著者
橋本 ゆかり 髙井 舞 中村 衣里 松浦 寿喜
出版者
日本食品化学学会
雑誌
日本食品化学学会誌 (ISSN:13412094)
巻号頁・発行日
vol.23, no.3, pp.113-117, 2016 (Released:2016-12-22)
参考文献数
14
被引用文献数
1

In recent years, many medical institutions have begun using water-soluble dietary fiber (WSDF) as a deglutition aid to improve oral medication compliance. WSDF has been reported to adsorb carbohydrates and lipids, and lower blood levels of glucose and lipids. Thus, dietary fiber could potentially adsorb drugs in a similar manner, thereby decreasing the amount of a drug absorbed and attenuating its efficacy. In the present study, we used the ultrafiltration method to assess the drug adsorption of three types of WSDFs with different physicochemical properties. Each WSDF was incubated with the various drugs in a 37ºC thermostatic bath for 10, 30, 60, 120, 240, and 360 minutes and then subjected to ultrafiltration to elute the unadsorbed drug, which was measured by HPLC. Glucomannan showed higher drug adsorption than the other types of WSDF. The adsorption of atorvastatin calcium hydrate to glucomannan and pectin was about 60%, which showed almost no change from 10 to 360 minutes after the start of incubation. On the other hand, the adsorption to xanthan gum was increased from 22% at 10 minutes to 47% at 360 minutes. The present results demonstrate that there are cases of time-dependent increases in drug adsorption depending on the WSDF and drug combination.
著者
橋本 ゆかり 杉本 陽子 Hashimoto Yukari Sugimoto Youko
出版者
三重大学医学部看護学科
雑誌
三重看護学誌 (ISSN:13446983)
巻号頁・発行日
vol.9, pp.31-40, 2007-03-20
被引用文献数
1

本研究の目的は, 処置前・中・後を通しての他者の関わりによって, 静脈麻酔下で髄腔内注入を受ける小児がんの子どもの認知にどのような変化があったのかを明らかにすることである. 小児がんで小児病棟に入院しており, 髄腔内注入が予定されている 3 ~11 歳の子ども 4 名に対して処置前・中・後を通して介入を行い, 得られたデータを質的に分析し, 以下の結果を得た. 1. 4 事例すべてにおいて, 子どもは眠っている間に何が行われているのかを知らなかったが, 処置前にそのことについての説明を受けたことで, 処置室入室後の麻酔導入までの間, 混乱することなく処置を受け入れていた. また, 処置後の遊ぶ様子や子どもの話から髄注の手順や内容について理解していることがわかった. 2. 4 事例すべてにおいて, 処置中, 子どもは交渉したり好きな遊びに集中したりして自分なりの対処法を選択し, 自分で乗り越えたという気持ちがあった. 3. 幼児 3 例において, 髄注の手順について断片的な理解を示していたが, 処置場面では医療者が助言することで子どもは受けた説明内容を思い出し, 混乱はみられなかった. 4. 3 歳男児は, 処置前や処置中において特に変わった様子はみられなかったが, 処置後の遊びの中で医師役のアンパンマンの手を縛ることで処置を施行できないようにし, 「またされるから」 「怖い」 など, 拒否を示す情緒反応がみられた. We conducted a study with pediatric cancer patients who received intrathecal injection under intravenous anesthesia, with an objective to elucidate how pre-, per-, and post-treatment interventions affect childrens perception of the treatment. Four pediatric cancer patients (age range 3-11 years) who were hospitalized in the pediatric ward and scheduled to receive intrathecal injection underwent pre-, per-, and post-treatment interventions. A qualitative analysis of data revealed the following findings:1. None of the four patients knew what was done to them while they were asleep under anesthesia. Following a pre-treatment intervention that informed them of the treatment, patients showed no sign of confusion in the surgery room before receiving anesthesia. Moreover, post-treatment observation of their activities and conversations suggested their understanding of the treatment and its procedures.2. All four patients chose their own means to cope during the treatment, such as negotiating with the physician or focusing on their favorite activities, and created a feeling that they underwent treatment by themselves.3. Following a pre-treatment intervention that explained procedures, three patients had fragmentary understanding. With help from healthcare professionals during the treatment, these patients were able to recall details of the explanation; they did not show any signs of confusion.4. A three-year-old male patient showed no unusual behavior during pre- or per-treatment observations. During post-treatment playtime, however, he showed emotional responses that suggested refusal of the treatment, such as tying the hands of an Anpanman doll that was in the role of a physician, in order to prevent the toy from giving him the treatment, saying, He will do it again and Im scared.Key Words: childrens perception, pediatric cancer patients, intrathecal injection, intravenous anesthesia
著者
中村 衣里 上田 友佳子 橋本 ゆかり 和田 宏美 松浦 寿喜
出版者
日本食品化学学会
雑誌
日本食品化学学会誌 (ISSN:13412094)
巻号頁・発行日
vol.21, no.3, pp.163-168, 2014-12-24 (Released:2017-01-27)
参考文献数
14
被引用文献数
2

