐野 伸行

巻号頁・発行日

2012

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011

著者

内山 洋司

巻号頁・発行日

2012

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011

著者

Kim Junghoon Tanabe Kai Yoshizawa Yasuyo Yokoyama Noriko Suga Yoko Kuno Shinya

出版者

Tohoku University Medical Press

雑誌

Tohoku journal of experimental medicine (ISSN:00408727)

巻号頁・発行日

vol.229, no.1, pp.11-17, 2013

被引用文献数

25 5

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Regular physical activity is associated with improvements of metabolic syndrome (MetS) risk factors. Furthermore, recent physical activity guidelines for health promotion recommend that moderate to vigorous physical activity should be performed in bouts lasting ≥ 10 min. Brisk walking is a popular and readily attainable form of moderate intensity physical activity and is suitable for the majority of individuals. However, it is unclear whether brisk walking lasting ≥ 10 min is associated with improvement in MetS. This study aimed to determine the effects of a 1-year lifestyle-based physical activity intervention with brisk walking of ≥ 10 min using a pedometer on the improvement in MetS. Three hundred and seventy-six overweight male employees with ≥ 1 MetS component(s) participated in this intervention study from 2008 to 2009 (age, 30-62 years; body mass index, 23.0-45.5 kg/m2). Overall, 316 participants (84%) completed the 1-year intervention. MetS was defined according to the Japanese criteria at baseline and after 1 year. Brisk walking lasting ≥ 10 min was significantly associated with the decrease in waist circumference (β = −1.479) and triglyceride (β = −31.260), and the increase in high-density lipoprotein cholesterol (β = 2.117). The brisk walking step counts were also significantly associated with higher odds for an improvement in MetS (OR, 1.48; 95% CI, 1.05-2.09) and abdominal obesity (OR, 1.45; 95% CI, 1.12-1.87). In conclusion, the lifestyle-based intervention with brisk walking of ≥ 10 min is an effective strategy to improve MetS in overweight male employees.

著者

Maeda Shinichi Sumiya Satoshi Kasahara Jiro Matsuo Akiko

出版者

Elsevier Inc.

雑誌

Proceedings of the Combustion Institute (ISSN:15407489)

巻号頁・発行日

vol.34, no.2, pp.1973-1980, 2013

被引用文献数

27

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Direct initiations and stabilizations of three-dimensional conical detonation waves were attained by launching spheres with 1.06–1.31 times the C–J velocities into detonable mixtures. We conducted high time-resolution Schlieren visualizations of the whole processes over unsteady initiations to stable propagations of the stabilized Oblique Detonation Waves (ODWs) using a high-speed camera. The detonable mixtures were stoichiometric oxygen mixtures with acetylene, ethylene or hydrogen. They were diluted with argon in a 50% volumetric fraction, and a 75% diluted mixture was also tested for the acetylene/oxygen. The direct initiation of detonation by the projectile and the DDT process like the re-initiation appeared in the initiation process of stabilized ODW. This process eventually led to the stabilized ODW supported by the projectile velocity and the ringed shape detonation wave originating in the re-initiation. We modeled the spatial evolution of stabilized ODW after the re-initiation based on its C–J velocity and angle. The model qualitatively reproduced the measured development rate of stabilized ODW. We also discussed about the detonation stability for the curvature effect arising from the three-dimensional nature of stabilized ODW around the projectile. The curvature effect attenuated the detonation wave below its C–J velocity at the vicinity of projectile. The propagation limits of curvature effect will be responsible for the criticality to attain the stabilized ODWs. By accessing the detailed distributions of propagation velocities and curvature radiuses, the critical curvature radiuses normalized by the cell sizes experimentally revealed to be 8–10 or 15–18 for mixtures diluted with each 50% argon or 75% argon/krypton.

著者

Nagura Yuto Kasahara Jiro Sugiyama Yuta Matsuo Akiko

出版者

Elsevier Inc.

