文献一覧: 波多野力 (著者)

4 0 0 0 OA Candida属真菌に対する各種精油及び精油成分の抗真菌作用,及びAmphotericin Bの抗真菌作用に及ぼす影響

著者: 野崎阿季子高橋栄造岡本敬の介伊東秀之波多野力
出版者: 公益社団法人日本薬学会
雑誌: YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日: vol.130, no.6, pp.895-902, 2010 (Released:2010-06-01)
参考文献数: 9
被引用文献数: 3 5

Candidiasis is a common opportunistic fungal infection that responds well to amphotericin B (AMPH) treatment. However, AMPH often causes adverse effects such as kidney injury and hypokalemia. Because some essential oils have been reported to have antifungal effects, we investigated the antifungal activity of various essential oils and their major constituents against Candida spp. Most essential oils examined in this study showed antifungal activity, and several enhanced the antifungal effect of AMPH. Clove oil in particular, and its major constituent eugenol, had potent effects. These findings suggest that combining certain essential oils or their constituents with AMPH may be useful for suppressing the adverse effects of AMPH treatment.

2017-10-09 00:38:47
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1 0 0 0 タンニン及びフラボノイドによる自動酸化抑制機構(第2報1)) : ヨモギ類のカフェータンニン類によるリポキシゲナーゼ依存脂質過酸化抑制機構

著者: 藤田勇三郎上原郁恵森本泰子中嶋真由美波多野力奥田拓男
出版者: 公益社団法人日本薬学会
雑誌: 藥學雜誌 (ISSN:00316903)
巻号頁・発行日: vol.108, no.2, pp.129-135, 1988
被引用文献数: 38

Inhibitory effects of caffeoylquinic acids isolated from leaves of Artemisia species and other related compounds on the lipoxygenase dependent peroxidation of linoleic acid were studied by kinetic and electron spin resonance(ESR) measurements. The order of inhibition activity was as follows : 3, 5-dicaffeoylquinic acid (ID50=2.0×10-5 M)=rosmarinic acid > geraniin (2.8×10-5 M)>α-tocopherol (3.7×10-5 M)>chlorogenic acid (7.5×10-5 M)=caffeic acid>ferulic acid (2.5×10-4 M). This order coincided well with that obtained from the measurement of radical scavenging activities of these compounds against 1, 1-diphenyl-2-picryl hydrazyl. The inhibition profile of these compounds on lipid peroxidation in the lipoxygenase system was quite similar to those obtained previously in the biological systems of rat liver mitochondria and microsomes. In the separate ESR measurements in alkaline dimethyl sulfoxide solution, all caffeoyl-quinic acids exhibited relatively stable ESR signals assigned as a radical derived from the one-electron oxidation of dihydroxyphenyl group. From these results, it was concluded that the radical scavenging mechanism is commonly operative in both chemical and biological peroxidation systems.

2022-03-13 01:45:07
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1 0 0 0 タンニン及びフラボノイドによる自動酸化抑制機構-2-ヨモギ類のカフェ-タンニン類によるリポキシゲナ-ゼ依存脂質過酸化抑制機構

著者: 藤田勇三郎上原郁恵森本泰子中嶋真由美波多野力奥田拓男
出版者: 公益社団法人日本薬学会
雑誌: 薬学雑誌 (ISSN:00316903)
巻号頁・発行日: vol.108, no.2, pp.p129-135, 1988-02
被引用文献数: 7

Inhibitory effects of caffeoylquinic acids isolated from leaves of Artemisia species and other related compounds on the lipoxygenase dependent peroxidation of linoleic acid were studied by kinetic and electron spin resonance(ESR) measurements. The order of inhibition activity was as follows : 3,5-dicaffeoylquinic acid (ID_50=2.0×10^-5 M)=rosmarinic acid > geraniin (2.8×10^-5 M)>α-tocopherol (3.7×10^-5 M)>chlorogenic acid (7.5×10^-5 M)=caffeic acid>ferulic acid (2.5×10^-4 M). This order coincided well with that obtained from the measurement of radical scavenging activities of these compounds against 1,1-diphenyl-2-picryl hydrazyl. The inhibition profile of these compounds on lipid peroxidation in the lipoxygenase system was quite similar to those obtained previously in the biological systems of rat liver mitochondria and microsomes. In the separate ESR measurements in alkaline dimethyl sulfoxide solution, all caffeoyl-quinic acids exhibited relatively stable ESR signals assigned as a radical derived from the one-electron oxidation of dihydroxyphenyl group. From these results, it was concluded that the radical scavenging mechanism is commonly operative in both chemical and biological peroxidation systems.

