著者

Nobuo Sugimoto Yoshitaka Jin Atsushi Shimizu Tomoaki Nishizawa Keiya Yumimoto

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.257-261, 2019 (Released:2019-12-26)

参考文献数

19

被引用文献数

1 8

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Mineral dust transported from Africa and Middle East was observed with the Asian Dust and aerosol lidar observation Network (AD-Net). In March 2018, the dense Sahara dust, reported by mass media as that snow in Sochi, Russia stained into orange, was transported to Sapporo in 4 days from Sochi and observed by the lidar. In April 2015, dust from Middle East was transported to Nagasaki passing across the Taklamakan desert. Dust source areas and transport paths were studied with the global aerosol transport model MASINGAR mk-2 separately calculated for different dust sources regions. The results showed that dust from Sahara and Middle East was transported to East Asia and sometimes mixed with dust from the Gobi desert and the Taklamakan desert. The analysis of recent AD-Net data after 2015 showed such long-range transport cases were observed every year in March or April. The transport path often led over the Caspian Sea, Kazakhstan, and Russia. Sahara dust transported north and reached around the Black Sea was transported long range by strong westerly in springtime.

著者

Takashi Maki Taichu Y. Tanaka Tsuyoshi Koshiro Atsushi Shimizu Tsuyoshi T. Sekiyama Mizuo Kajino Yasunori Kurosaki Toshiya Okuro Naga Oshima

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2022-035, (Released:2022-09-06)

被引用文献数

1

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Ensemble future climate projections were performed using the Meteorological Research Institute Earth System Model version 2.0 (MRI-ESM2.0) for sand and dust storms (SDS), which have a significant social, economic, and climatic impact on East Asia. A past replication experiment using MRI-ESM2.0 reproduced the decreasing trend of SDS in the Gobi Desert in the early 21st century. Prediction experiments by MRI_ESM2.0 in CMIP6 future scenarios indicated no significant differences in the total amount of SDS emissions in the Gobi Desert for 2015-2100; however, SDS emissions increased with warmer scenarios in spring and autumn. In particular, March in the highest warming scenario (SSP5-8.5) exhibited an annual increase rate in SDS emissions of 3.0% for 2015-2100. Friction velocity was the factor most highly correlated with SDS emissions, with a correlation generally higher than 0.6 for all climate scenarios throughout the year. In spring and autumn, snow cover exhibited a low negative correlation with SDS emissions, while ground temperature exhibited a positive correlation. The increase in SDS emissions and subsequent dust transport by midlatitude westerlies in spring and autumn in the accelerated warming scenarios is likely due to the changes in friction velocity and erodibility due to the decrease in snow accumulation.

著者

Shinichi Kuriyama Nobuo Yaegashi Fuji Nagami Tomohiko Arai Yoshio Kawaguchi Noriko Osumi Masaki Sakaida Yoichi Suzuki Keiko Nakayama Hiroaki Hashizume Gen Tamiya Hiroshi Kawame Kichiya Suzuki Atsushi Hozawa Naoki Nakaya Masahiro Kikuya Hirohito Metoki Ichiro Tsuji Nobuo Fuse Hideyasu Kiyomoto Junichi Sugawara Akito Tsuboi Shinichi Egawa Kiyoshi Ito Koichi Chida Tadashi Ishii Hiroaki Tomita Yasuyuki Taki Naoko Minegishi Naoto Ishii Jun Yasuda Kazuhiko Igarashi Ritsuko Shimizu Masao Nagasaki Seizo Koshiba Kengo Kinoshita Soichi Ogishima Takako Takai-Igarashi Teiji Tominaga Osamu Tanabe Noriaki Ohuchi Toru Shimosegawa Shigeo Kure Hiroshi Tanaka Sadayoshi Ito Jiro Hitomi Kozo Tanno Motoyuki Nakamura Kuniaki Ogasawara Seiichiro Kobayashi Kiyomi Sakata Mamoru Satoh Atsushi Shimizu Makoto Sasaki Ryujin Endo Kenji Sobue the Tohoku Medical Megabank Project Study Group Masayuki Yamamoto

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20150268, (Released:2016-07-02)

参考文献数

64

被引用文献数

1 227

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The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.