雑誌

Proceedings of the Combustion Institute (ISSN:15407489)

巻号頁・発行日

vol.34, no.2, pp.1949-1956, 2013

被引用文献数

26

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The geometry and characteristic length of diffraction and re-initiation during a two-dimensional detonation propagation were revealed by visualization. C2H4 + 3O2 (unstable), 2C2H2 + 5O2 + 7Ar (stable) and 2C2H2 + 5O2 + 21Ar (stable) were used as the test mixtures. Experiments were performed over the deviation angle range from 30° to 150° and the initial pressure range from 15.8 to 102.3 kPa. By self-emitting photography, we confirmed that the geometry and the characteristic length of diffraction are not different among test gases, with the exception of the fan-like structure of re-initiation that occurred regardless of whether the mixture was unstable or stable. We conducted a compensative experiment by changing the deviation angle and initial pressure, and summarized the detonation diffraction by shadowgraph. At deviation angles larger than 60°, we measured the distances from the vertex of the channel corner to the point where the transverse detonation wave reflected on the under wall (= wall reflection distance) and confirmed that wall reflection distances are approximately in the range of 10–15 times the cell width, whether the mixture is unstable or stable.

著者

Cuong Nguyen Thanh Otani Minoru Okada Susumu

出版者

American Physical Society

雑誌

Physical review B (ISSN:10980121)

巻号頁・発行日

vol.87, no.4, pp.045424, 2013

被引用文献数

14 3

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Based on first-principles total-energy calculations, we studied the energetics and electronic structure of zigzag graphene nanoribbons with nanometer-scale corners. We found that the formation energy of a short zigzag edge with a 120∘ corner is substantially smaller than that of a straight zigzag edge with an infinite length. We also found that zigzag graphene ribbons with 120∘ corners are semiconductors for which the band-gap decreases with increasing length between adjacent corners. The edge state is absent for zigzag graphene ribbons with short corner-corner distances, while the edge state emerges for zigzag ribbons that have a corner-corner distance greater than 1.5 nm. The remarkable stability of the 120∘ corner of the short zigzag edges is in good agreement with the experimental observation of such corners of graphene edges.

著者

Hirata Satoshi Matsuda Goh Ueno Ari Fukushima Hirokata Fuwa Koki Sugama Keiko Kusunoki Kiyo Tomonaga Masaki Hiraki Kazuo Hasegawa Toshikazu

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, 2013-02-26

被引用文献数

14

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チンパンジーも他者の表情を素早く察知 -脳波測定による解明-.京都大学プレスリリース. 2013-02-26.

著者

合田 正毅

出版者

物性研究刊行会

雑誌

物性研究 (ISSN:05272997)

巻号頁・発行日

vol.48, no.2, pp.A53-A55, 1987-05-20

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この論文は国立情報学研究所の電子図書館事業により電子化されました。

著者

山守 伸也 Shinya Yamamori

雑誌

KG社会学批評 : KG Sociological Review (ISSN:21870683)

巻号頁・発行日

no.創刊号, pp.121-129, 2012-03-10

著者

トカチェンコ スヴィトラナ [Ткаченко Свiтлана]

出版者

筑波大学教育制度研究室

雑誌

教育制度研究紀要

巻号頁・発行日

no.7, pp.41-50, 2012-02

著者

Nakayama Hisahiro Kasahara Jiro Matsuo Akiko Funaki Ikkoh

出版者

Elsevier Inc.

雑誌

Proceedings of the Combustion Institute (ISSN:15407489)

巻号頁・発行日

vol.34, no.2, pp.1939-1947, 2013

被引用文献数

61

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The propagation of curved detonation waves of gaseous explosives stabilized in rectangular-cross-section curved channels is investigated. Three types of stoichiometric test gases, C2H4 + 3O2, 2H2 + O2, and 2C2H2 + 5O2 + 7Ar, are evaluated. The ratio of the inner radius of the curved channel (ri) to the normal detonation cell width (λ) is an important factor in stabilizing curved detonation waves. The lower boundary of stabilization is around ri/λ = 23, regardless of the test gas. The stabilized curved detonation waves eventually attain a specific curved shape as they propagate through the curved channels. The specific curved shapes of stabilized curved detonation waves are approximately formulated, and the normal detonation velocity (Dn)−curvature (κ) relations are evaluated. The Dn nondimensionalized by the Chapman–Jouguet (CJ) detonation velocity (DCJ) is a function of the κ nondimensionalized by λ. The Dn/DCJ−λκ relation does not depend on the type of test gas. The propagation behavior of the stabilized curved detonation waves is controlled by the Dn/DCJ−λκ relation. Due to this propagation characteristic, the fully-developed, stabilized curved detonation waves propagate through the curved channels while maintaining a specific curved shape with a constant angular velocity. Self-similarity is seen in the front shock shapes of the stabilized curved detonation waves with the same ri/λ, regardless of the curved channel and test gas.

著者

大野 忠士

巻号頁・発行日

2012

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011