2022-03-12 23:15:19
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https://ci.nii.ac.jp/naid/110003648622

1 0 0 0 38 植物中のC-配糖体型タンニンおよび加水分解性タンニンオリゴマーの形成について : フウのタンニンその他(口頭発表の部)

著者: 波多野力貴良礼子安原多恵子奥田拓男
出版者: 天然有機化合物討論会実行委員会
雑誌: 天然有機化合物討論会講演要旨集
巻号頁・発行日: vol.30, pp.292-299, 1988

1)Four new hydrolyzable tannins, liquidambin (3), isorugosin A (12), isorugosin B (9) and isorugosin D (13), were isolated from the leaves of Liquidambar formosana. 2) Liquidambin (3), which could be a biogenetic precursor of C-glucosidic tannins, was isolated as an equilibrium mixture. The equilibration was found to be due to hydration of the aldehyde group at C-1 of the glucose residue in 3. 3) Isorugosin D (13), biogenetically producible from two molecules of tellimagrandin II (17), had a valoneoyl group of the orientation different from that of rugosin D (6). Isorugosins A (12) and B (9), monomeric tannins from the same plant, were isomers of rugosins A (4) and B (5) concerning the orientation of valoneoyl group. 4) Rugosins A (4), B (5) and D (6) were absent in L. formosana, and isorugosins A (12), B (9) and D (13) have not been found in Rosa rugosa and Coriaria japonica, which contain 4, 5 and 6. The C-O oxidative coupling in the formation of valoneoyl group in L. formosana, therefore will have been effected by an enzyme different from that of R. rugosa and C. japonica. 5) Cornusiin A, a major component of the fruits of Cornus officinalis, should be formulated as 19, on the basis of the chemical conversion of 19 to isorugosin B (9). Structures of camptothins A and B, which were isolated from the leaves of Camptotheca acuminata, and that of cornusiin C from the Cornus and Camptotheca species, were determined to be 20, 21 and 22, respectively.

2021-12-03 15:00:35
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1 0 0 0 Studies on the Activities of Tannins and Related Compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

著者: 木村善行奥田拓道奥田拓男吉田隆志波多野力有地滋
出版者: 公益社団法人日本薬学会
雑誌: Chemical & pharmaceutical bulletin (ISSN:00092363)
巻号頁・発行日: vol.31, no.7, pp.2501-2506, 1983-07-25

The effects of various tannins and related compounds on the actions of adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats were investigated. Hydrolyzable tannins such as geraniin, mallotusinic acid, chebulinic acid and chebulagic acid enhanced the ACTH-induced lipolysis at the concentration of 20 μg/ml or 5 μg/ml. On the other hand, these hydrolyzable tannins had no effect on the insulin-stimulated lipogenesis from glucose. Condensed tannins such as Ss-tannin 1 and RSF-tannin H showed weak inhibitory effects on the ACTH-induced lipolysis, while they enhanced the insulin-stimulated lipogenesis from glucose. Based on these results, the relationship between the structures and physiological actions of these tannins is discussed.

2020-08-26 12:47:14
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https://ci.nii.ac.jp/naid/110003624448

1 0 0 0 フウロソウ属およびトウダイグサ科植物からGeraniinの単離

著者: 奥田拓男毛利和子寺山香代子樋口恵子波多野力
出版者: 公益社団法人日本薬学会
雑誌: 藥學雜誌 (ISSN:00316903)
巻号頁・発行日: vol.99, no.5, pp.543-545, 1979
被引用文献数: 10

Geraniin was isolated from herbs of Geranium carolinianum, G. wilfordii, G. wilfordii var. hastatum, G. sibiricum var. glabrius, G. tripartitum, and G. yoshinoi, and also from root bark of Triadica sebifera. The isolations were improved by application of droplet counter-current chromatography. Hyperin was isolated from G. carolinianum, and quercetin from G. yoshinoi.