著者

Takashi Maki Taichu Y. Tanaka Tsuyoshi Koshiro Atsushi Shimizu Tsuyoshi T. Sekiyama Mizuo Kajino Yasunori Kurosaki Toshiya Okuro Naga Oshima

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.18, pp.218-224, 2022 (Released:2022-10-27)

参考文献数

29

被引用文献数

1

---

Ensemble future climate projections were performed using the Meteorological Research Institute Earth System Model version 2.0 (MRI-ESM2.0) for sand and dust storms (SDS), which have a significant social and climatic impact on East Asia. A replication experiment using MRI-ESM2.0 reproduced the decreasing trend of SDS emissions in the Gobi Desert in the early 21st century. Prediction experiments using MRI-ESM2.0 in Coupled Model Intercomparison Project phase 6 future scenarios indicated no considerable differences in the total amount of SDS emissions in the Gobi Desert for 2015-2100; however, SDS emissions increased with warmer scenarios in spring and autumn. In particular, March in the highest warming scenario (SSP5-8.5) exhibited an annual increase rate of 3.0% in SDS emissions for the years 2015-2100. Friction velocity was highly correlated with SDS emissions, with a correlation of ∼0.6 for all climate scenarios throughout the year. In spring and autumn, snow cover exhibited a low negative correlation with SDS emissions, while ground temperature exhibited a positive correlation. The increase in SDS emissions and subsequent dust transport by midlatitude westerlies in spring and autumn during accelerated warming scenarios could be attributed to the changes in friction velocity and erodibility due to the decrease in snow accumulation.

著者

Kei Kawai Yuta Nishio Kenji Kai Jun Noda Erdenebadrakh Munkhjargal Masato Shinoda Nobuo Sugimoto Atsushi Shimizu Enkhbaatar Davaanyam Dashdondog Batdorj

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.52-56, 2019 (Released:2019-03-07)

参考文献数

21

被引用文献数

4

---

Asian dust is transported over a long range via the mid-latitude westerlies when dust is lifted to the free troposphere over the source regions, whereas dust remaining in the atmospheric boundary layer is not transported far. In the Gobi Desert, a major source region of Asian dust, a ceilometer (compact lidar) monitors the vertical distribution of dust at Dalanzadgad, Mongolia. On 29-30 April 2015, the ceilometer observed a developed dust storm over the ground, followed by a dust layer within a height of 1.2-1.8 km. The dust storm had already developed in the upwind region before reaching Dalanzadgad. This feature was also shown in the ceilometer observation data. The dust layer remained at almost the same height for 12 h, because the dust became trapped within an inversion layer at a height of 1.2-1.5 km over cold air. This result suggests that the inversion layer prevented the dust from reaching the free troposphere, thereby restraining the long-range transport of the dust via the westerlies. This is the first paper that reports this type of vertical distribution of dust in the source region based on observation data.

著者

Sei Harada Hideki Ohmomo Minako Matsumoto Mizuki Sata Miho Iida Aya Hirata Naoko Miyagawa Kazuyo Kuwabara Suzuka Kato Ryota Toki Shun Edagawa Daisuke Sugiyama Asako Sato Akiyoshi Hirayama Masahiro Sugimoto Tomoyoshi Soga Masaru Tomita Atsushi Shimizu Tomonori Okamura Toru Takebayashi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230170, (Released:2023-11-04)