The present study compared differently grades of powdered green tea (matcha) in order to clarify the relationship of matcha grade with their chemical constituents and functionality. The inhibitory effects of matcha on intestinal absorption of sucrose were examined in rats using portal cannulae. The contents of theanine, arginine and glutamic acid showed positive correlations with the quality of matcha. On the other hand, comparison of the catechin contents of differently grades of matcha revealed negative correlations between the quality of matcha and EGC, EC and EGCG content. Functionality was determined based on the duration of glucose absorption inhibition following matcha intake in portal vein-cannulated rats. Comparison between the high quality and low quality of matcha revealed a significantly reduced blood glucose concentration was observed with the low quality matcha as compared with the high quality of matcha, confirming glucose absorption inhibition. In the present study, we have shown that the relationship of quality of matcha with their chemical components and functionality.
著者
木戸 和貴子 吉川 友佳子 中村 衣里 橋本 ゆかり 戸根 瑛美 松浦 寿喜
出版者
日本食品化学学会
雑誌
日本食品化学学会誌 (ISSN:13412094)
巻号頁・発行日
vol.19, no.3, pp.185-190, 2012-12-21 (Released:2017-01-27)
参考文献数
11

The inhibitory effects against hyperglycemia of "alleged health foods" containing mulberry leaves as an ingredient were compared using an experimental model of digestion and absorption in rats. Rats, after gastric and portal venous catheterization, were continuously fed an aqueous sucrose solution by intragastric administration, and portal venous glucose concentrations were maintained at a constant level. The rats were administered either five types of mulberry leaf tea or three types of mulberry leaf granules, and the time period during which the portal venous glucose concentration showed levels significantly lower than baseline, i.e., the duration of the inhibitory effect on hyperglycemia, was compared. The results showed that although all of these health foods demonstrated an inhibitory effect against hyperglycemia, a comparison of the efficacy based on the duration of this inhibitory effect revealed large disparities among the products, of a magnitude of 17-fold among the mulberry leaf teas and 11-fold among the granular mulberry leaf products. This discrepancy in the efficacy of these types of products could not be discerned by analogy based on the label or the ingredients described on the product. Although alleged health foods are ordinary foods, and efficacy is not demanded, a uniform level of quality assurance is necessary, given that the general consumer purchases these products in expectation of a certain level of effect.
著者
齋藤 ひろみ 森 篤嗣 橋本 ゆかり 岩田 一成 菅原 雅枝
出版者
東京学芸大学
雑誌
基盤研究(B)
巻号頁・発行日
2014-04-01

国内でも外国人の児童生徒が増加しているが、日本生まれ日本育ちの子どもの言語発達支援・教育が新たな課題となっている。本研究では、こうした日本生育外国人児童生徒(日本籍の児童も含む)のリテラシーの発達について、作文を書く力に焦点化して調査を行った。外国児童生徒と日本人児童生徒から、出来事作文と意見文作文という2つのジャンルの作文データを収集し、産出量、表記、語彙、文法、内容構成等の観点で分析を行った。その結果、産出量、社会性の表出には日本人児童と同等の発達が見られたが、特殊音表記、文法適格性、結束性、陳述の適確さ・多様さ、論理性にやや遅れが見られ、これらを意識した指導が求められる。
著者
濱田 麻里 市瀬 智紀 上田 崇仁 金田 智子 河野 俊之 齋藤 ひろみ 徳井 厚子 川口 直巳 橋本 ゆかり
出版者
京都教育大学
雑誌
基盤研究(B)
巻号頁・発行日
2010-04-01

本研究は,多言語・多文化化する学校に対応できる教員(以下,多文化教員と呼ぶ)を養成する学部教員と現職教員を対象とする教師教育システムを開発するためのアクション・リサーチである。研究では,海外との比較調査,受講者へのアンケート調査等による実践したプログラムの分析を行った。最終成果として,開発されたプログラムの一部を『実践例集』として公開した。