2020-06-26 12:07:47
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1 0 0 0 フウロソウ属およびトウダイグサ科植物からGeraniinの単離

著者: 奥田拓男毛利和子寺山香代子樋口恵子波多野力
出版者: 公益社団法人日本薬学会
雑誌: 薬学雑誌 (ISSN:00316903)
巻号頁・発行日: vol.99, no.5, pp.p543-545, 1979-05

2015-10-08 19:22:46
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https://ci.nii.ac.jp/naid/110003652995

1 0 0 0 OA 天然ナノ分子タンニン

著者: 吉田隆志波多野力伊東秀之
出版者: 社団法人有機合成化学協会
雑誌: 有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日: vol.62, no.5, pp.500-507, 2004-05-01 (Released:2009-11-13)
参考文献数: 24
被引用文献数: 5 14

Large-size secondary metabolites with dimeric-oligomeric and/or dendrine-type structure from higher plants are regarded as natural nanomolecules which are constructed in a bottom-up pathway from small molecules under biological condition. Among them are polyphenols classified as tannins which have large molecular weights ranging from 500 to 4000, and strong affinity to proteins, alkaloids and heavy metals to form complex molecules (precipitates). They constitute two major groups : one is condensed tannins (proantocyanidins), which are composed of flavan-3-ol units linked through C-C bond, and the other is hydrolyzable tannins, which are principally multiple esters of D-glucose with gallic acid and its oxidative metabolites. This paper reviews the diverse structural characteristics of both tannins, especially ellagitannin oligomers up to pentamers, and examples of their biological activities. Formation of insoluble and soluble complex between tannins and proteins are also described.

2014-05-17 00:30:00
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1 0 0 0 スギヒラタケに含まれる特徴的な長鎖脂肪酸について

著者: 天倉吉章近藤一成穐山浩伊東秀之波多野力吉田隆志米谷民雄
出版者: Japanese Society for Food Hygiene and Safety
雑誌: 食品衛生学雑誌 = Journal of the Food Hygienics Society of Japan (ISSN:00156426)
巻号頁・発行日: vol.47, no.4, pp.178-181, 2006-08-25
被引用文献数: 1 11

キシメジ科スギヒラタケの化学成分に関する研究の一環として,本キノコ中のUV検出成分についてHPLC分析を行った.UV検出による主要ピークの1つを単離したところ,各種分光法の結果に基づき,共役トリエン構造を有するα-エレオステアリン酸であると同定した.α-エレオステアリン酸は,試験した他の8種の食用キノコからは検出されなかったため,スギヒラタケ特有の脂肪酸であることが示唆された.またスギヒラタケおよび他の食用キノコ中の遊離長鎖脂肪酸について,2-ニトロフェニルヒドラジドへ変換後,HPLC分析した.スギヒラタケの主要脂肪酸としてオレイン酸が検出され,α-エレオステアリン酸のほか,リノール酸,パルミチン酸,ステアリン酸などの飽和長鎖脂肪酸が検出された.

2012-05-15 01:40:44
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1 0 0 0 Effects of the Interaction of Tannins with Co-existing Substances. VI. : Effects of Tannins and Related Polyphenols on Superoxide Anion Radical, and on 1,1-Diphenyl-2-picrylhydrazyl Radical

著者: 波多野力枝松礼平松緑森昭胤藤田勇三郎安原多恵子吉田隆志奥田拓男
出版者: 公益社団法人日本薬学会
雑誌: Chemical & pharmaceutical bulletin (ISSN:00092363)
巻号頁・発行日: vol.37, no.8, pp.2016-2021, 1989-08-25
被引用文献数: 14 532

The scavenging effects of twenty-five tannins including low-molecular polyphenols on the superoxide anion radical (O_2^-) generated in the hypoxanthine-xanthine oxidase system were estimated by electron spin resonance (ESR) measurements of the adducts formed by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and the radical. The scavenging effects of tannins and related polyphenols having ortho-trihydroxyl (pyrogallol) structure [galloyl, hexahydroxydiphenoyl (HHDP) groups in hydrolyzable tannins, galloyl group in acylated proanthocyanidins, and the B-ring of some flavan-3-ols] were stronger than the effects of unacylated proanthocyanidins. The effects of tannins and related polyphenols on the superoxide anion radical were also compared with those on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Each tannin in an ethanol solution of DPPH radical reduced the intensity of the signal of the DPPH radical, and gave a weak signal assignable to a radical derived from that tannin, in a similar way to the appearance of the signal of dl-α-tocopherol radical, accompanied with reduction of the signal of DPPH radical, in a mixture of dl-α-tocopherol and the DPPH radical. In contrast to the case of the superoxide anion radical, the effects of unacylated proanthocyanidins on DPPH radical were comparable with those of the other types of tannins. The scavenging effects of all of the tannins and related polyphenols tested in the experiments on DPPH radical were stronger than that of dl-α-tocopherol.