参考文献数

33

被引用文献数

1

---

Background: Heated tobacco products (HTPs) have gained global popularity, but their health risks remain unclear. Therefore, the current study aimed to identify plasma metabolites associated with smoking and HTP use in a large Japanese population to improve health risk assessment.Methods: Metabolomics data from 9,922 baseline participants of the Tsuruoka Metabolomics Cohort Study (TMCS) were analyzed to determine the association between smoking habits and plasma metabolites. Moreover, alterations in smoking-related metabolites among HTP users were examined based on data obtained from 3,334 participants involved from April 2018 to June 2019 in a follow-up survey.Results: Our study revealed that cigarette smokers had metabolomics profiles distinct from never smokers, with 22 polar metabolites identified as candidate biomarkers for smoking. These biomarker profiles of HTP users were closer to those of cigarette smokers than those of never smokers. The concentration of glutamate was higher in cigarette smokers, and biomarkers involved in glutamate metabolism were also associated with cigarette smoking and HTP use. Network pathway analysis showed that smoking was associated with the glutamate pathway, which could lead to endothelial dysfunction and atherosclerosis of the vessels.Conclusions: Our study showed that the glutamate pathway is affected by habitual smoking. These changes in the glutamate pathway may partly explain the mechanism by which cigarette smoking causes cardiovascular disease. HTP use was also associated with glutamate metabolism, indicating that HTP use may contribute to the development of cardiovascular disease through mechanisms similar to those in cigarette use.

著者

Teppei J. Yasunari Masashi Niwano Yasushi Fujiyoshi Atsushi Shimizu Masamitsu Hayasaki Teruo Aoki Arlindo M. da Silva Brent N. Holben Sumito Matoba Naoto Murao Sadamu Yamagata Kyu-Myong Kim

出版者

(公社)日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.13, pp.96-101, 2017 (Released:2017-06-01)

参考文献数

32

被引用文献数

2

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Monitoring particulate matter is essential to alert the public about health risks. The Terra/MODIS true color image clearly captured a yellow band over Hokkaido prefecture in Japan on 7 March 2016. We investigated whether this event was an Asian dust (Kosa) transport or not with the ground-based observations in Sapporo and Takikawa in Hokkaido and NASA's MERRA-2 re-analysis data. The timing of increased particle number concentrations (PNCs; greater than 0.5 μm) was clearly measured by a low-cost aerosol sensor at Sapporo and Takikawa in the early afternoon. For this particle size range, the PNC by this aerosol sensor had greater agreement with another commercial instrument for the 1-hourly mean data. The lidar data at Takikawa and NASA's AERONET at Sapporo also implied the increased dust particles (i.e., dominance of non-spherical and coarse particles, respectively), which supported that the PNC increase was due to the dust transport. The hourly PM2.5 data in Sapporo significantly increased in the evening rather than around the noon to early afternoon. We concluded that this event was judged as an Asian dust (Kosa) event in Hokkaido starting from the early afternoon, which was, however, not reported by Japan Meteorological Agency (JMA) based on their visible observations.

著者

Sei Harada Miho Iida Naoko Miyagawa Aya Hirata Kazuyo Kuwabara Minako Matsumoto Tomonori Okamura Shun Edagawa Yoko Kawada Atsuko Miyake Ryota Toki Miki Akiyama Atsuki Kawai Daisuke Sugiyama Yasunori Sato Ryo Takemura Kota Fukai Yoshiki Ishibashi Suzuka Kato Ayako Kurihara Mizuki Sata Takuma Shibuki Ayano Takeuchi Shun Kohsaka Mitsuaki Sawano Satoshi Shoji Yoshikane Izawa Masahiro Katsumata Koichi Oki Shinichi Takahashi Tsubasa Takizawa Hiroshi Maruya Yuji Nishiwaki Ryo Kawasaki Akiyoshi Hirayama Takamasa Ishikawa Rintaro Saito Asako Sato Tomoyoshi Soga Masahiro Sugimoto Masaru Tomita Shohei Komaki Hideki Ohmomo Kanako Ono Yayoi Otsuka-Yamasaki Atsushi Shimizu Yoichi Sutoh Atsushi Hozawa Kengo Kinoshita Seizo Koshiba Kazuki Kumada Soichi Ogishima Mika Sakurai-Yageta Gen Tamiya Toru Takebayashi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230192, (Released:2024-01-06)

参考文献数

40

被引用文献数

1

---

The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This study aimed to enhance the precision prevention of multi-factorial, complex diseases, including non-communicable and aging-associated diseases, by improving risk stratification and prediction measures. At baseline, 11,002 participants aged 35–74 years were recruited in Tsuruoka City, Yamagata Prefecture, Japan, between 2012 and 2015, with an ongoing follow-up survey. Participants underwent various measurements, examinations, tests, and questionnaires on their health, lifestyle, and social factors. This study used an integrative approach with deep molecular profiling to identify potential biomarkers linked to phenotypes that underpin disease pathophysiology and provide better mechanistic insights into social health determinants. The TMCS incorporates multi-omics data, including genetic and metabolomic analyses of 10,933 participants and comprehensive data collection ranging from physical, psychological, behavioral, and social to biological data. The metabolome is used as a phenotypic probe because it is sensitive to changes in physiological and external conditions. The TMCS focuses on collecting outcomes for cardiovascular disease, cancer incidence and mortality, disability, functional decline due to aging and disease sequelae, and the variation in health status within the body represented by omics analysis that lies between exposure and disease. It contains several sub-studies on aging, heated tobacco products, and women's health. This study is notable for its robust design, high participation rate (89%), and long-term repeated surveys. Moreover, it contributes to precision prevention in Japan and East Asia as a well-established multi-omics platform.

著者

Atsushi Hozawa Kozo Tanno Naoki Nakaya Tomohiro Nakamura Naho Tsuchiya Takumi Hirata Akira Narita Mana Kogure Kotaro Nochioka Ryohei Sasaki Nobuyuki Takanashi Kotaro Otsuka Kiyomi Sakata Shinichi Kuriyama Masahiro Kikuya Osamu Tanabe Junichi Sugawara Kichiya Suzuki Yoichi Suzuki Eiichi N Kodama Nobuo Fuse Hideyasu Kiyomoto Hiroaki Tomita Akira Uruno Yohei Hamanaka Hirohito Metoki Mami Ishikuro Taku Obara Tomoko Kobayashi Kazuyuki Kitatani Takako Takai-Igarashi Soichi Ogishima Mamoru Satoh Hideki Ohmomo Akito Tsuboi Shinichi Egawa Tadashi Ishii Kiyoshi Ito Sadayoshi Ito Yasuyuki Taki Naoko Minegishi Naoto Ishii Masao Nagasaki Kazuhiko Igarashi Seizo Koshiba Ritsuko Shimizu Gen Tamiya Keiko Nakayama Hozumi Motohashi Jun Yasuda Atsushi Shimizu Tsuyoshi Hachiya Yuh Shiwa Teiji Tominaga Hiroshi Tanaka Kotaro Oyama Ryoichi Tanaka Hiroshi Kawame Akimune Fukushima Yasushi Ishigaki Tomoharu Tokutomi Noriko Osumi Tadao Kobayashi Fuji Nagami Hiroaki Hashizume Tomohiko Arai Yoshio Kawaguchi Shinichi Higuchi Masaki Sakaida Ryujin Endo Satoshi Nishizuka Ichiro Tsuji Jiro Hitomi Motoyuki Nakamura Kuniaki Ogasawara Nobuo Yaegashi Kengo Kinoshita Shigeo Kure Akio Sakai Seiichiro Kobayashi Kenji Sobue Makoto Sasaki Masayuki Yamamoto

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.31, no.1, pp.65-76, 2021-01-05 (Released:2021-01-05)

参考文献数

34

被引用文献数

54 78

---

Background: We established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environment interactions on the incidence of major diseases, such as cancer and cardiovascular diseases.Methods: We asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria were aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), such as carotid echography and calcaneal ultrasound bone mineral density. All participants agreed to measure genome information and to distribute their information widely.Results: As a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants in the Type 1 survey were more likely to have psychological distress than those in the Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents, regardless of sex.Conclusion: This cohort comprised a large sample size and it contains information on the natural disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of the disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.

著者

Atsushi Goto Shiori Suzuki Ryoko Katagiri Taiki Yamaji Norie Sawada Masahiro Nakatochi Kenji Wakai Atsushi Hozawa Kengo Kinoshita Kozo Tanno Atsushi Shimizu Hidemi Ito Keitaro Matsuo Motoki Iwasaki

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.2, pp.115-116, 2022-02-05 (Released:2022-02-05)

参考文献数

5

著者

Junichi Sugawara Mami Ishikuro Taku Obara Tomomi Onuma Keiko Murakami Masahiro Kikuya Fumihiko Ueno Aoi Noda Satoshi Mizuno Tomoko Kobayashi Yohei Hamanaka Kichiya Suzuki Eiichi Kodama Naho Tsuchiya Akira Uruno Yoichi Suzuki Osamu Tanabe Hideyasu Kiyomoto Akito Tsuboi Atsushi Shimizu Seizo Koshiba Naoko Minegishi Soichi Ogishima Gen Tamiya Hirohito Metoki Atsushi Hozawa Nobuo Fuse Kengo Kinoshita Shigeo Kure Nobuo Yaegashi Shinichi Kuriyama Masayuki Yamamoto

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.32, no.2, pp.69-79, 2022-02-05 (Released:2022-02-05)

参考文献数

33

被引用文献数

3 11

---

Background: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants.Methods: Expectant mothers living in Miyagi Prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group.Results: A total of 23,406 pregnancies involving 23,730 fetuses resulted in 23,143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes, and hypertensive disorders of pregnancy.Conclusions: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.

著者

Kazunori UEDA Tomoyuki KAWAI Haruki SENNO Atsushi SHIMIZU Akira ISHIKO Masahiko NAGATA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0115, (Released:2018-07-06)

被引用文献数

7

---

Patellar luxation is abnormal displacement of the patella from the femoral trochlear groove. It is seen primarily in small breed dogs and causes pain and limited mobility of the stifle joint. This study aimed to investigate the relationship among patellar luxation, skin extension, and skin collagen fibril diameter. Nine dogs with patellar luxation and five clinically normal dogs were enrolled in the study. We measured the skin extension and investigated the ultrastructure of the skin and patellofemoral ligament by histopathology and transmission electron microscopy. The mean skin extension in dogs with patellar luxation was 18.5 ± 5.5% which is greater than the reference value (14.5%). Mean skin extension in controls was 8.8 ± 1.7% and was within the normal range. In dogs with patellar luxation, histopathology of the skin and patellofemoral ligament showed sparse and unevenly distributed collagen fibers. Transmission electron microscopy identified poorly organized, irregularly shaped, thin collagen fibrils. Collagen fibril thickness in dogs with patellar luxation was significantly less than fibril thickness in controls (P<0.001). There was a significant negative correlation (ρ= −0.863; P<0.001) between skin collagen fibril diameter and skin extension. Skin extension was correlated with patellar luxation and disease severity. Dogs with patellar luxation, joint dysplasia, and hyperextensible skin appear to be pathologically related. This might represent a phenotype of the Ehlers–Danlos syndrome, a hereditary connective tissue disorder in humans.

著者

Takahiro Nakamura Masahiro Hashizume Kayo Ueda Tatsuhiko Kubo Atsushi Shimizu Tomonori Okamura Yuji Nishiwaki

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.25, no.4, pp.289-296, 2015-04-05 (Released:2015-04-05)

参考文献数

21

被引用文献数

1 12

---

Background: Asian dust events are caused by dust storms that originate in the deserts of China and Mongolia and drift across East Asia. We hypothesized that the dust events would increase incidence of out-of-hospital cardiac arrests by triggering acute events or exacerbating chronic diseases.Methods: We analyzed the Utstein-Style data collected in 2005 to 2008 from seven prefectures covering almost the entire length of Japan to investigate the effect of Asian dust events on out-of-hospital cardiac arrests. Asian dust events were defined by the measurement of light detection and ranging. A time-stratified case-crossover analysis was performed. The strength of the association between Asian dust events and out-of-hospital cardiac arrests was shown by odds ratios and 95% confidence intervals in two conditional logistic models. A pooled estimate was obtained from area-specific results by random-effect meta-analysis.Results: The total number of cases of out-of-hospital cardiac arrest was 59 273, of which 35 460 were in men and 23 813 were in women. The total number of event days during the study period was smallest in Miyagi and Niigata and largest in Shimane and Nagasaki. There was no significant relationship between Asian dust events and out-of-hospital cardiac arrests by area in either of the models. In the pooled analysis, the highest odds ratios were observed at lag day 1 in both model 1 (OR 1.07; 95% CI, 0.97–1.19) and model 2 (OR 1.08; 95% CI, 0.97–1.20). However, these results were not statistically significant.Conclusions: We found no evidence of an association between Asian dust events and out-of-hospital cardiac arrests.

著者

Tomoshige BABA Atsushi SHIMIZU Tamio OHMURO Naohiro UCHIDA Kumiko SHIBATA Masahiko NAGATA Kinji SHIROTA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.71, no.1, pp.79-82, 2009 (Released:2009-02-05)

参考文献数

12

被引用文献数

2 8 2

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An adult, Japanese domestic cat presented with bilateral swelling, distortion, and erythema of ears and deformation of the limbs. Biopsy of the pinnae confirmed auricular chondritis. These lesions and the cat's general condition subsequently deteriorated, and the cat died. At necropsy, chondral changes were present in the pinnae, costae, larynx, trachea, and limbs. Histopathologically, these chondral tissues showed marked deformation with lymphocytic inflammation. The limb joint inflammation was associated with chondral erosion, deformation of subchondral bones with pannus, and thinning of cancellous bones. These lesions were consistent with the diagnostic criteria for human relapsing polychondritis. However, the cat had erosive arthritis, which appeared to be different from human relapsing polychondritis.

著者

Atsushi YABUZOE Koji NISHIFUJI Maiko SEKIGUCHI Atsushi SHIMIZU Yasuyuki MOMOI Akira ISHIKO Toshiroh IWASAKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.70, no.8, pp.807-812, 2008 (Released:2008-09-05)

参考文献数

19

被引用文献数

3 8

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Pemphigus foliaceus (PF) is an autoimmune blistering skin disease that affects certain mammals including dogs. In canine PF, neutrophils are infiltrated intensely into pustular lesions including acantholytic cells, although neutrophilic infiltration is not characterized in human PF. The roles of the neutrophils in the cutaneous lesions of canine PF have not yet been understood. The purpose of this study was to characterize the ultrastructural features underlying the acantholysis with pustule formation in canine PF. Four dogs diagnosed as PF on the basis of clinical signs, histopathological findings, and direct and indirect immunofluorescence examinations were performed. Electron microscopy revealed that the acantholytic cells were adjacent to multiple neutrophils in the pustules. At the contact points between neutrophils and acantholytic keratinocytes, half-desmosomes of acantholytic keratinocytes with intact attachment plaques were observed within invaginations of neutrophils. Furthermore, on the surface of acantholytic cells in the pustules, neutrophil granules seemed to be secreted to the surface of acantholytic cells and to degenerate the half-desmosome structures. Neutrophils were also observed within the epidermis adjacent to the pustule. At the intercellular gap between two dissociated keratinocytes, neutrophils inserted its pseudopodia into the gap between the two half-desmosomes of keratinocytes. These findings taken together suggested that, at least in the areas where we analyzed ultrastructurally, neutrophils contact desmosomal structures and seem to play some parts in separation of keratinocytes and degeneration of split-desmosomes in pustules of dogs with PF.